BiopestPeptidV1, Main, Exploration, bibRecord, 000A96

Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria.

Identifieur interne : 000A96 ( Main/Exploration ); précédent : 000A95; suivant : 000A97

Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria.

Auteurs : Jongsung Lee [Corée du Sud] ; Youn Hwa Nho [Corée du Sud] ; Seok Kyun Yun [Corée du Sud] ; Young Sun Hwang [Corée du Sud]

Source :

BMC complementary and alternative medicine [ 1472-6882 ] ; 2017.

RBID : pubmed:28202081

Descripteurs français

KwdFr :
- Animaux (MeSH), Anti-inflammatoires (pharmacologie), Anti-inflammatoires (usage thérapeutique), Antibactériens (pharmacologie), Antibactériens (usage thérapeutique), Bactéries (croissance et développement), Bactéries (effets des médicaments et des substances chimiques), Bouche (microbiologie), Cellules RAW 264.7 (MeSH), Cyclooxygenase 2 (métabolisme), Cytokines (métabolisme), Dinoprostone (métabolisme), Extraits de plantes (pharmacologie), Extraits de plantes (usage thérapeutique), Gingivite (microbiologie), Gingivite (prévention et contrôle), Inflammation (microbiologie), Inflammation (prévention et contrôle), Ligand de RANK (métabolisme), Maladies parodontales (anatomopathologie), Maladies parodontales (microbiologie), Maladies parodontales (prévention et contrôle), Ostéoblastes (effets des médicaments et des substances chimiques), Ostéoclastes (effets des médicaments et des substances chimiques), Parodontite (microbiologie), Parodontite (prévention et contrôle), Peptide hydrolases (métabolisme), Phytothérapie (MeSH), Plaque dentaire (microbiologie), Résorption osseuse (microbiologie), Résorption osseuse (prévention et contrôle), Souris (MeSH), Terminalia (MeSH).
MESH :
- anatomopathologie : Maladies parodontales.
- croissance et développement : Bactéries.
- effets des médicaments et des substances chimiques : Bactéries, Ostéoblastes, Ostéoclastes.
- microbiologie : Bouche, Gingivite, Inflammation, Maladies parodontales, Parodontite, Plaque dentaire, Résorption osseuse.
- métabolisme : Cyclooxygenase 2, Cytokines, Dinoprostone, Ligand de RANK, Peptide hydrolases.
- pharmacologie : Anti-inflammatoires, Antibactériens, Extraits de plantes.
- prévention et contrôle : Gingivite, Inflammation, Maladies parodontales, Parodontite, Résorption osseuse.
- usage thérapeutique : Anti-inflammatoires, Antibactériens, Extraits de plantes.
- Animaux, Cellules RAW 264.7, Phytothérapie, Souris, Terminalia.

English descriptors

KwdEn :
- Animals (MeSH), Anti-Bacterial Agents (pharmacology), Anti-Bacterial Agents (therapeutic use), Anti-Inflammatory Agents (pharmacology), Anti-Inflammatory Agents (therapeutic use), Bacteria (drug effects), Bacteria (growth & development), Bone Resorption (microbiology), Bone Resorption (prevention & control), Cyclooxygenase 2 (metabolism), Cytokines (metabolism), Dental Plaque (microbiology), Dinoprostone (metabolism), Gingivitis (microbiology), Gingivitis (prevention & control), Inflammation (microbiology), Inflammation (prevention & control), Mice (MeSH), Mouth (microbiology), Osteoblasts (drug effects), Osteoclasts (drug effects), Peptide Hydrolases (metabolism), Periodontal Diseases (microbiology), Periodontal Diseases (pathology), Periodontal Diseases (prevention & control), Periodontitis (microbiology), Periodontitis (prevention & control), Phytotherapy (MeSH), Plant Extracts (pharmacology), Plant Extracts (therapeutic use), RANK Ligand (metabolism), RAW 264.7 Cells (MeSH), Terminalia (MeSH).
MESH :
- chemical , metabolism : Cyclooxygenase 2, Cytokines, Dinoprostone, Peptide Hydrolases, RANK Ligand.
- chemical , pharmacology : Anti-Bacterial Agents, Anti-Inflammatory Agents, Plant Extracts.
- chemical , therapeutic use : Anti-Bacterial Agents, Anti-Inflammatory Agents, Plant Extracts.
- drug effects : Bacteria, Osteoblasts, Osteoclasts.
- growth & development : Bacteria.
- microbiology : Bone Resorption, Dental Plaque, Gingivitis, Inflammation, Mouth, Periodontal Diseases, Periodontitis.
- pathology : Periodontal Diseases.
- prevention & control : Bone Resorption, Gingivitis, Inflammation, Periodontal Diseases, Periodontitis.
- Animals, Mice, Phytotherapy, RAW 264.7 Cells, Terminalia.

Abstract

BACKGROUND

The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption.

METHODS

The anti-bacterial effect of EETC was analyzed using the disc diffusion method. The anti-inflammatory effect of EETC was determined by molecular biological analysis of the DPB-mediated culture cells. Prevention of osteoclastic bone resorption by EETC was explored using osteoclast formation and pit formation assays.

RESULTS

EETC suppressed the growth of oral bacteria and reduced the induction of inflammatory cytokines and proteases, abolishing the expression of PGE2 and COX-2 and inhibiting matrix damage. By stimulating the DPB-derived lipopolysaccharides, EETC inhibited both osteoclast formation in osteoclast precursors and RANKL expression in osteoblasts, thereby contributing to the prevention of bone resorption.

CONCLUSIONS

EETC may be a beneficial supplement to help prevent DPB-mediated periodontal disease.

DOI: 10.1186/s12906-017-1619-1
PubMed: 28202081
PubMed Central: PMC5312597

Affiliations:

Corée du Sud

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000D84
to stream Main, to step Curation: 000D84

Le document en format XML

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<term>Anti-Bacterial Agents (pharmacology)</term>
<term>Anti-Bacterial Agents (therapeutic use)</term>
<term>Anti-Inflammatory Agents (pharmacology)</term>
<term>Anti-Inflammatory Agents (therapeutic use)</term>
<term>Bacteria (drug effects)</term>
<term>Bacteria (growth & development)</term>
<term>Bone Resorption (microbiology)</term>
<term>Bone Resorption (prevention & control)</term>
<term>Cyclooxygenase 2 (metabolism)</term>
<term>Cytokines (metabolism)</term>
<term>Dental Plaque (microbiology)</term>
<term>Dinoprostone (metabolism)</term>
<term>Gingivitis (microbiology)</term>
<term>Gingivitis (prevention & control)</term>
<term>Inflammation (microbiology)</term>
<term>Inflammation (prevention & control)</term>
<term>Mice (MeSH)</term>
<term>Mouth (microbiology)</term>
<term>Osteoblasts (drug effects)</term>
<term>Osteoclasts (drug effects)</term>
<term>Peptide Hydrolases (metabolism)</term>
<term>Periodontal Diseases (microbiology)</term>
<term>Periodontal Diseases (pathology)</term>
<term>Periodontal Diseases (prevention & control)</term>
<term>Periodontitis (microbiology)</term>
<term>Periodontitis (prevention & control)</term>
<term>Phytotherapy (MeSH)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plant Extracts (therapeutic use)</term>
<term>RANK Ligand (metabolism)</term>
<term>RAW 264.7 Cells (MeSH)</term>
<term>Terminalia (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Anti-inflammatoires (pharmacologie)</term>
<term>Anti-inflammatoires (usage thérapeutique)</term>
<term>Antibactériens (pharmacologie)</term>
<term>Antibactériens (usage thérapeutique)</term>
<term>Bactéries (croissance et développement)</term>
<term>Bactéries (effets des médicaments et des substances chimiques)</term>
<term>Bouche (microbiologie)</term>
<term>Cellules RAW 264.7 (MeSH)</term>
<term>Cyclooxygenase 2 (métabolisme)</term>
<term>Cytokines (métabolisme)</term>
<term>Dinoprostone (métabolisme)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Extraits de plantes (usage thérapeutique)</term>
<term>Gingivite (microbiologie)</term>
<term>Gingivite (prévention et contrôle)</term>
<term>Inflammation (microbiologie)</term>
<term>Inflammation (prévention et contrôle)</term>
<term>Ligand de RANK (métabolisme)</term>
<term>Maladies parodontales (anatomopathologie)</term>
<term>Maladies parodontales (microbiologie)</term>
<term>Maladies parodontales (prévention et contrôle)</term>
<term>Ostéoblastes (effets des médicaments et des substances chimiques)</term>
<term>Ostéoclastes (effets des médicaments et des substances chimiques)</term>
<term>Parodontite (microbiologie)</term>
<term>Parodontite (prévention et contrôle)</term>
<term>Peptide hydrolases (métabolisme)</term>
<term>Phytothérapie (MeSH)</term>
<term>Plaque dentaire (microbiologie)</term>
<term>Résorption osseuse (microbiologie)</term>
<term>Résorption osseuse (prévention et contrôle)</term>
<term>Souris (MeSH)</term>
<term>Terminalia (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclooxygenase 2</term>
<term>Cytokines</term>
<term>Dinoprostone</term>
<term>Peptide Hydrolases</term>
<term>RANK Ligand</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Anti-Inflammatory Agents</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Anti-Inflammatory Agents</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies parodontales</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Bactéries</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bacteria</term>
<term>Osteoblasts</term>
<term>Osteoclasts</term>
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<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Bactéries</term>
<term>Ostéoblastes</term>
<term>Ostéoclastes</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Bacteria</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Bouche</term>
<term>Gingivite</term>
<term>Inflammation</term>
<term>Maladies parodontales</term>
<term>Parodontite</term>
<term>Plaque dentaire</term>
<term>Résorption osseuse</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bone Resorption</term>
<term>Dental Plaque</term>
<term>Gingivitis</term>
<term>Inflammation</term>
<term>Mouth</term>
<term>Periodontal Diseases</term>
<term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cyclooxygenase 2</term>
<term>Cytokines</term>
<term>Dinoprostone</term>
<term>Ligand de RANK</term>
<term>Peptide hydrolases</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Periodontal Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-inflammatoires</term>
<term>Antibactériens</term>
<term>Extraits de plantes</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Bone Resorption</term>
<term>Gingivitis</term>
<term>Inflammation</term>
<term>Periodontal Diseases</term>
<term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Gingivite</term>
<term>Inflammation</term>
<term>Maladies parodontales</term>
<term>Parodontite</term>
<term>Résorption osseuse</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anti-inflammatoires</term>
<term>Antibactériens</term>
<term>Extraits de plantes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Mice</term>
<term>Phytotherapy</term>
<term>RAW 264.7 Cells</term>
<term>Terminalia</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules RAW 264.7</term>
<term>Phytothérapie</term>
<term>Souris</term>
<term>Terminalia</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>The anti-bacterial effect of EETC was analyzed using the disc diffusion method. The anti-inflammatory effect of EETC was determined by molecular biological analysis of the DPB-mediated culture cells. Prevention of osteoclastic bone resorption by EETC was explored using osteoclast formation and pit formation assays.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>EETC suppressed the growth of oral bacteria and reduced the induction of inflammatory cytokines and proteases, abolishing the expression of PGE2 and COX-2 and inhibiting matrix damage. By stimulating the DPB-derived lipopolysaccharides, EETC inhibited both osteoclast formation in osteoclast precursors and RANKL expression in osteoblasts, thereby contributing to the prevention of bone resorption.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>EETC may be a beneficial supplement to help prevent DPB-mediated periodontal disease.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2017</Year>
<Month>02</Month>
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<Month>11</Month>
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<ArticleTitle>Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The anti-bacterial effect of EETC was analyzed using the disc diffusion method. The anti-inflammatory effect of EETC was determined by molecular biological analysis of the DPB-mediated culture cells. Prevention of osteoclastic bone resorption by EETC was explored using osteoclast formation and pit formation assays.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">EETC suppressed the growth of oral bacteria and reduced the induction of inflammatory cytokines and proteases, abolishing the expression of PGE2 and COX-2 and inhibiting matrix damage. By stimulating the DPB-derived lipopolysaccharides, EETC inhibited both osteoclast formation in osteoclast precursors and RANKL expression in osteoblasts, thereby contributing to the prevention of bone resorption.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">EETC may be a beneficial supplement to help prevent DPB-mediated periodontal disease.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Jongsung</ForeName>
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<AffiliationInfo><Affiliation>Department of Genetic Engineering, Sungkyunkwan University, Suwon, 164-19, Republic of Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Nho</LastName>
<ForeName>Youn Hwa</ForeName>
<Initials>YH</Initials>
<AffiliationInfo><Affiliation>COSMAX R&I Center, COSMAX Inc., Seongnam, 134-86, Republic of Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Yun</LastName>
<ForeName>Seok Kyun</ForeName>
<Initials>SK</Initials>
<AffiliationInfo><Affiliation>COSMAX R&I Center, COSMAX Inc., Seongnam, 134-86, Republic of Korea.</Affiliation>
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<Author ValidYN="Y"><LastName>Hwang</LastName>
<ForeName>Young Sun</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>Department of Dental Hygiene, College of Health Science, Eulji University, 553, Sansung-Daero, Soojung-Gu, Seongnam City, Republic of Korea. kiteys@eulji.ac.kr.</Affiliation>
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Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria.

Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria.

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