Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.
Identifieur interne : 003458 ( PubMed/Curation ); précédent : 003457; suivant : 003459Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.
Auteurs : Jose M C. Tubio [Royaume-Uni] ; Yilong Li [Royaume-Uni] ; Young Seok Ju [Royaume-Uni] ; Inigo Martincorena [Royaume-Uni] ; Susanna L. Cooke [Royaume-Uni] ; Marta Tojo [Espagne] ; Gunes Gundem [Royaume-Uni] ; Christodoulos P. Pipinikas [Royaume-Uni] ; Jorge Zamora [Royaume-Uni] ; Keiran Raine [Royaume-Uni] ; Andrew Menzies [Royaume-Uni] ; Pablo Roman-Garcia [Royaume-Uni] ; Anthony Fullam [Royaume-Uni] ; Moritz Gerstung [Royaume-Uni] ; Adam Shlien [Royaume-Uni] ; Patrick S. Tarpey [Royaume-Uni] ; Elli Papaemmanuil [Royaume-Uni] ; Stian Knappskog [Royaume-Uni] ; Peter Van Loo [Royaume-Uni] ; Manasa Ramakrishna [Royaume-Uni] ; Helen R. Davies [Royaume-Uni] ; John Marshall [Royaume-Uni] ; David C. Wedge [Royaume-Uni] ; Jon W. Teague [Royaume-Uni] ; Adam P. Butler [Royaume-Uni] ; Serena Nik-Zainal [Royaume-Uni] ; Ludmil Alexandrov [Royaume-Uni] ; Sam Behjati [Royaume-Uni] ; Lucy R. Yates [Royaume-Uni] ; Niccolo Bolli [Royaume-Uni] ; Laura Mudie [Royaume-Uni] ; Claire Hardy [Royaume-Uni] ; Sancha Martin [Royaume-Uni] ; Stuart Mclaren [Royaume-Uni] ; Sarah O'Meara [Royaume-Uni] ; Elizabeth Anderson [Royaume-Uni] ; Mark Maddison [Royaume-Uni] ; Stephen Gamble [Royaume-Uni] ; Christopher Foster [Royaume-Uni] ; Anne Y. Warren [Royaume-Uni] ; Hayley Whitaker [Royaume-Uni] ; Daniel Brewer [Royaume-Uni] ; Rosalind Eeles [Royaume-Uni] ; Colin Cooper [Royaume-Uni] ; David Neal [Royaume-Uni] ; Andy G. Lynch [Royaume-Uni] ; Tapio Visakorpi [Finlande] ; William B. Isaacs [États-Unis] ; Laura Van'T Veer [Pays-Bas] ; Carlos Caldas [Royaume-Uni] ; Christine Desmedt [Belgique] ; Christos Sotiriou [Belgique] ; Sam Aparicio [Canada] ; John A. Foekens [Pays-Bas] ; J Runn Erla Eyfjörd [Islande] ; Sunil R. Lakhani [Australie] ; Gilles Thomas [France] ; Ola Myklebost [Norvège] ; Paul N. Span [Pays-Bas] ; Anne-Lise B Rresen-Dale [Norvège] ; Andrea L. Richardson [États-Unis] ; Marc Van De Vijver [Pays-Bas] ; Anne Vincent-Salomon [France] ; Gert G. Van Den Eynden [Belgique] ; Adrienne M. Flanagan [Royaume-Uni] ; P Andrew Futreal [Royaume-Uni] ; Sam M. Janes [Royaume-Uni] ; G Steven Bova [Finlande] ; Michael R. Stratton [Royaume-Uni] ; Ultan Mcdermott [Royaume-Uni] ; Peter J. Campbell [Royaume-Uni]Source :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Chromatin.
- genetics : Carcinogenesis, Neoplasms.
- chemical : DNA Transposable Elements, Exons, Genome, Human, Humans, Long Interspersed Nucleotide Elements, Mutagenesis, Insertional, Transduction, Genetic, Translocation, Genetic.
Abstract
Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive sequences are occasionally mobilized by the L1 machinery, a process called 3' transduction. Because 3' transductions are potentially mutagenic, we explored the extent to which they occur somatically during tumorigenesis. Studying cancer genomes from 244 patients, we found that tumors from 53% of the patients had somatic retrotranspositions, of which 24% were 3' transductions. Fingerprinting of donor L1s revealed that a handful of source L1 elements in a tumor can spawn from tens to hundreds of 3' transductions, which can themselves seed further retrotranspositions. The activity of individual L1 elements fluctuated during tumor evolution and correlated with L1 promoter hypomethylation. The 3' transductions disseminated genes, exons, and regulatory elements to new locations, most often to heterochromatic regions of the genome.
DOI: 10.1126/science.1251343
PubMed: 25082706
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<author><name sortKey="Gundem, Gunes" sort="Gundem, Gunes" uniqKey="Gundem G" first="Gunes" last="Gundem">Gunes Gundem</name>
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<author><name sortKey="Menzies, Andrew" sort="Menzies, Andrew" uniqKey="Menzies A" first="Andrew" last="Menzies">Andrew Menzies</name>
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<author><name sortKey="Roman Garcia, Pablo" sort="Roman Garcia, Pablo" uniqKey="Roman Garcia P" first="Pablo" last="Roman-Garcia">Pablo Roman-Garcia</name>
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<author><name sortKey="Knappskog, Stian" sort="Knappskog, Stian" uniqKey="Knappskog S" first="Stian" last="Knappskog">Stian Knappskog</name>
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<author><name sortKey="Van Loo, Peter" sort="Van Loo, Peter" uniqKey="Van Loo P" first="Peter" last="Van Loo">Peter Van Loo</name>
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<author><name sortKey="Davies, Helen R" sort="Davies, Helen R" uniqKey="Davies H" first="Helen R" last="Davies">Helen R. Davies</name>
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<author><name sortKey="Wedge, David C" sort="Wedge, David C" uniqKey="Wedge D" first="David C" last="Wedge">David C. Wedge</name>
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<author><name sortKey="Teague, Jon W" sort="Teague, Jon W" uniqKey="Teague J" first="Jon W" last="Teague">Jon W. Teague</name>
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<author><name sortKey="Butler, Adam P" sort="Butler, Adam P" uniqKey="Butler A" first="Adam P" last="Butler">Adam P. Butler</name>
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<author><name sortKey="Nik Zainal, Serena" sort="Nik Zainal, Serena" uniqKey="Nik Zainal S" first="Serena" last="Nik-Zainal">Serena Nik-Zainal</name>
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<author><name sortKey="Alexandrov, Ludmil" sort="Alexandrov, Ludmil" uniqKey="Alexandrov L" first="Ludmil" last="Alexandrov">Ludmil Alexandrov</name>
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<author><name sortKey="Behjati, Sam" sort="Behjati, Sam" uniqKey="Behjati S" first="Sam" last="Behjati">Sam Behjati</name>
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<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="Yates, Lucy R" sort="Yates, Lucy R" uniqKey="Yates L" first="Lucy R" last="Yates">Lucy R. Yates</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="Bolli, Niccolo" sort="Bolli, Niccolo" uniqKey="Bolli N" first="Niccolo" last="Bolli">Niccolo Bolli</name>
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<author><name sortKey="Mudie, Laura" sort="Mudie, Laura" uniqKey="Mudie L" first="Laura" last="Mudie">Laura Mudie</name>
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<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="Hardy, Claire" sort="Hardy, Claire" uniqKey="Hardy C" first="Claire" last="Hardy">Claire Hardy</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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</author>
<author><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name>
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<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="Mclaren, Stuart" sort="Mclaren, Stuart" uniqKey="Mclaren S" first="Stuart" last="Mclaren">Stuart Mclaren</name>
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<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="O Meara, Sarah" sort="O Meara, Sarah" uniqKey="O Meara S" first="Sarah" last="O'Meara">Sarah O'Meara</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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</author>
<author><name sortKey="Anderson, Elizabeth" sort="Anderson, Elizabeth" uniqKey="Anderson E" first="Elizabeth" last="Anderson">Elizabeth Anderson</name>
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<author><name sortKey="Maddison, Mark" sort="Maddison, Mark" uniqKey="Maddison M" first="Mark" last="Maddison">Mark Maddison</name>
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<author><name sortKey="Gamble, Stephen" sort="Gamble, Stephen" uniqKey="Gamble S" first="Stephen" last="Gamble">Stephen Gamble</name>
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<author><name sortKey="Foster, Christopher" sort="Foster, Christopher" uniqKey="Foster C" first="Christopher" last="Foster">Christopher Foster</name>
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<author><name sortKey="Warren, Anne Y" sort="Warren, Anne Y" uniqKey="Warren A" first="Anne Y" last="Warren">Anne Y. Warren</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge</wicri:regionArea>
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<author><name sortKey="Whitaker, Hayley" sort="Whitaker, Hayley" uniqKey="Whitaker H" first="Hayley" last="Whitaker">Hayley Whitaker</name>
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<wicri:regionArea>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
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<author><name sortKey="Brewer, Daniel" sort="Brewer, Daniel" uniqKey="Brewer D" first="Daniel" last="Brewer">Daniel Brewer</name>
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<wicri:regionArea>Institute of Cancer Research, Sutton, London</wicri:regionArea>
</affiliation>
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<author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Sutton, London</wicri:regionArea>
</affiliation>
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<author><name sortKey="Cooper, Colin" sort="Cooper, Colin" uniqKey="Cooper C" first="Colin" last="Cooper">Colin Cooper</name>
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<wicri:regionArea>Institute of Cancer Research, Sutton, London</wicri:regionArea>
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<author><name sortKey="Neal, David" sort="Neal, David" uniqKey="Neal D" first="David" last="Neal">David Neal</name>
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<wicri:regionArea>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
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<author><name sortKey="Lynch, Andy G" sort="Lynch, Andy G" uniqKey="Lynch A" first="Andy G" last="Lynch">Andy G. Lynch</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
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<author><name sortKey="Visakorpi, Tapio" sort="Visakorpi, Tapio" uniqKey="Visakorpi T" first="Tapio" last="Visakorpi">Tapio Visakorpi</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere</wicri:regionArea>
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<author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B" last="Isaacs">William B. Isaacs</name>
<affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, Baltimore, MD</wicri:regionArea>
</affiliation>
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<author><name sortKey="Veer, Laura Van T" sort="Veer, Laura Van T" uniqKey="Veer L" first="Laura Van'T" last="Veer">Laura Van'T Veer</name>
<affiliation wicri:level="1"><nlm:affiliation>Netherlands Cancer Institute, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
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</author>
<author><name sortKey="Desmedt, Christine" sort="Desmedt, Christine" uniqKey="Desmedt C" first="Christine" last="Desmedt">Christine Desmedt</name>
<affiliation wicri:level="1"><nlm:affiliation>Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea>
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<author><name sortKey="Sotiriou, Christos" sort="Sotiriou, Christos" uniqKey="Sotiriou C" first="Christos" last="Sotiriou">Christos Sotiriou</name>
<affiliation wicri:level="1"><nlm:affiliation>Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea>
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<author><name sortKey="Aparicio, Sam" sort="Aparicio, Sam" uniqKey="Aparicio S" first="Sam" last="Aparicio">Sam Aparicio</name>
<affiliation wicri:level="1"><nlm:affiliation>British Columbia Cancer Agency, Vancouver, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>British Columbia Cancer Agency, Vancouver</wicri:regionArea>
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<author><name sortKey="Foekens, John A" sort="Foekens, John A" uniqKey="Foekens J" first="John A" last="Foekens">John A. Foekens</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eyfjord, J Runn Erla" sort="Eyfjord, J Runn Erla" uniqKey="Eyfjord J" first="J Runn Erla" last="Eyfjörd">J Runn Erla Eyfjörd</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research Laboratory, University of Iceland, Reykjavik, Iceland.</nlm:affiliation>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Cancer Research Laboratory, University of Iceland, Reykjavik</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R" last="Lakhani">Sunil R. Lakhani</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University of Queensland, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea>
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<author><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name>
<affiliation wicri:level="1"><nlm:affiliation>Université Lyon 1, Institut National du Cancer (INCa)-Synergie, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lyon 1, Institut National du Cancer (INCa)-Synergie, Lyon</wicri:regionArea>
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<author><name sortKey="Myklebost, Ola" sort="Myklebost, Ola" uniqKey="Myklebost O" first="Ola" last="Myklebost">Ola Myklebost</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute for Cancer Research, Oslo University Hospital, Oslo</wicri:regionArea>
</affiliation>
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<author><name sortKey="Span, Paul N" sort="Span, Paul N" uniqKey="Span P" first="Paul N" last="Span">Paul N. Span</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute for Cancer Research, Oslo University Hospital, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L" last="Richardson">Andrea L. Richardson</name>
<affiliation wicri:level="1"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea>
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</author>
<author><name sortKey="Van De Vijver, Marc" sort="Van De Vijver, Marc" uniqKey="Van De Vijver M" first="Marc" last="Van De Vijver">Marc Van De Vijver</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Bergonié, 229 cours de l'Argone, 33076 Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Bergonié, 229 cours de l'Argone, 33076 Bordeaux</wicri:regionArea>
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</author>
<author><name sortKey="Van Den Eynden, Gert G" sort="Van Den Eynden, Gert G" uniqKey="Van Den Eynden G" first="Gert G" last="Van Den Eynden">Gert G. Van Den Eynden</name>
<affiliation wicri:level="1"><nlm:affiliation>Translational Cancer Research Unit and Department of Pathology, GZA Hospitals, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Translational Cancer Research Unit and Department of Pathology, GZA Hospitals, Antwerp</wicri:regionArea>
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</author>
<author><name sortKey="Flanagan, Adrienne M" sort="Flanagan, Adrienne M" uniqKey="Flanagan A" first="Adrienne M" last="Flanagan">Adrienne M. Flanagan</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal National Orthopaedic Hospital, Middlesex, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal National Orthopaedic Hospital, Middlesex</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P Andrew" last="Futreal">P Andrew Futreal</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Janes, Sam M" sort="Janes, Sam M" uniqKey="Janes S" first="Sam M" last="Janes">Sam M. Janes</name>
<affiliation wicri:level="1"><nlm:affiliation>Lungs for Living Research Centre, Rayne Institute, University College London (UCL), London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Lungs for Living Research Centre, Rayne Institute, University College London (UCL), London</wicri:regionArea>
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</author>
<author><name sortKey="Bova, G Steven" sort="Bova, G Steven" uniqKey="Bova G" first="G Steven" last="Bova">G Steven Bova</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere</wicri:regionArea>
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<author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R" last="Stratton">Michael R. Stratton</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcdermott, Ultan" sort="Mcdermott, Ultan" uniqKey="Mcdermott U" first="Ultan" last="Mcdermott">Ultan Mcdermott</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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</author>
</titleStmt>
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<date when="2014">2014</date>
<idno type="RBID">pubmed:25082706</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.</title>
<author><name sortKey="Tubio, Jose M C" sort="Tubio, Jose M C" uniqKey="Tubio J" first="Jose M C" last="Tubio">Jose M C. Tubio</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Yilong" sort="Li, Yilong" uniqKey="Li Y" first="Yilong" last="Li">Yilong Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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</author>
<author><name sortKey="Ju, Young Seok" sort="Ju, Young Seok" uniqKey="Ju Y" first="Young Seok" last="Ju">Young Seok Ju</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="Martincorena, Inigo" sort="Martincorena, Inigo" uniqKey="Martincorena I" first="Inigo" last="Martincorena">Inigo Martincorena</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cooke, Susanna L" sort="Cooke, Susanna L" uniqKey="Cooke S" first="Susanna L" last="Cooke">Susanna L. Cooke</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tojo, Marta" sort="Tojo, Marta" uniqKey="Tojo M" first="Marta" last="Tojo">Marta Tojo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Physiology, School of Medicine-Center for Resesarch in Molecular Medicine and Chronic Diseases, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Physiology, School of Medicine-Center for Resesarch in Molecular Medicine and Chronic Diseases, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela</wicri:regionArea>
</affiliation>
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<author><name sortKey="Gundem, Gunes" sort="Gundem, Gunes" uniqKey="Gundem G" first="Gunes" last="Gundem">Gunes Gundem</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pipinikas, Christodoulos P" sort="Pipinikas, Christodoulos P" uniqKey="Pipinikas C" first="Christodoulos P" last="Pipinikas">Christodoulos P. Pipinikas</name>
<affiliation wicri:level="1"><nlm:affiliation>Lungs for Living Research Centre, Rayne Institute, University College London (UCL), London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Lungs for Living Research Centre, Rayne Institute, University College London (UCL), London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zamora, Jorge" sort="Zamora, Jorge" uniqKey="Zamora J" first="Jorge" last="Zamora">Jorge Zamora</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Raine, Keiran" sort="Raine, Keiran" uniqKey="Raine K" first="Keiran" last="Raine">Keiran Raine</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menzies, Andrew" sort="Menzies, Andrew" uniqKey="Menzies A" first="Andrew" last="Menzies">Andrew Menzies</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roman Garcia, Pablo" sort="Roman Garcia, Pablo" uniqKey="Roman Garcia P" first="Pablo" last="Roman-Garcia">Pablo Roman-Garcia</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fullam, Anthony" sort="Fullam, Anthony" uniqKey="Fullam A" first="Anthony" last="Fullam">Anthony Fullam</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gerstung, Moritz" sort="Gerstung, Moritz" uniqKey="Gerstung M" first="Moritz" last="Gerstung">Moritz Gerstung</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shlien, Adam" sort="Shlien, Adam" uniqKey="Shlien A" first="Adam" last="Shlien">Adam Shlien</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tarpey, Patrick S" sort="Tarpey, Patrick S" uniqKey="Tarpey P" first="Patrick S" last="Tarpey">Patrick S. Tarpey</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Papaemmanuil, Elli" sort="Papaemmanuil, Elli" uniqKey="Papaemmanuil E" first="Elli" last="Papaemmanuil">Elli Papaemmanuil</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Knappskog, Stian" sort="Knappskog, Stian" uniqKey="Knappskog S" first="Stian" last="Knappskog">Stian Knappskog</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Loo, Peter" sort="Van Loo, Peter" uniqKey="Van Loo P" first="Peter" last="Van Loo">Peter Van Loo</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ramakrishna, Manasa" sort="Ramakrishna, Manasa" uniqKey="Ramakrishna M" first="Manasa" last="Ramakrishna">Manasa Ramakrishna</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davies, Helen R" sort="Davies, Helen R" uniqKey="Davies H" first="Helen R" last="Davies">Helen R. Davies</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marshall, John" sort="Marshall, John" uniqKey="Marshall J" first="John" last="Marshall">John Marshall</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wedge, David C" sort="Wedge, David C" uniqKey="Wedge D" first="David C" last="Wedge">David C. Wedge</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teague, Jon W" sort="Teague, Jon W" uniqKey="Teague J" first="Jon W" last="Teague">Jon W. Teague</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Butler, Adam P" sort="Butler, Adam P" uniqKey="Butler A" first="Adam P" last="Butler">Adam P. Butler</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nik Zainal, Serena" sort="Nik Zainal, Serena" uniqKey="Nik Zainal S" first="Serena" last="Nik-Zainal">Serena Nik-Zainal</name>
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<country xml:lang="fr">Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Alexandrov, Ludmil" sort="Alexandrov, Ludmil" uniqKey="Alexandrov L" first="Ludmil" last="Alexandrov">Ludmil Alexandrov</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Behjati, Sam" sort="Behjati, Sam" uniqKey="Behjati S" first="Sam" last="Behjati">Sam Behjati</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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</author>
<author><name sortKey="Yates, Lucy R" sort="Yates, Lucy R" uniqKey="Yates L" first="Lucy R" last="Yates">Lucy R. Yates</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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</author>
<author><name sortKey="Bolli, Niccolo" sort="Bolli, Niccolo" uniqKey="Bolli N" first="Niccolo" last="Bolli">Niccolo Bolli</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mudie, Laura" sort="Mudie, Laura" uniqKey="Mudie L" first="Laura" last="Mudie">Laura Mudie</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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</author>
<author><name sortKey="Hardy, Claire" sort="Hardy, Claire" uniqKey="Hardy C" first="Claire" last="Hardy">Claire Hardy</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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</author>
<author><name sortKey="Martin, Sancha" sort="Martin, Sancha" uniqKey="Martin S" first="Sancha" last="Martin">Sancha Martin</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mclaren, Stuart" sort="Mclaren, Stuart" uniqKey="Mclaren S" first="Stuart" last="Mclaren">Stuart Mclaren</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="O Meara, Sarah" sort="O Meara, Sarah" uniqKey="O Meara S" first="Sarah" last="O'Meara">Sarah O'Meara</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Anderson, Elizabeth" sort="Anderson, Elizabeth" uniqKey="Anderson E" first="Elizabeth" last="Anderson">Elizabeth Anderson</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maddison, Mark" sort="Maddison, Mark" uniqKey="Maddison M" first="Mark" last="Maddison">Mark Maddison</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gamble, Stephen" sort="Gamble, Stephen" uniqKey="Gamble S" first="Stephen" last="Gamble">Stephen Gamble</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Foster, Christopher" sort="Foster, Christopher" uniqKey="Foster C" first="Christopher" last="Foster">Christopher Foster</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Liverpool and HCA Pathology Laboratories, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Liverpool and HCA Pathology Laboratories, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Warren, Anne Y" sort="Warren, Anne Y" uniqKey="Warren A" first="Anne Y" last="Warren">Anne Y. Warren</name>
<affiliation wicri:level="1"><nlm:affiliation>Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Whitaker, Hayley" sort="Whitaker, Hayley" uniqKey="Whitaker H" first="Hayley" last="Whitaker">Hayley Whitaker</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brewer, Daniel" sort="Brewer, Daniel" uniqKey="Brewer D" first="Daniel" last="Brewer">Daniel Brewer</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Sutton, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Sutton, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cooper, Colin" sort="Cooper, Colin" uniqKey="Cooper C" first="Colin" last="Cooper">Colin Cooper</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Sutton, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neal, David" sort="Neal, David" uniqKey="Neal D" first="David" last="Neal">David Neal</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lynch, Andy G" sort="Lynch, Andy G" uniqKey="Lynch A" first="Andy G" last="Lynch">Andy G. Lynch</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Visakorpi, Tapio" sort="Visakorpi, Tapio" uniqKey="Visakorpi T" first="Tapio" last="Visakorpi">Tapio Visakorpi</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B" last="Isaacs">William B. Isaacs</name>
<affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, Baltimore, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Veer, Laura Van T" sort="Veer, Laura Van T" uniqKey="Veer L" first="Laura Van'T" last="Veer">Laura Van'T Veer</name>
<affiliation wicri:level="1"><nlm:affiliation>Netherlands Cancer Institute, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Cancer Institute, Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caldas, Carlos" sort="Caldas, Carlos" uniqKey="Caldas C" first="Carlos" last="Caldas">Carlos Caldas</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge</wicri:regionArea>
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</author>
<author><name sortKey="Desmedt, Christine" sort="Desmedt, Christine" uniqKey="Desmedt C" first="Christine" last="Desmedt">Christine Desmedt</name>
<affiliation wicri:level="1"><nlm:affiliation>Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sotiriou, Christos" sort="Sotiriou, Christos" uniqKey="Sotiriou C" first="Christos" last="Sotiriou">Christos Sotiriou</name>
<affiliation wicri:level="1"><nlm:affiliation>Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aparicio, Sam" sort="Aparicio, Sam" uniqKey="Aparicio S" first="Sam" last="Aparicio">Sam Aparicio</name>
<affiliation wicri:level="1"><nlm:affiliation>British Columbia Cancer Agency, Vancouver, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>British Columbia Cancer Agency, Vancouver</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Foekens, John A" sort="Foekens, John A" uniqKey="Foekens J" first="John A" last="Foekens">John A. Foekens</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eyfjord, J Runn Erla" sort="Eyfjord, J Runn Erla" uniqKey="Eyfjord J" first="J Runn Erla" last="Eyfjörd">J Runn Erla Eyfjörd</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research Laboratory, University of Iceland, Reykjavik, Iceland.</nlm:affiliation>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Cancer Research Laboratory, University of Iceland, Reykjavik</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R" last="Lakhani">Sunil R. Lakhani</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University of Queensland, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Queensland, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomas, Gilles" sort="Thomas, Gilles" uniqKey="Thomas G" first="Gilles" last="Thomas">Gilles Thomas</name>
<affiliation wicri:level="1"><nlm:affiliation>Université Lyon 1, Institut National du Cancer (INCa)-Synergie, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lyon 1, Institut National du Cancer (INCa)-Synergie, Lyon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Myklebost, Ola" sort="Myklebost, Ola" uniqKey="Myklebost O" first="Ola" last="Myklebost">Ola Myklebost</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute for Cancer Research, Oslo University Hospital, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Span, Paul N" sort="Span, Paul N" uniqKey="Span P" first="Paul N" last="Span">Paul N. Span</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiation Oncology and Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute for Cancer Research, Oslo University Hospital, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Richardson, Andrea L" sort="Richardson, Andrea L" uniqKey="Richardson A" first="Andrea L" last="Richardson">Andrea L. Richardson</name>
<affiliation wicri:level="1"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van De Vijver, Marc" sort="Van De Vijver, Marc" uniqKey="Van De Vijver M" first="Marc" last="Van De Vijver">Marc Van De Vijver</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vincent Salomon, Anne" sort="Vincent Salomon, Anne" uniqKey="Vincent Salomon A" first="Anne" last="Vincent-Salomon">Anne Vincent-Salomon</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Bergonié, 229 cours de l'Argone, 33076 Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Bergonié, 229 cours de l'Argone, 33076 Bordeaux</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Eynden, Gert G" sort="Van Den Eynden, Gert G" uniqKey="Van Den Eynden G" first="Gert G" last="Van Den Eynden">Gert G. Van Den Eynden</name>
<affiliation wicri:level="1"><nlm:affiliation>Translational Cancer Research Unit and Department of Pathology, GZA Hospitals, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Translational Cancer Research Unit and Department of Pathology, GZA Hospitals, Antwerp</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flanagan, Adrienne M" sort="Flanagan, Adrienne M" uniqKey="Flanagan A" first="Adrienne M" last="Flanagan">Adrienne M. Flanagan</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal National Orthopaedic Hospital, Middlesex, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal National Orthopaedic Hospital, Middlesex</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Futreal, P Andrew" sort="Futreal, P Andrew" uniqKey="Futreal P" first="P Andrew" last="Futreal">P Andrew Futreal</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="Janes, Sam M" sort="Janes, Sam M" uniqKey="Janes S" first="Sam M" last="Janes">Sam M. Janes</name>
<affiliation wicri:level="1"><nlm:affiliation>Lungs for Living Research Centre, Rayne Institute, University College London (UCL), London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Lungs for Living Research Centre, Rayne Institute, University College London (UCL), London</wicri:regionArea>
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<author><name sortKey="Bova, G Steven" sort="Bova, G Steven" uniqKey="Bova G" first="G Steven" last="Bova">G Steven Bova</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Biosciences and Medical Technology-BioMediTech, University of Tampere and Tampere University Hospital, Tampere</wicri:regionArea>
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<author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R" last="Stratton">Michael R. Stratton</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="Mcdermott, Ultan" sort="Mcdermott, Ultan" uniqKey="Mcdermott U" first="Ultan" last="Mcdermott">Ultan Mcdermott</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<author><name sortKey="Campbell, Peter J" sort="Campbell, Peter J" uniqKey="Campbell P" first="Peter J" last="Campbell">Peter J. Campbell</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire</wicri:regionArea>
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<series><title level="j">Science (New York, N.Y.)</title>
<idno type="eISSN">1095-9203</idno>
<imprint><date when="2014" type="published">2014</date>
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</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carcinogenesis (genetics)</term>
<term>Chromatin (chemistry)</term>
<term>DNA Transposable Elements</term>
<term>Exons</term>
<term>Genome, Human</term>
<term>Humans</term>
<term>Long Interspersed Nucleotide Elements</term>
<term>Mutagenesis, Insertional</term>
<term>Neoplasms (genetics)</term>
<term>Transduction, Genetic</term>
<term>Translocation, Genetic</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Carcinogenèse (génétique)</term>
<term>Chromatine ()</term>
<term>Exons</term>
<term>Génome humain</term>
<term>Humains</term>
<term>Mutagenèse par insertion</term>
<term>Transduction génétique</term>
<term>Translocation génétique</term>
<term>Tumeurs (génétique)</term>
<term>Éléments LINE</term>
<term>Éléments transposables d'ADN</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Chromatin</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinogenesis</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinogenèse</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA Transposable Elements</term>
<term>Exons</term>
<term>Genome, Human</term>
<term>Humans</term>
<term>Long Interspersed Nucleotide Elements</term>
<term>Mutagenesis, Insertional</term>
<term>Transduction, Genetic</term>
<term>Translocation, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Chromatine</term>
<term>Exons</term>
<term>Génome humain</term>
<term>Humains</term>
<term>Mutagenèse par insertion</term>
<term>Transduction génétique</term>
<term>Translocation génétique</term>
<term>Éléments LINE</term>
<term>Éléments transposables d'ADN</term>
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<front><div type="abstract" xml:lang="en">Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive sequences are occasionally mobilized by the L1 machinery, a process called 3' transduction. Because 3' transductions are potentially mutagenic, we explored the extent to which they occur somatically during tumorigenesis. Studying cancer genomes from 244 patients, we found that tumors from 53% of the patients had somatic retrotranspositions, of which 24% were 3' transductions. Fingerprinting of donor L1s revealed that a handful of source L1 elements in a tumor can spawn from tens to hundreds of 3' transductions, which can themselves seed further retrotranspositions. The activity of individual L1 elements fluctuated during tumor evolution and correlated with L1 promoter hypomethylation. The 3' transductions disseminated genes, exons, and regulatory elements to new locations, most often to heterochromatic regions of the genome.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25082706</PMID>
<DateCreated><Year>2014</Year>
<Month>08</Month>
<Day>01</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>08</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1095-9203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>345</Volume>
<Issue>6196</Issue>
<PubDate><Year>2014</Year>
<Month>Aug</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Science (New York, N.Y.)</Title>
<ISOAbbreviation>Science</ISOAbbreviation>
</Journal>
<ArticleTitle>Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.</ArticleTitle>
<Pagination><MedlinePgn>1251343</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1126/science.1251343</ELocationID>
<Abstract><AbstractText>Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive sequences are occasionally mobilized by the L1 machinery, a process called 3' transduction. Because 3' transductions are potentially mutagenic, we explored the extent to which they occur somatically during tumorigenesis. Studying cancer genomes from 244 patients, we found that tumors from 53% of the patients had somatic retrotranspositions, of which 24% were 3' transductions. Fingerprinting of donor L1s revealed that a handful of source L1 elements in a tumor can spawn from tens to hundreds of 3' transductions, which can themselves seed further retrotranspositions. The activity of individual L1 elements fluctuated during tumor evolution and correlated with L1 promoter hypomethylation. The 3' transductions disseminated genes, exons, and regulatory elements to new locations, most often to heterochromatic regions of the genome.</AbstractText>
<CopyrightInformation>Copyright © 2014, American Association for the Advancement of Science.</CopyrightInformation>
</Abstract>
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<AffiliationInfo><Affiliation>Department of Clinical Science, University of Bergen, Bergen, Norway.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Oncology, Haukeland University Hospital, Bergen, Norway.</Affiliation>
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<AffiliationInfo><Affiliation>Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK.</Affiliation>
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<ForeName>Lucy R</ForeName>
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<AffiliationInfo><Affiliation>Department of Haematology, University of Cambridge, Cambridge, UK.</Affiliation>
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<ForeName>Elizabeth</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</Affiliation>
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<ForeName>Christopher</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University of Liverpool and HCA Pathology Laboratories, London, UK.</Affiliation>
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<ForeName>Anne Y</ForeName>
<Initials>AY</Initials>
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<ForeName>Hayley</ForeName>
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<ForeName>Daniel</ForeName>
<Initials>D</Initials>
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<AffiliationInfo><Affiliation>University of East Anglia, Norwich, UK.</Affiliation>
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<ForeName>Rosalind</ForeName>
<Initials>R</Initials>
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<ForeName>Colin</ForeName>
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<AffiliationInfo><Affiliation>University of East Anglia, Norwich, UK.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Eyfjörd</LastName>
<ForeName>Jórunn Erla</ForeName>
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<AffiliationInfo><Affiliation>Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia.</Affiliation>
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<AffiliationInfo><Affiliation>UQ Centre for Clinical Research, University of Queensland, Brisbane, Australia.</Affiliation>
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<ForeName>Paul N</ForeName>
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<ForeName>Anne-Lise</ForeName>
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<AffiliationInfo><Affiliation>Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.</Affiliation>
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<ForeName>Andrea L</ForeName>
<Initials>AL</Initials>
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<ForeName>Marc</ForeName>
<Initials>M</Initials>
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<ForeName>Anne</ForeName>
<Initials>A</Initials>
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<AffiliationInfo><Affiliation>Institut Curie, Department of Tumor Biology, 26 rue d'Ulm, 75248 Paris cédex 05, France.</Affiliation>
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<Initials>GG</Initials>
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<AffiliationInfo><Affiliation>UCL Cancer Institute, University College London, London, UK.</Affiliation>
</AffiliationInfo>
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<ForeName>P Andrew</ForeName>
<Initials>PA</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</Affiliation>
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<AffiliationInfo><Affiliation>MD Anderson Cancer Center, Houston, TX, USA.</Affiliation>
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<ForeName>Sam M</ForeName>
<Initials>SM</Initials>
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<Author ValidYN="Y"><LastName>Bova</LastName>
<ForeName>G Steven</ForeName>
<Initials>GS</Initials>
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</AffiliationInfo>
</Author>
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<ForeName>Michael R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</Affiliation>
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</Author>
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<ForeName>Ultan</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</Affiliation>
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</Author>
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<ForeName>Peter J</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Haematology, University of Cambridge, Cambridge, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>ICGC Breast Cancer Group</CollectiveName>
</Author>
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</Author>
<Author ValidYN="Y"><CollectiveName>ICGC Prostate Cancer Group</CollectiveName>
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<Language>eng</Language>
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<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
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<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
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