Combining data from genomes, Y2H and 3D structure indicates that BolA is a reductase interacting with a glutaredoxin.
Identifieur interne : 000E32 ( Main/Corpus ); précédent : 000E31; suivant : 000E33Combining data from genomes, Y2H and 3D structure indicates that BolA is a reductase interacting with a glutaredoxin.
Auteurs : Martijn A. Huynen ; Chris A E M. Spronk ; Toni Gabald N ; Berend SnelSource :
- FEBS letters [ 0014-5793 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Oxidoreductases.
- chemical , metabolism : Oxidoreductases.
- chemical : Glutaredoxins.
- Genome, Models, Molecular, Phylogeny, Protein Conformation.
Abstract
Genomes, functional genomics data and 3D structure reflect different aspects of protein function. Here, we combine these data to predict that BolA, a widely distributed protein family with unknown function, is a reductase that interacts with a glutaredoxin. Comparisons at the 3D structure level as well as at the sequence profile level indicate homology between BolA and OsmC, an enzyme that reduces organic peroxides. Complementary to this, comparative analyses of genomes and genomics data provide strong evidence of an interaction between BolA and the mono-thiol glutaredoxin family. The interaction between BolA and a mono-thiol glutaredoxin is of particular interest because BolA does not, in contrast to its homolog OsmC, have evolutionarily conserved cysteines to provide it with reducing equivalents. We propose that BolA uses the mono-thiol glutaredoxin as the source for these.
DOI: 10.1016/j.febslet.2004.11.111
PubMed: 15670813
Links to Exploration step
pubmed:15670813Le document en format XML
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<author><name sortKey="Huynen, Martijn A" sort="Huynen, Martijn A" uniqKey="Huynen M" first="Martijn A" last="Huynen">Martijn A. Huynen</name>
<affiliation><nlm:affiliation>CMBI, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Toernooiveld 1, 6525ED Nijmegen, The Netherlands. huynen@cmbi.ru.nl</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Spronk, Chris A E M" sort="Spronk, Chris A E M" uniqKey="Spronk C" first="Chris A E M" last="Spronk">Chris A E M. Spronk</name>
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<author><name sortKey="Gabald N, Toni" sort="Gabald N, Toni" uniqKey="Gabald N T" first="Toni" last="Gabald N">Toni Gabald N</name>
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<author><name sortKey="Snel, Berend" sort="Snel, Berend" uniqKey="Snel B" first="Berend" last="Snel">Berend Snel</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Genome (MeSH)</term>
<term>Glutaredoxins (MeSH)</term>
<term>Models, Molecular (MeSH)</term>
<term>Oxidoreductases (chemistry)</term>
<term>Oxidoreductases (metabolism)</term>
<term>Phylogeny (MeSH)</term>
<term>Protein Conformation (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Oxidoreductases</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Oxidoreductases</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Glutaredoxins</term>
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<front><div type="abstract" xml:lang="en">Genomes, functional genomics data and 3D structure reflect different aspects of protein function. Here, we combine these data to predict that BolA, a widely distributed protein family with unknown function, is a reductase that interacts with a glutaredoxin. Comparisons at the 3D structure level as well as at the sequence profile level indicate homology between BolA and OsmC, an enzyme that reduces organic peroxides. Complementary to this, comparative analyses of genomes and genomics data provide strong evidence of an interaction between BolA and the mono-thiol glutaredoxin family. The interaction between BolA and a mono-thiol glutaredoxin is of particular interest because BolA does not, in contrast to its homolog OsmC, have evolutionarily conserved cysteines to provide it with reducing equivalents. We propose that BolA uses the mono-thiol glutaredoxin as the source for these.</div>
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<Abstract><AbstractText>Genomes, functional genomics data and 3D structure reflect different aspects of protein function. Here, we combine these data to predict that BolA, a widely distributed protein family with unknown function, is a reductase that interacts with a glutaredoxin. Comparisons at the 3D structure level as well as at the sequence profile level indicate homology between BolA and OsmC, an enzyme that reduces organic peroxides. Complementary to this, comparative analyses of genomes and genomics data provide strong evidence of an interaction between BolA and the mono-thiol glutaredoxin family. The interaction between BolA and a mono-thiol glutaredoxin is of particular interest because BolA does not, in contrast to its homolog OsmC, have evolutionarily conserved cysteines to provide it with reducing equivalents. We propose that BolA uses the mono-thiol glutaredoxin as the source for these.</AbstractText>
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