Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
Identifieur interne : 003725 ( PubMed/Curation ); précédent : 003724; suivant : 003726Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
Auteurs : M. Li [République populaire de Chine] ; X-J Luo [États-Unis] ; M. Rietschel [Allemagne] ; C M Lewis [Royaume-Uni] ; M. Mattheisen [États-Unis] ; B. Müller-Myhsok [Allemagne] ; S. Jamain [France] ; M. Leboyer [France] ; M. Landén [Suède] ; P M Thompson [États-Unis] ; S. Cichon [Allemagne] ; M M Nöthen [Allemagne] ; T G Schulze [Allemagne] ; P F Sullivan [États-Unis] ; S E Bergen [États-Unis] ; G. Donohoe [Irlande (pays)] ; D W Morris [Irlande (pays)] ; A. Hargreaves [Irlande (pays)] ; M. Gill [Irlande (pays)] ; A. Corvin [Irlande (pays)] ; C. Hultman [Suède] ; A W Toga [États-Unis] ; L. Shi [République populaire de Chine] ; Q. Lin [République populaire de Chine] ; H. Shi [République populaire de Chine] ; L. Gan [République populaire de Chine] ; A. Meyer-Lindenberg [Allemagne] ; D. Czamara [Allemagne] ; C. Henry [France] ; B. Etain [France] ; J C Bis [États-Unis] ; M A Ikram [Pays-Bas] ; M. Fornage [États-Unis] ; S. Debette [France] ; L J Launer [États-Unis] ; S. Seshadri [États-Unis] ; S. Erk [Allemagne] ; H. Walter [Allemagne] ; A. Heinz [Allemagne] ; F. Bellivier [France] ; J L Stein [États-Unis] ; S E Medland [États-Unis] ; A. Arias Vasquez [Pays-Bas] ; D P Hibar [États-Unis] ; B. Franke [Pays-Bas] ; N G Martin [Australie] ; M J Wright [Australie] ; B. Su [République populaire de Chine]Source :
- Molecular psychiatry [ 1476-5578 ] ; 2014.
Descripteurs français
- KwdFr :
- ARN messager (métabolisme), Adulte, Adulte d'âge moyen, Biologie informatique, Facteurs de l'âge, Femelle, Fréquence d'allèle (génétique), Hippocampe (anatomopathologie), Humains, Mâle, Neuroimagerie, Phénotype, Polymorphisme de nucléotide simple (génétique), Population d'origine asiatique (génétique), Population d'origine européenne (génétique), Protéine de liaison à l'élément de réponse à l'AMP cyclique (génétique), Prédisposition génétique à une maladie, Régulation de l'expression des gènes (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Tests neuropsychologiques, Trouble bipolaire (ethnologie), Trouble bipolaire (génétique), Études cas-témoins, Études d'associations génétiques.
- MESH :
- anatomopathologie : Hippocampe.
- ethnologie : Trouble bipolaire.
- génétique : Fréquence d'allèle, Polymorphisme de nucléotide simple, Population d'origine asiatique, Population d'origine européenne, Protéine de liaison à l'élément de réponse à l'AMP cyclique, Régulation de l'expression des gènes, Trouble bipolaire.
- métabolisme : ARN messager.
- Adulte, Adulte d'âge moyen, Biologie informatique, Facteurs de l'âge, Femelle, Humains, Mâle, Neuroimagerie, Phénotype, Prédisposition génétique à une maladie, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests neuropsychologiques, Études cas-témoins, Études d'associations génétiques.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Asian Continental Ancestry Group (genetics), Bipolar Disorder (ethnology), Bipolar Disorder (genetics), Case-Control Studies, Computational Biology, Cyclic AMP Response Element-Binding Protein (genetics), European Continental Ancestry Group (genetics), Female, Gene Expression Regulation (genetics), Gene Frequency (genetics), Genetic Association Studies, Genetic Predisposition to Disease, Hippocampus (pathology), Humans, Male, Middle Aged, Neuroimaging, Neuropsychological Tests, Phenotype, Polymorphism, Single Nucleotide (genetics), RNA, Messenger (metabolism).
- MESH :
- chemical , genetics : Cyclic AMP Response Element-Binding Protein.
- ethnology : Bipolar Disorder.
- genetics : Asian Continental Ancestry Group, Bipolar Disorder, European Continental Ancestry Group, Gene Expression Regulation, Gene Frequency, Polymorphism, Single Nucleotide.
- chemical , metabolism : RNA, Messenger.
- pathology : Hippocampus.
- Adult, Age Factors, Aged, Aged, 80 and over, Case-Control Studies, Computational Biology, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Neuroimaging, Neuropsychological Tests, Phenotype.
Abstract
Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64,888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785[A], P=6.32 × 10(-5), odds ratio (OR)=1.090). Risk SNPs were then subjected to further analyses in healthy Europeans for intermediate phenotypes of BD, including hippocampal volume, hippocampal function and cognitive performance. Our results showed that the risk SNPs were significantly associated with hippocampal volume and hippocampal function, with the risk alleles showing a decreased hippocampal volume and diminished activation of the left hippocampus, adding further evidence for their involvement in BD susceptibility. We also found the risk SNPs were strongly associated with CREB1 expression in lymphoblastoid cells (P<0.005) and the prefrontal cortex (P<1.0 × 10(-6)). Remarkably, population genetic analysis indicated that CREB1 displayed striking differences in allele frequencies between continental populations, and the risk alleles were completely absent in East Asian populations. We demonstrated that the regional prevalence of the CREB1 risk alleles in Europeans is likely caused by genetic hitchhiking due to natural selection acting on a nearby gene. Our results suggest that differential population histories due to natural selection on regional populations may lead to genetic heterogeneity of susceptibility to complex diseases, such as BD, and explain inconsistencies in detecting the genetic markers of these diseases among different ethnic populations.
DOI: 10.1038/mp.2013.37
PubMed: 23568192
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Li</name><affiliation wicri:level="1"><nlm:affiliation>1] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China [2] University of Chinese Academy of Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China [2] University of Chinese Academy of Sciences, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Luo, X J" sort="Luo, X J" uniqKey="Luo X" first="X-J" last="Luo">X-J Luo</name><affiliation wicri:level="1"><nlm:affiliation>University of Rochester Flaum Eye Institute, University of Rochester, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester Flaum Eye Institute, University of Rochester, Rochester, NY</wicri:regionArea></affiliation></author><author><name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M" last="Rietschel">M. Rietschel</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Department of Psychiatry, University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Department of Psychiatry, University of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Lewis, C M" sort="Lewis, C M" uniqKey="Lewis C" first="C M" last="Lewis">C M Lewis</name><affiliation wicri:level="1"><nlm:affiliation>MRC SGDP Centre, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC SGDP Centre, Institute of Psychiatry, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Mattheisen, M" sort="Mattheisen, M" uniqKey="Mattheisen M" first="M" last="Mattheisen">M. Mattheisen</name><affiliation wicri:level="1"><nlm:affiliation>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Muller Myhsok, B" sort="Muller Myhsok, B" uniqKey="Muller Myhsok B" first="B" last="Müller-Myhsok">B. Müller-Myhsok</name><affiliation wicri:level="1"><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Jamain, S" sort="Jamain, S" uniqKey="Jamain S" first="S" last="Jamain">S. Jamain</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Leboyer, M" sort="Leboyer, M" uniqKey="Leboyer M" first="M" last="Leboyer">M. Leboyer</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Landen, M" sort="Landen, M" uniqKey="Landen M" first="M" last="Landén">M. Landén</name><affiliation wicri:level="1"><nlm:affiliation>1] Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>1] Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, P M" sort="Thompson, P M" uniqKey="Thompson P" first="P M" last="Thompson">P M Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name><affiliation wicri:level="1"><nlm:affiliation>1] Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany [2] Department of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany [2] Department of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Nothen, M M" sort="Nothen, M M" uniqKey="Nothen M" first="M M" last="Nöthen">M M Nöthen</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Schulze, T G" sort="Schulze, T G" uniqKey="Schulze T" first="T G" last="Schulze">T G Schulze</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Section on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Section on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen</wicri:regionArea></affiliation></author><author><name sortKey="Sullivan, P F" sort="Sullivan, P F" uniqKey="Sullivan P" first="P F" last="Sullivan">P F Sullivan</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Genetics, Psychiatry and Epidemiology, University of North Carolina, Chapel Hill, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Genetics, Psychiatry and Epidemiology, University of North Carolina, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Bergen, S E" sort="Bergen, S E" uniqKey="Bergen S" first="S E" last="Bergen">S E Bergen</name><affiliation wicri:level="1"><nlm:affiliation>1] Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA [2] Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA [2] Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Donohoe, G" sort="Donohoe, G" uniqKey="Donohoe G" first="G" last="Donohoe">G. Donohoe</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Morris, D W" sort="Morris, D W" uniqKey="Morris D" first="D W" last="Morris">D W Morris</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Hargreaves, A" sort="Hargreaves, A" uniqKey="Hargreaves A" first="A" last="Hargreaves">A. Hargreaves</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Gill, M" sort="Gill, M" uniqKey="Gill M" first="M" last="Gill">M. Gill</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Corvin, A" sort="Corvin, A" uniqKey="Corvin A" first="A" last="Corvin">A. Corvin</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Hultman, C" sort="Hultman, C" uniqKey="Hultman C" first="C" last="Hultman">C. Hultman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Toga, A W" sort="Toga, A W" uniqKey="Toga A" first="A W" last="Toga">A W Toga</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Shi, L" sort="Shi, L" uniqKey="Shi L" first="L" last="Shi">L. Shi</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Q" sort="Lin, Q" uniqKey="Lin Q" first="Q" last="Lin">Q. Lin</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea></affiliation></author><author><name sortKey="Shi, H" sort="Shi, H" uniqKey="Shi H" first="H" last="Shi">H. Shi</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea></affiliation></author><author><name sortKey="Gan, L" sort="Gan, L" uniqKey="Gan L" first="L" last="Gan">L. Gan</name><affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Chinese Academy of Sciences, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Meyer Lindenberg, A" sort="Meyer Lindenberg, A" uniqKey="Meyer Lindenberg A" first="A" last="Meyer-Lindenberg">A. Meyer-Lindenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim</wicri:regionArea></affiliation></author><author><name sortKey="Czamara, D" sort="Czamara, D" uniqKey="Czamara D" first="D" last="Czamara">D. Czamara</name><affiliation wicri:level="1"><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Henry, C" sort="Henry, C" uniqKey="Henry C" first="C" last="Henry">C. Henry</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Etain, B" sort="Etain, B" uniqKey="Etain B" first="B" last="Etain">B. Etain</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Bis, J C" sort="Bis, J C" uniqKey="Bis J" first="J C" last="Bis">J C Bis</name><affiliation wicri:level="1"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Radiology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands [2] The Netherlands Consortium of Healthy Aging, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1] Department of Radiology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands [2] The Netherlands Consortium of Healthy Aging, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Fornage, M" sort="Fornage, M" uniqKey="Fornage M" first="M" last="Fornage">M. Fornage</name><affiliation wicri:level="1"><nlm:affiliation>Brown Foundation Institute of Molecular Medicine and Human Genetics Center School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brown Foundation Institute of Molecular Medicine and Human Genetics Center School of Public Health, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Debette, S" sort="Debette, S" uniqKey="Debette S" first="S" last="Debette">S. Debette</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology, Paris, France [3] Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology, Paris, France [3] Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Launer, L J" sort="Launer, L J" uniqKey="Launer L" first="L J" last="Launer">L J Launer</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] The National, Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] The National, Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Erk, S" sort="Erk, S" uniqKey="Erk S" first="S" last="Erk">S. Erk</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany [2] Division of Mind and Brain Research, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany [2] Division of Mind and Brain Research, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Walter, H" sort="Walter, H" uniqKey="Walter H" first="H" last="Walter">H. Walter</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany [3] Division of Mind and Brain Research, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany [3] Division of Mind and Brain Research, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Heinz, A" sort="Heinz, A" uniqKey="Heinz A" first="A" last="Heinz">A. Heinz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Bellivier, F" sort="Bellivier, F" uniqKey="Bellivier F" first="F" last="Bellivier">F. Bellivier</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] AP-HP, Hôpital St-Louis-Lariboisière-F Widal, Service Universitaire de Psychiatrie, Paris, France [4] Faculté de Médecine, Université Denis Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] AP-HP, Hôpital St-Louis-Lariboisière-F Widal, Service Universitaire de Psychiatrie, Paris, France [4] Faculté de Médecine, Université Denis Diderot, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Stein, J L" sort="Stein, J L" uniqKey="Stein J" first="J L" last="Stein">J L Stein</name><affiliation wicri:level="1"><nlm:affiliation>1] Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA [2] Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA [2] Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Medland, S E" sort="Medland, S E" uniqKey="Medland S" first="S E" last="Medland">S E Medland</name><affiliation wicri:level="1"><nlm:affiliation>1] Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [2] Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [3] Broad Institute of Harvard and MIT, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [2] Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [3] Broad Institute of Harvard and MIT, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Arias Vasquez, A" sort="Arias Vasquez, A" uniqKey="Arias Vasquez A" first="A" last="Arias Vasquez">A. Arias Vasquez</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Hibar, D P" sort="Hibar, D P" uniqKey="Hibar D" first="D P" last="Hibar">D P Hibar</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Franke, B" sort="Franke, B" uniqKey="Franke B" first="B" last="Franke">B. Franke</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Martin, N G" sort="Martin, N G" uniqKey="Martin N" first="N G" last="Martin">N G Martin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Wright, M J" sort="Wright, M J" uniqKey="Wright M" first="M J" last="Wright">M J Wright</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Su, B" sort="Su, B" uniqKey="Su B" first="B" last="Su">B. Su</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23568192</idno><idno type="pmid">23568192</idno><idno type="doi">10.1038/mp.2013.37</idno><idno type="wicri:Area/PubMed/Corpus">003839</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003839</idno><idno type="wicri:Area/PubMed/Curation">003725</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003725</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.</title><author><name sortKey="Li, M" sort="Li, M" uniqKey="Li M" first="M" last="Li">M. Li</name><affiliation wicri:level="1"><nlm:affiliation>1] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China [2] University of Chinese Academy of Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China [2] University of Chinese Academy of Sciences, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Luo, X J" sort="Luo, X J" uniqKey="Luo X" first="X-J" last="Luo">X-J Luo</name><affiliation wicri:level="1"><nlm:affiliation>University of Rochester Flaum Eye Institute, University of Rochester, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester Flaum Eye Institute, University of Rochester, Rochester, NY</wicri:regionArea></affiliation></author><author><name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M" last="Rietschel">M. Rietschel</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Department of Psychiatry, University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Department of Psychiatry, University of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Lewis, C M" sort="Lewis, C M" uniqKey="Lewis C" first="C M" last="Lewis">C M Lewis</name><affiliation wicri:level="1"><nlm:affiliation>MRC SGDP Centre, Institute of Psychiatry, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC SGDP Centre, Institute of Psychiatry, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Mattheisen, M" sort="Mattheisen, M" uniqKey="Mattheisen M" first="M" last="Mattheisen">M. Mattheisen</name><affiliation wicri:level="1"><nlm:affiliation>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Muller Myhsok, B" sort="Muller Myhsok, B" uniqKey="Muller Myhsok B" first="B" last="Müller-Myhsok">B. Müller-Myhsok</name><affiliation wicri:level="1"><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Jamain, S" sort="Jamain, S" uniqKey="Jamain S" first="S" last="Jamain">S. Jamain</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Leboyer, M" sort="Leboyer, M" uniqKey="Leboyer M" first="M" last="Leboyer">M. Leboyer</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Landen, M" sort="Landen, M" uniqKey="Landen M" first="M" last="Landén">M. Landén</name><affiliation wicri:level="1"><nlm:affiliation>1] Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>1] Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, P M" sort="Thompson, P M" uniqKey="Thompson P" first="P M" last="Thompson">P M Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name><affiliation wicri:level="1"><nlm:affiliation>1] Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany [2] Department of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany [2] Department of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Nothen, M M" sort="Nothen, M M" uniqKey="Nothen M" first="M M" last="Nöthen">M M Nöthen</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Genomics, Life and Brain Center and Institute of Human Genetics, University of Bonn, Bonn, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Schulze, T G" sort="Schulze, T G" uniqKey="Schulze T" first="T G" last="Schulze">T G Schulze</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Section on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Section on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen</wicri:regionArea></affiliation></author><author><name sortKey="Sullivan, P F" sort="Sullivan, P F" uniqKey="Sullivan P" first="P F" last="Sullivan">P F Sullivan</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Genetics, Psychiatry and Epidemiology, University of North Carolina, Chapel Hill, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Genetics, Psychiatry and Epidemiology, University of North Carolina, Chapel Hill, NC</wicri:regionArea></affiliation></author><author><name sortKey="Bergen, S E" sort="Bergen, S E" uniqKey="Bergen S" first="S E" last="Bergen">S E Bergen</name><affiliation wicri:level="1"><nlm:affiliation>1] Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA [2] Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA [2] Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Donohoe, G" sort="Donohoe, G" uniqKey="Donohoe G" first="G" last="Donohoe">G. Donohoe</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Morris, D W" sort="Morris, D W" uniqKey="Morris D" first="D W" last="Morris">D W Morris</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Hargreaves, A" sort="Hargreaves, A" uniqKey="Hargreaves A" first="A" last="Hargreaves">A. Hargreaves</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Gill, M" sort="Gill, M" uniqKey="Gill M" first="M" last="Gill">M. Gill</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Corvin, A" sort="Corvin, A" uniqKey="Corvin A" first="A" last="Corvin">A. Corvin</name><affiliation wicri:level="1"><nlm:affiliation>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Neuropsychiatric Genetics Group and Department of Psychiatry, Institute of Molecular Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, St James Hospital, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Hultman, C" sort="Hultman, C" uniqKey="Hultman C" first="C" last="Hultman">C. Hultman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Toga, A W" sort="Toga, A W" uniqKey="Toga A" first="A W" last="Toga">A W Toga</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Shi, L" sort="Shi, L" uniqKey="Shi L" first="L" last="Shi">L. Shi</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Q" sort="Lin, Q" uniqKey="Lin Q" first="Q" last="Lin">Q. Lin</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea></affiliation></author><author><name sortKey="Shi, H" sort="Shi, H" uniqKey="Shi H" first="H" last="Shi">H. Shi</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea></affiliation></author><author><name sortKey="Gan, L" sort="Gan, L" uniqKey="Gan L" first="L" last="Gan">L. Gan</name><affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Chinese Academy of Sciences, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Meyer Lindenberg, A" sort="Meyer Lindenberg, A" uniqKey="Meyer Lindenberg A" first="A" last="Meyer-Lindenberg">A. Meyer-Lindenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim</wicri:regionArea></affiliation></author><author><name sortKey="Czamara, D" sort="Czamara, D" uniqKey="Czamara D" first="D" last="Czamara">D. Czamara</name><affiliation wicri:level="1"><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Henry, C" sort="Henry, C" uniqKey="Henry C" first="C" last="Henry">C. Henry</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Etain, B" sort="Etain, B" uniqKey="Etain B" first="B" last="Etain">B. Etain</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Bis, J C" sort="Bis, J C" uniqKey="Bis J" first="J C" last="Bis">J C Bis</name><affiliation wicri:level="1"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Radiology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands [2] The Netherlands Consortium of Healthy Aging, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1] Department of Radiology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands [2] The Netherlands Consortium of Healthy Aging, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Fornage, M" sort="Fornage, M" uniqKey="Fornage M" first="M" last="Fornage">M. Fornage</name><affiliation wicri:level="1"><nlm:affiliation>Brown Foundation Institute of Molecular Medicine and Human Genetics Center School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brown Foundation Institute of Molecular Medicine and Human Genetics Center School of Public Health, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Debette, S" sort="Debette, S" uniqKey="Debette S" first="S" last="Debette">S. Debette</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology, Paris, France [3] Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology, Paris, France [3] Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Launer, L J" sort="Launer, L J" uniqKey="Launer L" first="L J" last="Launer">L J Launer</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] The National, Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] The National, Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Erk, S" sort="Erk, S" uniqKey="Erk S" first="S" last="Erk">S. Erk</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany [2] Division of Mind and Brain Research, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany [2] Division of Mind and Brain Research, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Walter, H" sort="Walter, H" uniqKey="Walter H" first="H" last="Walter">H. Walter</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany [3] Division of Mind and Brain Research, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany [3] Division of Mind and Brain Research, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Heinz, A" sort="Heinz, A" uniqKey="Heinz A" first="A" last="Heinz">A. Heinz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Bellivier, F" sort="Bellivier, F" uniqKey="Bellivier F" first="F" last="Bellivier">F. Bellivier</name><affiliation wicri:level="1"><nlm:affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] AP-HP, Hôpital St-Louis-Lariboisière-F Widal, Service Universitaire de Psychiatrie, Paris, France [4] Faculté de Médecine, Université Denis Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] AP-HP, Hôpital St-Louis-Lariboisière-F Widal, Service Universitaire de Psychiatrie, Paris, France [4] Faculté de Médecine, Université Denis Diderot, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Stein, J L" sort="Stein, J L" uniqKey="Stein J" first="J L" last="Stein">J L Stein</name><affiliation wicri:level="1"><nlm:affiliation>1] Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA [2] Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA [2] Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Medland, S E" sort="Medland, S E" uniqKey="Medland S" first="S E" last="Medland">S E Medland</name><affiliation wicri:level="1"><nlm:affiliation>1] Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [2] Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [3] Broad Institute of Harvard and MIT, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>1] Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [2] Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [3] Broad Institute of Harvard and MIT, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Arias Vasquez, A" sort="Arias Vasquez, A" uniqKey="Arias Vasquez A" first="A" last="Arias Vasquez">A. Arias Vasquez</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Hibar, D P" sort="Hibar, D P" uniqKey="Hibar D" first="D P" last="Hibar">D P Hibar</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Franke, B" sort="Franke, B" uniqKey="Franke B" first="B" last="Franke">B. Franke</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Martin, N G" sort="Martin, N G" uniqKey="Martin N" first="N G" last="Martin">N G Martin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Wright, M J" sort="Wright, M J" uniqKey="Wright M" first="M J" last="Wright">M J Wright</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD</wicri:regionArea></affiliation></author><author><name sortKey="Su, B" sort="Su, B" uniqKey="Su B" first="B" last="Su">B. Su</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Molecular psychiatry</title><idno type="eISSN">1476-5578</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Asian Continental Ancestry Group (genetics)</term><term>Bipolar Disorder (ethnology)</term><term>Bipolar Disorder (genetics)</term><term>Case-Control Studies</term><term>Computational Biology</term><term>Cyclic AMP Response Element-Binding Protein (genetics)</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Gene Expression Regulation (genetics)</term><term>Gene Frequency (genetics)</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Hippocampus (pathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuroimaging</term><term>Neuropsychological Tests</term><term>Phenotype</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>RNA, Messenger (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (métabolisme)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Biologie informatique</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Fréquence d'allèle (génétique)</term><term>Hippocampe (anatomopathologie)</term><term>Humains</term><term>Mâle</term><term>Neuroimagerie</term><term>Phénotype</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Population d'origine asiatique (génétique)</term><term>Population d'origine européenne (génétique)</term><term>Protéine de liaison à l'élément de réponse à l'AMP cyclique (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Régulation de l'expression des gènes (génétique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests neuropsychologiques</term><term>Trouble bipolaire (ethnologie)</term><term>Trouble bipolaire (génétique)</term><term>Études cas-témoins</term><term>Études d'associations génétiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclic AMP Response Element-Binding Protein</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hippocampe</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Trouble bipolaire</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Bipolar Disorder</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term><term>Bipolar Disorder</term><term>European Continental Ancestry Group</term><term>Gene Expression Regulation</term><term>Gene Frequency</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Fréquence d'allèle</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine asiatique</term><term>Population d'origine européenne</term><term>Protéine de liaison à l'élément de réponse à l'AMP cyclique</term><term>Régulation de l'expression des gènes</term><term>Trouble bipolaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hippocampus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Computational Biology</term><term>Female</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuroimaging</term><term>Neuropsychological Tests</term><term>Phenotype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Biologie informatique</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Neuroimagerie</term><term>Phénotype</term><term>Prédisposition génétique à une maladie</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests neuropsychologiques</term><term>Études cas-témoins</term><term>Études d'associations génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64,888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785[A], P=6.32 × 10(-5), odds ratio (OR)=1.090). Risk SNPs were then subjected to further analyses in healthy Europeans for intermediate phenotypes of BD, including hippocampal volume, hippocampal function and cognitive performance. Our results showed that the risk SNPs were significantly associated with hippocampal volume and hippocampal function, with the risk alleles showing a decreased hippocampal volume and diminished activation of the left hippocampus, adding further evidence for their involvement in BD susceptibility. We also found the risk SNPs were strongly associated with CREB1 expression in lymphoblastoid cells (P<0.005) and the prefrontal cortex (P<1.0 × 10(-6)). Remarkably, population genetic analysis indicated that CREB1 displayed striking differences in allele frequencies between continental populations, and the risk alleles were completely absent in East Asian populations. We demonstrated that the regional prevalence of the CREB1 risk alleles in Europeans is likely caused by genetic hitchhiking due to natural selection acting on a nearby gene. Our results suggest that differential population histories due to natural selection on regional populations may lead to genetic heterogeneity of susceptibility to complex diseases, such as BD, and explain inconsistencies in detecting the genetic markers of these diseases among different ethnic populations.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23568192</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>24</Day></DateCreated><DateCompleted><Year>2014</Year><Month>11</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5578</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>4</Issue><PubDate><Year>2014</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Molecular psychiatry</Title><ISOAbbreviation>Mol. Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.</ArticleTitle><Pagination><MedlinePgn>452-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/mp.2013.37</ELocationID><Abstract><AbstractText>Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64,888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785[A], P=6.32 × 10(-5), odds ratio (OR)=1.090). Risk SNPs were then subjected to further analyses in healthy Europeans for intermediate phenotypes of BD, including hippocampal volume, hippocampal function and cognitive performance. Our results showed that the risk SNPs were significantly associated with hippocampal volume and hippocampal function, with the risk alleles showing a decreased hippocampal volume and diminished activation of the left hippocampus, adding further evidence for their involvement in BD susceptibility. We also found the risk SNPs were strongly associated with CREB1 expression in lymphoblastoid cells (P<0.005) and the prefrontal cortex (P<1.0 × 10(-6)). Remarkably, population genetic analysis indicated that CREB1 displayed striking differences in allele frequencies between continental populations, and the risk alleles were completely absent in East Asian populations. We demonstrated that the regional prevalence of the CREB1 risk alleles in Europeans is likely caused by genetic hitchhiking due to natural selection acting on a nearby gene. Our results suggest that differential population histories due to natural selection on regional populations may lead to genetic heterogeneity of susceptibility to complex diseases, such as BD, and explain inconsistencies in detecting the genetic markers of these diseases among different ethnic populations.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China [2] University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>X-J</ForeName><Initials>XJ</Initials><AffiliationInfo><Affiliation>University of Rochester Flaum Eye Institute, University of Rochester, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rietschel</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany [2] Department of Psychiatry, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>C M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>MRC SGDP Centre, Institute of Psychiatry, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mattheisen</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller-Myhsok</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jamain</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leboyer</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] Pôle de Psychiatrie, AP-HP, Hôpital H. Mondor-A. Chenevier, Créteil, France [4] Faculté de Médecine, Université Paris Est, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landén</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1] Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>P M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cichon</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>1] Institute of Neuroscience and Medicine (INM-1), 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USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Debette</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology, Paris, France [3] Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Launer</LastName><ForeName>L J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seshadri</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>1] Department of Neurology, Boston University School of Medicine, Boston, MA, USA [2] The National, 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Charité Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellivier</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>1] Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France [2] Fondation Fondamental, Créteil, France [3] AP-HP, Hôpital St-Louis-Lariboisière-F Widal, Service Universitaire de Psychiatrie, Paris, France [4] Faculté de Médecine, Université Denis Diderot, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stein</LastName><ForeName>J L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>1] Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA [2] Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Medland</LastName><ForeName>S E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>1] Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [2] Quantitative Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia [3] Broad Institute of Harvard and MIT, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arias Vasquez</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hibar</LastName><ForeName>D P</ForeName><Initials>DP</Initials><AffiliationInfo><Affiliation>Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franke</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>1] Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands [2] Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>N G</ForeName><Initials>NG</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>M J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Genetic 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NS017950</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 AG021886</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG008122</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HD050735</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AG049505</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>04</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol 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