Antiviral drug allergy.
Identifieur interne : 003462 ( PubMed/Curation ); précédent : 003461; suivant : 003463Antiviral drug allergy.
Auteurs : Brigitte Milpied-Homsi [France] ; Ellen M. Moran [Australie] ; Elizabeth J. Phillips [États-Unis]Source :
- Immunology and allergy clinics of North America [ 1557-8607 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Hypersensibilité médicamenteuse.
- effets indésirables : Antiviraux.
- étiologie : Hypersensibilité médicamenteuse.
- Antiviraux, Humains, Hypersensibilité médicamenteuse, Prise en charge de la maladie.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Antiviral Agents.
- chemical , classification : Antiviral Agents.
- diagnosis : Drug Hypersensitivity.
- etiology : Drug Hypersensitivity.
- therapy : Drug Hypersensitivity.
- Disease Management, Humans.
Abstract
Antiviral drugs used to treat HIV and hepatitis C are common causes of delayed drug hypersensitivities for which many of the more severe reactions have been recently shown to be immunogenetically mediated such as abacavir hypersensitivity where HLA-B(∗)57:01 is now used routinely as a screening test to exclude patients carrying this allele from abacavir prescription. Most antiviral drug allergies consist of mild to moderate delayed rash without other serious features (eg, fever, mucosal involvement, blistering rash, organ impairment. In these cases treatment can be continued with careful observation and symptomatic management and the discontinuation rate is low.
DOI: 10.1016/j.iac.2014.04.011
PubMed: 25017682
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pubmed:25017682Le document en format XML
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<term>Drug Hypersensitivity (etiology)</term>
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<front><div type="abstract" xml:lang="en">Antiviral drugs used to treat HIV and hepatitis C are common causes of delayed drug hypersensitivities for which many of the more severe reactions have been recently shown to be immunogenetically mediated such as abacavir hypersensitivity where HLA-B(∗)57:01 is now used routinely as a screening test to exclude patients carrying this allele from abacavir prescription. Most antiviral drug allergies consist of mild to moderate delayed rash without other serious features (eg, fever, mucosal involvement, blistering rash, organ impairment. In these cases treatment can be continued with careful observation and symptomatic management and the discontinuation rate is low.</div>
</front>
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<Abstract><AbstractText>Antiviral drugs used to treat HIV and hepatitis C are common causes of delayed drug hypersensitivities for which many of the more severe reactions have been recently shown to be immunogenetically mediated such as abacavir hypersensitivity where HLA-B(∗)57:01 is now used routinely as a screening test to exclude patients carrying this allele from abacavir prescription. Most antiviral drug allergies consist of mild to moderate delayed rash without other serious features (eg, fever, mucosal involvement, blistering rash, organ impairment. In these cases treatment can be continued with careful observation and symptomatic management and the discontinuation rate is low.</AbstractText>
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<Keyword MajorTopicYN="N">Altered peptide repertoire</Keyword>
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<Keyword MajorTopicYN="N">Human leukocyte antigen</Keyword>
<Keyword MajorTopicYN="N">Major histocompatibility complex</Keyword>
<Keyword MajorTopicYN="N">Nevirapine</Keyword>
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