Evolution of CDC42, a putative virulence factor triggering meristematic growth in black yeasts
Identifieur interne : 000059 ( Ncbi/Checkpoint ); précédent : 000058; suivant : 000060Evolution of CDC42, a putative virulence factor triggering meristematic growth in black yeasts
Auteurs : S. Deng ; A. H. G. Gerrits Van Den Ende ; A. F. J. Ram ; M. Arentshorst ; Y. Gr Ser ; H. Hu ; G. S. De HoogSource :
- Studies in Mycology [ 0166-0616 ] ; 2008.
Abstract
The cell division cycle gene (
Url:
DOI: 10.3114/sim.2008.61.12
PubMed: 19287534
PubMed Central: 2610298
Affiliations:
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, a putative virulence factor triggering
meristematic growth in black yeasts</title>
<author><name sortKey="Deng, S" sort="Deng, S" uniqKey="Deng S" first="S." last="Deng">S. Deng</name>
<affiliation><nlm:aff id="aff1"><italic>Department of Dermatology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China</italic>
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<affiliation><nlm:aff id="aff2"><italic>CBS Fungal Biodiversity Centre, Utrecht, The Netherlands</italic>
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<author><name sortKey="Van Den Ende, A H G Gerrits" sort="Van Den Ende, A H G Gerrits" uniqKey="Van Den Ende A" first="A. H. G. Gerrits" last="Van Den Ende">A. H. G. Gerrits Van Den Ende</name>
<affiliation><nlm:aff id="aff2"><italic>CBS Fungal Biodiversity Centre, Utrecht, The Netherlands</italic>
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<author><name sortKey="Ram, A F J" sort="Ram, A F J" uniqKey="Ram A" first="A. F. J." last="Ram">A. F. J. Ram</name>
<affiliation><nlm:aff id="aff3"><italic>Institute of Biology, Department of Molecular Microbiology, Kluyver Center for Genomics of Industrial Fermentation, Leiden, The Netherlands</italic>
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<author><name sortKey="Arentshorst, M" sort="Arentshorst, M" uniqKey="Arentshorst M" first="M." last="Arentshorst">M. Arentshorst</name>
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<author><name sortKey="Gr Ser, Y" sort="Gr Ser, Y" uniqKey="Gr Ser Y" first="Y." last="Gr Ser">Y. Gr Ser</name>
<affiliation><nlm:aff id="aff5"><italic>Institut für Mikrobiologie und Hygiene, Department of Parasitology (Charité), Humboldt University, Berlin, Germany</italic>
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<author><name sortKey="Hu, H" sort="Hu, H" uniqKey="Hu H" first="H." last="Hu">H. Hu</name>
<affiliation><nlm:aff id="aff6"><italic>Xinjiang Medical University, Urumqi, Xinjiang, China</italic>
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<author><name sortKey="De Hoog, G S" sort="De Hoog, G S" uniqKey="De Hoog G" first="G. S." last="De Hoog">G. S. De Hoog</name>
<affiliation><nlm:aff id="aff2"><italic>CBS Fungal Biodiversity Centre, Utrecht, The Netherlands</italic>
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<affiliation><nlm:aff id="aff4"><italic>Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands</italic>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evolution of <italic>CDC42</italic>
, a putative virulence factor triggering
meristematic growth in black yeasts</title>
<author><name sortKey="Deng, S" sort="Deng, S" uniqKey="Deng S" first="S." last="Deng">S. Deng</name>
<affiliation><nlm:aff id="aff1"><italic>Department of Dermatology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China</italic>
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<affiliation><nlm:aff id="aff2"><italic>CBS Fungal Biodiversity Centre, Utrecht, The Netherlands</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Den Ende, A H G Gerrits" sort="Van Den Ende, A H G Gerrits" uniqKey="Van Den Ende A" first="A. H. G. Gerrits" last="Van Den Ende">A. H. G. Gerrits Van Den Ende</name>
<affiliation><nlm:aff id="aff2"><italic>CBS Fungal Biodiversity Centre, Utrecht, The Netherlands</italic>
</nlm:aff>
</affiliation>
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<author><name sortKey="Ram, A F J" sort="Ram, A F J" uniqKey="Ram A" first="A. F. J." last="Ram">A. F. J. Ram</name>
<affiliation><nlm:aff id="aff3"><italic>Institute of Biology, Department of Molecular Microbiology, Kluyver Center for Genomics of Industrial Fermentation, Leiden, The Netherlands</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arentshorst, M" sort="Arentshorst, M" uniqKey="Arentshorst M" first="M." last="Arentshorst">M. Arentshorst</name>
<affiliation><nlm:aff id="aff3"><italic>Institute of Biology, Department of Molecular Microbiology, Kluyver Center for Genomics of Industrial Fermentation, Leiden, The Netherlands</italic>
</nlm:aff>
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<author><name sortKey="Gr Ser, Y" sort="Gr Ser, Y" uniqKey="Gr Ser Y" first="Y." last="Gr Ser">Y. Gr Ser</name>
<affiliation><nlm:aff id="aff5"><italic>Institut für Mikrobiologie und Hygiene, Department of Parasitology (Charité), Humboldt University, Berlin, Germany</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hu, H" sort="Hu, H" uniqKey="Hu H" first="H." last="Hu">H. Hu</name>
<affiliation><nlm:aff id="aff6"><italic>Xinjiang Medical University, Urumqi, Xinjiang, China</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Hoog, G S" sort="De Hoog, G S" uniqKey="De Hoog G" first="G. S." last="De Hoog">G. S. De Hoog</name>
<affiliation><nlm:aff id="aff2"><italic>CBS Fungal Biodiversity Centre, Utrecht, The Netherlands</italic>
</nlm:aff>
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<affiliation><nlm:aff id="aff4"><italic>Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands</italic>
</nlm:aff>
</affiliation>
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<series><title level="j">Studies in Mycology</title>
<idno type="ISSN">0166-0616</idno>
<idno type="eISSN">1872-9797</idno>
<imprint><date when="2008">2008</date>
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<front><div type="abstract" xml:lang="en"><p>The cell division cycle gene (<italic>CDC42</italic>
) controlling cellular
polarization was studied in members of <italic>Chaetothyriales</italic>
. Based on
ribosomal genes, ancestral members of the order exhibit meristematic growth in
view of their colonization of inert surfaces such as rock, whereas in derived
members of the order the gene is a putative virulence factor involved in
expression of the muriform cell, the invasive phase in human
chromoblastomycosis. Specific primers were developed to amplify a portion of
the gene of 32 members of the order with known position according to ribosomal
phylogeny. Phylogeny of <italic>CDC42</italic>
proved to be very different. In all
members of <italic>Chaetohyriales</italic>
the protein sequence is highly conserved.
In most species, distributed all over the phylogenetic tree, introns and
3<sup>rd</sup>
codon positions are also invariant. However, a number of
species had paralogues with considerable deviation in non-coding exon
positions, and synchronous variation in introns, although non-synonomous
variation had remained very limited. In some strains both orthologues and
paralogues were present. It is concluded that <italic>CDC42</italic>
does not show any
orthologous evolution, and that its paralogues haves the same function but are
structurally relaxed. The variation or absence thereof could not be linked to
ecological changes, from rock-inhabiting to pathogenic life style. It is
concluded that eventual pathogenicity in <italic>Chaetothyriales</italic>
is not
expressed at the DNA level in <italic>CDC42</italic>
evolution.</p>
</div>
</front>
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<tree><noCountry><name sortKey="Arentshorst, M" sort="Arentshorst, M" uniqKey="Arentshorst M" first="M." last="Arentshorst">M. Arentshorst</name>
<name sortKey="De Hoog, G S" sort="De Hoog, G S" uniqKey="De Hoog G" first="G. S." last="De Hoog">G. S. De Hoog</name>
<name sortKey="Deng, S" sort="Deng, S" uniqKey="Deng S" first="S." last="Deng">S. Deng</name>
<name sortKey="Gr Ser, Y" sort="Gr Ser, Y" uniqKey="Gr Ser Y" first="Y." last="Gr Ser">Y. Gr Ser</name>
<name sortKey="Hu, H" sort="Hu, H" uniqKey="Hu H" first="H." last="Hu">H. Hu</name>
<name sortKey="Ram, A F J" sort="Ram, A F J" uniqKey="Ram A" first="A. F. J." last="Ram">A. F. J. Ram</name>
<name sortKey="Van Den Ende, A H G Gerrits" sort="Van Den Ende, A H G Gerrits" uniqKey="Van Den Ende A" first="A. H. G. Gerrits" last="Van Den Ende">A. H. G. Gerrits Van Den Ende</name>
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