Protective effects of a red orange extract on UVB‐induced damage in human keratinocytes
Identifieur interne : 000678 ( Istex/Corpus ); précédent : 000677; suivant : 000679Protective effects of a red orange extract on UVB‐induced damage in human keratinocytes
Auteurs : Francesco Cimino ; Mariateresa Cristani ; Antonina Saija ; Franco Paolo Bonina ; Fabio VirgiliSource :
- BioFactors [ 0951-6433 ] ; 2007.
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Abstract
UV light is considered one of the major etiological factor in skin aging, cancer and also to systemic impairment such as immunosuppression. Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB‐induced response, and in particular some events associated to inflammation and apoptosis, such as NF‐kB and AP‐1 translocation and procaspase‐3 cleavage. This activity is probably due to a block of cellular oxidative stress‐related events. Thus we can propose ROE as a useful natural standardised extract in skin photoprotection with promising applications in the field of dermatology.
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DOI: 10.1002/biof.5520300206
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ISTEX:2697DE5976F5FB3A405AEE61F3CDD43D8F588445Le document en format XML
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Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB‐induced response, and in particular some events associated to inflammation and apoptosis, such as NF‐kB and AP‐1 translocation and procaspase‐3 cleavage. This activity is probably due to a block of cellular oxidative stress‐related events. 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Tel.: +39 090 6766574; Fax: +39 090 6766474</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mariateresa</namePart><namePart type="family">Cristani</namePart><affiliation>Department of Farmaco‐Biologico, University of Messina, Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonina</namePart><namePart type="family">Saija</namePart><affiliation>Department of Farmaco‐Biologico, University of Messina, Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Franco Paolo</namePart><namePart type="family">Bonina</namePart><affiliation>Department of Scienze Farmaceutiche, Universit a di Catania, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabio</namePart><namePart type="family">Virgili</namePart><affiliation>Istituto Nazionale di Ricerca per gli Alimenti e Nutrizione (I.N.R.A.N.), Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>IOS Press</publisher><place><placeTerm type="text">Amsterdam</placeTerm></place><dateIssued encoding="w3cdtf">2007</dateIssued><dateCaptured encoding="w3cdtf">2007-09-10</dateCaptured><dateValid encoding="w3cdtf">2007-12-08</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="references">44</extent></physicalDescription><abstract lang="en">UV light is considered one of the major etiological factor in skin aging, cancer and also to systemic impairment such as immunosuppression. Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB‐induced response, and in particular some events associated to inflammation and apoptosis, such as NF‐kB and AP‐1 translocation and procaspase‐3 cleavage. This activity is probably due to a block of cellular oxidative stress‐related events. Thus we can propose ROE as a useful natural standardised extract in skin photoprotection with promising applications in the field of dermatology.</abstract><note type="funding">Italian Government</note><subject lang="en"><genre>keywords</genre><topic>Red orange extract</topic><topic>UVB</topic><topic>skin</topic><topic>inflammation</topic><topic>apoptosis</topic><topic>keratinocyte</topic></subject><relatedItem type="host"><titleInfo><title>BioFactors</title></titleInfo><titleInfo type="abbreviated"><title>BioFactors</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Article</topic></subject><identifier type="ISSN">0951-6433</identifier><identifier type="eISSN">1872-8081</identifier><identifier type="DOI">10.1002/(ISSN)1872-8081</identifier><identifier type="PublisherID">BIOF</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>129</start><end>138</end><total>10</total></extent></part></relatedItem><identifier type="istex">2697DE5976F5FB3A405AEE61F3CDD43D8F588445</identifier><identifier type="DOI">10.1002/biof.5520300206</identifier><identifier type="ArticleID">BIOF5520300206</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 International Union of Biochemistry and Molecular Biology, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>IOS Press</recordOrigin></recordInfo></mods></metadata><enrichments><json:item><type>multicat</type><uri>https://api.istex.fr/document/2697DE5976F5FB3A405AEE61F3CDD43D8F588445/enrichments/multicat</uri></json:item></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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