Fatty acids in arbuscular mycorrhizal fungi are synthesized by the host plant.
Identifieur interne : 000C39 ( Main/Corpus ); précédent : 000C38; suivant : 000C40Fatty acids in arbuscular mycorrhizal fungi are synthesized by the host plant.
Auteurs : Leonie H. Luginbuehl ; Guillaume N. Menard ; Smita Kurup ; Harrie Van Erp ; Guru V. Radhakrishnan ; Andrew Breakspear ; Giles E D. Oldroyd ; Peter J. EastmondSource :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2017.
English descriptors
- KwdEn :
- Fatty Acids (biosynthesis), Fatty Acids (metabolism), Gene Expression Regulation, Fungal (genetics), Gene Expression Regulation, Plant (genetics), Host-Parasite Interactions (physiology), Medicago truncatula (microbiology), Medicago truncatula (physiology), Mycorrhizae (metabolism), Plant Roots (metabolism), Plant Roots (microbiology), Symbiosis (MeSH).
- MESH :
- chemical , biosynthesis : Fatty Acids.
- chemical , metabolism : Fatty Acids.
- genetics : Gene Expression Regulation, Fungal, Gene Expression Regulation, Plant.
- metabolism : Mycorrhizae, Plant Roots.
- microbiology : Medicago truncatula, Plant Roots.
- physiology : Host-Parasite Interactions, Medicago truncatula.
- Symbiosis.
Abstract
Plants form beneficial associations with arbuscular mycorrhizal fungi, which facilitate nutrient acquisition from the soil. In return, the fungi receive organic carbon from the plants. The transcription factor RAM1 (REQUIRED FOR ARBUSCULAR MYCORRHIZATION 1) is crucial for this symbiosis, and we demonstrate that it is required and sufficient for the induction of a lipid biosynthetic pathway that is expressed in plant cells accommodating fungal arbuscules. Lipids are transferred from the plant to mycorrhizal fungi, which are fatty acid auxotrophs, and this lipid export requires the glycerol-3-phosphate acyltransferase RAM2, a direct target of RAM1. Our work shows that in addition to sugars, lipids are a major source of organic carbon delivered to the fungus, and this is necessary for the production of fungal lipids.
DOI: 10.1126/science.aan0081
PubMed: 28596311
Links to Exploration step
pubmed:28596311Le document en format XML
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Menard</name><affiliation><nlm:affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kurup, Smita" sort="Kurup, Smita" uniqKey="Kurup S" first="Smita" last="Kurup">Smita Kurup</name><affiliation><nlm:affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Erp, Harrie" sort="Van Erp, Harrie" uniqKey="Van Erp H" first="Harrie" last="Van Erp">Harrie Van Erp</name><affiliation><nlm:affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Radhakrishnan, Guru V" sort="Radhakrishnan, Guru V" uniqKey="Radhakrishnan G" first="Guru V" last="Radhakrishnan">Guru V. Radhakrishnan</name><affiliation><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Breakspear, Andrew" sort="Breakspear, Andrew" uniqKey="Breakspear A" first="Andrew" last="Breakspear">Andrew Breakspear</name><affiliation><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Oldroyd, Giles E D" sort="Oldroyd, Giles E D" uniqKey="Oldroyd G" first="Giles E D" last="Oldroyd">Giles E D. 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Eastmond</name><affiliation><nlm:affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK. giles.oldroyd@jic.ac.uk peter.eastmond@rothamsted.ac.uk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28596311</idno><idno type="pmid">28596311</idno><idno type="doi">10.1126/science.aan0081</idno><idno type="wicri:Area/Main/Corpus">000C39</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Fatty acids in arbuscular mycorrhizal fungi are synthesized by the host plant.</title><author><name sortKey="Luginbuehl, Leonie H" sort="Luginbuehl, Leonie H" uniqKey="Luginbuehl L" first="Leonie H" last="Luginbuehl">Leonie H. Luginbuehl</name><affiliation><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Menard, Guillaume N" sort="Menard, Guillaume N" uniqKey="Menard G" first="Guillaume N" last="Menard">Guillaume N. Menard</name><affiliation><nlm:affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kurup, Smita" sort="Kurup, Smita" uniqKey="Kurup S" first="Smita" last="Kurup">Smita Kurup</name><affiliation><nlm:affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Erp, Harrie" sort="Van Erp, Harrie" uniqKey="Van Erp H" first="Harrie" last="Van Erp">Harrie Van Erp</name><affiliation><nlm:affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Radhakrishnan, Guru V" sort="Radhakrishnan, Guru V" uniqKey="Radhakrishnan G" first="Guru V" last="Radhakrishnan">Guru V. Radhakrishnan</name><affiliation><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Breakspear, Andrew" sort="Breakspear, Andrew" uniqKey="Breakspear A" first="Andrew" last="Breakspear">Andrew Breakspear</name><affiliation><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Oldroyd, Giles E D" sort="Oldroyd, Giles E D" uniqKey="Oldroyd G" first="Giles E D" last="Oldroyd">Giles E D. Oldroyd</name><affiliation><nlm:affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. giles.oldroyd@jic.ac.uk peter.eastmond@rothamsted.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Eastmond, Peter J" sort="Eastmond, Peter J" uniqKey="Eastmond P" first="Peter J" last="Eastmond">Peter J. Eastmond</name><affiliation><nlm:affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK. giles.oldroyd@jic.ac.uk peter.eastmond@rothamsted.ac.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="eISSN">1095-9203</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fatty Acids (biosynthesis)</term><term>Fatty Acids (metabolism)</term><term>Gene Expression Regulation, Fungal (genetics)</term><term>Gene Expression Regulation, Plant (genetics)</term><term>Host-Parasite Interactions (physiology)</term><term>Medicago truncatula (microbiology)</term><term>Medicago truncatula (physiology)</term><term>Mycorrhizae (metabolism)</term><term>Plant Roots (metabolism)</term><term>Plant Roots (microbiology)</term><term>Symbiosis (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Fatty Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fatty Acids</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation, Fungal</term><term>Gene Expression Regulation, Plant</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mycorrhizae</term><term>Plant Roots</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Medicago truncatula</term><term>Plant Roots</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Host-Parasite Interactions</term><term>Medicago truncatula</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Symbiosis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plants form beneficial associations with arbuscular mycorrhizal fungi, which facilitate nutrient acquisition from the soil. In return, the fungi receive organic carbon from the plants. The transcription factor RAM1 (REQUIRED FOR ARBUSCULAR MYCORRHIZATION 1) is crucial for this symbiosis, and we demonstrate that it is required and sufficient for the induction of a lipid biosynthetic pathway that is expressed in plant cells accommodating fungal arbuscules. Lipids are transferred from the plant to mycorrhizal fungi, which are fatty acid auxotrophs, and this lipid export requires the glycerol-3-phosphate acyltransferase RAM2, a direct target of RAM1. Our work shows that in addition to sugars, lipids are a major source of organic carbon delivered to the fungus, and this is necessary for the production of fungal lipids.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28596311</PMID><DateCompleted><Year>2018</Year><Month>01</Month><Day>25</Day></DateCompleted><DateRevised><Year>2018</Year><Month>05</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9203</ISSN><JournalIssue CitedMedium="Internet"><Volume>356</Volume><Issue>6343</Issue><PubDate><Year>2017</Year><Month>06</Month><Day>16</Day></PubDate></JournalIssue><Title>Science (New York, N.Y.)</Title><ISOAbbreviation>Science</ISOAbbreviation></Journal><ArticleTitle>Fatty acids in arbuscular mycorrhizal fungi are synthesized by the host plant.</ArticleTitle><Pagination><MedlinePgn>1175-1178</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1126/science.aan0081</ELocationID><Abstract><AbstractText>Plants form beneficial associations with arbuscular mycorrhizal fungi, which facilitate nutrient acquisition from the soil. In return, the fungi receive organic carbon from the plants. The transcription factor RAM1 (REQUIRED FOR ARBUSCULAR MYCORRHIZATION 1) is crucial for this symbiosis, and we demonstrate that it is required and sufficient for the induction of a lipid biosynthetic pathway that is expressed in plant cells accommodating fungal arbuscules. Lipids are transferred from the plant to mycorrhizal fungi, which are fatty acid auxotrophs, and this lipid export requires the glycerol-3-phosphate acyltransferase RAM2, a direct target of RAM1. Our work shows that in addition to sugars, lipids are a major source of organic carbon delivered to the fungus, and this is necessary for the production of fungal lipids.</AbstractText><CopyrightInformation>Copyright © 2017, American Association for the Advancement of Science.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Luginbuehl</LastName><ForeName>Leonie H</ForeName><Initials>LH</Initials><Identifier Source="ORCID">0000-0002-7353-2556</Identifier><AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Menard</LastName><ForeName>Guillaume N</ForeName><Initials>GN</Initials><Identifier Source="ORCID">0000-0002-2187-9013</Identifier><AffiliationInfo><Affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kurup</LastName><ForeName>Smita</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0003-1035-7065</Identifier><AffiliationInfo><Affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Erp</LastName><ForeName>Harrie</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0002-4778-8988</Identifier><AffiliationInfo><Affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Radhakrishnan</LastName><ForeName>Guru V</ForeName><Initials>GV</Initials><Identifier Source="ORCID">0000-0003-0381-8804</Identifier><AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Breakspear</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-1863-3012</Identifier><AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oldroyd</LastName><ForeName>Giles E D</ForeName><Initials>GED</Initials><Identifier Source="ORCID">0000-0002-5245-6355</Identifier><AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. giles.oldroyd@jic.ac.uk peter.eastmond@rothamsted.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eastmond</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><Identifier Source="ORCID">0000-0003-4526-5136</Identifier><AffiliationInfo><Affiliation>Department of Plant Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK. giles.oldroyd@jic.ac.uk peter.eastmond@rothamsted.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>BBS/E/J/000CA336</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Science</MedlineTA><NlmUniqueID>0404511</NlmUniqueID><ISSNLinking>0036-8075</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005227">Fatty Acids</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D005227" MajorTopicYN="N">Fatty Acids</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018506" MajorTopicYN="N">Gene Expression Regulation, Plant</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006790" MajorTopicYN="N">Host-Parasite Interactions</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D046913" MajorTopicYN="N">Medicago truncatula</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D038821" MajorTopicYN="N">Mycorrhizae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013559" MajorTopicYN="Y">Symbiosis</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>1</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28596311</ArticleId><ArticleId IdType="pii">science.aan0081</ArticleId><ArticleId IdType="doi">10.1126/science.aan0081</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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