Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India
Identifieur interne : 000675 ( Main/Exploration ); précédent : 000674; suivant : 000676Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India
Auteurs : Joseph A. Lewnard ; Jeffrey P. TownsendSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.
Abstract
Whereas pathogens are a well-known selective pressure on host immunity, few empirical examples illustrate the coupled dynamics of transmission and evolution. After the arrival of plague in colonial India, a plague-resistant rat phenotype was reported to have become prevalent in the subcontinent’s hardest hit cities. Capitalizing on archival data from these investigations, we identify the evolution of resistance in rats as a driver of observed shifts of seasonal outbreaks in concert with the flea lifecycle and its climatic determinants. Disentangling climatic and evolutionary forcing, our findings—based on century-old observations and experiments by the Indian Plague Commission—substantiate the rapid emergence of host heterogeneity and show how evolutionary responses can buffer host populations against environmentally forced disease dynamics.
Url:
DOI: 10.1073/pnas.1604985113
PubMed: 27791071
PubMed Central: 5187705
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000521
- to stream Pmc, to step Curation: 000521
- to stream Pmc, to step Checkpoint: 000633
- to stream Ncbi, to step Merge: 000751
- to stream Ncbi, to step Curation: 000751
- to stream Ncbi, to step Checkpoint: 000751
- to stream Main, to step Merge: 000675
- to stream Main, to step Curation: 000675
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India</title>
<author><name sortKey="Lewnard, Joseph A" sort="Lewnard, Joseph A" uniqKey="Lewnard J" first="Joseph A." last="Lewnard">Joseph A. Lewnard</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology of Microbial Diseases,<institution>Yale School of Public Health</institution>
, New Haven,<addr-line>CT</addr-line>
06520;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Townsend, Jeffrey P" sort="Townsend, Jeffrey P" uniqKey="Townsend J" first="Jeffrey P." last="Townsend">Jeffrey P. Townsend</name>
<affiliation><nlm:aff id="aff2">Department of Biostatistics,<institution>Yale School of Public Health</institution>
, New Haven,<addr-line>CT</addr-line>
06510;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Program in Computational Biology and Bioinformatics,<institution>Yale University</institution>
, New Haven,<addr-line>CT</addr-line>
06511;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Department of Ecology and Evolutionary Biology,<institution>Yale University</institution>
, New Haven,<addr-line>CT</addr-line>
06520</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27791071</idno>
<idno type="pmc">5187705</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187705</idno>
<idno type="RBID">PMC:5187705</idno>
<idno type="doi">10.1073/pnas.1604985113</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000521</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000521</idno>
<idno type="wicri:Area/Pmc/Curation">000521</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000521</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000633</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000633</idno>
<idno type="wicri:Area/Ncbi/Merge">000751</idno>
<idno type="wicri:Area/Ncbi/Curation">000751</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000751</idno>
<idno type="wicri:doubleKey">0027-8424:2016:Lewnard J:climatic:and:evolutionary</idno>
<idno type="wicri:Area/Main/Merge">000675</idno>
<idno type="wicri:Area/Main/Curation">000675</idno>
<idno type="wicri:Area/Main/Exploration">000675</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India</title>
<author><name sortKey="Lewnard, Joseph A" sort="Lewnard, Joseph A" uniqKey="Lewnard J" first="Joseph A." last="Lewnard">Joseph A. Lewnard</name>
<affiliation><nlm:aff id="aff1">Department of Epidemiology of Microbial Diseases,<institution>Yale School of Public Health</institution>
, New Haven,<addr-line>CT</addr-line>
06520;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Townsend, Jeffrey P" sort="Townsend, Jeffrey P" uniqKey="Townsend J" first="Jeffrey P." last="Townsend">Jeffrey P. Townsend</name>
<affiliation><nlm:aff id="aff2">Department of Biostatistics,<institution>Yale School of Public Health</institution>
, New Haven,<addr-line>CT</addr-line>
06510;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Program in Computational Biology and Bioinformatics,<institution>Yale University</institution>
, New Haven,<addr-line>CT</addr-line>
06511;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Department of Ecology and Evolutionary Biology,<institution>Yale University</institution>
, New Haven,<addr-line>CT</addr-line>
06520</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>Whereas pathogens are a well-known selective pressure on host immunity, few empirical examples illustrate the coupled dynamics of transmission and evolution. After the arrival of plague in colonial India, a plague-resistant rat phenotype was reported to have become prevalent in the subcontinent’s hardest hit cities. Capitalizing on archival data from these investigations, we identify the evolution of resistance in rats as a driver of observed shifts of seasonal outbreaks in concert with the flea lifecycle and its climatic determinants. Disentangling climatic and evolutionary forcing, our findings—based on century-old observations and experiments by the Indian Plague Commission—substantiate the rapid emergence of host heterogeneity and show how evolutionary responses can buffer host populations against environmentally forced disease dynamics.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Lewnard, Joseph A" sort="Lewnard, Joseph A" uniqKey="Lewnard J" first="Joseph A." last="Lewnard">Joseph A. Lewnard</name>
<name sortKey="Townsend, Jeffrey P" sort="Townsend, Jeffrey P" uniqKey="Townsend J" first="Jeffrey P." last="Townsend">Jeffrey P. Townsend</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/MelampsoraV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000675 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000675 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Bois |area= MelampsoraV2 |flux= Main |étape= Exploration |type= RBID |clé= PMC:5187705 |texte= Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27791071" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MelampsoraV2
![]() | This area was generated with Dilib version V0.6.38. | ![]() |