Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India
Identifieur interne : 000675 ( Main/Exploration ); précédent : 000674; suivant : 000676Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India
Auteurs : Joseph A. Lewnard ; Jeffrey P. TownsendSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.
Abstract
Whereas pathogens are a well-known selective pressure on host immunity, few empirical examples illustrate the coupled dynamics of transmission and evolution. After the arrival of plague in colonial India, a plague-resistant rat phenotype was reported to have become prevalent in the subcontinent’s hardest hit cities. Capitalizing on archival data from these investigations, we identify the evolution of resistance in rats as a driver of observed shifts of seasonal outbreaks in concert with the flea lifecycle and its climatic determinants. Disentangling climatic and evolutionary forcing, our findings—based on century-old observations and experiments by the Indian Plague Commission—substantiate the rapid emergence of host heterogeneity and show how evolutionary responses can buffer host populations against environmentally forced disease dynamics.
Url:
DOI: 10.1073/pnas.1604985113
PubMed: 27791071
PubMed Central: 5187705
Affiliations:
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Lewnard</name><affiliation><nlm:aff id="aff1">Department of Epidemiology of Microbial Diseases,<institution>Yale School of Public Health</institution>, New Haven,<addr-line>CT</addr-line> 06520;</nlm:aff></affiliation></author><author><name sortKey="Townsend, Jeffrey P" sort="Townsend, Jeffrey P" uniqKey="Townsend J" first="Jeffrey P." last="Townsend">Jeffrey P. Townsend</name><affiliation><nlm:aff id="aff2">Department of Biostatistics,<institution>Yale School of Public Health</institution>, New Haven,<addr-line>CT</addr-line> 06510;</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Program in Computational Biology and Bioinformatics,<institution>Yale University</institution>, New Haven,<addr-line>CT</addr-line> 06511;</nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Department of Ecology and Evolutionary Biology,<institution>Yale University</institution>, New Haven,<addr-line>CT</addr-line> 06520</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Whereas pathogens are a well-known selective pressure on host immunity, few empirical examples illustrate the coupled dynamics of transmission and evolution. After the arrival of plague in colonial India, a plague-resistant rat phenotype was reported to have become prevalent in the subcontinent’s hardest hit cities. Capitalizing on archival data from these investigations, we identify the evolution of resistance in rats as a driver of observed shifts of seasonal outbreaks in concert with the flea lifecycle and its climatic determinants. Disentangling climatic and evolutionary forcing, our findings—based on century-old observations and experiments by the Indian Plague Commission—substantiate the rapid emergence of host heterogeneity and show how evolutionary responses can buffer host populations against environmentally forced disease dynamics.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Lewnard, Joseph A" sort="Lewnard, Joseph A" uniqKey="Lewnard J" first="Joseph A." last="Lewnard">Joseph A. Lewnard</name><name sortKey="Townsend, Jeffrey P" sort="Townsend, Jeffrey P" uniqKey="Townsend J" first="Jeffrey P." last="Townsend">Jeffrey P. Townsend</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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