Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health
Identifieur interne : 000057 ( Main/Exploration ); précédent : 000056; suivant : 000058Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health
Auteurs : Charlotte Grootaert ; Senem Kamiloglu [Turquie] ; Esra Capanoglu [Turquie] ; John Van CampSource :
- Nutrients [ 2072-6643 ] ; 2015.
Abstract
Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general. More specifically, many research groups have investigated their protective effect against cardiovascular diseases in several animal studies and human trials. Yet, because of the excessive processing of the polyphenol structure by human cells and the residing intestinal microbial community, which results in a large variability between the test subjects, the exact mechanisms of their protective effects are still under investigation. To this end, simplified cell culture systems have been used to decrease the inter-individual variability in mechanistic studies. In this review, we will discuss the different cell culture models that have been used so far for polyphenol research in the context of cardiovascular diseases. We will also review the current trends in cell culture research, including co-culture methodologies. Finally, we will discuss the potential of these advanced models to screen for cardiovascular effects of the large pool of bioactive polyphenols present in foods and their metabolites.
Url:
DOI: 10.3390/nu7115462
PubMed: 26569293
PubMed Central: 4663590
Affiliations:
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Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links, Ghent 653 B-9000, Belgium;<email>charlotte.grootaert@ugent.be</email> (C.G.);<email>senem.kamiloglu@ugent.be</email> (S.K.);<email>john.vancamp@ugent.be</email> (J.V.C.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-nutrients-07-05462">Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Capanoglu, Esra" sort="Capanoglu, Esra" uniqKey="Capanoglu E" first="Esra" last="Capanoglu">Esra Capanoglu</name><affiliation wicri:level="1"><nlm:aff id="af2-nutrients-07-05462">Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Van Camp, John" sort="Van Camp, John" uniqKey="Van Camp J" first="John" last="Van Camp">John Van Camp</name><affiliation><nlm:aff id="af1-nutrients-07-05462">Laboratory of Food Chemistry and Human Nutrition, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links, Ghent 653 B-9000, Belgium;<email>charlotte.grootaert@ugent.be</email> (C.G.);<email>senem.kamiloglu@ugent.be</email> (S.K.);<email>john.vancamp@ugent.be</email> (J.V.C.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno 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type="wicri:Area/Main/Exploration">000057</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health</title><author><name sortKey="Grootaert, Charlotte" sort="Grootaert, Charlotte" uniqKey="Grootaert C" first="Charlotte" last="Grootaert">Charlotte Grootaert</name><affiliation><nlm:aff id="af1-nutrients-07-05462">Laboratory of Food Chemistry and Human Nutrition, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links, Ghent 653 B-9000, Belgium;<email>charlotte.grootaert@ugent.be</email> (C.G.);<email>senem.kamiloglu@ugent.be</email> (S.K.);<email>john.vancamp@ugent.be</email> (J.V.C.)</nlm:aff></affiliation></author><author><name sortKey="Kamiloglu, Senem" sort="Kamiloglu, Senem" uniqKey="Kamiloglu S" first="Senem" last="Kamiloglu">Senem Kamiloglu</name><affiliation><nlm:aff id="af1-nutrients-07-05462">Laboratory of Food Chemistry and Human Nutrition, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links, Ghent 653 B-9000, Belgium;<email>charlotte.grootaert@ugent.be</email> (C.G.);<email>senem.kamiloglu@ugent.be</email> (S.K.);<email>john.vancamp@ugent.be</email> (J.V.C.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-nutrients-07-05462">Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Capanoglu, Esra" sort="Capanoglu, Esra" uniqKey="Capanoglu E" first="Esra" last="Capanoglu">Esra Capanoglu</name><affiliation wicri:level="1"><nlm:aff id="af2-nutrients-07-05462">Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Van Camp, John" sort="Van Camp, John" uniqKey="Van Camp J" first="John" last="Van Camp">John Van Camp</name><affiliation><nlm:aff id="af1-nutrients-07-05462">Laboratory of Food Chemistry and Human Nutrition, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links, Ghent 653 B-9000, Belgium;<email>charlotte.grootaert@ugent.be</email> (C.G.);<email>senem.kamiloglu@ugent.be</email> (S.K.);<email>john.vancamp@ugent.be</email> (J.V.C.)</nlm:aff></affiliation></author></analytic><series><title level="j">Nutrients</title><idno type="eISSN">2072-6643</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general. More specifically, many research groups have investigated their protective effect against cardiovascular diseases in several animal studies and human trials. Yet, because of the excessive processing of the polyphenol structure by human cells and the residing intestinal microbial community, which results in a large variability between the test subjects, the exact mechanisms of their protective effects are still under investigation. To this end, simplified cell culture systems have been used to decrease the inter-individual variability in mechanistic studies. In this review, we will discuss the different cell culture models that have been used so far for polyphenol research in the context of cardiovascular diseases. We will also review the current trends in cell culture research, including co-culture methodologies. 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Pinheiro</name></author><author><name sortKey="Possemiers, S" uniqKey="Possemiers S">S. Possemiers</name></author><author><name sortKey="Van Den Abbeele, P" uniqKey="Van Den Abbeele P">P. Van den Abbeele</name></author><author><name sortKey="Derycke, L" uniqKey="Derycke L">L. Derycke</name></author><author><name sortKey="Bracke, M" uniqKey="Bracke M">M. Bracke</name></author><author><name sortKey="Pieters, J" uniqKey="Pieters J">J. Pieters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, H J" uniqKey="Kim H">H.J. Kim</name></author><author><name sortKey="Ingber, D E" uniqKey="Ingber D">D.E. Ingber</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><noCountry><name sortKey="Grootaert, Charlotte" sort="Grootaert, Charlotte" uniqKey="Grootaert C" first="Charlotte" last="Grootaert">Charlotte Grootaert</name><name sortKey="Van Camp, John" sort="Van Camp, John" uniqKey="Van Camp J" first="John" last="Van Camp">John Van Camp</name></noCountry><country name="Turquie"><noRegion><name sortKey="Kamiloglu, Senem" sort="Kamiloglu, Senem" uniqKey="Kamiloglu S" first="Senem" last="Kamiloglu">Senem Kamiloglu</name></noRegion><name sortKey="Capanoglu, Esra" sort="Capanoglu, Esra" uniqKey="Capanoglu E" first="Esra" last="Capanoglu">Esra Capanoglu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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