AustralieFrV1, PubMed, Curation, bibRecord, 003741

Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial.

Identifieur interne : 003741 ( PubMed/Curation ); précédent : 003740; suivant : 003742

Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial.

Auteurs : Lisa Manning [Royaume-Uni] ; Yoichiro Hirakawa [Australie] ; Hisatomi Arima [Australie] ; Xia Wang [Australie] ; John Chalmers [Australie] ; Jiguang Wang [République populaire de Chine] ; Richard Lindley [Australie] ; Emma Heeley [Australie] ; Candice Delcourt [Australie] ; Bruce Neal [Australie] ; Pablo Lavados [Chili] ; Stephen M. Davis [Australie] ; Christophe Tzourio [France] ; Yining Huang [République populaire de Chine] ; Christian Stapf [France] ; Mark Woodward [Australie] ; Peter M. Rothwell [Royaume-Uni] ; Thompson G. Robinson [Royaume-Uni] ; Craig S. Anderson [Australie]

Source :

The Lancet. Neurology [ 1474-4465 ] ; 2014.

RBID : pubmed:24530176

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Antihypertenseurs (administration et posologie), Femelle, Humains, Hémorragie cérébrale (physiopathologie), Hémorragie cérébrale (traitement médicamenteux), Mâle, Pression sanguine (), Pression sanguine (physiologie), Pronostic, Résultat thérapeutique, Sujet âgé.
MESH :
- administration et posologie : Antihypertenseurs.
- physiologie : Pression sanguine.
- physiopathologie : Hémorragie cérébrale.
- traitement médicamenteux : Hémorragie cérébrale.
- Adulte d'âge moyen, Femelle, Humains, Mâle, Pression sanguine, Pronostic, Résultat thérapeutique, Sujet âgé.

English descriptors

KwdEn :
- Aged, Antihypertensive Agents (administration & dosage), Blood Pressure (drug effects), Blood Pressure (physiology), Cerebral Hemorrhage (drug therapy), Cerebral Hemorrhage (physiopathology), Female, Humans, Male, Middle Aged, Prognosis, Treatment Outcome.
MESH :
- chemical , administration & dosage : Antihypertensive Agents.
- drug effects : Blood Pressure.
- drug therapy : Cerebral Hemorrhage.
- physiology : Blood Pressure.
- physiopathology : Cerebral Hemorrhage.
- Aged, Female, Humans, Male, Middle Aged, Prognosis, Treatment Outcome.

Abstract

High blood pressure is a prognostic factor for acute stroke, but blood pressure variability might also independently predict outcome. We assessed the prognostic value of blood pressure variability in participants of INTERACT2, an open-label randomised controlled trial (ClinicalTrials.gov number NCT00716079).

DOI: 10.1016/S1474-4422(14)70018-3
PubMed: 24530176

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Le document en format XML

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<author><name sortKey="Hirakawa, Yoichiro" sort="Hirakawa, Yoichiro" uniqKey="Hirakawa Y" first="Yoichiro" last="Hirakawa">Yoichiro Hirakawa</name>
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<author><name sortKey="Delcourt, Candice" sort="Delcourt, Candice" uniqKey="Delcourt C" first="Candice" last="Delcourt">Candice Delcourt</name>
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<author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name>
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<author><name sortKey="Lavados, Pablo" sort="Lavados, Pablo" uniqKey="Lavados P" first="Pablo" last="Lavados">Pablo Lavados</name>
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<author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name>
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<author><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name>
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</affiliation>
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<author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M" last="Rothwell">Peter M. Rothwell</name>
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<author><name sortKey="Robinson, Thompson G" sort="Robinson, Thompson G" uniqKey="Robinson T" first="Thompson G" last="Robinson">Thompson G. Robinson</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester</wicri:regionArea>
</affiliation>
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<author><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S" last="Anderson">Craig S. Anderson</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial.</title>
<author><name sortKey="Manning, Lisa" sort="Manning, Lisa" uniqKey="Manning L" first="Lisa" last="Manning">Lisa Manning</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester</wicri:regionArea>
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<author><name sortKey="Hirakawa, Yoichiro" sort="Hirakawa, Yoichiro" uniqKey="Hirakawa Y" first="Yoichiro" last="Hirakawa">Yoichiro Hirakawa</name>
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<author><name sortKey="Wang, Xia" sort="Wang, Xia" uniqKey="Wang X" first="Xia" last="Wang">Xia Wang</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindley, Richard" sort="Lindley, Richard" uniqKey="Lindley R" first="Richard" last="Lindley">Richard Lindley</name>
<affiliation wicri:level="1"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heeley, Emma" sort="Heeley, Emma" uniqKey="Heeley E" first="Emma" last="Heeley">Emma Heeley</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea>
</affiliation>
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<author><name sortKey="Delcourt, Candice" sort="Delcourt, Candice" uniqKey="Delcourt C" first="Candice" last="Delcourt">Candice Delcourt</name>
<affiliation wicri:level="1"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Sydney, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name>
<affiliation wicri:level="1"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lavados, Pablo" sort="Lavados, Pablo" uniqKey="Lavados P" first="Pablo" last="Lavados">Pablo Lavados</name>
<affiliation wicri:level="1"><nlm:affiliation>Servicio de Neurología, Departamento de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile; Universidad de Chile, Santiago, Chile.</nlm:affiliation>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Servicio de Neurología, Departamento de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile; Universidad de Chile, Santiago</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name>
<affiliation wicri:level="1"><nlm:affiliation>Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U897, Bordeaux, France; University of Bordeaux, Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Peking University First Hospital, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Neurology, Peking University First Hospital, Beijing</wicri:regionArea>
</affiliation>
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<author><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, APHP - Hôpital Lariboisière, Paris, France; DHU NeuroVasc Paris - Sorbonne, Paris, France; Université Paris Diderot - Sorbonne Paris Cité, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, APHP - Hôpital Lariboisière, Paris, France; DHU NeuroVasc Paris - Sorbonne, Paris, France; Université Paris Diderot - Sorbonne Paris Cité, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
<affiliation wicri:level="1"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M" last="Rothwell">Peter M. Rothwell</name>
<affiliation wicri:level="1"><nlm:affiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea>
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<author><name sortKey="Robinson, Thompson G" sort="Robinson, Thompson G" uniqKey="Robinson T" first="Thompson G" last="Robinson">Thompson G. Robinson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S" last="Anderson">Craig S. Anderson</name>
<affiliation wicri:level="1"><nlm:affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Sydney, NSW, Australia. Electronic address: canderson@georgeinstitute.org.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Sydney, NSW</wicri:regionArea>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antihypertensive Agents (administration & dosage)</term>
<term>Blood Pressure (drug effects)</term>
<term>Blood Pressure (physiology)</term>
<term>Cerebral Hemorrhage (drug therapy)</term>
<term>Cerebral Hemorrhage (physiopathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prognosis</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Antihypertenseurs (administration et posologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémorragie cérébrale (physiopathologie)</term>
<term>Hémorragie cérébrale (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Pression sanguine ()</term>
<term>Pression sanguine (physiologie)</term>
<term>Pronostic</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antihypertensive Agents</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cerebral Hemorrhage</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Pression sanguine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hémorragie cérébrale</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Hemorrhage</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémorragie cérébrale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prognosis</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pression sanguine</term>
<term>Pronostic</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
</keywords>
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<front><div type="abstract" xml:lang="en">High blood pressure is a prognostic factor for acute stroke, but blood pressure variability might also independently predict outcome. We assessed the prognostic value of blood pressure variability in participants of INTERACT2, an open-label randomised controlled trial (ClinicalTrials.gov number NCT00716079).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24530176</PMID>
<DateCreated><Year>2014</Year>
<Month>03</Month>
<Day>20</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>05</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-4465</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>13</Volume>
<Issue>4</Issue>
<PubDate><Year>2014</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>The Lancet. Neurology</Title>
<ISOAbbreviation>Lancet Neurol</ISOAbbreviation>
</Journal>
<ArticleTitle>Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial.</ArticleTitle>
<Pagination><MedlinePgn>364-73</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/S1474-4422(14)70018-3</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1474-4422(14)70018-3</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">High blood pressure is a prognostic factor for acute stroke, but blood pressure variability might also independently predict outcome. We assessed the prognostic value of blood pressure variability in participants of INTERACT2, an open-label randomised controlled trial (ClinicalTrials.gov number NCT00716079).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">INTERACT2 enrolled 2839 adults with spontaneous intracerebral haemorrhage (ICH) and high systolic blood pressure (150-220 mm Hg) without a definite indication or contraindication to early intensive treatment to reduce blood pressure. Participants were randomly assigned to intensive treatment (target systolic blood pressure <140 mm Hg within 1 h using locally available intravenous drugs) or guideline-recommended treatment (target systolic blood pressure <180 mm Hg) within 6 h of onset of ICH. The primary outcome was death or major disability at 90 days (modified Rankin Scale score ≥3) and the secondary outcome was an ordinal shift in modified Rankin Scale scores at 90 days, assessed by investigators masked to treatment allocation. Blood pressure variability was defined according to standard criteria: five measurements were taken in the first 24 h (hyperacute phase) and 12 over days 2-7 (acute phase). We estimated associations between blood pressure variability and outcomes with logistic and proportional odds regression models. The key parameter for blood pressure variability was standard deviation (SD) of systolic blood pressure, categorised into quintiles.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">We studied 2645 (93·2%) participants in the hyperacute phase and 2347 (82·7%) in the acute phase. In both treatment cohorts combined, SD of systolic blood pressure had a significant linear association with the primary outcome for both the hyperacute phase (highest quintile adjusted OR 1·41, 95% CI 1·05-1·90; ptrend=0·0167) and the acute phase (highest quintile adjusted OR 1·57, 95% CI 1·14-2·17; ptrend=0·0124). The strongest predictors of outcome were maximum systolic blood pressure in the hyperacute phase and SD of systolic blood pressure in the acute phase. Associations were similar for the secondary outcome (for the hyperacute phase, highest quintile adjusted OR 1·43, 95% CI 1·14-1·80; ptrend=0·0014; for the acute phase OR 1·46, 95% CI 1·13-1·88; ptrend=0·0044).</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Systolic blood pressure variability seems to predict a poor outcome in patients with acute intracerebral haemorrhage. The benefits of early treatment to reduce systolic blood pressure to 140 mm Hg might be enhanced by smooth and sustained control, and particularly by avoiding peaks in systolic blood pressure.</AbstractText>
<AbstractText Label="FUNDING" NlmCategory="BACKGROUND">National Health and Medical Research Council of Australia.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Manning</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hirakawa</LastName>
<ForeName>Yoichiro</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arima</LastName>
<ForeName>Hisatomi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Xia</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chalmers</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jiguang</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>The Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lindley</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heeley</LastName>
<ForeName>Emma</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Delcourt</LastName>
<ForeName>Candice</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Neal</LastName>
<ForeName>Bruce</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lavados</LastName>
<ForeName>Pablo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Servicio de Neurología, Departamento de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile; Universidad de Chile, Santiago, Chile.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davis</LastName>
<ForeName>Stephen M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tzourio</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INSERM, U897, Bordeaux, France; University of Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yining</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Peking University First Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stapf</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, APHP - Hôpital Lariboisière, Paris, France; DHU NeuroVasc Paris - Sorbonne, Paris, France; Université Paris Diderot - Sorbonne Paris Cité, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Woodward</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rothwell</LastName>
<ForeName>Peter M</ForeName>
<Initials>PM</Initials>
<AffiliationInfo><Affiliation>Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robinson</LastName>
<ForeName>Thompson G</ForeName>
<Initials>TG</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anderson</LastName>
<ForeName>Craig S</ForeName>
<Initials>CS</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia; Royal Prince Alfred Hospital, Sydney, NSW, Australia. Electronic address: canderson@georgeinstitute.org.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>INTERACT2 investigators</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT00716079</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><GrantID>095626</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>02</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Lancet Neurol</MedlineTA>
<NlmUniqueID>101139309</NlmUniqueID>
<ISSNLinking>1474-4422</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000959">Antihypertensive Agents</NameOfSubstance>
</Chemical>
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<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Lancet Neurol. 2014 Apr;13(4):342-3</RefSource>
<PMID Version="1">24582531</PMID>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D000959" MajorTopicYN="N">Antihypertensive Agents</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002543" MajorTopicYN="N">Cerebral Hemorrhage</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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<Day>18</Day>
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<PubMedPubDate PubStatus="medline"><Year>2014</Year>
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Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial.

Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial.

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