Hormone levels and cognitive function in postmenopausal midlife women.
Identifieur interne : 003A40 ( PubMed/Curation ); précédent : 003A39; suivant : 003A41Hormone levels and cognitive function in postmenopausal midlife women.
Auteurs : Joanne Ryan [France] ; Frank Z. Stanczyk ; Lorraine Dennerstein ; Wendy J. Mack ; Margaret S. Clark ; Cassandra Szoeke ; Daniel Kildea ; Victor W. HendersonSource :
- Neurobiology of aging [ 1558-1497 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Apprentissage verbal (physiologie), Cognition (physiologie), Démence (sang), Démence (épidémiologie), Facteurs de risque, Femelle, Globuline de liaison aux hormones sexuelles (métabolisme), Humains, Marqueurs biologiques (sang), Mémoire (physiologie), Oestradiol (sang), Oestrone (sang), Post-ménopause (physiologie), Testostérone (sang), Tests neuropsychologiques, Études longitudinales, Études transversales.
- MESH :
- métabolisme : Globuline de liaison aux hormones sexuelles.
- physiologie : Apprentissage verbal, Cognition, Mémoire, Post-ménopause.
- sang : Démence, Marqueurs biologiques, Oestradiol, Oestrone, Testostérone.
- épidémiologie : Démence.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Tests neuropsychologiques, Études longitudinales, Études transversales.
English descriptors
- KwdEn :
- Biomarkers (blood), Cognition (physiology), Cross-Sectional Studies, Dementia (blood), Dementia (epidemiology), Estradiol (blood), Estrone (blood), Female, Humans, Longitudinal Studies, Memory (physiology), Middle Aged, Neuropsychological Tests, Postmenopause (physiology), Risk Factors, Sex Hormone-Binding Globulin (metabolism), Testosterone (blood), Verbal Learning (physiology).
- MESH :
- chemical , blood : Biomarkers, Estradiol, Estrone, Testosterone.
- blood : Dementia.
- epidemiology : Dementia.
- chemical , metabolism : Sex Hormone-Binding Globulin.
- physiology : Cognition, Memory, Postmenopause, Verbal Learning.
- Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Middle Aged, Neuropsychological Tests, Risk Factors.
Abstract
Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women's Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, and total and free testosterone levels were measured at time of the first testing. Principal-component analysis identified four cognitive factors. In multiple linear regression analyses, better semantic memory performance was associated with higher total (p = 0.02) and free (p = 0.03) estradiol levels and a lower ratio of testosterone to estradiol (p = 0.007). There were trends for associations between better verbal episodic memory and lower total testosterone (p = 0.08) and lower testosterone/estradiol ratio (p = 0.06). Lower free testosterone levels were associated with greater 2-year improvement on verbal episodic memory (p = 0.04); higher testosterone/estradiol predicted greater semantic memory improvement (p = 0.03). In postmenopausal midlife women, endogenous estradiol and testosterone levels and the testosterone/estradiol ratio are associated with semantic memory and verbal episodic memory abilities.
DOI: 10.1016/j.neurobiolaging.2010.07.014
PubMed: 20888079
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Henderson</name></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="eISSN">1558-1497</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers (blood)</term><term>Cognition (physiology)</term><term>Cross-Sectional Studies</term><term>Dementia (blood)</term><term>Dementia (epidemiology)</term><term>Estradiol (blood)</term><term>Estrone (blood)</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Memory (physiology)</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Postmenopause (physiology)</term><term>Risk Factors</term><term>Sex Hormone-Binding Globulin (metabolism)</term><term>Testosterone (blood)</term><term>Verbal Learning (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Apprentissage verbal (physiologie)</term><term>Cognition (physiologie)</term><term>Démence (sang)</term><term>Démence (épidémiologie)</term><term>Facteurs de risque</term><term>Femelle</term><term>Globuline de liaison aux hormones sexuelles (métabolisme)</term><term>Humains</term><term>Marqueurs biologiques (sang)</term><term>Mémoire (physiologie)</term><term>Oestradiol (sang)</term><term>Oestrone (sang)</term><term>Post-ménopause (physiologie)</term><term>Testostérone (sang)</term><term>Tests neuropsychologiques</term><term>Études longitudinales</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Estradiol</term><term>Estrone</term><term>Testosterone</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Sex Hormone-Binding Globulin</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Globuline de liaison aux hormones sexuelles</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apprentissage verbal</term><term>Cognition</term><term>Mémoire</term><term>Post-ménopause</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Memory</term><term>Postmenopause</term><term>Verbal Learning</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Démence</term><term>Marqueurs biologiques</term><term>Oestradiol</term><term>Oestrone</term><term>Testostérone</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Démence</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Tests neuropsychologiques</term><term>Études longitudinales</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women's Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, and total and free testosterone levels were measured at time of the first testing. Principal-component analysis identified four cognitive factors. In multiple linear regression analyses, better semantic memory performance was associated with higher total (p = 0.02) and free (p = 0.03) estradiol levels and a lower ratio of testosterone to estradiol (p = 0.007). There were trends for associations between better verbal episodic memory and lower total testosterone (p = 0.08) and lower testosterone/estradiol ratio (p = 0.06). Lower free testosterone levels were associated with greater 2-year improvement on verbal episodic memory (p = 0.04); higher testosterone/estradiol predicted greater semantic memory improvement (p = 0.03). In postmenopausal midlife women, endogenous estradiol and testosterone levels and the testosterone/estradiol ratio are associated with semantic memory and verbal episodic memory abilities.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20888079</PMID><DateCreated><Year>2012</Year><Month>01</Month><Day>16</Day></DateCreated><DateCompleted><Year>2012</Year><Month>09</Month><Day>28</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-1497</ISSN><JournalIssue CitedMedium="Internet"><Volume>33</Volume><Issue>3</Issue><PubDate><Year>2012</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Neurobiology of aging</Title><ISOAbbreviation>Neurobiol. 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In multiple linear regression analyses, better semantic memory performance was associated with higher total (p = 0.02) and free (p = 0.03) estradiol levels and a lower ratio of testosterone to estradiol (p = 0.007). There were trends for associations between better verbal episodic memory and lower total testosterone (p = 0.08) and lower testosterone/estradiol ratio (p = 0.06). Lower free testosterone levels were associated with greater 2-year improvement on verbal episodic memory (p = 0.04); higher testosterone/estradiol predicted greater semantic memory improvement (p = 0.03). In postmenopausal midlife women, endogenous estradiol and testosterone levels and the testosterone/estradiol ratio are associated with semantic memory and verbal episodic memory abilities.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ryan</LastName><ForeName>Joanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and National Ageing Research Institute, The University of Melbourne, Parkville 3010, Victoria, Australia; INSERM, U888, Montpellier, F-34093, France; University Montpellier 1, Montpellier, F-34000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stanczyk</LastName><ForeName>Frank Z</ForeName><Initials>FZ</Initials></Author><Author ValidYN="Y"><LastName>Dennerstein</LastName><ForeName>Lorraine</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Mack</LastName><ForeName>Wendy J</ForeName><Initials>WJ</Initials></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Margaret S</ForeName><Initials>MS</Initials></Author><Author 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