Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis.
Identifieur interne : 000821 ( Main/Exploration ); précédent : 000820; suivant : 000822Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis.
Auteurs : Haichong Wu [République populaire de Chine] ; Ailing Dai [République populaire de Chine] ; Xingxing Chen [République populaire de Chine] ; Xiaoyan Yang [République populaire de Chine] ; Xiaohua Li [République populaire de Chine] ; Cuiqin Huang [République populaire de Chine] ; Kangfeng Jiang [République populaire de Chine] ; Ganzhen Deng [République populaire de Chine]Source :
- International immunopharmacology [ 1878-1705 ] ; 2018.
Descripteurs français
- KwdFr :
- Acide gallique (analogues et dérivés), Acide gallique (usage thérapeutique), Animaux (MeSH), Anti-inflammatoires (usage thérapeutique), Bovins (MeSH), Cellules cultivées (MeSH), Cellules épithéliales (anatomopathologie), Cellules épithéliales (effets des médicaments et des substances chimiques), Endomètre (anatomopathologie), Endomètre (effets des médicaments et des substances chimiques), Endométrite (induit chimiquement), Endométrite (traitement médicamenteux), Facteur de nécrose tumorale alpha (métabolisme), Facteur de transcription NF-kappa B (métabolisme), Femelle (MeSH), Interleukine-1 bêta (métabolisme), Leonurus (immunologie), Lipopolysaccharides (immunologie), Modèles animaux de maladie humaine (MeSH), Souris (MeSH), Transduction du signal (MeSH).
- MESH :
- analogues et dérivés : Acide gallique.
- anatomopathologie : Cellules épithéliales, Endomètre.
- effets des médicaments et des substances chimiques : Cellules épithéliales, Endomètre.
- immunologie : Leonurus, Lipopolysaccharides.
- induit chimiquement : Endométrite.
- métabolisme : Facteur de nécrose tumorale alpha, Facteur de transcription NF-kappa B, Interleukine-1 bêta.
- traitement médicamenteux : Endométrite.
- usage thérapeutique : Acide gallique, Anti-inflammatoires.
- Animaux, Bovins, Cellules cultivées, Femelle, Modèles animaux de maladie humaine, Souris, Transduction du signal.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Inflammatory Agents (therapeutic use), Cattle (MeSH), Cells, Cultured (MeSH), Disease Models, Animal (MeSH), Endometritis (chemically induced), Endometritis (drug therapy), Endometrium (drug effects), Endometrium (pathology), Epithelial Cells (drug effects), Epithelial Cells (pathology), Female (MeSH), Gallic Acid (analogs & derivatives), Gallic Acid (therapeutic use), Interleukin-1beta (metabolism), Leonurus (immunology), Lipopolysaccharides (immunology), Mice (MeSH), NF-kappa B (metabolism), Signal Transduction (MeSH), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , analogs & derivatives : Gallic Acid.
- chemical , immunology : Lipopolysaccharides.
- chemical , metabolism : Interleukin-1beta, NF-kappa B, Tumor Necrosis Factor-alpha.
- chemical , therapeutic use : Anti-Inflammatory Agents, Gallic Acid.
- chemically induced : Endometritis.
- drug effects : Endometrium, Epithelial Cells.
- drug therapy : Endometritis.
- immunology : Leonurus.
- pathology : Endometrium, Epithelial Cells.
- Animals, Cattle, Cells, Cultured, Disease Models, Animal, Female, Mice, Signal Transduction.
Abstract
Endometritis is the inflammation of the endometrium that is associated with lower conception rates, increased intervals from calving to first service, and more culls for failure to conceive, which leads to serious economic losses in the dairy industry. Leonurine, a natural active compound of Leonurus cardiaca, has been proved to possess various biological activities. However, there is still no study about its anti-inflammatory effects on LPS-induced endometritis. The present study aimed to demonstrate the underlying mechanism responsible for the anti-inflammatory effects of leonurine on LPS induced endometritis in mice and in bovine endometrial epithelial cells (bEECs). The results of pathological section displayed that leonurine alleviated LPS induced uterine injury. qRT-PCR and ELISA experiments suggested that leonurine inhibited the expression levels of TNF-α and IL-1β in uterus tissues and bEECs. Molecular studies showed that TLR4 expression and nuclear factor (NF)-κB activation were both inhibited by leonurine treatment. These results suggested that the therapeutic effects of leonurine on LPS-induced endometritis in mice and bEECs may act by inhibiting the expression of TLR4 and its downstream mediated NF-κB pathway. Accordingly, leonurine may serve as an effective drug in preventing and treating LPS induced endometritis.
DOI: 10.1016/j.intimp.2018.06.002
PubMed: 29879659
Affiliations:
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Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China; Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Ailing" sort="Dai, Ailing" uniqKey="Dai A" first="Ailing" last="Dai">Ailing Dai</name><affiliation wicri:level="1"><nlm:affiliation>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xingxing" sort="Chen, Xingxing" uniqKey="Chen X" first="Xingxing" last="Chen">Xingxing Chen</name><affiliation wicri:level="1"><nlm:affiliation>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Xiaoyan" sort="Yang, Xiaoyan" uniqKey="Yang X" first="Xiaoyan" last="Yang">Xiaoyan Yang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences of Longyan University, Longyan 364012, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiaohua" sort="Li, Xiaohua" uniqKey="Li X" first="Xiaohua" last="Li">Xiaohua Li</name><affiliation wicri:level="1"><nlm:affiliation>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Cuiqin" sort="Huang, Cuiqin" uniqKey="Huang C" first="Cuiqin" last="Huang">Cuiqin Huang</name><affiliation wicri:level="1"><nlm:affiliation>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Kangfeng" sort="Jiang, Kangfeng" uniqKey="Jiang K" first="Kangfeng" last="Jiang">Kangfeng Jiang</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Deng, Ganzhen" sort="Deng, Ganzhen" uniqKey="Deng G" first="Ganzhen" last="Deng">Ganzhen Deng</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China. Electronic address: ganzhendeng@sohu.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">International immunopharmacology</title><idno type="eISSN">1878-1705</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Anti-Inflammatory Agents (therapeutic use)</term><term>Cattle (MeSH)</term><term>Cells, Cultured (MeSH)</term><term>Disease Models, Animal (MeSH)</term><term>Endometritis (chemically induced)</term><term>Endometritis (drug therapy)</term><term>Endometrium (drug effects)</term><term>Endometrium (pathology)</term><term>Epithelial Cells (drug effects)</term><term>Epithelial Cells (pathology)</term><term>Female (MeSH)</term><term>Gallic Acid (analogs & derivatives)</term><term>Gallic Acid (therapeutic use)</term><term>Interleukin-1beta (metabolism)</term><term>Leonurus (immunology)</term><term>Lipopolysaccharides (immunology)</term><term>Mice (MeSH)</term><term>NF-kappa B (metabolism)</term><term>Signal Transduction (MeSH)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide gallique (analogues et dérivés)</term><term>Acide gallique (usage thérapeutique)</term><term>Animaux (MeSH)</term><term>Anti-inflammatoires (usage thérapeutique)</term><term>Bovins (MeSH)</term><term>Cellules cultivées (MeSH)</term><term>Cellules épithéliales (anatomopathologie)</term><term>Cellules épithéliales (effets des médicaments et des substances chimiques)</term><term>Endomètre (anatomopathologie)</term><term>Endomètre (effets des médicaments et des substances chimiques)</term><term>Endométrite (induit chimiquement)</term><term>Endométrite (traitement médicamenteux)</term><term>Facteur de nécrose tumorale alpha (métabolisme)</term><term>Facteur de transcription NF-kappa B (métabolisme)</term><term>Femelle (MeSH)</term><term>Interleukine-1 bêta (métabolisme)</term><term>Leonurus (immunologie)</term><term>Lipopolysaccharides (immunologie)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Souris (MeSH)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Gallic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Lipopolysaccharides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukin-1beta</term><term>NF-kappa B</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Gallic Acid</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide gallique</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Endomètre</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Endometritis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Endometrium</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Endometritis</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cellules épithéliales</term><term>Endomètre</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Leonurus</term><term>Lipopolysaccharides</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Leonurus</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Endométrite</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term><term>Facteur de transcription NF-kappa B</term><term>Interleukine-1 bêta</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endometrium</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Endométrite</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acide gallique</term><term>Anti-inflammatoires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cattle</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Female</term><term>Mice</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Bovins</term><term>Cellules cultivées</term><term>Femelle</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Endometritis is the inflammation of the endometrium that is associated with lower conception rates, increased intervals from calving to first service, and more culls for failure to conceive, which leads to serious economic losses in the dairy industry. Leonurine, a natural active compound of Leonurus cardiaca, has been proved to possess various biological activities. However, there is still no study about its anti-inflammatory effects on LPS-induced endometritis. The present study aimed to demonstrate the underlying mechanism responsible for the anti-inflammatory effects of leonurine on LPS induced endometritis in mice and in bovine endometrial epithelial cells (bEECs). The results of pathological section displayed that leonurine alleviated LPS induced uterine injury. qRT-PCR and ELISA experiments suggested that leonurine inhibited the expression levels of TNF-α and IL-1β in uterus tissues and bEECs. Molecular studies showed that TLR4 expression and nuclear factor (NF)-κB activation were both inhibited by leonurine treatment. These results suggested that the therapeutic effects of leonurine on LPS-induced endometritis in mice and bEECs may act by inhibiting the expression of TLR4 and its downstream mediated NF-κB pathway. Accordingly, leonurine may serve as an effective drug in preventing and treating LPS induced endometritis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29879659</PMID><DateCompleted><Year>2018</Year><Month>11</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-1705</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><PubDate><Year>2018</Year><Month>Aug</Month></PubDate></JournalIssue><Title>International immunopharmacology</Title><ISOAbbreviation>Int Immunopharmacol</ISOAbbreviation></Journal><ArticleTitle>Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis.</ArticleTitle><Pagination><MedlinePgn>156-161</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1567-5769(18)30253-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.intimp.2018.06.002</ELocationID><Abstract><AbstractText>Endometritis is the inflammation of the endometrium that is associated with lower conception rates, increased intervals from calving to first service, and more culls for failure to conceive, which leads to serious economic losses in the dairy industry. Leonurine, a natural active compound of Leonurus cardiaca, has been proved to possess various biological activities. However, there is still no study about its anti-inflammatory effects on LPS-induced endometritis. The present study aimed to demonstrate the underlying mechanism responsible for the anti-inflammatory effects of leonurine on LPS induced endometritis in mice and in bovine endometrial epithelial cells (bEECs). The results of pathological section displayed that leonurine alleviated LPS induced uterine injury. qRT-PCR and ELISA experiments suggested that leonurine inhibited the expression levels of TNF-α and IL-1β in uterus tissues and bEECs. Molecular studies showed that TLR4 expression and nuclear factor (NF)-κB activation were both inhibited by leonurine treatment. These results suggested that the therapeutic effects of leonurine on LPS-induced endometritis in mice and bEECs may act by inhibiting the expression of TLR4 and its downstream mediated NF-κB pathway. Accordingly, leonurine may serve as an effective drug in preventing and treating LPS induced endometritis.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Haichong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China; Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>Ailing</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xingxing</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Xiaoyan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xiaohua</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Cuiqin</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan 364012, Fujian, China; College of Life Sciences of Longyan University, Longyan 364012, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Kangfeng</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Ganzhen</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China. Electronic address: ganzhendeng@sohu.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>06</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int Immunopharmacol</MedlineTA><NlmUniqueID>100965259</NlmUniqueID><ISSNLinking>1567-5769</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>09Q5W34QDA</RegistryNumber><NameOfSubstance UI="C013587">leonurine</NameOfSubstance></Chemical><Chemical><RegistryNumber>632XD903SP</RegistryNumber><NameOfSubstance UI="D005707">Gallic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004716" MajorTopicYN="N">Endometritis</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004717" MajorTopicYN="N">Endometrium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005707" MajorTopicYN="N">Gallic Acid</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D031332" MajorTopicYN="N">Leonurus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-inflammation</Keyword><Keyword MajorTopicYN="N">Endometritis</Keyword><Keyword MajorTopicYN="N">Leonurine</Keyword><Keyword MajorTopicYN="N">Nuclear factor-κB</Keyword><Keyword MajorTopicYN="N">Toll-like receptor 4</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>03</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>05</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>06</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>6</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>6</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29879659</ArticleId><ArticleId IdType="pii">S1567-5769(18)30253-4</ArticleId><ArticleId IdType="doi">10.1016/j.intimp.2018.06.002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Haichong" sort="Wu, Haichong" uniqKey="Wu H" first="Haichong" last="Wu">Haichong Wu</name></noRegion><name sortKey="Chen, Xingxing" sort="Chen, Xingxing" uniqKey="Chen X" first="Xingxing" last="Chen">Xingxing Chen</name><name sortKey="Dai, Ailing" sort="Dai, Ailing" uniqKey="Dai A" first="Ailing" last="Dai">Ailing Dai</name><name sortKey="Deng, Ganzhen" sort="Deng, Ganzhen" uniqKey="Deng G" first="Ganzhen" last="Deng">Ganzhen Deng</name><name sortKey="Huang, Cuiqin" sort="Huang, Cuiqin" uniqKey="Huang C" first="Cuiqin" last="Huang">Cuiqin Huang</name><name sortKey="Jiang, Kangfeng" sort="Jiang, Kangfeng" uniqKey="Jiang K" first="Kangfeng" last="Jiang">Kangfeng Jiang</name><name sortKey="Li, Xiaohua" sort="Li, Xiaohua" uniqKey="Li X" first="Xiaohua" last="Li">Xiaohua Li</name><name sortKey="Yang, Xiaoyan" sort="Yang, Xiaoyan" uniqKey="Yang X" first="Xiaoyan" last="Yang">Xiaoyan Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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