Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae.
Identifieur interne : 002215 ( Main/Exploration ); précédent : 002214; suivant : 002216Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae.
Auteurs : Taisuke Suzuki [Japon] ; Shun Tamura ; Hiromi Nakanishi ; Mitsuru Tashiro ; Naoko K. Nishizawa ; Etsuro YoshimuraSource :
- Biological trace element research [ 0163-4984 ] ; 2007.
Descripteurs français
- KwdFr :
- 2-Isopropylmalate synthase (génétique), Chlorure d'aluminium (MeSH), Chlorures (toxicité), Composés de l'aluminium (toxicité), Malates (pharmacologie), Protéines de Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (génétique).
- MESH :
- croissance et développement : Saccharomyces cerevisiae.
- effets des médicaments et des substances chimiques : Saccharomyces cerevisiae.
- génétique : 2-Isopropylmalate synthase, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- pharmacologie : Malates.
- toxicité : Chlorures, Composés de l'aluminium.
- Chlorure d'aluminium.
English descriptors
- KwdEn :
- 2-Isopropylmalate Synthase (genetics), Aluminum Chloride (MeSH), Aluminum Compounds (toxicity), Chlorides (toxicity), Malates (pharmacology), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae Proteins (genetics).
- MESH :
- chemical , genetics : 2-Isopropylmalate Synthase, Saccharomyces cerevisiae Proteins.
- chemical , pharmacology : Malates.
- chemical , toxicity : Aluminum Compounds, Chlorides.
- chemical : Aluminum Chloride.
- drug effects : Saccharomyces cerevisiae.
- genetics : Saccharomyces cerevisiae.
- growth & development : Saccharomyces cerevisiae.
Abstract
The budding yeast Saccharomyces cerevisiae secretes 2-isopropylmalic acid (2-iPMA), an intermediate in leucine biosynthesis. Because 2-iPMA binds Al(III) in the culture medium, it is thought to reduce toxicity by Al(III). The effects of 2-iPMA and malic acid (MA) on Al toxicity were investigated in a medium with a low pH and low concentrations of phosphates and magnesium. The reduction in the growth of S. cerevisiae observed in the presence of 100 muM Al(III) ions was relieved more by the addition of 1.0 mM 2-iPMA than by 1.0 mM MA, indicating that 2-iPMA possesses superior Al(III)-ion detoxification ability. Investigations using the wild type and the deltaleu4 and deltaleu9 mutant strains indicated that secretion of a sufficient level of 2-iPMA was required to enhance the Al tolerance. It is thought that 2-iPMA secreted from the yeast cells chelates Al ions and prevents them from entering the cells, resulting in Al tolerance.
DOI: 10.1007/s12011-007-8011-9
PubMed: 17916978
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae.</title><author><name sortKey="Suzuki, Taisuke" sort="Suzuki, Taisuke" uniqKey="Suzuki T" first="Taisuke" last="Suzuki">Taisuke Suzuki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-5687, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-5687</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tamura, Shun" sort="Tamura, Shun" uniqKey="Tamura S" first="Shun" last="Tamura">Shun Tamura</name></author><author><name sortKey="Nakanishi, Hiromi" sort="Nakanishi, Hiromi" uniqKey="Nakanishi H" first="Hiromi" last="Nakanishi">Hiromi Nakanishi</name></author><author><name sortKey="Tashiro, Mitsuru" sort="Tashiro, Mitsuru" uniqKey="Tashiro M" first="Mitsuru" last="Tashiro">Mitsuru Tashiro</name></author><author><name sortKey="Nishizawa, Naoko K" sort="Nishizawa, Naoko K" uniqKey="Nishizawa N" first="Naoko K" last="Nishizawa">Naoko K. Nishizawa</name></author><author><name sortKey="Yoshimura, Etsuro" sort="Yoshimura, Etsuro" uniqKey="Yoshimura E" first="Etsuro" last="Yoshimura">Etsuro Yoshimura</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17916978</idno><idno type="pmid">17916978</idno><idno type="doi">10.1007/s12011-007-8011-9</idno><idno type="wicri:Area/Main/Corpus">002193</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002193</idno><idno type="wicri:Area/Main/Curation">002193</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">002193</idno><idno type="wicri:Area/Main/Exploration">002193</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae.</title><author><name sortKey="Suzuki, Taisuke" sort="Suzuki, Taisuke" uniqKey="Suzuki T" first="Taisuke" last="Suzuki">Taisuke Suzuki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-5687, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-5687</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tamura, Shun" sort="Tamura, Shun" uniqKey="Tamura S" first="Shun" last="Tamura">Shun Tamura</name></author><author><name sortKey="Nakanishi, Hiromi" sort="Nakanishi, Hiromi" uniqKey="Nakanishi H" first="Hiromi" last="Nakanishi">Hiromi Nakanishi</name></author><author><name sortKey="Tashiro, Mitsuru" sort="Tashiro, Mitsuru" uniqKey="Tashiro M" first="Mitsuru" last="Tashiro">Mitsuru Tashiro</name></author><author><name sortKey="Nishizawa, Naoko K" sort="Nishizawa, Naoko K" uniqKey="Nishizawa N" first="Naoko K" last="Nishizawa">Naoko K. Nishizawa</name></author><author><name sortKey="Yoshimura, Etsuro" sort="Yoshimura, Etsuro" uniqKey="Yoshimura E" first="Etsuro" last="Yoshimura">Etsuro Yoshimura</name></author></analytic><series><title level="j">Biological trace element research</title><idno type="ISSN">0163-4984</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>2-Isopropylmalate Synthase (genetics)</term><term>Aluminum Chloride (MeSH)</term><term>Aluminum Compounds (toxicity)</term><term>Chlorides (toxicity)</term><term>Malates (pharmacology)</term><term>Saccharomyces cerevisiae (drug effects)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae (growth & development)</term><term>Saccharomyces cerevisiae Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>2-Isopropylmalate synthase (génétique)</term><term>Chlorure d'aluminium (MeSH)</term><term>Chlorures (toxicité)</term><term>Composés de l'aluminium (toxicité)</term><term>Malates (pharmacologie)</term><term>Protéines de Saccharomyces cerevisiae (génétique)</term><term>Saccharomyces cerevisiae (croissance et développement)</term><term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term><term>Saccharomyces cerevisiae (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>2-Isopropylmalate Synthase</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Malates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Aluminum Compounds</term><term>Chlorides</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Aluminum Chloride</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>2-Isopropylmalate synthase</term><term>Protéines de Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Malates</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Chlorures</term><term>Composés de l'aluminium</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Chlorure d'aluminium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The budding yeast Saccharomyces cerevisiae secretes 2-isopropylmalic acid (2-iPMA), an intermediate in leucine biosynthesis. Because 2-iPMA binds Al(III) in the culture medium, it is thought to reduce toxicity by Al(III). The effects of 2-iPMA and malic acid (MA) on Al toxicity were investigated in a medium with a low pH and low concentrations of phosphates and magnesium. The reduction in the growth of S. cerevisiae observed in the presence of 100 muM Al(III) ions was relieved more by the addition of 1.0 mM 2-iPMA than by 1.0 mM MA, indicating that 2-iPMA possesses superior Al(III)-ion detoxification ability. Investigations using the wild type and the deltaleu4 and deltaleu9 mutant strains indicated that secretion of a sufficient level of 2-iPMA was required to enhance the Al tolerance. It is thought that 2-iPMA secreted from the yeast cells chelates Al ions and prevents them from entering the cells, resulting in Al tolerance.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17916978</PMID><DateCompleted><Year>2007</Year><Month>12</Month><Day>27</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0163-4984</ISSN><JournalIssue CitedMedium="Print"><Volume>120</Volume><Issue>1-3</Issue><PubDate><Year>2007</Year><Season>Winter</Season></PubDate></JournalIssue><Title>Biological trace element research</Title><ISOAbbreviation>Biol Trace Elem Res</ISOAbbreviation></Journal><ArticleTitle>Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae.</ArticleTitle><Pagination><MedlinePgn>257-63</MedlinePgn></Pagination><Abstract><AbstractText>The budding yeast Saccharomyces cerevisiae secretes 2-isopropylmalic acid (2-iPMA), an intermediate in leucine biosynthesis. Because 2-iPMA binds Al(III) in the culture medium, it is thought to reduce toxicity by Al(III). The effects of 2-iPMA and malic acid (MA) on Al toxicity were investigated in a medium with a low pH and low concentrations of phosphates and magnesium. The reduction in the growth of S. cerevisiae observed in the presence of 100 muM Al(III) ions was relieved more by the addition of 1.0 mM 2-iPMA than by 1.0 mM MA, indicating that 2-iPMA possesses superior Al(III)-ion detoxification ability. Investigations using the wild type and the deltaleu4 and deltaleu9 mutant strains indicated that secretion of a sufficient level of 2-iPMA was required to enhance the Al tolerance. It is thought that 2-iPMA secreted from the yeast cells chelates Al ions and prevents them from entering the cells, resulting in Al tolerance.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Suzuki</LastName><ForeName>Taisuke</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-5687, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamura</LastName><ForeName>Shun</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Nakanishi</LastName><ForeName>Hiromi</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Tashiro</LastName><ForeName>Mitsuru</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Nishizawa</LastName><ForeName>Naoko K</ForeName><Initials>NK</Initials></Author><Author ValidYN="Y"><LastName>Yoshimura</LastName><ForeName>Etsuro</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biol Trace Elem Res</MedlineTA><NlmUniqueID>7911509</NlmUniqueID><ISSNLinking>0163-4984</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C502920">2-isopropylmalic acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017607">Aluminum Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002712">Chlorides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008293">Malates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>3CYT62D3GA</RegistryNumber><NameOfSubstance UI="D000077410">Aluminum Chloride</NameOfSubstance></Chemical><Chemical><RegistryNumber>817L1N4CKP</RegistryNumber><NameOfSubstance UI="C030298">malic acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.3.13</RegistryNumber><NameOfSubstance UI="D015079">2-Isopropylmalate Synthase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.3.13</RegistryNumber><NameOfSubstance UI="C080062">LEU4 protein, S cerevisiae</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015079" MajorTopicYN="N">2-Isopropylmalate Synthase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000077410" MajorTopicYN="N">Aluminum Chloride</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017607" MajorTopicYN="N">Aluminum Compounds</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002712" MajorTopicYN="N">Chlorides</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008293" MajorTopicYN="N">Malates</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2007</Year><Month>06</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2007</Year><Month>07</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>07</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>10</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>12</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>10</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17916978</ArticleId><ArticleId IdType="pii">BTER:120:1-3:257</ArticleId><ArticleId IdType="doi">10.1007/s12011-007-8011-9</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><noCountry><name sortKey="Nakanishi, Hiromi" sort="Nakanishi, Hiromi" uniqKey="Nakanishi H" first="Hiromi" last="Nakanishi">Hiromi Nakanishi</name><name sortKey="Nishizawa, Naoko K" sort="Nishizawa, Naoko K" uniqKey="Nishizawa N" first="Naoko K" last="Nishizawa">Naoko K. Nishizawa</name><name sortKey="Tamura, Shun" sort="Tamura, Shun" uniqKey="Tamura S" first="Shun" last="Tamura">Shun Tamura</name><name sortKey="Tashiro, Mitsuru" sort="Tashiro, Mitsuru" uniqKey="Tashiro M" first="Mitsuru" last="Tashiro">Mitsuru Tashiro</name><name sortKey="Yoshimura, Etsuro" sort="Yoshimura, Etsuro" uniqKey="Yoshimura E" first="Etsuro" last="Yoshimura">Etsuro Yoshimura</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Suzuki, Taisuke" sort="Suzuki, Taisuke" uniqKey="Suzuki T" first="Taisuke" last="Suzuki">Taisuke Suzuki</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/DetoxFungiV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002215 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002215 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= DetoxFungiV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:17916978
|texte= Reduction of aluminum toxicity by 2-isopropylmalic acid in the budding yeast Saccharomyces cerevisiae.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17916978" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a DetoxFungiV1
| This area was generated with Dilib version V0.6.38. |  |