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Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

Identifieur interne : 003500 ( PubMed/Curation ); précédent : 003499; suivant : 003501

Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

Auteurs : Alban Bessede ; Marco Gargaro ; Maria T. Pallotta [Italie] ; Davide Matino [Italie] ; Giuseppe Servillo [Italie] ; Cinzia Brunacci [Italie] ; Silvio Bicciato [Italie] ; Emilia M C. Mazza [Italie] ; Antonio Macchiarulo [Italie] ; Carmine Vacca [Italie] ; Rossana Iannitti [Italie] ; Luciana Tissi [Italie] ; Claudia Volpi [Italie] ; Maria L. Belladonna [Italie] ; Ciriana Orabona [Italie] ; Roberta Bianchi [Italie] ; Tobias V. Lanz [Allemagne] ; Michael Platten [Allemagne] ; Maria A. Della Fazia [Italie] ; Danilo Piobbico [Italie] ; Teresa Zelante [Italie] ; Hiroshi Funakoshi [Japon] ; Toshikazu Nakamura [Japon] ; David Gilot [France] ; Michael S. Denison [États-Unis] ; Gilles J. Guillemin [Australie] ; James B. Duhadaway [États-Unis] ; George C. Prendergast [États-Unis] ; Richard Metz [États-Unis] ; Michel Geffard [France] ; Louis Boon [Pays-Bas] ; Matteo Pirro [Italie] ; Alfonso Iorio [Canada] ; Bernard Veyret [France] ; Luigina Romani [Italie] ; Ursula Grohmann [Italie] ; Francesca Fallarino [Italie] ; Paolo Puccetti [Italie]

Source :

Nature [ 1476-4687 ] ; 2014.

RBID : pubmed:24930766

Descripteurs français

English descriptors

KwdEn :
- Animals, Bacterial Infections (immunology), Bacterial Infections (metabolism), Disease Resistance (drug effects), Disease Resistance (genetics), Disease Resistance (immunology), Endotoxemia (genetics), Endotoxemia (immunology), Endotoxemia (metabolism), Enzyme Activation (drug effects), Gene Expression Regulation (drug effects), Indoleamine-Pyrrole 2,3,-Dioxygenase (metabolism), Inflammation (enzymology), Inflammation (genetics), Inflammation (metabolism), Kynurenine (metabolism), Lipopolysaccharides (pharmacology), Mice, Phosphorylation, Receptors, Aryl Hydrocarbon (genetics), Receptors, Aryl Hydrocarbon (metabolism), Signal Transduction, Tryptophan Oxygenase (metabolism), src-Family Kinases (metabolism).
MESH :
- chemical , genetics : Receptors, Aryl Hydrocarbon.
- chemical , metabolism : Indoleamine-Pyrrole 2,3,-Dioxygenase, Kynurenine, Receptors, Aryl Hydrocarbon, Tryptophan Oxygenase, src-Family Kinases.
- drug effects : Disease Resistance, Enzyme Activation, Gene Expression Regulation.
- enzymology : Inflammation.
- genetics : Disease Resistance, Endotoxemia, Inflammation.
- immunology : Bacterial Infections, Disease Resistance, Endotoxemia.
- metabolism : Bacterial Infections, Endotoxemia, Inflammation.
- chemical , pharmacology : Lipopolysaccharides.
- Animals, Mice, Phosphorylation, Signal Transduction.

Abstract

Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin tolerance). We found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase, which provided an activating ligand to the former, to downregulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR-complex-associated Src kinase activity promoted IDO1 phosphorylation and signalling ability. The resulting endotoxin-tolerant state was found to protect mice against immunopathology in Gram-negative and Gram-positive infections, pointing to a role for AhR in contributing to host fitness.

DOI: 10.1038/nature13323
PubMed: 24930766

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Alban Bessede

<affiliation><nlm:affiliation>1] Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy [2] IMS Laboratory, University of Bordeaux, 33607 Pessac, France [3].</nlm:affiliation>
<wicri:noCountry code="subField">France [3]</wicri:noCountry>
</affiliation>

Marco Gargaro

<affiliation><nlm:affiliation>1] Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy [2].</nlm:affiliation>
<wicri:noCountry code="subField">Italy [2]</wicri:noCountry>
</affiliation>

Le document en format XML

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<author><name sortKey="Iannitti, Rossana" sort="Iannitti, Rossana" uniqKey="Iannitti R" first="Rossana" last="Iannitti">Rossana Iannitti</name>
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<author><name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name>
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<author><name sortKey="Della Fazia, Maria A" sort="Della Fazia, Maria A" uniqKey="Della Fazia M" first="Maria A" last="Della Fazia">Maria A. Della Fazia</name>
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<country xml:lang="fr">Italie</country>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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<author><name sortKey="Funakoshi, Hiroshi" sort="Funakoshi, Hiroshi" uniqKey="Funakoshi H" first="Hiroshi" last="Funakoshi">Hiroshi Funakoshi</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Gilot, David" sort="Gilot, David" uniqKey="Gilot D" first="David" last="Gilot">David Gilot</name>
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<author><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental Toxicology, University of California, Davis, 95616 California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Toxicology, University of California, Davis, 95616 California</wicri:regionArea>
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<author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J" last="Guillemin">Gilles J. Guillemin</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine (ASAM), Macquarie University, 2109 New South Wales</wicri:regionArea>
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<author><name sortKey="Duhadaway, James B" sort="Duhadaway, James B" uniqKey="Duhadaway J" first="James B" last="Duhadaway">James B. Duhadaway</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania</wicri:regionArea>
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<author><name sortKey="Prendergast, George C" sort="Prendergast, George C" uniqKey="Prendergast G" first="George C" last="Prendergast">George C. Prendergast</name>
<affiliation wicri:level="1"><nlm:affiliation>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania</wicri:regionArea>
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<author><name sortKey="Metz, Richard" sort="Metz, Richard" uniqKey="Metz R" first="Richard" last="Metz">Richard Metz</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Boon, Louis" sort="Boon, Louis" uniqKey="Boon L" first="Louis" last="Boon">Louis Boon</name>
<affiliation wicri:level="1"><nlm:affiliation>Bioceros, 3584 Utrecht, The Netherlands.</nlm:affiliation>
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<wicri:regionArea>Bioceros, 3584 Utrecht</wicri:regionArea>
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<author><name sortKey="Pirro, Matteo" sort="Pirro, Matteo" uniqKey="Pirro M" first="Matteo" last="Pirro">Matteo Pirro</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
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<author><name sortKey="Iorio, Alfonso" sort="Iorio, Alfonso" uniqKey="Iorio A" first="Alfonso" last="Iorio">Alfonso Iorio</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario L8S 4K1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario L8S 4K1</wicri:regionArea>
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<author><name sortKey="Veyret, Bernard" sort="Veyret, Bernard" uniqKey="Veyret B" first="Bernard" last="Veyret">Bernard Veyret</name>
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<author><name sortKey="Romani, Luigina" sort="Romani, Luigina" uniqKey="Romani L" first="Luigina" last="Romani">Luigina Romani</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Grohmann, Ursula" sort="Grohmann, Ursula" uniqKey="Grohmann U" first="Ursula" last="Grohmann">Ursula Grohmann</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Fallarino, Francesca" sort="Fallarino, Francesca" uniqKey="Fallarino F" first="Francesca" last="Fallarino">Francesca Fallarino</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
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<author><name sortKey="Puccetti, Paolo" sort="Puccetti, Paolo" uniqKey="Puccetti P" first="Paolo" last="Puccetti">Paolo Puccetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Aryl hydrocarbon receptor control of a disease tolerance defence pathway.</title>
<author><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name>
<affiliation><nlm:affiliation>1] Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy [2] IMS Laboratory, University of Bordeaux, 33607 Pessac, France [3].</nlm:affiliation>
<wicri:noCountry code="subField">France [3]</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gargaro, Marco" sort="Gargaro, Marco" uniqKey="Gargaro M" first="Marco" last="Gargaro">Marco Gargaro</name>
<affiliation><nlm:affiliation>1] Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy [2].</nlm:affiliation>
<wicri:noCountry code="subField">Italy [2]</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pallotta, Maria T" sort="Pallotta, Maria T" uniqKey="Pallotta M" first="Maria T" last="Pallotta">Maria T. Pallotta</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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</affiliation>
</author>
<author><name sortKey="Matino, Davide" sort="Matino, Davide" uniqKey="Matino D" first="Davide" last="Matino">Davide Matino</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Servillo, Giuseppe" sort="Servillo, Giuseppe" uniqKey="Servillo G" first="Giuseppe" last="Servillo">Giuseppe Servillo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brunacci, Cinzia" sort="Brunacci, Cinzia" uniqKey="Brunacci C" first="Cinzia" last="Brunacci">Cinzia Brunacci</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bicciato, Silvio" sort="Bicciato, Silvio" uniqKey="Bicciato S" first="Silvio" last="Bicciato">Silvio Bicciato</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Genome Research, University of Modena and Reggio Emilia, 41125 Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Genome Research, University of Modena and Reggio Emilia, 41125 Modena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mazza, Emilia M C" sort="Mazza, Emilia M C" uniqKey="Mazza E" first="Emilia M C" last="Mazza">Emilia M C. Mazza</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Genome Research, University of Modena and Reggio Emilia, 41125 Modena, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Genome Research, University of Modena and Reggio Emilia, 41125 Modena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Macchiarulo, Antonio" sort="Macchiarulo, Antonio" uniqKey="Macchiarulo A" first="Antonio" last="Macchiarulo">Antonio Macchiarulo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Technology of Drugs, University of Perugia, 06123 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Chemistry and Technology of Drugs, University of Perugia, 06123 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vacca, Carmine" sort="Vacca, Carmine" uniqKey="Vacca C" first="Carmine" last="Vacca">Carmine Vacca</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Iannitti, Rossana" sort="Iannitti, Rossana" uniqKey="Iannitti R" first="Rossana" last="Iannitti">Rossana Iannitti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tissi, Luciana" sort="Tissi, Luciana" uniqKey="Tissi L" first="Luciana" last="Tissi">Luciana Tissi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Volpi, Claudia" sort="Volpi, Claudia" uniqKey="Volpi C" first="Claudia" last="Volpi">Claudia Volpi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Belladonna, Maria L" sort="Belladonna, Maria L" uniqKey="Belladonna M" first="Maria L" last="Belladonna">Maria L. Belladonna</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Orabona, Ciriana" sort="Orabona, Ciriana" uniqKey="Orabona C" first="Ciriana" last="Orabona">Ciriana Orabona</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bianchi, Roberta" sort="Bianchi, Roberta" uniqKey="Bianchi R" first="Roberta" last="Bianchi">Roberta Bianchi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lanz, Tobias V" sort="Lanz, Tobias V" uniqKey="Lanz T" first="Tobias V" last="Lanz">Tobias V. Lanz</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Experimental Neuroimmunology Unit, German Cancer Research Center, 69120 Heidelberg, Germany [2] Department of Neurooncology, University Hospital, 69120 Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>1] Experimental Neuroimmunology Unit, German Cancer Research Center, 69120 Heidelberg, Germany [2] Department of Neurooncology, University Hospital, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Experimental Neuroimmunology Unit, German Cancer Research Center, 69120 Heidelberg, Germany [2] Department of Neurooncology, University Hospital, 69120 Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>1] Experimental Neuroimmunology Unit, German Cancer Research Center, 69120 Heidelberg, Germany [2] Department of Neurooncology, University Hospital, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Della Fazia, Maria A" sort="Della Fazia, Maria A" uniqKey="Della Fazia M" first="Maria A" last="Della Fazia">Maria A. Della Fazia</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piobbico, Danilo" sort="Piobbico, Danilo" uniqKey="Piobbico D" first="Danilo" last="Piobbico">Danilo Piobbico</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zelante, Teresa" sort="Zelante, Teresa" uniqKey="Zelante T" first="Teresa" last="Zelante">Teresa Zelante</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Funakoshi, Hiroshi" sort="Funakoshi, Hiroshi" uniqKey="Funakoshi H" first="Hiroshi" last="Funakoshi">Hiroshi Funakoshi</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research and Education, Asahikawa Medical University, 078-8510 Asahikawa, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Center for Advanced Research and Education, Asahikawa Medical University, 078-8510 Asahikawa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nakamura, Toshikazu" sort="Nakamura, Toshikazu" uniqKey="Nakamura T" first="Toshikazu" last="Nakamura">Toshikazu Nakamura</name>
<affiliation wicri:level="1"><nlm:affiliation>Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, 565-0871 Osaka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, 565-0871 Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gilot, David" sort="Gilot, David" uniqKey="Gilot D" first="David" last="Gilot">David Gilot</name>
<affiliation wicri:level="1"><nlm:affiliation>CNRS UMR6290, Institut de Génétique et Développement de Rennes, Université de Rennes 1, 35043 Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS UMR6290, Institut de Génétique et Développement de Rennes, Université de Rennes 1, 35043 Rennes</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental Toxicology, University of California, Davis, 95616 California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Toxicology, University of California, Davis, 95616 California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J" last="Guillemin">Gilles J. Guillemin</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine (ASAM), Macquarie University, 2109 New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine (ASAM), Macquarie University, 2109 New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Duhadaway, James B" sort="Duhadaway, James B" uniqKey="Duhadaway J" first="James B" last="Duhadaway">James B. Duhadaway</name>
<affiliation wicri:level="1"><nlm:affiliation>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prendergast, George C" sort="Prendergast, George C" uniqKey="Prendergast G" first="George C" last="Prendergast">George C. Prendergast</name>
<affiliation wicri:level="1"><nlm:affiliation>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Metz, Richard" sort="Metz, Richard" uniqKey="Metz R" first="Richard" last="Metz">Richard Metz</name>
<affiliation wicri:level="1"><nlm:affiliation>New Link Genetics Corporation, Ames, 50010 Iowa, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>New Link Genetics Corporation, Ames, 50010 Iowa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name>
<affiliation wicri:level="1"><nlm:affiliation>IMS Laboratory, University of Bordeaux, 33607 Pessac, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>IMS Laboratory, University of Bordeaux, 33607 Pessac</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boon, Louis" sort="Boon, Louis" uniqKey="Boon L" first="Louis" last="Boon">Louis Boon</name>
<affiliation wicri:level="1"><nlm:affiliation>Bioceros, 3584 Utrecht, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Bioceros, 3584 Utrecht</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pirro, Matteo" sort="Pirro, Matteo" uniqKey="Pirro M" first="Matteo" last="Pirro">Matteo Pirro</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Iorio, Alfonso" sort="Iorio, Alfonso" uniqKey="Iorio A" first="Alfonso" last="Iorio">Alfonso Iorio</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario L8S 4K1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario L8S 4K1</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Veyret, Bernard" sort="Veyret, Bernard" uniqKey="Veyret B" first="Bernard" last="Veyret">Bernard Veyret</name>
<affiliation wicri:level="1"><nlm:affiliation>IMS Laboratory, University of Bordeaux, 33607 Pessac, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>IMS Laboratory, University of Bordeaux, 33607 Pessac</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Romani, Luigina" sort="Romani, Luigina" uniqKey="Romani L" first="Luigina" last="Romani">Luigina Romani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grohmann, Ursula" sort="Grohmann, Ursula" uniqKey="Grohmann U" first="Ursula" last="Grohmann">Ursula Grohmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fallarino, Francesca" sort="Fallarino, Francesca" uniqKey="Fallarino F" first="Francesca" last="Fallarino">Francesca Fallarino</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Puccetti, Paolo" sort="Puccetti, Paolo" uniqKey="Puccetti P" first="Paolo" last="Puccetti">Paolo Puccetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, 06132 Perugia</wicri:regionArea>
</affiliation>
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<series><title level="j">Nature</title>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Bacterial Infections (immunology)</term>
<term>Bacterial Infections (metabolism)</term>
<term>Disease Resistance (drug effects)</term>
<term>Disease Resistance (genetics)</term>
<term>Disease Resistance (immunology)</term>
<term>Endotoxemia (genetics)</term>
<term>Endotoxemia (immunology)</term>
<term>Endotoxemia (metabolism)</term>
<term>Enzyme Activation (drug effects)</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Indoleamine-Pyrrole 2,3,-Dioxygenase (metabolism)</term>
<term>Inflammation (enzymology)</term>
<term>Inflammation (genetics)</term>
<term>Inflammation (metabolism)</term>
<term>Kynurenine (metabolism)</term>
<term>Lipopolysaccharides (pharmacology)</term>
<term>Mice</term>
<term>Phosphorylation</term>
<term>Receptors, Aryl Hydrocarbon (genetics)</term>
<term>Receptors, Aryl Hydrocarbon (metabolism)</term>
<term>Signal Transduction</term>
<term>Tryptophan Oxygenase (metabolism)</term>
<term>src-Family Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation enzymatique ()</term>
<term>Animaux</term>
<term>Cynurénine (métabolisme)</term>
<term>Endotoxémie (génétique)</term>
<term>Endotoxémie (immunologie)</term>
<term>Endotoxémie (métabolisme)</term>
<term>Indoleamine-pyrrole 2,3,-dioxygenase (métabolisme)</term>
<term>Infections bactériennes (immunologie)</term>
<term>Infections bactériennes (métabolisme)</term>
<term>Inflammation (enzymologie)</term>
<term>Inflammation (génétique)</term>
<term>Inflammation (métabolisme)</term>
<term>Lipopolysaccharides (pharmacologie)</term>
<term>Phosphorylation</term>
<term>Récepteurs à hydrocarbure aromatique (génétique)</term>
<term>Récepteurs à hydrocarbure aromatique (métabolisme)</term>
<term>Régulation de l'expression des gènes ()</term>
<term>Résistance à la maladie ()</term>
<term>Résistance à la maladie (génétique)</term>
<term>Résistance à la maladie (immunologie)</term>
<term>Souris</term>
<term>Transduction du signal</term>
<term>Tryptophane 2,3-dioxygenase (métabolisme)</term>
<term>src-Family kinases (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Aryl Hydrocarbon</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Indoleamine-Pyrrole 2,3,-Dioxygenase</term>
<term>Kynurenine</term>
<term>Receptors, Aryl Hydrocarbon</term>
<term>Tryptophan Oxygenase</term>
<term>src-Family Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Disease Resistance</term>
<term>Enzyme Activation</term>
<term>Gene Expression Regulation</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Disease Resistance</term>
<term>Endotoxemia</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Endotoxémie</term>
<term>Inflammation</term>
<term>Récepteurs à hydrocarbure aromatique</term>
<term>Résistance à la maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Endotoxémie</term>
<term>Infections bactériennes</term>
<term>Résistance à la maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bacterial Infections</term>
<term>Disease Resistance</term>
<term>Endotoxemia</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bacterial Infections</term>
<term>Endotoxemia</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cynurénine</term>
<term>Endotoxémie</term>
<term>Indoleamine-pyrrole 2,3,-dioxygenase</term>
<term>Infections bactériennes</term>
<term>Inflammation</term>
<term>Récepteurs à hydrocarbure aromatique</term>
<term>Tryptophane 2,3-dioxygenase</term>
<term>src-Family kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Lipopolysaccharides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Lipopolysaccharides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Mice</term>
<term>Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term>
<term>Animaux</term>
<term>Phosphorylation</term>
<term>Régulation de l'expression des gènes</term>
<term>Résistance à la maladie</term>
<term>Souris</term>
<term>Transduction du signal</term>
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<front><div type="abstract" xml:lang="en">Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin tolerance). We found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase, which provided an activating ligand to the former, to downregulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR-complex-associated Src kinase activity promoted IDO1 phosphorylation and signalling ability. The resulting endotoxin-tolerant state was found to protect mice against immunopathology in Gram-negative and Gram-positive infections, pointing to a role for AhR in contributing to host fitness.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24930766</PMID>
<DateCreated><Year>2014</Year>
<Month>07</Month>
<Day>10</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>09</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>10</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>511</Volume>
<Issue>7508</Issue>
<PubDate><Year>2014</Year>
<Month>Jul</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>Nature</Title>
<ISOAbbreviation>Nature</ISOAbbreviation>
</Journal>
<ArticleTitle>Aryl hydrocarbon receptor control of a disease tolerance defence pathway.</ArticleTitle>
<Pagination><MedlinePgn>184-90</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/nature13323</ELocationID>
<Abstract><AbstractText>Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin tolerance). We found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase, which provided an activating ligand to the former, to downregulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR-complex-associated Src kinase activity promoted IDO1 phosphorylation and signalling ability. The resulting endotoxin-tolerant state was found to protect mice against immunopathology in Gram-negative and Gram-positive infections, pointing to a role for AhR in contributing to host fitness.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bessede</LastName>
<ForeName>Alban</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>1] Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy [2] IMS Laboratory, University of Bordeaux, 33607 Pessac, France [3].</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Marco</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>1] Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy [2].</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Maria T</ForeName>
<Initials>MT</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Matino</LastName>
<ForeName>Davide</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Servillo</LastName>
<ForeName>Giuseppe</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Cinzia</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Silvio</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Center for Genome Research, University of Modena and Reggio Emilia, 41125 Modena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mazza</LastName>
<ForeName>Emilia M C</ForeName>
<Initials>EM</Initials>
<AffiliationInfo><Affiliation>Center for Genome Research, University of Modena and Reggio Emilia, 41125 Modena, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Macchiarulo</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry and Technology of Drugs, University of Perugia, 06123 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vacca</LastName>
<ForeName>Carmine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Iannitti</LastName>
<ForeName>Rossana</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Luciana</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Volpi</LastName>
<ForeName>Claudia</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Belladonna</LastName>
<ForeName>Maria L</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Ciriana</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bianchi</LastName>
<ForeName>Roberta</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lanz</LastName>
<ForeName>Tobias V</ForeName>
<Initials>TV</Initials>
<AffiliationInfo><Affiliation>1] Experimental Neuroimmunology Unit, German Cancer Research Center, 69120 Heidelberg, Germany [2] Department of Neurooncology, University Hospital, 69120 Heidelberg, Germany.</Affiliation>
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<AffiliationInfo><Affiliation>1] Experimental Neuroimmunology Unit, German Cancer Research Center, 69120 Heidelberg, Germany [2] Department of Neurooncology, University Hospital, 69120 Heidelberg, Germany.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Della Fazia</LastName>
<ForeName>Maria A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Piobbico</LastName>
<ForeName>Danilo</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zelante</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Funakoshi</LastName>
<ForeName>Hiroshi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Center for Advanced Research and Education, Asahikawa Medical University, 078-8510 Asahikawa, Japan.</Affiliation>
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<Initials>MS</Initials>
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<ForeName>Gilles J</ForeName>
<Initials>GJ</Initials>
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<ForeName>James B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania, USA.</Affiliation>
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<Initials>GC</Initials>
<AffiliationInfo><Affiliation>Lankenau Institute for Medical Research, Wynnewood, 19096 Pennsylvania, USA.</Affiliation>
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<ForeName>Richard</ForeName>
<Initials>R</Initials>
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<ForeName>Michel</ForeName>
<Initials>M</Initials>
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<ForeName>Louis</ForeName>
<Initials>L</Initials>
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<ForeName>Matteo</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Iorio</LastName>
<ForeName>Alfonso</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Epidemiology & Biostatistics, McMaster University, Ontario L8S 4K1, Canada.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Veyret</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>IMS Laboratory, University of Bordeaux, 33607 Pessac, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Romani</LastName>
<ForeName>Luigina</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
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</Author>
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<ForeName>Ursula</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Fallarino</LastName>
<ForeName>Francesca</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Puccetti</LastName>
<ForeName>Paolo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.</Affiliation>
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</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 CA056036</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 CA109542</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 ES007685</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01ES007685</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nature</MedlineTA>
<NlmUniqueID>0410462</NlmUniqueID>
<ISSNLinking>0028-0836</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C583637">IDO1 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050503">Indoleamine-Pyrrole 2,3,-Dioxygenase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018336">Receptors, Aryl Hydrocarbon</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>343-65-7</RegistryNumber>
<NameOfSubstance UI="D007737">Kynurenine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.13.11.11</RegistryNumber>
<NameOfSubstance UI="D014366">Tryptophan Oxygenase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.2</RegistryNumber>
<NameOfSubstance UI="D019061">src-Family Kinases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060467" MajorTopicYN="N">Disease Resistance</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019446" MajorTopicYN="N">Endotoxemia</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004789" MajorTopicYN="N">Enzyme Activation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050503" MajorTopicYN="N">Indoleamine-Pyrrole 2,3,-Dioxygenase</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D007737" MajorTopicYN="N">Kynurenine</DescriptorName>
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   |area=    AustralieFrV1
   |flux=    PubMed
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   |texte=   Aryl hydrocarbon receptor control of a disease tolerance defence pathway.
}}

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

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