Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors.
Identifieur interne : 000147 ( Main/Corpus ); précédent : 000146; suivant : 000148Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors.
Auteurs : Michel L. Leite ; Kamila B. Sampaio ; Fabrício F. Costa ; Octávio L. Franco ; Simoni C. Dias ; Nicolau B. CunhaSource :
- Anais da Academia Brasileira de Ciencias [ 1678-2690 ] ; 2019.
English descriptors
- KwdEn :
- Agrobacterium tumefaciens (metabolism), Antimicrobial Cationic Peptides (biosynthesis), Antimicrobial Cationic Peptides (pharmacology), Biotechnology (methods), Genetic Vectors (genetics), Genetic Vectors (metabolism), Molecular Farming (methods), Plants, Genetically Modified (metabolism), Protein Biosynthesis (MeSH), Tobacco (metabolism).
- MESH :
- chemical , biosynthesis : Antimicrobial Cationic Peptides.
- genetics : Genetic Vectors.
- metabolism : Agrobacterium tumefaciens, Genetic Vectors, Plants, Genetically Modified, Tobacco.
- methods : Biotechnology, Molecular Farming.
- chemical , pharmacology : Antimicrobial Cationic Peptides.
- Protein Biosynthesis.
Abstract
The constant demand for new antibiotic drugs has driven efforts by the scientific community to prospect for peptides with a broad spectrum of action. In this context, antimicrobial peptides (AMPs) have acquired great scientific importance in recent years due to their ability to possess antimicrobial and immunomodulatory activity. In the last two decades, plants have attracted the interest of the scientific community and industry as regards their potential as biofactories of heterologous proteins. One of the most promising approaches is the use of viral vectors to maximize the transient expression of drugs in the leaves of the plant Nicotiana benthamiana. Recently, the MagnifectionTM expression system was launched. This sophisticated commercial platform allows the assembly of the viral particle in leaf cells and the systemic spread of heterologous protein biosynthesis in green tissues caused by Agrobacterium tumefaciens "gene delivery method". The system also presents increased gene expression levels mediated by potent viral expression machinery. These characteristics allow the mass recovery of heterologous proteins in the leaves of N. benthamiana in 8 to 10 days. This system was highly efficient for the synthesis of different classes of pharmacological proteins and contains enormous potential for the rapid and abundant biosynthesis of AMPs.
DOI: 10.1590/0001-3765201820180124
PubMed: 30365717
Links to Exploration step
pubmed:30365717Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors.</title>
<author><name sortKey="Leite, Michel L" sort="Leite, Michel L" uniqKey="Leite M" first="Michel L" last="Leite">Michel L. Leite</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sampaio, Kamila B" sort="Sampaio, Kamila B" uniqKey="Sampaio K" first="Kamila B" last="Sampaio">Kamila B. Sampaio</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Costa, Fabricio F" sort="Costa, Fabricio F" uniqKey="Costa F" first="Fabrício F" last="Costa">Fabrício F. Costa</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Cancer Biology and Epigenomics Program, Northwestern University's Feinberg School of Medicine, 60611, Chicago IL, USA.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Genomic Enterprise, 2405 N. Sheffield Av., 14088, 60614, Chicago, IL, USA.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>MATTER Chicago, 222 W. Merchandise Mart Plaza, 12th Floor, 60654, Chicago, IL, USA.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>The Founder Institute, 3337 El Camino Real, 94306, Palo Alto, CA USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Franco, Octavio L" sort="Franco, Octavio L" uniqKey="Franco O" first="Octávio L" last="Franco">Octávio L. Franco</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Av. Tamandaré, 6000, Jardim Seminário, 79117-010 Campo Grande, MS, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dias, Simoni C" sort="Dias, Simoni C" uniqKey="Dias S" first="Simoni C" last="Dias">Simoni C. Dias</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cunha, Nicolau B" sort="Cunha, Nicolau B" uniqKey="Cunha N" first="Nicolau B" last="Cunha">Nicolau B. Cunha</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:30365717</idno>
<idno type="pmid">30365717</idno>
<idno type="doi">10.1590/0001-3765201820180124</idno>
<idno type="wicri:Area/Main/Corpus">000147</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000147</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors.</title>
<author><name sortKey="Leite, Michel L" sort="Leite, Michel L" uniqKey="Leite M" first="Michel L" last="Leite">Michel L. Leite</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sampaio, Kamila B" sort="Sampaio, Kamila B" uniqKey="Sampaio K" first="Kamila B" last="Sampaio">Kamila B. Sampaio</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Costa, Fabricio F" sort="Costa, Fabricio F" uniqKey="Costa F" first="Fabrício F" last="Costa">Fabrício F. Costa</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Cancer Biology and Epigenomics Program, Northwestern University's Feinberg School of Medicine, 60611, Chicago IL, USA.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Genomic Enterprise, 2405 N. Sheffield Av., 14088, 60614, Chicago, IL, USA.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>MATTER Chicago, 222 W. Merchandise Mart Plaza, 12th Floor, 60654, Chicago, IL, USA.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>The Founder Institute, 3337 El Camino Real, 94306, Palo Alto, CA USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Franco, Octavio L" sort="Franco, Octavio L" uniqKey="Franco O" first="Octávio L" last="Franco">Octávio L. Franco</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Av. Tamandaré, 6000, Jardim Seminário, 79117-010 Campo Grande, MS, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dias, Simoni C" sort="Dias, Simoni C" uniqKey="Dias S" first="Simoni C" last="Dias">Simoni C. Dias</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cunha, Nicolau B" sort="Cunha, Nicolau B" uniqKey="Cunha N" first="Nicolau B" last="Cunha">Nicolau B. Cunha</name>
<affiliation><nlm:affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Anais da Academia Brasileira de Ciencias</title>
<idno type="eISSN">1678-2690</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agrobacterium tumefaciens (metabolism)</term>
<term>Antimicrobial Cationic Peptides (biosynthesis)</term>
<term>Antimicrobial Cationic Peptides (pharmacology)</term>
<term>Biotechnology (methods)</term>
<term>Genetic Vectors (genetics)</term>
<term>Genetic Vectors (metabolism)</term>
<term>Molecular Farming (methods)</term>
<term>Plants, Genetically Modified (metabolism)</term>
<term>Protein Biosynthesis (MeSH)</term>
<term>Tobacco (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antimicrobial Cationic Peptides</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Vectors</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Agrobacterium tumefaciens</term>
<term>Genetic Vectors</term>
<term>Plants, Genetically Modified</term>
<term>Tobacco</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biotechnology</term>
<term>Molecular Farming</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimicrobial Cationic Peptides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Protein Biosynthesis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The constant demand for new antibiotic drugs has driven efforts by the scientific community to prospect for peptides with a broad spectrum of action. In this context, antimicrobial peptides (AMPs) have acquired great scientific importance in recent years due to their ability to possess antimicrobial and immunomodulatory activity. In the last two decades, plants have attracted the interest of the scientific community and industry as regards their potential as biofactories of heterologous proteins. One of the most promising approaches is the use of viral vectors to maximize the transient expression of drugs in the leaves of the plant Nicotiana benthamiana. Recently, the MagnifectionTM expression system was launched. This sophisticated commercial platform allows the assembly of the viral particle in leaf cells and the systemic spread of heterologous protein biosynthesis in green tissues caused by Agrobacterium tumefaciens "gene delivery method". The system also presents increased gene expression levels mediated by potent viral expression machinery. These characteristics allow the mass recovery of heterologous proteins in the leaves of N. benthamiana in 8 to 10 days. This system was highly efficient for the synthesis of different classes of pharmacological proteins and contains enormous potential for the rapid and abundant biosynthesis of AMPs.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30365717</PMID>
<DateCompleted><Year>2019</Year>
<Month>03</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>03</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1678-2690</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>91</Volume>
<Issue>suppl 1</Issue>
<PubDate><Year>2019</Year>
</PubDate>
</JournalIssue>
<Title>Anais da Academia Brasileira de Ciencias</Title>
<ISOAbbreviation>An Acad Bras Cienc</ISOAbbreviation>
</Journal>
<ArticleTitle>Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors.</ArticleTitle>
<Pagination><MedlinePgn>e20180124</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0001-37652019000200851</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1590/0001-3765201820180124</ELocationID>
<Abstract><AbstractText>The constant demand for new antibiotic drugs has driven efforts by the scientific community to prospect for peptides with a broad spectrum of action. In this context, antimicrobial peptides (AMPs) have acquired great scientific importance in recent years due to their ability to possess antimicrobial and immunomodulatory activity. In the last two decades, plants have attracted the interest of the scientific community and industry as regards their potential as biofactories of heterologous proteins. One of the most promising approaches is the use of viral vectors to maximize the transient expression of drugs in the leaves of the plant Nicotiana benthamiana. Recently, the MagnifectionTM expression system was launched. This sophisticated commercial platform allows the assembly of the viral particle in leaf cells and the systemic spread of heterologous protein biosynthesis in green tissues caused by Agrobacterium tumefaciens "gene delivery method". The system also presents increased gene expression levels mediated by potent viral expression machinery. These characteristics allow the mass recovery of heterologous proteins in the leaves of N. benthamiana in 8 to 10 days. This system was highly efficient for the synthesis of different classes of pharmacological proteins and contains enormous potential for the rapid and abundant biosynthesis of AMPs.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Leite</LastName>
<ForeName>Michel L</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sampaio</LastName>
<ForeName>Kamila B</ForeName>
<Initials>KB</Initials>
<AffiliationInfo><Affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Costa</LastName>
<ForeName>Fabrício F</ForeName>
<Initials>FF</Initials>
<AffiliationInfo><Affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Cancer Biology and Epigenomics Program, Northwestern University's Feinberg School of Medicine, 60611, Chicago IL, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Genomic Enterprise, 2405 N. Sheffield Av., 14088, 60614, Chicago, IL, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>MATTER Chicago, 222 W. Merchandise Mart Plaza, 12th Floor, 60654, Chicago, IL, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>The Founder Institute, 3337 El Camino Real, 94306, Palo Alto, CA USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Franco</LastName>
<ForeName>Octávio L</ForeName>
<Initials>OL</Initials>
<AffiliationInfo><Affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Av. Tamandaré, 6000, Jardim Seminário, 79117-010 Campo Grande, MS, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dias</LastName>
<ForeName>Simoni C</ForeName>
<Initials>SC</Initials>
<AffiliationInfo><Affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cunha</LastName>
<ForeName>Nicolau B</ForeName>
<Initials>NB</Initials>
<AffiliationInfo><Affiliation>Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília/UCB, SGAN 916, Modulo B, Bloco C, 70790-160 Brasilia, DF, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>10</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Brazil</Country>
<MedlineTA>An Acad Bras Cienc</MedlineTA>
<NlmUniqueID>7503280</NlmUniqueID>
<ISSNLinking>0001-3765</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D023181">Antimicrobial Cationic Peptides</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D016960" MajorTopicYN="N">Agrobacterium tumefaciens</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D023181" MajorTopicYN="N">Antimicrobial Cationic Peptides</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001709" MajorTopicYN="N">Biotechnology</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005822" MajorTopicYN="N">Genetic Vectors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058634" MajorTopicYN="N">Molecular Farming</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014176" MajorTopicYN="Y">Protein Biosynthesis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014026" MajorTopicYN="N">Tobacco</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>02</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>06</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>3</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30365717</ArticleId>
<ArticleId IdType="pii">S0001-37652018005015115</ArticleId>
<ArticleId IdType="doi">10.1590/0001-3765201820180124</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/AgrobacTransV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000147 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000147 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Bois |area= AgrobacTransV1 |flux= Main |étape= Corpus |type= RBID |clé= pubmed:30365717 |texte= Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:30365717" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a AgrobacTransV1
![]() | This area was generated with Dilib version V0.6.38. | ![]() |