How relevant is panallergen sensitization in the development of allergies?
Identifieur interne : 000177 ( Main/Exploration ); précédent : 000176; suivant : 000178How relevant is panallergen sensitization in the development of allergies?
Auteurs : Olivia E. Mckenna ; Claudia Asam ; Galber R. Araujo ; Anargyros Roulias ; Luiz R. Goulart ; Fatima FerreiraSource :
- Pediatric Allergy and Immunology [ 0905-6157 ] ; 2016.
Abstract
Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross‐reactivity between related and unrelated allergenic sources. Such cross‐reactivities include reactions between various pollen sources, pollen and plant‐derived foods as well as invertebrate‐derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non‐specific lipid transfer proteins, pathogenesis‐related protein family 10 members) and on the prominent animal‐derived panallergen family, tropomyosins. In addition, we explore the role of panallergens in the sensitization process and progress of the allergic disease. Emphasis is given on epidemiological aspects of panallergen sensitization and clinical manifestations. Finally, the issues related to diagnosis and therapy of patients sensitized to panallergens are outlined, and the use of panallergens as predictors for cross‐reactive allergy and as biomarkers for disease severity is discussed.
Url:
DOI: 10.1111/pai.12589
PubMed: 27129102
PubMed Central: 5006871
Affiliations:
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Such cross‐reactivities include reactions between various pollen sources, pollen and plant‐derived foods as well as invertebrate‐derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non‐specific lipid transfer proteins, pathogenesis‐related protein family 10 members) and on the prominent animal‐derived panallergen family, tropomyosins. In addition, we explore the role of panallergens in the sensitization process and progress of the allergic disease. Emphasis is given on epidemiological aspects of panallergen sensitization and clinical manifestations. 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