Overcoming matrix effects using the dilution approach in multiresidue methods for fruits and vegetables.
Identifieur interne : 001676 ( Main/Curation ); précédent : 001675; suivant : 001677Overcoming matrix effects using the dilution approach in multiresidue methods for fruits and vegetables.
Auteurs : Carmen Ferrer [Espagne] ; Ana Lozano ; Ana Agüera ; A Jiménez Gir N ; A R Fernández-AlbaSource :
- Journal of chromatography. A [ 1873-3778 ] ; 2011.
English descriptors
- KwdEn :
- Calibration, Chromatography, Liquid (methods), Citrus sinensis, Food Analysis (methods), Food Analysis (standards), Fruit (chemistry), Indicator Dilution Techniques, Lycopersicon esculentum, Onions, Pesticide Residues (analysis), Sensitivity and Specificity, Tandem Mass Spectrometry (methods), Vegetables (chemistry).
- MESH :
- chemical , analysis : Pesticide Residues.
- chemistry : Fruit, Vegetables.
- methods : Chromatography, Liquid, Food Analysis, Tandem Mass Spectrometry.
- standards : Food Analysis.
- Calibration, Citrus sinensis, Indicator Dilution Techniques, Lycopersicon esculentum, Onions, Sensitivity and Specificity.
Abstract
During recent years matrix effects in liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) have quickly become a major concern in food analysis. The phenomenon of ion suppression can lead to errors in the quantification of the analytes of interest, as well as can affect detection capability, precision, and accuracy of the method. Sample dilution is an easy and effective method to reduce interfering compounds, and so, to diminish matrix effects. In this work, matrix effects of 53 pesticides in three different matrices (orange, tomato and leek) were evaluated. Several dilutions of the matrix were tested in order to study the evolution of signal suppression. Dilution of the extracts led to a reduction of the signal suppression in most of the cases. A dilution factor of 15 demonstrated to be enough to eliminate most of the matrix effects, opening the possibility to perform quantification with solvent based standards in the majority of the cases. In those cases where signal suppression could not be reduced, a possible solution would be to use stable isotope-labelled internal standards for quantification of the problematic pesticides.
DOI: 10.1016/j.chroma.2011.07.033
PubMed: 21820661
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Overcoming matrix effects using the dilution approach in multiresidue methods for fruits and vegetables.</title><author><name sortKey="Ferrer, Carmen" sort="Ferrer, Carmen" uniqKey="Ferrer C" first="Carmen" last="Ferrer">Carmen Ferrer</name><affiliation wicri:level="1"><nlm:affiliation>European Union Reference Laboratory (DG SANCO) for Residues of Pesticides in Fruits and Vegetables, Pesticide Residue Research Group, Department of Hydrogeology and Analytical Chemistry, University of Almería, 04120 La Cañada de San Urbano, Almería, Spain. cferrer@ual.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>European Union Reference Laboratory (DG SANCO) for Residues of Pesticides in Fruits and Vegetables, Pesticide Residue Research Group, Department of Hydrogeology and Analytical Chemistry, University of Almería, 04120 La Cañada de San Urbano, Almería</wicri:regionArea><wicri:noRegion>Almería</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, Ana" sort="Lozano, Ana" uniqKey="Lozano A" first="Ana" last="Lozano">Ana Lozano</name></author><author><name sortKey="Aguera, Ana" sort="Aguera, Ana" uniqKey="Aguera A" first="Ana" last="Agüera">Ana Agüera</name></author><author><name sortKey="Gir N, A Jimenez" sort="Gir N, A Jimenez" uniqKey="Gir N A" first="A Jiménez" last="Gir N">A Jiménez Gir N</name></author><author><name sortKey="Fernandez Alba, A R" sort="Fernandez Alba, A R" uniqKey="Fernandez Alba A" first="A R" last="Fernández-Alba">A R Fernández-Alba</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21820661</idno><idno type="pmid">21820661</idno><idno type="doi">10.1016/j.chroma.2011.07.033</idno><idno type="wicri:Area/PubMed/Corpus">000694</idno><idno type="wicri:Area/PubMed/Curation">000694</idno><idno type="wicri:Area/PubMed/Checkpoint">000694</idno><idno type="wicri:Area/Ncbi/Merge">000D88</idno><idno type="wicri:Area/Ncbi/Curation">000D88</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D88</idno><idno type="wicri:Area/Main/Merge">001698</idno><idno type="wicri:Area/Main/Curation">001676</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Overcoming matrix effects using the dilution approach in multiresidue methods for fruits and vegetables.</title><author><name sortKey="Ferrer, Carmen" sort="Ferrer, Carmen" uniqKey="Ferrer C" first="Carmen" last="Ferrer">Carmen Ferrer</name><affiliation wicri:level="1"><nlm:affiliation>European Union Reference Laboratory (DG SANCO) for Residues of Pesticides in Fruits and Vegetables, Pesticide Residue Research Group, Department of Hydrogeology and Analytical Chemistry, University of Almería, 04120 La Cañada de San Urbano, Almería, Spain. cferrer@ual.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>European Union Reference Laboratory (DG SANCO) for Residues of Pesticides in Fruits and Vegetables, Pesticide Residue Research Group, Department of Hydrogeology and Analytical Chemistry, University of Almería, 04120 La Cañada de San Urbano, Almería</wicri:regionArea><wicri:noRegion>Almería</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, Ana" sort="Lozano, Ana" uniqKey="Lozano A" first="Ana" last="Lozano">Ana Lozano</name></author><author><name sortKey="Aguera, Ana" sort="Aguera, Ana" uniqKey="Aguera A" first="Ana" last="Agüera">Ana Agüera</name></author><author><name sortKey="Gir N, A Jimenez" sort="Gir N, A Jimenez" uniqKey="Gir N A" first="A Jiménez" last="Gir N">A Jiménez Gir N</name></author><author><name sortKey="Fernandez Alba, A R" sort="Fernandez Alba, A R" uniqKey="Fernandez Alba A" first="A R" last="Fernández-Alba">A R Fernández-Alba</name></author></analytic><series><title level="j">Journal of chromatography. A</title><idno type="eISSN">1873-3778</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calibration</term><term>Chromatography, Liquid (methods)</term><term>Citrus sinensis</term><term>Food Analysis (methods)</term><term>Food Analysis (standards)</term><term>Fruit (chemistry)</term><term>Indicator Dilution Techniques</term><term>Lycopersicon esculentum</term><term>Onions</term><term>Pesticide Residues (analysis)</term><term>Sensitivity and Specificity</term><term>Tandem Mass Spectrometry (methods)</term><term>Vegetables (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Pesticide Residues</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fruit</term><term>Vegetables</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Liquid</term><term>Food Analysis</term><term>Tandem Mass Spectrometry</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Food Analysis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Calibration</term><term>Citrus sinensis</term><term>Indicator Dilution Techniques</term><term>Lycopersicon esculentum</term><term>Onions</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During recent years matrix effects in liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) have quickly become a major concern in food analysis. The phenomenon of ion suppression can lead to errors in the quantification of the analytes of interest, as well as can affect detection capability, precision, and accuracy of the method. Sample dilution is an easy and effective method to reduce interfering compounds, and so, to diminish matrix effects. In this work, matrix effects of 53 pesticides in three different matrices (orange, tomato and leek) were evaluated. Several dilutions of the matrix were tested in order to study the evolution of signal suppression. Dilution of the extracts led to a reduction of the signal suppression in most of the cases. A dilution factor of 15 demonstrated to be enough to eliminate most of the matrix effects, opening the possibility to perform quantification with solvent based standards in the majority of the cases. In those cases where signal suppression could not be reduced, a possible solution would be to use stable isotope-labelled internal standards for quantification of the problematic pesticides.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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