Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Identifieur interne : 002291 ( Main/Curation ); précédent : 002290; suivant : 002292Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Auteurs : Shiming Li [États-Unis] ; Min-Hsiung Pan ; Ching-Shu Lai ; Chih-Yu Lo ; Slavik Dushenkov ; Chi-Tang HoSource :
- Bioorganic & medicinal chemistry [ 0968-0896 ] ; 2007.
English descriptors
- KwdEn :
- Anticarcinogenic Agents (chemical synthesis), Anticarcinogenic Agents (pharmacology), Antineoplastic Agents, Phytogenic (chemical synthesis), Antineoplastic Agents, Phytogenic (isolation & purification), Antineoplastic Agents, Phytogenic (pharmacology), Apoptosis (drug effects), Cell Proliferation (drug effects), Chromatography, High Pressure Liquid, Citrus (chemistry), Flavones (isolation & purification), Flavones (physiology), Fruit (chemistry), HL-60 Cells, Humans, Hydroxylation, Indicators and Reagents, Magnetic Resonance Spectroscopy, Plant Extracts (chemistry), Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Ultraviolet.
- MESH :
- chemical , chemical synthesis : Anticarcinogenic Agents, Antineoplastic Agents, Phytogenic.
- chemical , chemistry : Plant Extracts.
- chemical , isolation & purification : Antineoplastic Agents, Phytogenic, Flavones.
- chemical , pharmacology : Anticarcinogenic Agents, Antineoplastic Agents, Phytogenic.
- chemistry : Citrus, Fruit.
- drug effects : Apoptosis, Cell Proliferation.
- chemical , physiology : Flavones.
- Chromatography, High Pressure Liquid, HL-60 Cells, Humans, Hydroxylation, Indicators and Reagents, Magnetic Resonance Spectroscopy, Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Ultraviolet.
Abstract
Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.
DOI: 10.1016/j.bmc.2007.03.021
PubMed: 17391969
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pubmed:17391969Le document en format XML
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<series><title level="j">Bioorganic & medicinal chemistry</title>
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<front><div type="abstract" xml:lang="en">Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.</div>
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