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Validation of the DRAGON score in 12 stroke centers in anterior and posterior circulation.

Identifieur interne : 003986 ( PubMed/Curation ); précédent : 003985; suivant : 003987

Validation of the DRAGON score in 12 stroke centers in anterior and posterior circulation.

Auteurs : Daniel Strbian ; David J. Seiffge ; Lorenz Breuer ; Heikki Numminen ; Patrik Michel ; Atte Meretoja ; Skye Coote ; Régis Bordet ; Victor Obach ; Bruno Weder ; Simon Jung ; Valeria Caso ; Sami Curtze ; Jyrki Ollikainen ; Philippe A. Lyrer ; Ashraf Eskandari ; Heinrich P. Mattle ; Angel Chamorro ; Didier Leys ; Christopher Bladin ; Stephen M. Davis ; Martin Köhrmann ; Stefan T. Engelter ; Turgut Tatlisumak

Source :

RBID : pubmed:23929752

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English descriptors

Abstract

The DRAGON score predicts functional outcome in the hyperacute phase of intravenous thrombolysis treatment of ischemic stroke patients. We aimed to validate the score in a large multicenter cohort in anterior and posterior circulation.

DOI: 10.1161/STROKEAHA.113.002033
PubMed: 23929752

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Daniel Strbian
<affiliation>
<nlm:affiliation>From the Department of Neurology and Stroke Unit, Helsinki University Central Hospital, Helsinki, Finland (D.S., A.M., S.C., T.T.); Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland (D.J.S., P.A.L., S.T.E.); Department of Neurology, Universitätsklinikum Erlangen, Erlangen, Germany (L.B., M.K.); Department of Neurology, Tampere University Hospital, Tampere, Finland (H.N., J.O.); Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P.M., A.E.); Department of Neurology, The Royal Melbourne Hospital, Parkville, Australia (A.M., C.B., S.M.D.); Department of Neurology, Box Hill Hospital, Box Hill, Australia (S.C., C.B.); Department of Neurology, University Lille Nord de France, Lille, France (R.B., D.L.); Department of Neurology, Hospital Clínic Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain (V.O., A.C.); Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland (B.W.); Department of Neurology, University of Bern, Bern, Switzerland (S.J., H.P.M.); and Department of Neurology, University of Perugia, Perugia, Italy (V.C.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (V.C.).</wicri:noCountry>
</affiliation>

Le document en format XML

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<nlm:affiliation>From the Department of Neurology and Stroke Unit, Helsinki University Central Hospital, Helsinki, Finland (D.S., A.M., S.C., T.T.); Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland (D.J.S., P.A.L., S.T.E.); Department of Neurology, Universitätsklinikum Erlangen, Erlangen, Germany (L.B., M.K.); Department of Neurology, Tampere University Hospital, Tampere, Finland (H.N., J.O.); Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P.M., A.E.); Department of Neurology, The Royal Melbourne Hospital, Parkville, Australia (A.M., C.B., S.M.D.); Department of Neurology, Box Hill Hospital, Box Hill, Australia (S.C., C.B.); Department of Neurology, University Lille Nord de France, Lille, France (R.B., D.L.); Department of Neurology, Hospital Clínic Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain (V.O., A.C.); Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland (B.W.); Department of Neurology, University of Bern, Bern, Switzerland (S.J., H.P.M.); and Department of Neurology, University of Perugia, Perugia, Italy (V.C.).</nlm:affiliation>
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<name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name>
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<name sortKey="Bladin, Christopher" sort="Bladin, Christopher" uniqKey="Bladin C" first="Christopher" last="Bladin">Christopher Bladin</name>
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<nlm:affiliation>From the Department of Neurology and Stroke Unit, Helsinki University Central Hospital, Helsinki, Finland (D.S., A.M., S.C., T.T.); Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland (D.J.S., P.A.L., S.T.E.); Department of Neurology, Universitätsklinikum Erlangen, Erlangen, Germany (L.B., M.K.); Department of Neurology, Tampere University Hospital, Tampere, Finland (H.N., J.O.); Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P.M., A.E.); Department of Neurology, The Royal Melbourne Hospital, Parkville, Australia (A.M., C.B., S.M.D.); Department of Neurology, Box Hill Hospital, Box Hill, Australia (S.C., C.B.); Department of Neurology, University Lille Nord de France, Lille, France (R.B., D.L.); Department of Neurology, Hospital Clínic Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain (V.O., A.C.); Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland (B.W.); Department of Neurology, University of Bern, Bern, Switzerland (S.J., H.P.M.); and Department of Neurology, University of Perugia, Perugia, Italy (V.C.).</nlm:affiliation>
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<name sortKey="Seiffge, David J" sort="Seiffge, David J" uniqKey="Seiffge D" first="David J" last="Seiffge">David J. Seiffge</name>
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<name sortKey="Coote, Skye" sort="Coote, Skye" uniqKey="Coote S" first="Skye" last="Coote">Skye Coote</name>
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<name sortKey="Jung, Simon" sort="Jung, Simon" uniqKey="Jung S" first="Simon" last="Jung">Simon Jung</name>
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<name sortKey="Caso, Valeria" sort="Caso, Valeria" uniqKey="Caso V" first="Valeria" last="Caso">Valeria Caso</name>
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<name sortKey="Curtze, Sami" sort="Curtze, Sami" uniqKey="Curtze S" first="Sami" last="Curtze">Sami Curtze</name>
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<name sortKey="Ollikainen, Jyrki" sort="Ollikainen, Jyrki" uniqKey="Ollikainen J" first="Jyrki" last="Ollikainen">Jyrki Ollikainen</name>
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<name sortKey="Lyrer, Philippe A" sort="Lyrer, Philippe A" uniqKey="Lyrer P" first="Philippe A" last="Lyrer">Philippe A. Lyrer</name>
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<name sortKey="Mattle, Heinrich P" sort="Mattle, Heinrich P" uniqKey="Mattle H" first="Heinrich P" last="Mattle">Heinrich P. Mattle</name>
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<name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name>
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<name sortKey="Bladin, Christopher" sort="Bladin, Christopher" uniqKey="Bladin C" first="Christopher" last="Bladin">Christopher Bladin</name>
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<name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name>
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<name sortKey="Kohrmann, Martin" sort="Kohrmann, Martin" uniqKey="Kohrmann M" first="Martin" last="Köhrmann">Martin Köhrmann</name>
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<name sortKey="Tatlisumak, Turgut" sort="Tatlisumak, Turgut" uniqKey="Tatlisumak T" first="Turgut" last="Tatlisumak">Turgut Tatlisumak</name>
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<title level="j">Stroke</title>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain Ischemia (mortality)</term>
<term>Brain Ischemia (physiopathology)</term>
<term>Brain Ischemia (therapy)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Prospective Studies</term>
<term>Severity of Illness Index</term>
<term>Stroke (mortality)</term>
<term>Stroke (physiopathology)</term>
<term>Stroke (therapy)</term>
<term>Thrombolytic Therapy</term>
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<keywords scheme="KwdFr" xml:lang="fr">
<term>Accident vasculaire cérébral ()</term>
<term>Accident vasculaire cérébral (mortalité)</term>
<term>Accident vasculaire cérébral (physiopathologie)</term>
<term>Adulte d'âge moyen</term>
<term>Encéphalopathie ischémique ()</term>
<term>Encéphalopathie ischémique (mortalité)</term>
<term>Encéphalopathie ischémique (physiopathologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Traitement thrombolytique</term>
<term>Valeur prédictive des tests</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Brain Ischemia</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Accident vasculaire cérébral</term>
<term>Encéphalopathie ischémique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Accident vasculaire cérébral</term>
<term>Encéphalopathie ischémique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Brain Ischemia</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Brain Ischemia</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Prospective Studies</term>
<term>Severity of Illness Index</term>
<term>Thrombolytic Therapy</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Accident vasculaire cérébral</term>
<term>Adulte d'âge moyen</term>
<term>Encéphalopathie ischémique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Traitement thrombolytique</term>
<term>Valeur prédictive des tests</term>
<term>Études prospectives</term>
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<front>
<div type="abstract" xml:lang="en">The DRAGON score predicts functional outcome in the hyperacute phase of intravenous thrombolysis treatment of ischemic stroke patients. We aimed to validate the score in a large multicenter cohort in anterior and posterior circulation.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">23929752</PMID>
<DateCreated>
<Year>2013</Year>
<Month>09</Month>
<Day>24</Day>
</DateCreated>
<DateCompleted>
<Year>2013</Year>
<Month>12</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised>
<Year>2016</Year>
<Month>11</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1524-4628</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>44</Volume>
<Issue>10</Issue>
<PubDate>
<Year>2013</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Stroke</Title>
<ISOAbbreviation>Stroke</ISOAbbreviation>
</Journal>
<ArticleTitle>Validation of the DRAGON score in 12 stroke centers in anterior and posterior circulation.</ArticleTitle>
<Pagination>
<MedlinePgn>2718-21</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/STROKEAHA.113.002033</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">The DRAGON score predicts functional outcome in the hyperacute phase of intravenous thrombolysis treatment of ischemic stroke patients. We aimed to validate the score in a large multicenter cohort in anterior and posterior circulation.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Prospectively collected data of consecutive ischemic stroke patients who received intravenous thrombolysis in 12 stroke centers were merged (n=5471). We excluded patients lacking data necessary to calculate the score and patients with missing 3-month modified Rankin scale scores. The final cohort comprised 4519 eligible patients. We assessed the performance of the DRAGON score with area under the receiver operating characteristic curve in the whole cohort for both good (modified Rankin scale score, 0-2) and miserable (modified Rankin scale score, 5-6) outcomes.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Area under the receiver operating characteristic curve was 0.84 (0.82-0.85) for miserable outcome and 0.82 (0.80-0.83) for good outcome. Proportions of patients with good outcome were 96%, 93%, 78%, and 0% for 0 to 1, 2, 3, and 8 to 10 score points, respectively. Proportions of patients with miserable outcome were 0%, 2%, 4%, 89%, and 97% for 0 to 1, 2, 3, 8, and 9 to 10 points, respectively. When tested separately for anterior and posterior circulation, there was no difference in performance (P=0.55); areas under the receiver operating characteristic curve were 0.84 (0.83-0.86) and 0.82 (0.78-0.87), respectively. No sex-related difference in performance was observed (P=0.25).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The DRAGON score showed very good performance in the large merged cohort in both anterior and posterior circulation strokes. The DRAGON score provides rapid estimation of patient prognosis and supports clinical decision-making in the hyperacute phase of stroke care (eg, when invasive add-on strategies are considered).</AbstractText>
</Abstract>
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<LastName>Strbian</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
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<Affiliation>From the Department of Neurology and Stroke Unit, Helsinki University Central Hospital, Helsinki, Finland (D.S., A.M., S.C., T.T.); Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland (D.J.S., P.A.L., S.T.E.); Department of Neurology, Universitätsklinikum Erlangen, Erlangen, Germany (L.B., M.K.); Department of Neurology, Tampere University Hospital, Tampere, Finland (H.N., J.O.); Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland (P.M., A.E.); Department of Neurology, The Royal Melbourne Hospital, Parkville, Australia (A.M., C.B., S.M.D.); Department of Neurology, Box Hill Hospital, Box Hill, Australia (S.C., C.B.); Department of Neurology, University Lille Nord de France, Lille, France (R.B., D.L.); Department of Neurology, Hospital Clínic Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain (V.O., A.C.); Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland (B.W.); Department of Neurology, University of Bern, Bern, Switzerland (S.J., H.P.M.); and Department of Neurology, University of Perugia, Perugia, Italy (V.C.).</Affiliation>
</AffiliationInfo>
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<LastName>Seiffge</LastName>
<ForeName>David J</ForeName>
<Initials>DJ</Initials>
</Author>
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<LastName>Breuer</LastName>
<ForeName>Lorenz</ForeName>
<Initials>L</Initials>
</Author>
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<LastName>Numminen</LastName>
<ForeName>Heikki</ForeName>
<Initials>H</Initials>
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<LastName>Michel</LastName>
<ForeName>Patrik</ForeName>
<Initials>P</Initials>
</Author>
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<LastName>Meretoja</LastName>
<ForeName>Atte</ForeName>
<Initials>A</Initials>
</Author>
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<LastName>Coote</LastName>
<ForeName>Skye</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Bordet</LastName>
<ForeName>Régis</ForeName>
<Initials>R</Initials>
</Author>
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<LastName>Obach</LastName>
<ForeName>Victor</ForeName>
<Initials>V</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Weder</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Jung</LastName>
<ForeName>Simon</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Caso</LastName>
<ForeName>Valeria</ForeName>
<Initials>V</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Curtze</LastName>
<ForeName>Sami</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Ollikainen</LastName>
<ForeName>Jyrki</ForeName>
<Initials>J</Initials>
</Author>
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<LastName>Lyrer</LastName>
<ForeName>Philippe A</ForeName>
<Initials>PA</Initials>
</Author>
<Author ValidYN="Y">
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