Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma.
Identifieur interne : 003590 ( PubMed/Curation ); précédent : 003589; suivant : 003591Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma.
Auteurs : Jesús San-Miguel [Espagne] ; Joan Bladé [Espagne] ; Ofer Shpilberg [Israël] ; Sebastian Grosicki [Pologne] ; Frédéric Maloisel [France] ; Chang-Ki Min [Corée du Sud] ; Marta Polo Zarzuela [Espagne] ; Tadeusz Robak [Pologne] ; Sripada V S S. Prasad [Inde] ; Yeow Tee Goh [Singapour] ; Jacob Laubach [États-Unis] ; Andrew Spencer [Australie] ; María-Victoria Mateos [Espagne] ; Antonio Palumbo [Italie] ; Tom Puchalski [États-Unis] ; Manjula Reddy [États-Unis] ; Clarissa Uhlar [États-Unis] ; Xiang Qin [États-Unis] ; Helgi Van De Velde ; Hong Xie [États-Unis] ; Robert Z. Orlowski [États-Unis]Source :
- Blood [ 1528-0020 ] ; 2014.
Descripteurs français
- KwdFr :
- Acides boroniques (administration et posologie), Adulte d'âge moyen, Anticorps monoclonaux (administration et posologie), Bortézomib, Chromosomes humains de la paire 17, Délétion de segment de chromosome, Femelle, Humains, Immunoglobuline A (sang), Interleukine-6 (antagonistes et inhibiteurs), Melphalan (administration et posologie), Myélome multiple (génétique), Myélome multiple (mortalité), Myélome multiple (sang), Myélome multiple (traitement médicamenteux), Mâle, Prednisone (administration et posologie), Protocoles de polychimiothérapie antinéoplasique (administration et posologie), Pyrazines (administration et posologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Taux de survie, Études de suivi.
- MESH :
- administration et posologie : Acides boroniques, Anticorps monoclonaux, Melphalan, Prednisone, Protocoles de polychimiothérapie antinéoplasique, Pyrazines.
- antagonistes et inhibiteurs : Interleukine-6.
- génétique : Myélome multiple.
- mortalité : Myélome multiple.
- sang : Immunoglobuline A, Myélome multiple.
- traitement médicamenteux : Myélome multiple.
- Adulte d'âge moyen, Bortézomib, Chromosomes humains de la paire 17, Délétion de segment de chromosome, Femelle, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Taux de survie, Études de suivi.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antibodies, Monoclonal (administration & dosage), Antineoplastic Combined Chemotherapy Protocols (administration & dosage), Boronic Acids (administration & dosage), Bortezomib, Chromosome Deletion, Chromosomes, Human, Pair 17, Disease-Free Survival, Female, Follow-Up Studies, Humans, Immunoglobulin A (blood), Interleukin-6 (antagonists & inhibitors), Male, Melphalan (administration & dosage), Middle Aged, Multiple Myeloma (blood), Multiple Myeloma (drug therapy), Multiple Myeloma (genetics), Multiple Myeloma (mortality), Prednisone (administration & dosage), Pyrazines (administration & dosage), Survival Rate.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Boronic Acids, Melphalan, Prednisone, Pyrazines.
- administration & dosage : Antineoplastic Combined Chemotherapy Protocols.
- chemical , antagonists & inhibitors : Interleukin-6.
- chemical , blood : Immunoglobulin A, Multiple Myeloma.
- drug therapy : Multiple Myeloma.
- genetics : Multiple Myeloma.
- mortality : Multiple Myeloma.
- Aged, Aged, 80 and over, Bortezomib, Chromosome Deletion, Chromosomes, Human, Pair 17, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, Survival Rate.
Abstract
Because interleukin-6 (IL-6) is considered important in the proliferation of early multiple myeloma (MM), we hypothesized that the addition of the anti-IL-6 monoclonal antibody siltuximab to the bortezomib-melphalan-prednisone (VMP) regimen would improve outcomes in transplant-ineligible patients with newly diagnosed MM. One hundred and six patients were randomized to receive 9 cycles of VMP or VMP plus siltuximab (11 mg/kg every 3 weeks) followed by siltuximab maintenance. Baseline characteristics were well balanced except for immunoglobulin A subtype and 17p deletions. With a complete response (CR) rate of 27% on siltuximab plus VMP (S+VMP) and 22% on VMP, the study did not confirm its hypothesis that the addition of siltuximab would increase the CR rate by at least 10%. Overall response rate was 88% on S+VMP and 80% on VMP, and at least very good partial response rates were 71% and 51% (P = .0382), respectively. Median progression-free survival (17 months) and 1-year overall survival (88%) were identical in the 2 arms. Grade ≥3 adverse-event incidence was 92% on S+VMP and 81% on VMP (P = .09), with trends toward more hematologic events and infections on S+VMP. Maintenance therapy with siltuximab was well tolerated. In conclusion, the addition of siltuximab to VMP did not improve the CR rate or long-term outcomes. This study was registered at http://clinicaltrials.gov as #NCT00911859.
DOI: 10.1182/blood-2013-12-546374
PubMed: 24833354
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003704
Links to Exploration step
pubmed:24833354Curation
No country items
Helgi Van De Velde<affiliation><nlm:affiliation>Janssen Research & Development, Beerse, Belgium; and.</nlm:affiliation>
<wicri:noCountry code="subField">Belgium; and</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma.</title>
<author><name sortKey="San Miguel, Jesus" sort="San Miguel, Jesus" uniqKey="San Miguel J" first="Jesús" last="San-Miguel">Jesús San-Miguel</name>
<affiliation wicri:level="1"><nlm:affiliation>Centro de Investigación Medica Aplicada, Clinica Universidad de Navarra, Navarra, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación Medica Aplicada, Clinica Universidad de Navarra, Navarra</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Bladé">Joan Bladé</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigacions Biomediques August Pi I Sunyer, Hospital Clinic I Provincial, Barcelona, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomediques August Pi I Sunyer, Hospital Clinic I Provincial, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shpilberg, Ofer" sort="Shpilberg, Ofer" uniqKey="Shpilberg O" first="Ofer" last="Shpilberg">Ofer Shpilberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel;</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grosicki, Sebastian" sort="Grosicki, Sebastian" uniqKey="Grosicki S" first="Sebastian" last="Grosicki">Sebastian Grosicki</name>
<affiliation wicri:level="1"><nlm:affiliation>Oddzial Hematologiczny SPZOZ Zespol Szpitali Miejskich w Chorzowie, Chorzow, Poland;</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Oddzial Hematologiczny SPZOZ Zespol Szpitali Miejskich w Chorzowie, Chorzow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maloisel, Frederic" sort="Maloisel, Frederic" uniqKey="Maloisel F" first="Frédéric" last="Maloisel">Frédéric Maloisel</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinique Saint Anne, Strasbourg, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Saint Anne, Strasbourg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Min, Chang Ki" sort="Min, Chang Ki" uniqKey="Min C" first="Chang-Ki" last="Min">Chang-Ki Min</name>
<affiliation wicri:level="1"><nlm:affiliation>Seoul St. Mary's Hospital, Seoul, Republic of Korea;</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Seoul St. Mary's Hospital, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Polo Zarzuela, Marta" sort="Polo Zarzuela, Marta" uniqKey="Polo Zarzuela M" first="Marta" last="Polo Zarzuela">Marta Polo Zarzuela</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Clinico San Carlos, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical University of Lodz, Lodz, Poland;</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Medical University of Lodz, Lodz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prasad, Sripada V S S" sort="Prasad, Sripada V S S" uniqKey="Prasad S" first="Sripada V S S" last="Prasad">Sripada V S S. Prasad</name>
<affiliation wicri:level="1"><nlm:affiliation>Apollo Hospitals & Research Foundation, Hyderabad, India;</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Apollo Hospitals & Research Foundation, Hyderabad</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tee Goh, Yeow" sort="Tee Goh, Yeow" uniqKey="Tee Goh Y" first="Yeow" last="Tee Goh">Yeow Tee Goh</name>
<affiliation wicri:level="1"><nlm:affiliation>Singapore General Hospital, Singapore, Singapore;</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore General Hospital, Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laubach, Jacob" sort="Laubach, Jacob" uniqKey="Laubach J" first="Jacob" last="Laubach">Jacob Laubach</name>
<affiliation wicri:level="2"><nlm:affiliation>Dana Farber Cancer Institute, Boston, MA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name>
<affiliation wicri:level="1"><nlm:affiliation>Alfred Health-Monash University, Melbourne, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Alfred Health-Monash University, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mateos, Maria Victoria" sort="Mateos, Maria Victoria" uniqKey="Mateos M" first="María-Victoria" last="Mateos">María-Victoria Mateos</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Salamanca, Salamanca, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario Salamanca, Salamanca</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name>
<affiliation wicri:level="1"><nlm:affiliation>Ospedale Le Molinette, Torino, Italy;</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale Le Molinette, Torino</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Puchalski, Tom" sort="Puchalski, Tom" uniqKey="Puchalski T" first="Tom" last="Puchalski">Tom Puchalski</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reddy, Manjula" sort="Reddy, Manjula" uniqKey="Reddy M" first="Manjula" last="Reddy">Manjula Reddy</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Uhlar, Clarissa" sort="Uhlar, Clarissa" uniqKey="Uhlar C" first="Clarissa" last="Uhlar">Clarissa Uhlar</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Qin, Xiang" sort="Qin, Xiang" uniqKey="Qin X" first="Xiang" last="Qin">Xiang Qin</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van De Velde, Helgi" sort="Van De Velde, Helgi" uniqKey="Van De Velde H" first="Helgi" last="Van De Velde">Helgi Van De Velde</name>
<affiliation><nlm:affiliation>Janssen Research & Development, Beerse, Belgium; and.</nlm:affiliation>
<wicri:noCountry code="subField">Belgium; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Xie, Hong" sort="Xie, Hong" uniqKey="Xie H" first="Hong" last="Xie">Hong Xie</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Orlowski, Robert Z" sort="Orlowski, Robert Z" uniqKey="Orlowski R" first="Robert Z" last="Orlowski">Robert Z. Orlowski</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24833354</idno>
<idno type="pmid">24833354</idno>
<idno type="doi">10.1182/blood-2013-12-546374</idno>
<idno type="wicri:Area/PubMed/Corpus">003704</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003704</idno>
<idno type="wicri:Area/PubMed/Curation">003590</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003590</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma.</title>
<author><name sortKey="San Miguel, Jesus" sort="San Miguel, Jesus" uniqKey="San Miguel J" first="Jesús" last="San-Miguel">Jesús San-Miguel</name>
<affiliation wicri:level="1"><nlm:affiliation>Centro de Investigación Medica Aplicada, Clinica Universidad de Navarra, Navarra, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación Medica Aplicada, Clinica Universidad de Navarra, Navarra</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Bladé">Joan Bladé</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut d'Investigacions Biomediques August Pi I Sunyer, Hospital Clinic I Provincial, Barcelona, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut d'Investigacions Biomediques August Pi I Sunyer, Hospital Clinic I Provincial, Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shpilberg, Ofer" sort="Shpilberg, Ofer" uniqKey="Shpilberg O" first="Ofer" last="Shpilberg">Ofer Shpilberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel;</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Sackler School of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grosicki, Sebastian" sort="Grosicki, Sebastian" uniqKey="Grosicki S" first="Sebastian" last="Grosicki">Sebastian Grosicki</name>
<affiliation wicri:level="1"><nlm:affiliation>Oddzial Hematologiczny SPZOZ Zespol Szpitali Miejskich w Chorzowie, Chorzow, Poland;</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Oddzial Hematologiczny SPZOZ Zespol Szpitali Miejskich w Chorzowie, Chorzow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maloisel, Frederic" sort="Maloisel, Frederic" uniqKey="Maloisel F" first="Frédéric" last="Maloisel">Frédéric Maloisel</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinique Saint Anne, Strasbourg, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Saint Anne, Strasbourg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Min, Chang Ki" sort="Min, Chang Ki" uniqKey="Min C" first="Chang-Ki" last="Min">Chang-Ki Min</name>
<affiliation wicri:level="1"><nlm:affiliation>Seoul St. Mary's Hospital, Seoul, Republic of Korea;</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Seoul St. Mary's Hospital, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Polo Zarzuela, Marta" sort="Polo Zarzuela, Marta" uniqKey="Polo Zarzuela M" first="Marta" last="Polo Zarzuela">Marta Polo Zarzuela</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Clinico San Carlos, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical University of Lodz, Lodz, Poland;</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Medical University of Lodz, Lodz</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prasad, Sripada V S S" sort="Prasad, Sripada V S S" uniqKey="Prasad S" first="Sripada V S S" last="Prasad">Sripada V S S. Prasad</name>
<affiliation wicri:level="1"><nlm:affiliation>Apollo Hospitals & Research Foundation, Hyderabad, India;</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Apollo Hospitals & Research Foundation, Hyderabad</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tee Goh, Yeow" sort="Tee Goh, Yeow" uniqKey="Tee Goh Y" first="Yeow" last="Tee Goh">Yeow Tee Goh</name>
<affiliation wicri:level="1"><nlm:affiliation>Singapore General Hospital, Singapore, Singapore;</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore General Hospital, Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laubach, Jacob" sort="Laubach, Jacob" uniqKey="Laubach J" first="Jacob" last="Laubach">Jacob Laubach</name>
<affiliation wicri:level="2"><nlm:affiliation>Dana Farber Cancer Institute, Boston, MA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name>
<affiliation wicri:level="1"><nlm:affiliation>Alfred Health-Monash University, Melbourne, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Alfred Health-Monash University, Melbourne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mateos, Maria Victoria" sort="Mateos, Maria Victoria" uniqKey="Mateos M" first="María-Victoria" last="Mateos">María-Victoria Mateos</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Salamanca, Salamanca, Spain;</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario Salamanca, Salamanca</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name>
<affiliation wicri:level="1"><nlm:affiliation>Ospedale Le Molinette, Torino, Italy;</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale Le Molinette, Torino</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Puchalski, Tom" sort="Puchalski, Tom" uniqKey="Puchalski T" first="Tom" last="Puchalski">Tom Puchalski</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reddy, Manjula" sort="Reddy, Manjula" uniqKey="Reddy M" first="Manjula" last="Reddy">Manjula Reddy</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Uhlar, Clarissa" sort="Uhlar, Clarissa" uniqKey="Uhlar C" first="Clarissa" last="Uhlar">Clarissa Uhlar</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Qin, Xiang" sort="Qin, Xiang" uniqKey="Qin X" first="Xiang" last="Qin">Xiang Qin</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van De Velde, Helgi" sort="Van De Velde, Helgi" uniqKey="Van De Velde H" first="Helgi" last="Van De Velde">Helgi Van De Velde</name>
<affiliation><nlm:affiliation>Janssen Research & Development, Beerse, Belgium; and.</nlm:affiliation>
<wicri:noCountry code="subField">Belgium; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Xie, Hong" sort="Xie, Hong" uniqKey="Xie H" first="Hong" last="Xie">Hong Xie</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research & Development, Spring House, PA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Orlowski, Robert Z" sort="Orlowski, Robert Z" uniqKey="Orlowski R" first="Robert Z" last="Orlowski">Robert Z. Orlowski</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibodies, Monoclonal (administration & dosage)</term>
<term>Antineoplastic Combined Chemotherapy Protocols (administration & dosage)</term>
<term>Boronic Acids (administration & dosage)</term>
<term>Bortezomib</term>
<term>Chromosome Deletion</term>
<term>Chromosomes, Human, Pair 17</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Immunoglobulin A (blood)</term>
<term>Interleukin-6 (antagonists & inhibitors)</term>
<term>Male</term>
<term>Melphalan (administration & dosage)</term>
<term>Middle Aged</term>
<term>Multiple Myeloma (blood)</term>
<term>Multiple Myeloma (drug therapy)</term>
<term>Multiple Myeloma (genetics)</term>
<term>Multiple Myeloma (mortality)</term>
<term>Prednisone (administration & dosage)</term>
<term>Pyrazines (administration & dosage)</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides boroniques (administration et posologie)</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux (administration et posologie)</term>
<term>Bortézomib</term>
<term>Chromosomes humains de la paire 17</term>
<term>Délétion de segment de chromosome</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunoglobuline A (sang)</term>
<term>Interleukine-6 (antagonistes et inhibiteurs)</term>
<term>Melphalan (administration et posologie)</term>
<term>Myélome multiple (génétique)</term>
<term>Myélome multiple (mortalité)</term>
<term>Myélome multiple (sang)</term>
<term>Myélome multiple (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Prednisone (administration et posologie)</term>
<term>Protocoles de polychimiothérapie antinéoplasique (administration et posologie)</term>
<term>Pyrazines (administration et posologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Boronic Acids</term>
<term>Melphalan</term>
<term>Prednisone</term>
<term>Pyrazines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Acides boroniques</term>
<term>Anticorps monoclonaux</term>
<term>Melphalan</term>
<term>Prednisone</term>
<term>Protocoles de polychimiothérapie antinéoplasique</term>
<term>Pyrazines</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Interleukine-6</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Interleukin-6</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin A</term>
<term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline A</term>
<term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Bortezomib</term>
<term>Chromosome Deletion</term>
<term>Chromosomes, Human, Pair 17</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Bortézomib</term>
<term>Chromosomes humains de la paire 17</term>
<term>Délétion de segment de chromosome</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Because interleukin-6 (IL-6) is considered important in the proliferation of early multiple myeloma (MM), we hypothesized that the addition of the anti-IL-6 monoclonal antibody siltuximab to the bortezomib-melphalan-prednisone (VMP) regimen would improve outcomes in transplant-ineligible patients with newly diagnosed MM. One hundred and six patients were randomized to receive 9 cycles of VMP or VMP plus siltuximab (11 mg/kg every 3 weeks) followed by siltuximab maintenance. Baseline characteristics were well balanced except for immunoglobulin A subtype and 17p deletions. With a complete response (CR) rate of 27% on siltuximab plus VMP (S+VMP) and 22% on VMP, the study did not confirm its hypothesis that the addition of siltuximab would increase the CR rate by at least 10%. Overall response rate was 88% on S+VMP and 80% on VMP, and at least very good partial response rates were 71% and 51% (P = .0382), respectively. Median progression-free survival (17 months) and 1-year overall survival (88%) were identical in the 2 arms. Grade ≥3 adverse-event incidence was 92% on S+VMP and 81% on VMP (P = .09), with trends toward more hematologic events and infections on S+VMP. Maintenance therapy with siltuximab was well tolerated. In conclusion, the addition of siltuximab to VMP did not improve the CR rate or long-term outcomes. This study was registered at http://clinicaltrials.gov as #NCT00911859.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24833354</PMID>
<DateCreated><Year>2014</Year>
<Month>06</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>09</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1528-0020</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>123</Volume>
<Issue>26</Issue>
<PubDate><Year>2014</Year>
<Month>Jun</Month>
<Day>26</Day>
</PubDate>
</JournalIssue>
<Title>Blood</Title>
<ISOAbbreviation>Blood</ISOAbbreviation>
</Journal>
<ArticleTitle>Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma.</ArticleTitle>
<Pagination><MedlinePgn>4136-42</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1182/blood-2013-12-546374</ELocationID>
<Abstract><AbstractText>Because interleukin-6 (IL-6) is considered important in the proliferation of early multiple myeloma (MM), we hypothesized that the addition of the anti-IL-6 monoclonal antibody siltuximab to the bortezomib-melphalan-prednisone (VMP) regimen would improve outcomes in transplant-ineligible patients with newly diagnosed MM. One hundred and six patients were randomized to receive 9 cycles of VMP or VMP plus siltuximab (11 mg/kg every 3 weeks) followed by siltuximab maintenance. Baseline characteristics were well balanced except for immunoglobulin A subtype and 17p deletions. With a complete response (CR) rate of 27% on siltuximab plus VMP (S+VMP) and 22% on VMP, the study did not confirm its hypothesis that the addition of siltuximab would increase the CR rate by at least 10%. Overall response rate was 88% on S+VMP and 80% on VMP, and at least very good partial response rates were 71% and 51% (P = .0382), respectively. Median progression-free survival (17 months) and 1-year overall survival (88%) were identical in the 2 arms. Grade ≥3 adverse-event incidence was 92% on S+VMP and 81% on VMP (P = .09), with trends toward more hematologic events and infections on S+VMP. Maintenance therapy with siltuximab was well tolerated. In conclusion, the addition of siltuximab to VMP did not improve the CR rate or long-term outcomes. This study was registered at http://clinicaltrials.gov as #NCT00911859.</AbstractText>
<CopyrightInformation>© 2014 by The American Society of Hematology.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>San-Miguel</LastName>
<ForeName>Jesús</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centro de Investigación Medica Aplicada, Clinica Universidad de Navarra, Navarra, Spain;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bladé</LastName>
<ForeName>Joan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institut d'Investigacions Biomediques August Pi I Sunyer, Hospital Clinic I Provincial, Barcelona, Spain;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shpilberg</LastName>
<ForeName>Ofer</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grosicki</LastName>
<ForeName>Sebastian</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Oddzial Hematologiczny SPZOZ Zespol Szpitali Miejskich w Chorzowie, Chorzow, Poland;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maloisel</LastName>
<ForeName>Frédéric</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Clinique Saint Anne, Strasbourg, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Min</LastName>
<ForeName>Chang-Ki</ForeName>
<Initials>CK</Initials>
<AffiliationInfo><Affiliation>Seoul St. Mary's Hospital, Seoul, Republic of Korea;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Polo Zarzuela</LastName>
<ForeName>Marta</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Madrid, Spain;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robak</LastName>
<ForeName>Tadeusz</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Medical University of Lodz, Lodz, Poland;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Prasad</LastName>
<ForeName>Sripada V S S</ForeName>
<Initials>SV</Initials>
<AffiliationInfo><Affiliation>Apollo Hospitals & Research Foundation, Hyderabad, India;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tee Goh</LastName>
<ForeName>Yeow</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Singapore General Hospital, Singapore, Singapore;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laubach</LastName>
<ForeName>Jacob</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Dana Farber Cancer Institute, Boston, MA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Spencer</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Alfred Health-Monash University, Melbourne, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mateos</LastName>
<ForeName>María-Victoria</ForeName>
<Initials>MV</Initials>
<AffiliationInfo><Affiliation>Hospital Universitario Salamanca, Salamanca, Spain;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Palumbo</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Ospedale Le Molinette, Torino, Italy;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Puchalski</LastName>
<ForeName>Tom</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Janssen Research & Development, Spring House, PA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reddy</LastName>
<ForeName>Manjula</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Janssen Research & Development, Spring House, PA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uhlar</LastName>
<ForeName>Clarissa</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Janssen Research & Development, Spring House, PA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qin</LastName>
<ForeName>Xiang</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Janssen Research & Development, Spring House, PA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van de Velde</LastName>
<ForeName>Helgi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Janssen Research & Development, Beerse, Belgium; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Hong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Janssen Research & Development, Spring House, PA;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Orlowski</LastName>
<ForeName>Robert Z</ForeName>
<Initials>RZ</Initials>
<AffiliationInfo><Affiliation>The University of Texas MD Anderson Cancer Center, Houston, TX.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT00911859</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 CA016672</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P50 CA142509</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 CA102278</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1 TR000371</GrantID>
<Acronym>TR</Acronym>
<Agency>NCATS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D017427">Clinical Trial, Phase II</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>05</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Blood</MedlineTA>
<NlmUniqueID>7603509</NlmUniqueID>
<ISSNLinking>0006-4971</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001897">Boronic Acids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011719">Pyrazines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C504234">siltuximab</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>69G8BD63PP</RegistryNumber>
<NameOfSubstance UI="D000069286">Bortezomib</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>Q41OR9510P</RegistryNumber>
<NameOfSubstance UI="D008558">Melphalan</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>VB0R961HZT</RegistryNumber>
<NameOfSubstance UI="D011241">Prednisone</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Blood. 2000 Dec 1;96(12):3880-6</RefSource>
<PMID Version="1">11090073</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Treat Rep. 1985 Dec;69(12):1375-81</RefSource>
<PMID Version="1">4075313</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2003 Oct 15;9(13):4653-65</RefSource>
<PMID Version="1">14581334</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Oncogene. 2003 Nov 20;22(52):8386-93</RefSource>
<PMID Version="1">14627979</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 1989 Jul;74(1):1-10</RefSource>
<PMID Version="1">2473791</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 1993 Jun 15;81(12):3357-64</RefSource>
<PMID Version="1">8507873</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 1995 Feb 1;85(3):765-71</RefSource>
<PMID Version="1">7530507</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1995 Jul 1;182(1):243-8</RefSource>
<PMID Version="1">7790819</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 1996 Feb 1;87(3):1104-12</RefSource>
<PMID Version="1">8562936</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 1998 Sep;102(5):1115-23</RefSource>
<PMID Version="1">9753033</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2005 May 20;23(15):3412-20</RefSource>
<PMID Version="1">15809451</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood Rev. 2007 Sep;21(5):255-65</RefSource>
<PMID Version="1">17367905</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2007 Nov 1;13(21):6469-78</RefSource>
<PMID Version="1">17975159</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2008 Aug 28;359(9):906-17</RefSource>
<PMID Version="1">18753647</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mayo Clin Proc. 2009 Feb;84(2):114-22</RefSource>
<PMID Version="1">19181644</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 2009 May;145(4):481-90</RefSource>
<PMID Version="1">19344406</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2010 Aug 10;28(23):3701-8</RefSource>
<PMID Version="1">20625121</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 2011 Mar;152(5):579-92</RefSource>
<PMID Version="1">21241278</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Oncol. 2011 May;12(5):431-40</RefSource>
<PMID Version="1">21507715</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 May 5;117(18):4691-5</RefSource>
<PMID Version="1">21292775</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 May 5;117(18):4696-700</RefSource>
<PMID Version="1">21292777</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2013 Feb 1;31(4):448-55</RefSource>
<PMID Version="1">23233713</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 2013 May;161(3):357-66</RefSource>
<PMID Version="1">23432640</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2013 Jul 1;19(13):3659-70</RefSource>
<PMID Version="1">23659971</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2013 Sep 10;31(26):3279-87</RefSource>
<PMID Version="1">23897961</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="ErratumIn"><RefSource>Blood. 2014 Aug 14;124(7):1201</RefSource>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000971" MajorTopicYN="N">Antineoplastic Combined Chemotherapy Protocols</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001897" MajorTopicYN="N">Boronic Acids</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000069286" MajorTopicYN="N">Bortezomib</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002872" MajorTopicYN="N">Chromosome Deletion</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002886" MajorTopicYN="N">Chromosomes, Human, Pair 17</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018572" MajorTopicYN="N">Disease-Free Survival</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008558" MajorTopicYN="N">Melphalan</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009101" MajorTopicYN="N">Multiple Myeloma</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011241" MajorTopicYN="N">Prednisone</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011719" MajorTopicYN="N">Pyrazines</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC4123433</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>5</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>5</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>9</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">24833354</ArticleId>
<ArticleId IdType="pii">blood-2013-12-546374</ArticleId>
<ArticleId IdType="doi">10.1182/blood-2013-12-546374</ArticleId>
<ArticleId IdType="pmc">PMC4123433</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003590 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 003590 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:24833354 |texte= Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:24833354" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |