Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.
Identifieur interne : 003418 ( PubMed/Curation ); précédent : 003417; suivant : 003419Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.
Auteurs : Violette Da Cunha [France] ; Mark R. Davies [Royaume-Uni] ; Pierre-Emmanuel Douarre [France] ; Isabelle Rosinski-Chupin [France] ; Immaculada Margarit [Italie] ; Sebastien Spinali [France] ; Tim Perkins [Italie] ; Pierre Lechat [France] ; Nicolas Dmytruk [France] ; Elisabeth Sauvage [France] ; Laurence Ma [France] ; Benedetta Romi [Italie] ; Magali Tichit [France] ; Maria-José Lopez-Sanchez [France] ; Stéphane Descorps-Declere [France] ; Erika Souche [France] ; Carmen Buchrieser [France] ; Patrick Trieu-Cuot [France] ; Ivan Moszer [France] ; Dominique Clermont [France] ; Domenico Maione [Italie] ; Christiane Bouchier [France] ; David J. Mcmillan [Australie] ; Julian Parkhill [Royaume-Uni] ; John L. Telford [Italie] ; Gordan Dougan [Royaume-Uni] ; Mark J. Walker [Australie] ; Matthew T G. Holden [Royaume-Uni] ; Claire Poyart [France] ; Philippe Glaser [France]Source :
- Nature communications [ 2041-1723 ] ; 2014.
Descripteurs français
- KwdFr :
- Amérique du Nord (épidémiologie), Antibactériens (pharmacologie), Clones cellulaires, Données de séquences moléculaires, Europe (épidémiologie), Gènes bactériens, Génome bactérien, Humains, Infections à streptocoques (microbiologie), Infections à streptocoques (traitement médicamenteux), Infections à streptocoques (épidémiologie), Phylogénie, Polymorphisme de nucléotide simple, Résistance à la tétracycline (), Résistance à la tétracycline (génétique), Streptococcus agalactiae (), Streptococcus agalactiae (génétique), Streptococcus agalactiae (isolement et purification), Sélection génétique, Séquence nucléotidique, Séquençage nucléotidique à haut débit, Tétracycline (pharmacologie), Éléments transposables d'ADN.
- MESH :
- génétique : Résistance à la tétracycline, Streptococcus agalactiae.
- isolement et purification : Streptococcus agalactiae.
- microbiologie : Infections à streptocoques.
- pharmacologie : Antibactériens, Tétracycline.
- traitement médicamenteux : Infections à streptocoques.
- épidémiologie : Amérique du Nord, Europe, Infections à streptocoques.
- Clones cellulaires, Données de séquences moléculaires, Gènes bactériens, Génome bactérien, Humains, Phylogénie, Polymorphisme de nucléotide simple, Résistance à la tétracycline, Streptococcus agalactiae, Sélection génétique, Séquence nucléotidique, Séquençage nucléotidique à haut débit, Éléments transposables d'ADN.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (pharmacology), Base Sequence, Clone Cells, DNA Transposable Elements, Europe (epidemiology), Genes, Bacterial, Genome, Bacterial, High-Throughput Nucleotide Sequencing, Humans, Molecular Sequence Data, North America (epidemiology), Phylogeny, Polymorphism, Single Nucleotide, Selection, Genetic, Streptococcal Infections (drug therapy), Streptococcal Infections (epidemiology), Streptococcal Infections (microbiology), Streptococcus agalactiae (classification), Streptococcus agalactiae (drug effects), Streptococcus agalactiae (genetics), Streptococcus agalactiae (isolation & purification), Tetracycline (pharmacology), Tetracycline Resistance (drug effects), Tetracycline Resistance (genetics).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents, Tetracycline.
- geographic , epidemiology : Europe, North America.
- classification : Streptococcus agalactiae.
- drug effects : Streptococcus agalactiae, Tetracycline Resistance.
- drug therapy : Streptococcal Infections.
- epidemiology : Streptococcal Infections.
- genetics : Streptococcus agalactiae, Tetracycline Resistance.
- isolation & purification : Streptococcus agalactiae.
- microbiology : Streptococcal Infections.
- Base Sequence, Clone Cells, DNA Transposable Elements, Genes, Bacterial, Genome, Bacterial, High-Throughput Nucleotide Sequencing, Humans, Molecular Sequence Data, Phylogeny, Polymorphism, Single Nucleotide, Selection, Genetic.
Abstract
Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.
DOI: 10.1038/ncomms5544
PubMed: 25088811
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Mcmillan</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, 7006 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane, 7006 Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Parkhill, Julian" sort="Parkhill, Julian" uniqKey="Parkhill J" first="Julian" last="Parkhill">Julian Parkhill</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A</wicri:regionArea></affiliation></author><author><name sortKey="Telford, John L" sort="Telford, John L" uniqKey="Telford J" first="John L" last="Telford">John L. 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Davies</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A</wicri:regionArea></affiliation></author><author><name sortKey="Douarre, Pierre Emmanuel" sort="Douarre, Pierre Emmanuel" uniqKey="Douarre P" first="Pierre-Emmanuel" last="Douarre">Pierre-Emmanuel Douarre</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Rosinski Chupin, Isabelle" sort="Rosinski Chupin, Isabelle" uniqKey="Rosinski Chupin I" first="Isabelle" last="Rosinski-Chupin">Isabelle Rosinski-Chupin</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Margarit, Immaculada" sort="Margarit, Immaculada" uniqKey="Margarit I" first="Immaculada" last="Margarit">Immaculada Margarit</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Novartis Vaccines and Diagnostics, Siena 53100</wicri:regionArea></affiliation></author><author><name sortKey="Spinali, Sebastien" sort="Spinali, Sebastien" uniqKey="Spinali S" first="Sebastien" last="Spinali">Sebastien Spinali</name><affiliation wicri:level="1"><nlm:affiliation>Centre National de Référence des Streptocoques, Hôpitaux Universitaires, Paris Centre Cochin-Hôtel Dieu-Broca, Paris 75014, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Référence des Streptocoques, Hôpitaux Universitaires, Paris Centre Cochin-Hôtel Dieu-Broca, Paris 75014</wicri:regionArea></affiliation></author><author><name sortKey="Perkins, Tim" sort="Perkins, Tim" uniqKey="Perkins T" first="Tim" last="Perkins">Tim Perkins</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Novartis Vaccines and Diagnostics, Siena 53100</wicri:regionArea></affiliation></author><author><name sortKey="Lechat, Pierre" sort="Lechat, Pierre" uniqKey="Lechat P" first="Pierre" last="Lechat">Pierre Lechat</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Bioinformatics platform, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Dmytruk, Nicolas" sort="Dmytruk, Nicolas" uniqKey="Dmytruk N" first="Nicolas" last="Dmytruk">Nicolas Dmytruk</name><affiliation wicri:level="1"><nlm:affiliation>Centre National de Référence des Streptocoques, Hôpitaux Universitaires, Paris Centre Cochin-Hôtel Dieu-Broca, Paris 75014, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Référence des Streptocoques, Hôpitaux Universitaires, Paris Centre Cochin-Hôtel Dieu-Broca, Paris 75014</wicri:regionArea></affiliation></author><author><name sortKey="Sauvage, Elisabeth" sort="Sauvage, Elisabeth" uniqKey="Sauvage E" first="Elisabeth" last="Sauvage">Elisabeth Sauvage</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Laurence" sort="Ma, Laurence" uniqKey="Ma L" first="Laurence" last="Ma">Laurence Ma</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur Genomic platform, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur Genomic platform, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Romi, Benedetta" sort="Romi, Benedetta" uniqKey="Romi B" first="Benedetta" last="Romi">Benedetta Romi</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Novartis Vaccines and Diagnostics, Siena 53100</wicri:regionArea></affiliation></author><author><name sortKey="Tichit, Magali" sort="Tichit, Magali" uniqKey="Tichit M" first="Magali" last="Tichit">Magali Tichit</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur Genomic platform, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur Genomic platform, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Lopez Sanchez, Maria Jose" sort="Lopez Sanchez, Maria Jose" uniqKey="Lopez Sanchez M" first="Maria-José" last="Lopez-Sanchez">Maria-José Lopez-Sanchez</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Descorps Declere, Stephane" sort="Descorps Declere, Stephane" uniqKey="Descorps Declere S" first="Stéphane" last="Descorps-Declere">Stéphane Descorps-Declere</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Bioinformatics platform, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Souche, Erika" sort="Souche, Erika" uniqKey="Souche E" first="Erika" last="Souche">Erika Souche</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Bioinformatics platform, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Buchrieser, Carmen" sort="Buchrieser, Carmen" uniqKey="Buchrieser C" first="Carmen" last="Buchrieser">Carmen Buchrieser</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR3525, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR3525, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Trieu Cuot, Patrick" sort="Trieu Cuot, Patrick" uniqKey="Trieu Cuot P" first="Patrick" last="Trieu-Cuot">Patrick Trieu-Cuot</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Moszer, Ivan" sort="Moszer, Ivan" uniqKey="Moszer I" first="Ivan" last="Moszer">Ivan Moszer</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Bioinformatics platform, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Clermont, Dominique" sort="Clermont, Dominique" uniqKey="Clermont D" first="Dominique" last="Clermont">Dominique Clermont</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Collection de l'Institut Pasteur (CIP), Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Collection de l'Institut Pasteur (CIP), Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Maione, Domenico" sort="Maione, Domenico" uniqKey="Maione D" first="Domenico" last="Maione">Domenico Maione</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Novartis Vaccines and Diagnostics, Siena 53100</wicri:regionArea></affiliation></author><author><name sortKey="Bouchier, Christiane" sort="Bouchier, Christiane" uniqKey="Bouchier C" first="Christiane" last="Bouchier">Christiane Bouchier</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur Genomic platform, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur Genomic platform, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Mcmillan, David J" sort="Mcmillan, David J" uniqKey="Mcmillan D" first="David J" last="Mcmillan">David J. Mcmillan</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, 7006 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane, 7006 Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Parkhill, Julian" sort="Parkhill, Julian" uniqKey="Parkhill J" first="Julian" last="Parkhill">Julian Parkhill</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A</wicri:regionArea></affiliation></author><author><name sortKey="Telford, John L" sort="Telford, John L" uniqKey="Telford J" first="John L" last="Telford">John L. Telford</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Novartis Vaccines and Diagnostics, Siena 53100</wicri:regionArea></affiliation></author><author><name sortKey="Dougan, Gordan" sort="Dougan, Gordan" uniqKey="Dougan G" first="Gordan" last="Dougan">Gordan Dougan</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A</wicri:regionArea></affiliation></author><author><name sortKey="Walker, Mark J" sort="Walker, Mark J" uniqKey="Walker M" first="Mark J" last="Walker">Mark J. Walker</name><affiliation wicri:level="1"><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072 Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072 Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Holden, Matthew T G" sort="Holden, Matthew T G" uniqKey="Holden M" first="Matthew T G" last="Holden">Matthew T G. Holden</name><affiliation wicri:level="1"><nlm:affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A</wicri:regionArea></affiliation></author><author><name sortKey="Poyart, Claire" sort="Poyart, Claire" uniqKey="Poyart C" first="Claire" last="Poyart">Claire Poyart</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015</wicri:regionArea></affiliation></author><author><name sortKey="Glaser, Philippe" sort="Glaser, Philippe" uniqKey="Glaser P" first="Philippe" last="Glaser">Philippe Glaser</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (pharmacology)</term><term>Base Sequence</term><term>Clone Cells</term><term>DNA Transposable Elements</term><term>Europe (epidemiology)</term><term>Genes, Bacterial</term><term>Genome, Bacterial</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Molecular Sequence Data</term><term>North America (epidemiology)</term><term>Phylogeny</term><term>Polymorphism, Single Nucleotide</term><term>Selection, Genetic</term><term>Streptococcal Infections (drug therapy)</term><term>Streptococcal Infections (epidemiology)</term><term>Streptococcal Infections (microbiology)</term><term>Streptococcus agalactiae (classification)</term><term>Streptococcus agalactiae (drug effects)</term><term>Streptococcus agalactiae (genetics)</term><term>Streptococcus agalactiae (isolation & purification)</term><term>Tetracycline (pharmacology)</term><term>Tetracycline Resistance (drug effects)</term><term>Tetracycline Resistance (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amérique du Nord (épidémiologie)</term><term>Antibactériens (pharmacologie)</term><term>Clones cellulaires</term><term>Données de séquences moléculaires</term><term>Europe (épidémiologie)</term><term>Gènes bactériens</term><term>Génome bactérien</term><term>Humains</term><term>Infections à streptocoques (microbiologie)</term><term>Infections à streptocoques (traitement médicamenteux)</term><term>Infections à streptocoques (épidémiologie)</term><term>Phylogénie</term><term>Polymorphisme de nucléotide simple</term><term>Résistance à la tétracycline ()</term><term>Résistance à la tétracycline (génétique)</term><term>Streptococcus agalactiae ()</term><term>Streptococcus agalactiae (génétique)</term><term>Streptococcus agalactiae (isolement et purification)</term><term>Sélection génétique</term><term>Séquence nucléotidique</term><term>Séquençage nucléotidique à haut débit</term><term>Tétracycline (pharmacologie)</term><term>Éléments transposables d'ADN</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Tetracycline</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term><term>North America</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Streptococcus agalactiae</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Streptococcus agalactiae</term><term>Tetracycline Resistance</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Streptococcal Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Streptococcal Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Streptococcus agalactiae</term><term>Tetracycline Resistance</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Résistance à la tétracycline</term><term>Streptococcus agalactiae</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Streptococcus agalactiae</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Streptococcus agalactiae</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections à streptocoques</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Streptococcal Infections</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term><term>Tétracycline</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à streptocoques</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Amérique du Nord</term><term>Europe</term><term>Infections à streptocoques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term><term>Clone Cells</term><term>DNA Transposable Elements</term><term>Genes, Bacterial</term><term>Genome, Bacterial</term><term>High-Throughput Nucleotide Sequencing</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Polymorphism, Single Nucleotide</term><term>Selection, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Clones cellulaires</term><term>Données de séquences moléculaires</term><term>Gènes bactériens</term><term>Génome bactérien</term><term>Humains</term><term>Phylogénie</term><term>Polymorphisme de nucléotide simple</term><term>Résistance à la tétracycline</term><term>Streptococcus agalactiae</term><term>Sélection génétique</term><term>Séquence nucléotidique</term><term>Séquençage nucléotidique à haut débit</term><term>Éléments transposables d'ADN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25088811</PMID><DateCreated><Year>2014</Year><Month>08</Month><Day>04</Day></DateCreated><DateCompleted><Year>2015</Year><Month>11</Month><Day>02</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>07</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><PubDate><Year>2014</Year><Month>Aug</Month><Day>04</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.</ArticleTitle><Pagination><MedlinePgn>4544</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms5544</ELocationID><Abstract><AbstractText>Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Da Cunha</LastName><ForeName>Violette</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS UMR3525, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Davies</LastName><ForeName>Mark R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072 Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Douarre</LastName><ForeName>Pierre-Emmanuel</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS UMR3525, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosinski-Chupin</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS UMR3525, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Margarit</LastName><ForeName>Immaculada</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spinali</LastName><ForeName>Sebastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre National de Référence des Streptocoques, Hôpitaux Universitaires, Paris Centre Cochin-Hôtel Dieu-Broca, Paris 75014, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perkins</LastName><ForeName>Tim</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lechat</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dmytruk</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Centre National de Référence des Streptocoques, Hôpitaux Universitaires, Paris Centre Cochin-Hôtel Dieu-Broca, Paris 75014, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sauvage</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS UMR3525, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Laurence</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institut Pasteur Genomic platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romi</LastName><ForeName>Benedetta</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tichit</LastName><ForeName>Magali</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut Pasteur Genomic platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez-Sanchez</LastName><ForeName>Maria-José</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS UMR3525, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Descorps-Declere</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Souche</LastName><ForeName>Erika</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buchrieser</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CNRS UMR3525, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trieu-Cuot</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS ERL3526, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moszer</LastName><ForeName>Ivan</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clermont</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Collection de l'Institut Pasteur (CIP), Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maione</LastName><ForeName>Domenico</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouchier</LastName><ForeName>Christiane</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut Pasteur Genomic platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMillan</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, 7006 Queensland, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inflammation and Healing Research Cluster, University of the Sunshine Coast, Sippy Downs, 4556 Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parkhill</LastName><ForeName>Julian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Telford</LastName><ForeName>John L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Novartis Vaccines and Diagnostics, Siena 53100, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dougan</LastName><ForeName>Gordan</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072 Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>DEVANI Consortium</CollectiveName></Author><Author ValidYN="Y"><LastName>Holden</LastName><ForeName>Matthew T G</ForeName><Initials>MTG</Initials><AffiliationInfo><Affiliation>The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 15A, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poyart</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre National de Référence des Streptocoques, Hôpitaux Universitaires, Paris Centre Cochin-Hôtel Dieu-Broca, Paris 75014, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Cochin, Université Sorbonne Paris Descartes, Paris 75014, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM, U1016, Paris 75014, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glaser</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Biologie des Bacteries Pathogènes à Gram-positif, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS UMR3525, Paris 75015, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Pasteur, Bioinformatics platform, Paris 75015, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>HG939456</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>079643</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>098051</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Commun</MedlineTA><NlmUniqueID>101528555</NlmUniqueID><ISSNLinking>2041-1723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004251">DNA Transposable Elements</NameOfSubstance></Chemical><Chemical><RegistryNumber>F8VB5M810T</RegistryNumber><NameOfSubstance UI="D013752">Tetracycline</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Nat Commun. 2015;6:6108</RefSource><PMID Version="1">25629801</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2013;14:277</RefSource><PMID Version="1">24053737</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dtsch Med Wochenschr. 1965 Feb 5;90:258-61</RefSource><PMID Version="1">14237948</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Microbiol. 2007 Jul;56(Pt 7):947-55</RefSource><PMID Version="1">17577061</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2010 Oct 25;207(11):2313-22</RefSource><PMID Version="1">20956545</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Vet Scand. 2011;53:4</RefSource><PMID Version="1">21299911</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Microbiol. 2008 Apr;46(4):1285-91</RefSource><PMID Version="1">18287314</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Biol Evol. 2012 Sep;29(9):2157-67</RefSource><PMID Version="1">22403239</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2008;9:75</RefSource><PMID Version="1">18261238</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vet Microbiol. 2013 Jan 25;161(3-4):286-94</RefSource><PMID Version="1">22964008</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Microbiol. 2005 Dec;43(12):5899-906</RefSource><PMID Version="1">16333073</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Microbiol. 2002 Sep;45(6):1499-513</RefSource><PMID Version="1">12354221</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bacteriol Rev. 1976 Sep;40(3):774-92</RefSource><PMID Version="1">791241</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Microbiol. 2011 Oct;49(10):3652-5</RefSource><PMID Version="1">21865428</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2008 May;18(5):821-9</RefSource><PMID Version="1">18349386</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Microbiol. 2009 Apr;47(4):1143-8</RefSource><PMID Version="1">19158264</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Microbiol. 1998 Apr;28(1):103-17</RefSource><PMID Version="1">9593300</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Biol Evol. 2011 Oct;28(10):2731-9</RefSource><PMID Version="1">21546353</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Microbiol Rev. 2005 Jan;18(1):102-27</RefSource><PMID Version="1">15653821</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>MBio. 2010;1(3). pii: e00178-10. doi: 10.1128/mBio.00178-10</RefSource><PMID Version="1">20824105</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Microbiol. 2005 Aug;43(8):3727-33</RefSource><PMID Version="1">16081902</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Microbiol. 2003 Jun;41(6):2530-6</RefSource><PMID Version="1">12791877</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Microbiol. 2012 Apr;10(4):266-78</RefSource><PMID Version="1">22421879</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Antimicrob Chemother. 2009 Sep;64(3):441-6</RefSource><PMID Version="1">19608582</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Appl Environ Microbiol. 2010 Dec;76(24):7957-65</RefSource><PMID Version="1">20952646</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12391-6</RefSource><PMID Version="1">12200547</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Microbiol. 2012 Jan;61(Pt 1):126-31</RefSource><PMID Version="1">21903822</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>MBio. 2013;4(6):e00889-13</RefSource><PMID Version="1">24345744</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60 ; second page, table of contents</RefSource><PMID Version="1">11381101</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2009 Aug 15;25(16):2078-9</RefSource><PMID Version="1">19505943</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2006 May;4(5):e88</RefSource><PMID Version="1">16683862</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Microbiol. 2009 Mar;47(3):800-3</RefSource><PMID Version="1">19109468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Jan;45(1):109-13</RefSource><PMID Version="1">23222960</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Biol Evol. 2012 Aug;29(8):1969-73</RefSource><PMID Version="1">22367748</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Microbiol. 2012 Aug;61(Pt 8):1109-13</RefSource><PMID Version="1">22538994</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2013 Aug 15;29(16):1970-9</RefSource><PMID Version="1">23766415</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Antimicrob Chemother. 2010 Sep;65(9):1907-14</RefSource><PMID Version="1">20584746</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antimicrob Agents Chemother. 1998 Sep;42(9):2312-8</RefSource><PMID Version="1">9736555</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2013;14:500</RefSource><PMID Version="1">23879707</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1964 Dec 10;271:1221-8</RefSource><PMID Version="1">14234266</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Mol Life Sci. 2010 Feb;67(3):419-31</RefSource><PMID Version="1">19862477</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>MBio. 2013;4(4). pii: e00534-13. doi: 10.1128/mBio.00534-13</RefSource><PMID Version="1">23963180</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Clin Microbiol Infect Dis. 2012 Sep;31(9):2301-10</RefSource><PMID Version="1">22358726</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13950-5</RefSource><PMID Version="1">16172379</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15961-6</RefSource><PMID Version="1">18832470</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Clin Microbiol Infect Dis. 2012 Aug;31(8):1741-7</RefSource><PMID Version="1">22120421</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2009 Jul 15;25(14):1754-60</RefSource><PMID Version="1">19451168</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2012 Feb 11;379(9815):547-56</RefSource><PMID Version="1">22226047</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33</RefSource><PMID Version="1">20805405</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2004 Jul;14(7):1394-403</RefSource><PMID Version="1">15231754</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2011 Jan 28;331(6016):430-4</RefSource><PMID Version="1">21273480</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Commun. 2013;4:2151</RefSource><PMID Version="1">23877117</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Microbiol. 2013 Mar 06;4:15</RefSource><PMID Version="1">23508522</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>MBio. 2012;3(4):e00151-12</RefSource><PMID Version="1">22807567</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>MMWR Recomm Rep. 2010 Nov 19;59(RR-10):1-36</RefSource><PMID Version="1">21088663</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Evol Biol. 2007;7:214</RefSource><PMID Version="1">17996036</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEMS Microbiol Rev. 2011 Sep;35(5):856-71</RefSource><PMID Version="1">21658082</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2013;14:252</RefSource><PMID Version="1">23586779</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial 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