Positive selection in AvrP4 avirulence gene homologues across the genus Melampsora.
Identifieur interne : 000126 ( PubMed/Corpus ); précédent : 000125; suivant : 000127Positive selection in AvrP4 avirulence gene homologues across the genus Melampsora.
Auteurs : Marlien M. Van Der Merwe ; Mark W. Kinnear ; Luke G. Barrett ; Peter N. Dodds ; Lars Ericson ; Peter H. Thrall ; Jeremy J. BurdonSource :
- Proceedings. Biological sciences [ 0962-8452 ] ; 2009.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Fungal Proteins (chemistry), Fungal Proteins (genetics), Fungal Proteins (metabolism), Fungi (classification), Fungi (genetics), Fungi (pathogenicity), Gene Expression Regulation, Fungal (physiology), Genetic Variation (MeSH), Molecular Sequence Data (MeSH), Phylogeny (MeSH), Plant Diseases (microbiology), Selection, Genetic (MeSH), Virulence (MeSH).
- MESH :
- chemical , chemistry : Fungal Proteins.
- chemical , genetics : Fungal Proteins.
- chemical , metabolism : Fungal Proteins.
- classification : Fungi.
- genetics : Fungi.
- microbiology : Plant Diseases.
- pathogenicity : Fungi.
- physiology : Gene Expression Regulation, Fungal.
- Amino Acid Sequence, Genetic Variation, Molecular Sequence Data, Phylogeny, Selection, Genetic, Virulence.
Abstract
Pathogen genes involved in interactions with their plant hosts are expected to evolve under positive Darwinian selection or balancing selection. In this study a single copy avirulence gene, AvrP4, in the plant pathogen Melampsora lini, was used to investigate the evolution of such a gene across species. Partial translation elongation factor 1-alpha sequences were obtained to establish phylogenetic relationships among the Melampsora species. We amplified AvrP4 homologues from species pathogenic on hosts from different plant families and orders, across the inferred phylogeny. Translations of the AvrP4 sequences revealed a predicted signal peptide and towards the C-terminus of the protein, six identically spaced cysteines were identified in all sequences. Maximum likelihood analysis of synonymous versus non-synonymous substitution rates indicated that positive selection played a role in the evolution of the gene during the diversification of the genus. Fourteen codons under significant positive selection reside in the C-terminal 28 amino acid region, suggesting that this region interacts with host molecules in most sequenced accessions. Selection pressures on the gene may be either due to the pathogenicity or avirulence function of the gene or both.
DOI: 10.1098/rspb.2009.0328
PubMed: 19457888
PubMed Central: PMC2817207
Links to Exploration step
pubmed:19457888Le document en format XML
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<front><div type="abstract" xml:lang="en">Pathogen genes involved in interactions with their plant hosts are expected to evolve under positive Darwinian selection or balancing selection. In this study a single copy avirulence gene, AvrP4, in the plant pathogen Melampsora lini, was used to investigate the evolution of such a gene across species. Partial translation elongation factor 1-alpha sequences were obtained to establish phylogenetic relationships among the Melampsora species. We amplified AvrP4 homologues from species pathogenic on hosts from different plant families and orders, across the inferred phylogeny. Translations of the AvrP4 sequences revealed a predicted signal peptide and towards the C-terminus of the protein, six identically spaced cysteines were identified in all sequences. Maximum likelihood analysis of synonymous versus non-synonymous substitution rates indicated that positive selection played a role in the evolution of the gene during the diversification of the genus. Fourteen codons under significant positive selection reside in the C-terminal 28 amino acid region, suggesting that this region interacts with host molecules in most sequenced accessions. Selection pressures on the gene may be either due to the pathogenicity or avirulence function of the gene or both.</div>
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<Abstract><AbstractText>Pathogen genes involved in interactions with their plant hosts are expected to evolve under positive Darwinian selection or balancing selection. In this study a single copy avirulence gene, AvrP4, in the plant pathogen Melampsora lini, was used to investigate the evolution of such a gene across species. Partial translation elongation factor 1-alpha sequences were obtained to establish phylogenetic relationships among the Melampsora species. We amplified AvrP4 homologues from species pathogenic on hosts from different plant families and orders, across the inferred phylogeny. Translations of the AvrP4 sequences revealed a predicted signal peptide and towards the C-terminus of the protein, six identically spaced cysteines were identified in all sequences. Maximum likelihood analysis of synonymous versus non-synonymous substitution rates indicated that positive selection played a role in the evolution of the gene during the diversification of the genus. Fourteen codons under significant positive selection reside in the C-terminal 28 amino acid region, suggesting that this region interacts with host molecules in most sequenced accessions. Selection pressures on the gene may be either due to the pathogenicity or avirulence function of the gene or both.</AbstractText>
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