AustralieFrV1, PubMed, Curation, bibRecord, 003791

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails.

Identifieur interne : 003791 ( PubMed/Curation ); précédent : 003790; suivant : 003792

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails.

Auteurs : Sébastien Dutertre [France] ; Ai-Hua Jin [Australie] ; Irina Vetter [Australie] ; Brett Hamilton [Australie] ; Kartik Sunagar [Portugal] ; Vincent Lavergne [Australie] ; Valentin Dutertre [Australie] ; Bryan G. Fry [Australie] ; Agostinho Antunes [Portugal] ; Deon J. Venter [Australie] ; Paul F. Alewood [Australie] ; Richard J. Lewis [Australie]

Source :

Nature communications [ 2041-1723 ] ; 2014.

RBID : pubmed:24662800

Descripteurs français

English descriptors

KwdEn :
- Adaptation, Biological (physiology), Animals, Base Sequence, Cell Line, Tumor, Chromatography, High Pressure Liquid, Conus Snail (chemistry), Evolution, Molecular, Gene Expression Profiling, Histological Techniques, Humans, Likelihood Functions, Models, Biological, Molecular Sequence Data, Mollusk Venoms (chemistry), Mollusk Venoms (pharmacology), Predatory Behavior (physiology), Sequence Analysis, DNA.
MESH :
- chemical , chemistry : Mollusk Venoms.
- chemistry : Conus Snail.
- chemical , pharmacology : Mollusk Venoms.
- physiology : Adaptation, Biological, Predatory Behavior.
- Animals, Base Sequence, Cell Line, Tumor, Chromatography, High Pressure Liquid, Evolution, Molecular, Gene Expression Profiling, Histological Techniques, Humans, Likelihood Functions, Models, Biological, Molecular Sequence Data, Sequence Analysis, DNA.

Abstract

Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the defence-evoked venom of Conus geographus contains high levels of paralytic toxins that potently block neuromuscular receptors, consistent with its lethal effects on humans. In contrast, C. geographus predation-evoked venom contains prey-specific toxins mostly inactive at human targets. Predation- and defence-evoked venoms originate from the distal and proximal regions of the venom duct, respectively, explaining how different stimuli can generate two distinct venoms. A specialized defensive envenomation strategy is widely evolved across worm, mollusk and fish-hunting cone snails. We propose that defensive toxins, originally evolved in ancestral worm-hunting cone snails to protect against cephalopod and fish predation, have been repurposed in predatory venoms to facilitate diversification to fish and mollusk diets.

DOI: 10.1038/ncomms4521
PubMed: 24662800

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Le document en format XML

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<term>Base Sequence</term>
<term>Cell Line, Tumor</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Conus Snail (chemistry)</term>
<term>Evolution, Molecular</term>
<term>Gene Expression Profiling</term>
<term>Histological Techniques</term>
<term>Humans</term>
<term>Likelihood Functions</term>
<term>Models, Biological</term>
<term>Molecular Sequence Data</term>
<term>Mollusk Venoms (chemistry)</term>
<term>Mollusk Venoms (pharmacology)</term>
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<term>Sequence Analysis, DNA</term>
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<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
<term>Chromatographie en phase liquide à haute performance</term>
<term>Comportement prédateur (physiologie)</term>
<term>Conus ()</term>
<term>Données de séquences moléculaires</term>
<term>Fonctions de vraisemblance</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles biologiques</term>
<term>Séquence nucléotidique</term>
<term>Techniques histologiques</term>
<term>Venins de mollusque ()</term>
<term>Venins de mollusque (pharmacologie)</term>
<term>Évolution moléculaire</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Mollusk Venoms</term>
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<term>Comportement prédateur</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Biological</term>
<term>Predatory Behavior</term>
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<term>Base Sequence</term>
<term>Cell Line, Tumor</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Evolution, Molecular</term>
<term>Gene Expression Profiling</term>
<term>Histological Techniques</term>
<term>Humans</term>
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<term>Models, Biological</term>
<term>Molecular Sequence Data</term>
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<term>Chromatographie en phase liquide à haute performance</term>
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<term>Données de séquences moléculaires</term>
<term>Fonctions de vraisemblance</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles biologiques</term>
<term>Séquence nucléotidique</term>
<term>Techniques histologiques</term>
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<front><div type="abstract" xml:lang="en">Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the defence-evoked venom of Conus geographus contains high levels of paralytic toxins that potently block neuromuscular receptors, consistent with its lethal effects on humans. In contrast, C. geographus predation-evoked venom contains prey-specific toxins mostly inactive at human targets. Predation- and defence-evoked venoms originate from the distal and proximal regions of the venom duct, respectively, explaining how different stimuli can generate two distinct venoms. A specialized defensive envenomation strategy is widely evolved across worm, mollusk and fish-hunting cone snails. We propose that defensive toxins, originally evolved in ancestral worm-hunting cone snails to protect against cephalopod and fish predation, have been repurposed in predatory venoms to facilitate diversification to fish and mollusk diets.</div>
</front>
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<Abstract><AbstractText>Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the defence-evoked venom of Conus geographus contains high levels of paralytic toxins that potently block neuromuscular receptors, consistent with its lethal effects on humans. In contrast, C. geographus predation-evoked venom contains prey-specific toxins mostly inactive at human targets. Predation- and defence-evoked venoms originate from the distal and proximal regions of the venom duct, respectively, explaining how different stimuli can generate two distinct venoms. A specialized defensive envenomation strategy is widely evolved across worm, mollusk and fish-hunting cone snails. We propose that defensive toxins, originally evolved in ancestral worm-hunting cone snails to protect against cephalopod and fish predation, have been repurposed in predatory venoms to facilitate diversification to fish and mollusk diets.</AbstractText>
</Abstract>
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<ForeName>Sébastien</ForeName>
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<AffiliationInfo><Affiliation>1] Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 Queensland, Australia [2] Institut des Biomolécules Max Mousseron, UMR 5247, Université Montpellier 2-CNRS, Place Eugène Bataillon, Montpellier Cedex 5 34095, France.</Affiliation>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails.

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails.

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