AustralieFrV1, PubMed, Curation, bibRecord, 003622

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension.

Identifieur interne : 003622 ( PubMed/Curation ); précédent : 003621; suivant : 003623

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension.

Auteurs : Silvia Rain ; Denielli Da Silva Goncalves Bos ; M Louis Handoko ; Nico Westerhof ; Ger Stienen ; Coen Ottenheijm ; Max Goebel ; Peter Dorfmüller [France] ; Christophe Guignabert [France] ; Marc Humbert [France] ; Harm-Jan Bogaard ; Cris Dos Remedios [Australie] ; Chandra Saripalli ; Carlos G. Hidalgo ; Henk L. Granzier ; Anton Vonk-Noordegraaf ; Jolanda Van Der Velden ; Frances S. De Man

Source :

Journal of the American Heart Association [ 2047-9980 ] ; 2014.

RBID : pubmed:24895160

Descripteurs français

English descriptors

KwdEn :
- Adult, Blotting, Western, Calcium-Calmodulin-Dependent Protein Kinase Type 2 (analysis), Calcium-Calmodulin-Dependent Protein Kinase Type 2 (physiology), Case-Control Studies, Connectin (analysis), Connectin (physiology), Cyclic AMP-Dependent Protein Kinases (analysis), Cyclic AMP-Dependent Protein Kinases (physiology), Female, Heart Ventricles (chemistry), Heart Ventricles (physiopathology), Humans, Hypertension, Pulmonary (physiopathology), Male, Myocytes, Cardiac (chemistry), Myocytes, Cardiac (physiology), Phosphorylation, Protein Kinase C-alpha (analysis), Protein Kinase C-alpha (physiology), Troponin I (physiology), Ventricular Dysfunction, Right (physiopathology).
MESH :
- chemical , analysis : Calcium-Calmodulin-Dependent Protein Kinase Type 2, Connectin, Cyclic AMP-Dependent Protein Kinases, Protein Kinase C-alpha.
- chemical , physiology : Calcium-Calmodulin-Dependent Protein Kinase Type 2, Connectin, Cyclic AMP-Dependent Protein Kinases, Protein Kinase C-alpha, Troponin I.
- chemistry : Heart Ventricles, Myocytes, Cardiac.
- physiology : Myocytes, Cardiac.
- physiopathology : Heart Ventricles, Hypertension, Pulmonary, Ventricular Dysfunction, Right.
- Adult, Blotting, Western, Case-Control Studies, Female, Humans, Male, Phosphorylation.

Abstract

Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to cellular diastolic dysfunction in PAH.

DOI: 10.1161/JAHA.113.000716
PubMed: 24895160

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Silvia Rain

<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>

Denielli Da Silva Goncalves Bos

<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>

M Louis Handoko

<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) Department of Cardiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (L.H.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (L.H.).</wicri:noCountry>
</affiliation>

Nico Westerhof

<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>

Ger Stienen

<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) Department of Physics and Astronomy, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (G.S.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (G.S.).</wicri:noCountry>
</affiliation>

Coen Ottenheijm

<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>

Max Goebel

<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>

Harm-Jan Bogaard

<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>

Chandra Saripalli

<affiliation><nlm:affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</nlm:affiliation>
<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
</affiliation>

Carlos G. Hidalgo

<affiliation><nlm:affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</nlm:affiliation>
<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
</affiliation>

Henk L. Granzier

<affiliation><nlm:affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</nlm:affiliation>
<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
</affiliation>

Anton Vonk-Noordegraaf

<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>

Jolanda Van Der Velden

<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) ICIN - The Netherlands Heart Institute, Amsterdam, The Netherlands (J.V.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (J.V.).</wicri:noCountry>
</affiliation>

Frances S. De Man

<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>

Le document en format XML

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<author><name sortKey="Guignabert, Christophe" sort="Guignabert, Christophe" uniqKey="Guignabert C" first="Christophe" last="Guignabert">Christophe Guignabert</name>
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<author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
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<author><name sortKey="Bogaard, Harm Jan" sort="Bogaard, Harm Jan" uniqKey="Bogaard H" first="Harm-Jan" last="Bogaard">Harm-Jan Bogaard</name>
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<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
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<author><name sortKey="Remedios, Cris Dos" sort="Remedios, Cris Dos" uniqKey="Remedios C" first="Cris Dos" last="Remedios">Cris Dos Remedios</name>
<affiliation wicri:level="4"><nlm:affiliation>Muscle Research Unit, Discipline of Anatomy & Histology, Bosch Institute, The University of Sydney, Sydney, Australia (C.R.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
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<author><name sortKey="Saripalli, Chandra" sort="Saripalli, Chandra" uniqKey="Saripalli C" first="Chandra" last="Saripalli">Chandra Saripalli</name>
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<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
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<author><name sortKey="Hidalgo, Carlos G" sort="Hidalgo, Carlos G" uniqKey="Hidalgo C" first="Carlos G" last="Hidalgo">Carlos G. Hidalgo</name>
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<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
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<author><name sortKey="Granzier, Henk L" sort="Granzier, Henk L" uniqKey="Granzier H" first="Henk L" last="Granzier">Henk L. Granzier</name>
<affiliation><nlm:affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</nlm:affiliation>
<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
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<author><name sortKey="Vonk Noordegraaf, Anton" sort="Vonk Noordegraaf, Anton" uniqKey="Vonk Noordegraaf A" first="Anton" last="Vonk-Noordegraaf">Anton Vonk-Noordegraaf</name>
<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>
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<author><name sortKey="Van Der Velden, Jolanda" sort="Van Der Velden, Jolanda" uniqKey="Van Der Velden J" first="Jolanda" last="Van Der Velden">Jolanda Van Der Velden</name>
<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) ICIN - The Netherlands Heart Institute, Amsterdam, The Netherlands (J.V.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (J.V.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Man, Frances S" sort="De Man, Frances S" uniqKey="De Man F" first="Frances S" last="De Man">Frances S. De Man</name>
<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension.</title>
<author><name sortKey="Rain, Silvia" sort="Rain, Silvia" uniqKey="Rain S" first="Silvia" last="Rain">Silvia Rain</name>
<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
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<author><name sortKey="Bos, Denielli Da Silva Goncalves" sort="Bos, Denielli Da Silva Goncalves" uniqKey="Bos D" first="Denielli Da Silva Goncalves" last="Bos">Denielli Da Silva Goncalves Bos</name>
<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Handoko, M Louis" sort="Handoko, M Louis" uniqKey="Handoko M" first="M Louis" last="Handoko">M Louis Handoko</name>
<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) Department of Cardiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (L.H.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (L.H.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Westerhof, Nico" sort="Westerhof, Nico" uniqKey="Westerhof N" first="Nico" last="Westerhof">Nico Westerhof</name>
<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Stienen, Ger" sort="Stienen, Ger" uniqKey="Stienen G" first="Ger" last="Stienen">Ger Stienen</name>
<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) Department of Physics and Astronomy, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (G.S.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (G.S.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ottenheijm, Coen" sort="Ottenheijm, Coen" uniqKey="Ottenheijm C" first="Coen" last="Ottenheijm">Coen Ottenheijm</name>
<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Goebel, Max" sort="Goebel, Max" uniqKey="Goebel M" first="Max" last="Goebel">Max Goebel</name>
<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Dorfmuller, Peter" sort="Dorfmuller, Peter" uniqKey="Dorfmuller P" first="Peter" last="Dorfmüller">Peter Dorfmüller</name>
<affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre, France (P.D., C.G., M.H.) Inserm U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., C.G., M.H.).</nlm:affiliation>
<orgName type="university">Université Paris-Sud</orgName>
<country>France</country>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
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<author><name sortKey="Guignabert, Christophe" sort="Guignabert, Christophe" uniqKey="Guignabert C" first="Christophe" last="Guignabert">Christophe Guignabert</name>
<affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre, France (P.D., C.G., M.H.) Inserm U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., C.G., M.H.).</nlm:affiliation>
<orgName type="university">Université Paris-Sud</orgName>
<country>France</country>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
<affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre, France (P.D., C.G., M.H.) Inserm U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., C.G., M.H.) Service d'Anatomie Pathologique, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (M.H.) Assistance Publique-Hôspitaux de Paris, Service de Pneumologie, Département Hôspital Universitaire, Thorax innovation, (DHU-TORINO), Hôpital Bicêtre, France (M.H.).</nlm:affiliation>
<orgName type="university">Université Paris-Sud</orgName>
<country>France</country>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bogaard, Harm Jan" sort="Bogaard, Harm Jan" uniqKey="Bogaard H" first="Harm-Jan" last="Bogaard">Harm-Jan Bogaard</name>
<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Remedios, Cris Dos" sort="Remedios, Cris Dos" uniqKey="Remedios C" first="Cris Dos" last="Remedios">Cris Dos Remedios</name>
<affiliation wicri:level="4"><nlm:affiliation>Muscle Research Unit, Discipline of Anatomy & Histology, Bosch Institute, The University of Sydney, Sydney, Australia (C.R.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saripalli, Chandra" sort="Saripalli, Chandra" uniqKey="Saripalli C" first="Chandra" last="Saripalli">Chandra Saripalli</name>
<affiliation><nlm:affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</nlm:affiliation>
<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hidalgo, Carlos G" sort="Hidalgo, Carlos G" uniqKey="Hidalgo C" first="Carlos G" last="Hidalgo">Carlos G. Hidalgo</name>
<affiliation><nlm:affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</nlm:affiliation>
<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Granzier, Henk L" sort="Granzier, Henk L" uniqKey="Granzier H" first="Henk L" last="Granzier">Henk L. Granzier</name>
<affiliation><nlm:affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</nlm:affiliation>
<wicri:noCountry code="subField">H.L.G.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vonk Noordegraaf, Anton" sort="Vonk Noordegraaf, Anton" uniqKey="Vonk Noordegraaf A" first="Anton" last="Vonk-Noordegraaf">Anton Vonk-Noordegraaf</name>
<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Van Der Velden, Jolanda" sort="Van Der Velden, Jolanda" uniqKey="Van Der Velden J" first="Jolanda" last="Van Der Velden">Jolanda Van Der Velden</name>
<affiliation><nlm:affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) ICIN - The Netherlands Heart Institute, Amsterdam, The Netherlands (J.V.).</nlm:affiliation>
<wicri:noCountry code="subField">The Netherlands (J.V.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Man, Frances S" sort="De Man, Frances S" uniqKey="De Man F" first="Frances S" last="De Man">Frances S. De Man</name>
<affiliation><nlm:affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">F.S.M.).</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the American Heart Association</title>
<idno type="eISSN">2047-9980</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
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<term>Blotting, Western</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Type 2 (analysis)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Type 2 (physiology)</term>
<term>Case-Control Studies</term>
<term>Connectin (analysis)</term>
<term>Connectin (physiology)</term>
<term>Cyclic AMP-Dependent Protein Kinases (analysis)</term>
<term>Cyclic AMP-Dependent Protein Kinases (physiology)</term>
<term>Female</term>
<term>Heart Ventricles (chemistry)</term>
<term>Heart Ventricles (physiopathology)</term>
<term>Humans</term>
<term>Hypertension, Pulmonary (physiopathology)</term>
<term>Male</term>
<term>Myocytes, Cardiac (chemistry)</term>
<term>Myocytes, Cardiac (physiology)</term>
<term>Phosphorylation</term>
<term>Protein Kinase C-alpha (analysis)</term>
<term>Protein Kinase C-alpha (physiology)</term>
<term>Troponin I (physiology)</term>
<term>Ventricular Dysfunction, Right (physiopathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Type 2 (analyse)</term>
<term>Calcium-Calmodulin-Dependent Protein Kinase Type 2 (physiologie)</term>
<term>Connectine (analyse)</term>
<term>Connectine (physiologie)</term>
<term>Cyclic AMP-Dependent Protein Kinases (analyse)</term>
<term>Cyclic AMP-Dependent Protein Kinases (physiologie)</term>
<term>Dysfonction ventriculaire droite (physiopathologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hypertension pulmonaire (physiopathologie)</term>
<term>Myocytes cardiaques ()</term>
<term>Myocytes cardiaques (physiologie)</term>
<term>Mâle</term>
<term>Phosphorylation</term>
<term>Protein kinase C-alpha (analyse)</term>
<term>Protein kinase C-alpha (physiologie)</term>
<term>Technique de Western</term>
<term>Troponine I (physiologie)</term>
<term>Ventricules cardiaques ()</term>
<term>Ventricules cardiaques (physiopathologie)</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Calcium-Calmodulin-Dependent Protein Kinase Type 2</term>
<term>Connectin</term>
<term>Cyclic AMP-Dependent Protein Kinases</term>
<term>Protein Kinase C-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Calcium-Calmodulin-Dependent Protein Kinase Type 2</term>
<term>Connectin</term>
<term>Cyclic AMP-Dependent Protein Kinases</term>
<term>Protein Kinase C-alpha</term>
<term>Troponin I</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Calcium-Calmodulin-Dependent Protein Kinase Type 2</term>
<term>Connectine</term>
<term>Cyclic AMP-Dependent Protein Kinases</term>
<term>Protein kinase C-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Heart Ventricles</term>
<term>Myocytes, Cardiac</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Calcium-Calmodulin-Dependent Protein Kinase Type 2</term>
<term>Connectine</term>
<term>Cyclic AMP-Dependent Protein Kinases</term>
<term>Myocytes cardiaques</term>
<term>Protein kinase C-alpha</term>
<term>Troponine I</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Dysfonction ventriculaire droite</term>
<term>Hypertension pulmonaire</term>
<term>Ventricules cardiaques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Heart Ventricles</term>
<term>Hypertension, Pulmonary</term>
<term>Ventricular Dysfunction, Right</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Blotting, Western</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Phosphorylation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Femelle</term>
<term>Humains</term>
<term>Myocytes cardiaques</term>
<term>Mâle</term>
<term>Phosphorylation</term>
<term>Technique de Western</term>
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<front><div type="abstract" xml:lang="en">Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to cellular diastolic dysfunction in PAH.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24895160</PMID>
<DateCreated><Year>2014</Year>
<Month>06</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>02</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>12</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2047-9980</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>3</Volume>
<Issue>3</Issue>
<PubDate><Year>2014</Year>
<Month>Jun</Month>
<Day>03</Day>
</PubDate>
</JournalIssue>
<Title>Journal of the American Heart Association</Title>
<ISOAbbreviation>J Am Heart Assoc</ISOAbbreviation>
</Journal>
<ArticleTitle>Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension.</ArticleTitle>
<Pagination><MedlinePgn>e000716</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/JAHA.113.000716</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">e000716</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to cellular diastolic dysfunction in PAH.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">RV samples from PAH patients undergoing heart-lung transplantation were compared to non-failing donors (Don). Titin stiffness contribution to RV diastolic dysfunction was determined by Western-blot analyses using antibodies to protein-kinase-A (PKA), Cα (PKCα) and Ca(2+)/calmoduling-dependent-kinase (CamKIIδ) titin and phospholamban (PLN) phosphorylation sites: N2B (Ser469), PEVK (Ser170 and Ser26), and PLN (Thr17), respectively. PKA and PKCα sites were significantly less phosphorylated in PAH compared with donors (P<0.0001). To test the functional relevance of PKA-, PKCα-, and CamKIIδ-mediated titin phosphorylation, we measured the stiffness of single RV cardiomyocytes before and after kinase incubation. PKA significantly decreased PAH RV cardiomyocyte diastolic stiffness, PKCα further increased stiffness while CamKIIδ had no major effect. CamKIIδ activation was determined indirectly by measuring PLN Thr17phosphorylation level. No significant changes were found between the groups. Myofilament Ca(2+) sensitivity is mediated by sarcomeric troponin I (cTnI) phosphorylation. We observed increased unphosphorylated cTnI in PAH compared with donors (P<0.05) and reduced PKA-mediated cTnI phosphorylation (Ser22/23) (P<0.001). Finally, alterations in Ca(2+)-handling proteins contribute to RV diastolic dysfunction due to insufficient diastolic Ca(2+) clearance. PAH SERCA2a levels and PLN phosphorylation were significantly reduced compared with donors (P<0.05).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Increased titin stiffness, reduced cTnI phosphorylation, and altered levels of phosphorylation of Ca(2+) handling proteins contribute to RV diastolic dysfunction in PAH.</AbstractText>
<CopyrightInformation>© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rain</LastName>
<ForeName>Silvia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bos</LastName>
<ForeName>Denielli da Silva Goncalves</ForeName>
<Initials>Dda S</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Handoko</LastName>
<ForeName>M Louis</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) Department of Cardiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (L.H.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Westerhof</LastName>
<ForeName>Nico</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stienen</LastName>
<ForeName>Ger</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) Department of Physics and Astronomy, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (G.S.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ottenheijm</LastName>
<ForeName>Coen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goebel</LastName>
<ForeName>Max</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dorfmüller</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre, France (P.D., C.G., M.H.) Inserm U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., C.G., M.H.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guignabert</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre, France (P.D., C.G., M.H.) Inserm U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., C.G., M.H.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Humbert</LastName>
<ForeName>Marc</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre, France (P.D., C.G., M.H.) Inserm U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., C.G., M.H.) Service d'Anatomie Pathologique, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (M.H.) Assistance Publique-Hôspitaux de Paris, Service de Pneumologie, Département Hôspital Universitaire, Thorax innovation, (DHU-TORINO), Hôpital Bicêtre, France (M.H.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bogaard</LastName>
<ForeName>Harm-Jan</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Remedios</LastName>
<ForeName>Cris Dos</ForeName>
<Initials>CD</Initials>
<AffiliationInfo><Affiliation>Muscle Research Unit, Discipline of Anatomy & Histology, Bosch Institute, The University of Sydney, Sydney, Australia (C.R.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saripalli</LastName>
<ForeName>Chandra</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hidalgo</LastName>
<ForeName>Carlos G</ForeName>
<Initials>CG</Initials>
<AffiliationInfo><Affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Granzier</LastName>
<ForeName>Henk L</ForeName>
<Initials>HL</Initials>
<AffiliationInfo><Affiliation>Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson, AZ, The Netherlands (C.S., C.G.H., H.L.G.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vonk-Noordegraaf</LastName>
<ForeName>Anton</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van der Velden</LastName>
<ForeName>Jolanda</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.) ICIN - The Netherlands Heart Institute, Amsterdam, The Netherlands (J.V.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Man</LastName>
<ForeName>Frances S</ForeName>
<Initials>FS</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., D.S.G.B., N.W., H.J.B., A.V.N., F.S.M.) Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, The Netherlands (S.R., L.H., N.W., G.S., C.O., M.G., J.V., F.S.M.).</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 HL062881</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>HL062881</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>06</Month>
<Day>03</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Am Heart Assoc</MedlineTA>
<NlmUniqueID>101580524</NlmUniqueID>
<ISSNLinking>2047-9980</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064211">Connectin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019210">Troponin I</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.11</RegistryNumber>
<NameOfSubstance UI="D017868">Cyclic AMP-Dependent Protein Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.13</RegistryNumber>
<NameOfSubstance UI="D051571">Protein Kinase C-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.17</RegistryNumber>
<NameOfSubstance UI="D054732">Calcium-Calmodulin-Dependent Protein Kinase Type 2</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension.

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension.

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