Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
Identifieur interne : 003278 ( PubMed/Curation ); précédent : 003277; suivant : 003279Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
Auteurs : Pirro G. Hysi [Royaume-Uni] ; Ching-Yu Cheng [Singapour] ; Henriët Springelkamp [Pays-Bas] ; Stuart Macgregor ; Jessica N Cooke Bailey [États-Unis] ; Robert Wojciechowski [États-Unis] ; Veronique Vitart [Royaume-Uni] ; Abhishek Nag [Royaume-Uni] ; Alex W. Hewitt [Australie] ; René Höhn [Allemagne] ; Cristina Venturini [Royaume-Uni] ; Alireza Mirshahi [Allemagne] ; Wishal D. Ramdas [Pays-Bas] ; Gudmar Thorleifsson [Islande] ; Eranga Vithana [Singapour] ; Chiea-Chuen Khor [Singapour] ; Arni B. Stefansson [Islande] ; Jiemin Liao [Singapour] ; Jonathan L. Haines [États-Unis] ; Najaf Amin [Pays-Bas] ; Ya Xing Wang ; Philipp S. Wild [Allemagne] ; Ayse B. Ozel [États-Unis] ; Jun Z. Li [États-Unis] ; Brian W. Fleck [Royaume-Uni] ; Tanja Zeller [Allemagne] ; Sandra E. Staffieri [Australie] ; Yik-Ying Teo [Singapour] ; Gabriel Cuellar-Partida ; Xiaoyan Luo [États-Unis] ; R Rand Allingham [États-Unis] ; Julia E. Richards [Pays-Bas] ; Andrea Senft [Allemagne] ; Lennart C. Karssen [Pays-Bas] ; Yingfeng Zheng [Singapour] ; Céline Bellenguez [France] ; Liang Xu ; Adriana I. Iglesias [Pays-Bas] ; James F. Wilson [Royaume-Uni] ; Jae H. Kang [États-Unis] ; Elisabeth M. Van Leeuwen [Pays-Bas] ; Vesteinn Jonsson [Islande] ; Unnur Thorsteinsdottir [Islande] ; Dominiek D G. Despriet [Pays-Bas] ; Sarah Ennis [Royaume-Uni] ; Sayoko E. Moroi [États-Unis] ; Nicholas G. Martin [Australie] ; Nomdo M. Jansonius [Pays-Bas] ; Seyhan Yazar [Australie] ; E-Shyong Tai [Singapour] ; Philippe Amouyel [Allemagne] ; James Kirwan [Royaume-Uni] ; Leonieke M E. Van Koolwijk [Pays-Bas] ; Michael A. Hauser [États-Unis] ; Fridbert Jonasson [Islande] ; Paul Leo [Australie] ; Stephanie J. Loomis [États-Unis] ; Rhys Fogarty [Australie] ; Fernando Rivadeneira [Pays-Bas] ; Lisa Kearns [Australie] ; Karl J. Lackner [Allemagne] ; Paulus T V M. De Jong [Pays-Bas] ; Claire L. Simpson [États-Unis] ; Craig E. Pennell [Australie] ; Ben A. Oostra [Pays-Bas] ; André G. Uitterlinden [Pays-Bas] ; Seang-Mei Saw [Singapour] ; Andrew J. Lotery [Royaume-Uni] ; Joan E. Bailey-Wilson [États-Unis] ; Albert Hofman [Pays-Bas] ; Johannes R. Vingerling [Pays-Bas] ; Cécilia Maubaret [France] ; Norbert Pfeiffer [Allemagne] ; Roger C W. Wolfs [Pays-Bas] ; Hans G. Lemij [Pays-Bas] ; Terri L. Young [États-Unis] ; Louis R. Pasquale [États-Unis] ; Cécile Delcourt [France] ; Timothy D. Spector [Royaume-Uni] ; Caroline C W. Klaver [Pays-Bas] ; Kerrin S. Small [Royaume-Uni] ; Kathryn P. Burdon [Australie] ; Kari Stefansson [Islande] ; Tien-Yin Wong [Singapour] ; Ananth Viswanathan [Royaume-Uni] ; David A. Mackey [Australie] ; Jamie E. Craig [Australie] ; Janey L. Wiggs [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Christopher J. Hammond [Royaume-Uni] ; Tin Aung [Singapour]Source :
- Nature genetics [ 1546-1718 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Chromosomes humains de la paire 11 (génétique), Chromosomes humains de la paire 3 (génétique), Chromosomes humains de la paire 9 (génétique), Facteurs de risque, Femelle, Fibronectines (génétique), Glaucome (génétique), Glaucome à angle ouvert (génétique), Génotype, Humains, Jeune adulte, Locus génétiques (génétique), Mâle, Méta-analyse comme sujet, Polymorphisme de nucléotide simple, Pression intraoculaire (génétique), Prédisposition génétique à une maladie (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Système ABO de groupes sanguins (génétique), Transporteur-1 à cassette liant l'ATP (génétique), Étude d'association pangénomique, Études de cohortes.
- MESH :
- génétique : Chromosomes humains de la paire 11, Chromosomes humains de la paire 3, Chromosomes humains de la paire 9, Fibronectines, Glaucome, Glaucome à angle ouvert, Locus génétiques, Pression intraoculaire, Prédisposition génétique à une maladie, Système ABO de groupes sanguins, Transporteur-1 à cassette liant l'ATP.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Génotype, Humains, Jeune adulte, Mâle, Méta-analyse comme sujet, Polymorphisme de nucléotide simple, Sujet âgé, Sujet âgé de 80 ans ou plus, Étude d'association pangénomique, Études de cohortes.
English descriptors
- KwdEn :
- ABO Blood-Group System (genetics), ATP Binding Cassette Transporter 1 (genetics), Adult, Aged, Aged, 80 and over, Chromosomes, Human, Pair 11 (genetics), Chromosomes, Human, Pair 3 (genetics), Chromosomes, Human, Pair 9 (genetics), Cohort Studies, Female, Fibronectins (genetics), Genetic Loci (genetics), Genetic Predisposition to Disease (genetics), Genome-Wide Association Study, Genotype, Glaucoma (genetics), Glaucoma, Open-Angle (genetics), Humans, Intraocular Pressure (genetics), Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Young Adult.
- MESH :
- chemical , genetics : ABO Blood-Group System, ATP Binding Cassette Transporter 1, Fibronectins.
- genetics : Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 9, Genetic Loci, Genetic Predisposition to Disease, Glaucoma, Glaucoma, Open-Angle, Intraocular Pressure.
- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Young Adult.
Abstract
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.
DOI: 10.1038/ng.3087
PubMed: 25173106
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Stuart Macgregor<affiliation><nlm:affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.</nlm:affiliation><wicri:noCountry code="subField">Australia 4029</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.</nlm:affiliation><wicri:noCountry code="subField">China 100730</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.</nlm:affiliation><wicri:noCountry code="subField">Australia 4029</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.</nlm:affiliation><wicri:noCountry code="subField">China 100730</wicri:noCountry></affiliation>Le document en format XML
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Ramdas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Arni B" sort="Stefansson, Arni B" uniqKey="Stefansson A" first="Arni B" last="Stefansson">Arni B. Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>Eye Clinic, 105 Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Eye Clinic, 105 Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Liao, Jiemin" sort="Liao, Jiemin" uniqKey="Liao J" first="Jiemin" last="Liao">Jiemin Liao</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><affiliation><nlm:affiliation>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.</nlm:affiliation><wicri:noCountry code="subField">China 100730</wicri:noCountry></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine II, University Medical Center Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, University Medical Center Mainz, Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Ozel, Ayse B" sort="Ozel, Ayse B" uniqKey="Ozel A" first="Ayse B" last="Ozel">Ayse B. Ozel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jun Z" sort="Li, Jun Z" uniqKey="Li J" first="Jun Z" last="Li">Jun Z. Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Fleck, Brian W" sort="Fleck, Brian W" uniqKey="Fleck B" first="Brian W" last="Fleck">Brian W. Fleck</name><affiliation wicri:level="1"><nlm:affiliation>NHS Princess Alexandra Eye Pavilion, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Princess Alexandra Eye Pavilion, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation wicri:level="1"><nlm:affiliation>Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for General and Interventional Cardiology, University Heart Center Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Staffieri, Sandra E" sort="Staffieri, Sandra E" uniqKey="Staffieri S" first="Sandra E" last="Staffieri">Sandra E. Staffieri</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><affiliation wicri:level="1"><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Cuellar Partida, Gabriel" sort="Cuellar Partida, Gabriel" uniqKey="Cuellar Partida G" first="Gabriel" last="Cuellar-Partida">Gabriel Cuellar-Partida</name><affiliation><nlm:affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.</nlm:affiliation><wicri:noCountry code="subField">Australia 4029</wicri:noCountry></affiliation></author><author><name sortKey="Luo, Xiaoyan" sort="Luo, Xiaoyan" uniqKey="Luo X" first="Xiaoyan" last="Luo">Xiaoyan Luo</name><affiliation wicri:level="1"><nlm:affiliation>Duke University, Duke Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University, Duke Eye Center, Durham, NC</wicri:regionArea></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Senft, Andrea" sort="Senft, Andrea" uniqKey="Senft A" first="Andrea" last="Senft">Andrea Senft</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck</wicri:regionArea></affiliation></author><author><name sortKey="Karssen, Lennart C" sort="Karssen, Lennart C" uniqKey="Karssen L" first="Lennart C" last="Karssen">Lennart C. Karssen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Yingfeng" sort="Zheng, Yingfeng" uniqKey="Zheng Y" first="Yingfeng" last="Zheng">Yingfeng Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="1"><nlm:affiliation>Inserm, UMR774, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, UMR774, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name><affiliation><nlm:affiliation>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.</nlm:affiliation><wicri:noCountry code="subField">China 100730</wicri:noCountry></affiliation></author><author><name sortKey="Iglesias, Adriana I" sort="Iglesias, Adriana I" uniqKey="Iglesias A" first="Adriana I" last="Iglesias">Adriana I. Iglesias</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name><affiliation wicri:level="1"><nlm:affiliation>Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Van Leeuwen, Elisabeth M" sort="Van Leeuwen, Elisabeth M" uniqKey="Van Leeuwen E" first="Elisabeth M" last="Van Leeuwen">Elisabeth M. Van Leeuwen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Jonsson, Vesteinn" sort="Jonsson, Vesteinn" uniqKey="Jonsson V" first="Vesteinn" last="Jonsson">Vesteinn Jonsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Despriet, Dominiek D G" sort="Despriet, Dominiek D G" uniqKey="Despriet D" first="Dominiek D G" last="Despriet">Dominiek D G. Despriet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name><affiliation wicri:level="1"><nlm:affiliation>Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Jansonius, Nomdo M" sort="Jansonius, Nomdo M" uniqKey="Jansonius N" first="Nomdo M" last="Jansonius">Nomdo M. Jansonius</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, University Medical Center Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck</wicri:regionArea></affiliation></author><author><name sortKey="Kirwan, James" sort="Kirwan, James" uniqKey="Kirwan J" first="James" last="Kirwan">James Kirwan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth</wicri:regionArea></affiliation></author><author><name sortKey="Van Koolwijk, Leonieke M E" sort="Van Koolwijk, Leonieke M E" uniqKey="Van Koolwijk L" first="Leonieke M E" last="Van Koolwijk">Leonieke M E. Van Koolwijk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea></affiliation></author><author><name sortKey="Jonasson, Fridbert" sort="Jonasson, Fridbert" uniqKey="Jonasson F" first="Fridbert" last="Jonasson">Fridbert Jonasson</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name><affiliation wicri:level="1"><nlm:affiliation>The University of Queensland, Diamantina Institute, Woollongabba, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Queensland, Diamantina Institute, Woollongabba</wicri:regionArea></affiliation></author><author><name sortKey="Loomis, Stephanie J" sort="Loomis, Stephanie J" uniqKey="Loomis S" first="Stephanie J" last="Loomis">Stephanie J. Loomis</name><affiliation wicri:level="1"><nlm:affiliation>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Fogarty, Rhys" sort="Fogarty, Rhys" uniqKey="Fogarty R" first="Rhys" last="Fogarty">Rhys Fogarty</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kearns, Lisa" sort="Kearns, Lisa" uniqKey="Kearns L" first="Lisa" last="Kearns">Lisa Kearns</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Lackner, Karl J" sort="Lackner, Karl J" uniqKey="Lackner K" first="Karl J" last="Lackner">Karl J. Lackner</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Chemistry and Laboratory Medicine, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Chemistry and Laboratory Medicine, Mainz</wicri:regionArea></affiliation></author><author><name sortKey="De Jong, Paulus T V M" sort="De Jong, Paulus T V M" uniqKey="De Jong P" first="Paulus T V M" last="De Jong">Paulus T V M. De Jong</name><affiliation wicri:level="1"><nlm:affiliation>Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Institute for Neuroscience, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Simpson, Claire L" sort="Simpson, Claire L" uniqKey="Simpson C" first="Claire L" last="Simpson">Claire L. Simpson</name><affiliation wicri:level="1"><nlm:affiliation>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><affiliation wicri:level="1"><nlm:affiliation>School of Women's and Infants' Health, The University of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Women's and Infants' Health, The University of Western Australia, Perth</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name><affiliation wicri:level="1"><nlm:affiliation>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Bailey Wilson, Joan E" sort="Bailey Wilson, Joan E" uniqKey="Bailey Wilson J" first="Joan E" last="Bailey-Wilson">Joan E. Bailey-Wilson</name><affiliation wicri:level="1"><nlm:affiliation>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Vingerling, Johannes R" sort="Vingerling, Johannes R" uniqKey="Vingerling J" first="Johannes R" last="Vingerling">Johannes R. Vingerling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Maubaret, Cecilia" sort="Maubaret, Cecilia" uniqKey="Maubaret C" first="Cécilia" last="Maubaret">Cécilia Maubaret</name><affiliation wicri:level="1"><nlm:affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Wolfs, Roger C W" sort="Wolfs, Roger C W" uniqKey="Wolfs R" first="Roger C W" last="Wolfs">Roger C W. Wolfs</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lemij, Hans G" sort="Lemij, Hans G" uniqKey="Lemij H" first="Hans G" last="Lemij">Hans G. Lemij</name><affiliation wicri:level="1"><nlm:affiliation>Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name><affiliation wicri:level="1"><nlm:affiliation>Duke University, Duke Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University, Duke Eye Center, Durham, NC</wicri:regionArea></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="1"><nlm:affiliation>Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Delcourt, Cecile" sort="Delcourt, Cecile" uniqKey="Delcourt C" first="Cécile" last="Delcourt">Cécile Delcourt</name><affiliation wicri:level="1"><nlm:affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C W" last="Klaver">Caroline C W. Klaver</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S" last="Small">Kerrin S. Small</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P" last="Burdon">Kathryn P. Burdon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Viswanathan, Ananth" sort="Viswanathan, Ananth" uniqKey="Viswanathan A" first="Ananth" last="Viswanathan">Ananth Viswanathan</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="1"><nlm:affiliation>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25173106</idno><idno type="pmid">25173106</idno><idno type="doi">10.1038/ng.3087</idno><idno type="wicri:Area/PubMed/Corpus">003390</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003390</idno><idno type="wicri:Area/PubMed/Curation">003278</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003278</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.</title><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Springelkamp, Henriet" sort="Springelkamp, Henriet" uniqKey="Springelkamp H" first="Henriët" last="Springelkamp">Henriët Springelkamp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation><nlm:affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.</nlm:affiliation><wicri:noCountry code="subField">Australia 4029</wicri:noCountry></affiliation></author><author><name sortKey="Bailey, Jessica N Cooke" sort="Bailey, Jessica N Cooke" uniqKey="Bailey J" first="Jessica N Cooke" last="Bailey">Jessica N Cooke Bailey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Wojciechowski, Robert" sort="Wojciechowski, Robert" uniqKey="Wojciechowski R" first="Robert" last="Wojciechowski">Robert Wojciechowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name><affiliation wicri:level="3"><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><wicri:orgArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</wicri:orgArea></affiliation></author><author><name sortKey="Nag, Abhishek" sort="Nag, Abhishek" uniqKey="Nag A" first="Abhishek" last="Nag">Abhishek Nag</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Hohn, Rene" sort="Hohn, Rene" uniqKey="Hohn R" first="René" last="Höhn">René Höhn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Mirshahi, Alireza" sort="Mirshahi, Alireza" uniqKey="Mirshahi A" first="Alireza" last="Mirshahi">Alireza Mirshahi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Ramdas, Wishal D" sort="Ramdas, Wishal D" uniqKey="Ramdas W" first="Wishal D" last="Ramdas">Wishal D. Ramdas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga" sort="Vithana, Eranga" uniqKey="Vithana E" first="Eranga" last="Vithana">Eranga Vithana</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, National University of Singapore and National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Arni B" sort="Stefansson, Arni B" uniqKey="Stefansson A" first="Arni B" last="Stefansson">Arni B. Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>Eye Clinic, 105 Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Eye Clinic, 105 Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Liao, Jiemin" sort="Liao, Jiemin" uniqKey="Liao J" first="Jiemin" last="Liao">Jiemin Liao</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ya Xing" sort="Wang, Ya Xing" uniqKey="Wang Y" first="Ya Xing" last="Wang">Ya Xing Wang</name><affiliation><nlm:affiliation>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.</nlm:affiliation><wicri:noCountry code="subField">China 100730</wicri:noCountry></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine II, University Medical Center Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, University Medical Center Mainz, Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Ozel, Ayse B" sort="Ozel, Ayse B" uniqKey="Ozel A" first="Ayse B" last="Ozel">Ayse B. Ozel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jun Z" sort="Li, Jun Z" uniqKey="Li J" first="Jun Z" last="Li">Jun Z. Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Fleck, Brian W" sort="Fleck, Brian W" uniqKey="Fleck B" first="Brian W" last="Fleck">Brian W. Fleck</name><affiliation wicri:level="1"><nlm:affiliation>NHS Princess Alexandra Eye Pavilion, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Princess Alexandra Eye Pavilion, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation wicri:level="1"><nlm:affiliation>Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for General and Interventional Cardiology, University Heart Center Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Staffieri, Sandra E" sort="Staffieri, Sandra E" uniqKey="Staffieri S" first="Sandra E" last="Staffieri">Sandra E. Staffieri</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik-Ying" last="Teo">Yik-Ying Teo</name><affiliation wicri:level="1"><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Cuellar Partida, Gabriel" sort="Cuellar Partida, Gabriel" uniqKey="Cuellar Partida G" first="Gabriel" last="Cuellar-Partida">Gabriel Cuellar-Partida</name><affiliation><nlm:affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.</nlm:affiliation><wicri:noCountry code="subField">Australia 4029</wicri:noCountry></affiliation></author><author><name sortKey="Luo, Xiaoyan" sort="Luo, Xiaoyan" uniqKey="Luo X" first="Xiaoyan" last="Luo">Xiaoyan Luo</name><affiliation wicri:level="1"><nlm:affiliation>Duke University, Duke Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University, Duke Eye Center, Durham, NC</wicri:regionArea></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Senft, Andrea" sort="Senft, Andrea" uniqKey="Senft A" first="Andrea" last="Senft">Andrea Senft</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck</wicri:regionArea></affiliation></author><author><name sortKey="Karssen, Lennart C" sort="Karssen, Lennart C" uniqKey="Karssen L" first="Lennart C" last="Karssen">Lennart C. Karssen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Yingfeng" sort="Zheng, Yingfeng" uniqKey="Zheng Y" first="Yingfeng" last="Zheng">Yingfeng Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="1"><nlm:affiliation>Inserm, UMR774, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, UMR774, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Liang" sort="Xu, Liang" uniqKey="Xu L" first="Liang" last="Xu">Liang Xu</name><affiliation><nlm:affiliation>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.</nlm:affiliation><wicri:noCountry code="subField">China 100730</wicri:noCountry></affiliation></author><author><name sortKey="Iglesias, Adriana I" sort="Iglesias, Adriana I" uniqKey="Iglesias A" first="Adriana I" last="Iglesias">Adriana I. Iglesias</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name><affiliation wicri:level="1"><nlm:affiliation>Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Van Leeuwen, Elisabeth M" sort="Van Leeuwen, Elisabeth M" uniqKey="Van Leeuwen E" first="Elisabeth M" last="Van Leeuwen">Elisabeth M. Van Leeuwen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Jonsson, Vesteinn" sort="Jonsson, Vesteinn" uniqKey="Jonsson V" first="Vesteinn" last="Jonsson">Vesteinn Jonsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Despriet, Dominiek D G" sort="Despriet, Dominiek D G" uniqKey="Despriet D" first="Dominiek D G" last="Despriet">Dominiek D G. Despriet</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name><affiliation wicri:level="1"><nlm:affiliation>Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Jansonius, Nomdo M" sort="Jansonius, Nomdo M" uniqKey="Jansonius N" first="Nomdo M" last="Jansonius">Nomdo M. Jansonius</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, University Medical Center Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Groningen</wicri:regionArea></affiliation></author><author><name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck</wicri:regionArea></affiliation></author><author><name sortKey="Kirwan, James" sort="Kirwan, James" uniqKey="Kirwan J" first="James" last="Kirwan">James Kirwan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth</wicri:regionArea></affiliation></author><author><name sortKey="Van Koolwijk, Leonieke M E" sort="Van Koolwijk, Leonieke M E" uniqKey="Van Koolwijk L" first="Leonieke M E" last="Van Koolwijk">Leonieke M E. Van Koolwijk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea></affiliation></author><author><name sortKey="Jonasson, Fridbert" sort="Jonasson, Fridbert" uniqKey="Jonasson F" first="Fridbert" last="Jonasson">Fridbert Jonasson</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Leo, Paul" sort="Leo, Paul" uniqKey="Leo P" first="Paul" last="Leo">Paul Leo</name><affiliation wicri:level="1"><nlm:affiliation>The University of Queensland, Diamantina Institute, Woollongabba, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Queensland, Diamantina Institute, Woollongabba</wicri:regionArea></affiliation></author><author><name sortKey="Loomis, Stephanie J" sort="Loomis, Stephanie J" uniqKey="Loomis S" first="Stephanie J" last="Loomis">Stephanie J. Loomis</name><affiliation wicri:level="1"><nlm:affiliation>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Fogarty, Rhys" sort="Fogarty, Rhys" uniqKey="Fogarty R" first="Rhys" last="Fogarty">Rhys Fogarty</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Kearns, Lisa" sort="Kearns, Lisa" uniqKey="Kearns L" first="Lisa" last="Kearns">Lisa Kearns</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Lackner, Karl J" sort="Lackner, Karl J" uniqKey="Lackner K" first="Karl J" last="Lackner">Karl J. Lackner</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Chemistry and Laboratory Medicine, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Chemistry and Laboratory Medicine, Mainz</wicri:regionArea></affiliation></author><author><name sortKey="De Jong, Paulus T V M" sort="De Jong, Paulus T V M" uniqKey="De Jong P" first="Paulus T V M" last="De Jong">Paulus T V M. De Jong</name><affiliation wicri:level="1"><nlm:affiliation>Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Institute for Neuroscience, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Simpson, Claire L" sort="Simpson, Claire L" uniqKey="Simpson C" first="Claire L" last="Simpson">Claire L. Simpson</name><affiliation wicri:level="1"><nlm:affiliation>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea></affiliation></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E" last="Pennell">Craig E. Pennell</name><affiliation wicri:level="1"><nlm:affiliation>School of Women's and Infants' Health, The University of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Women's and Infants' Health, The University of Western Australia, Perth</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name><affiliation wicri:level="1"><nlm:affiliation>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Bailey Wilson, Joan E" sort="Bailey Wilson, Joan E" uniqKey="Bailey Wilson J" first="Joan E" last="Bailey-Wilson">Joan E. Bailey-Wilson</name><affiliation wicri:level="1"><nlm:affiliation>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Vingerling, Johannes R" sort="Vingerling, Johannes R" uniqKey="Vingerling J" first="Johannes R" last="Vingerling">Johannes R. Vingerling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Maubaret, Cecilia" sort="Maubaret, Cecilia" uniqKey="Maubaret C" first="Cécilia" last="Maubaret">Cécilia Maubaret</name><affiliation wicri:level="1"><nlm:affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea></affiliation></author><author><name sortKey="Wolfs, Roger C W" sort="Wolfs, Roger C W" uniqKey="Wolfs R" first="Roger C W" last="Wolfs">Roger C W. Wolfs</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lemij, Hans G" sort="Lemij, Hans G" uniqKey="Lemij H" first="Hans G" last="Lemij">Hans G. Lemij</name><affiliation wicri:level="1"><nlm:affiliation>Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name><affiliation wicri:level="1"><nlm:affiliation>Duke University, Duke Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University, Duke Eye Center, Durham, NC</wicri:regionArea></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="1"><nlm:affiliation>Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Delcourt, Cecile" sort="Delcourt, Cecile" uniqKey="Delcourt C" first="Cécile" last="Delcourt">Cécile Delcourt</name><affiliation wicri:level="1"><nlm:affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, ISPED, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C W" last="Klaver">Caroline C W. Klaver</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Small, Kerrin S" sort="Small, Kerrin S" uniqKey="Small K" first="Kerrin S" last="Small">Kerrin S. Small</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P" last="Burdon">Kathryn P. Burdon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE/Amgen, 101 Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author><author><name sortKey="Viswanathan, Ananth" sort="Viswanathan, Ananth" uniqKey="Viswanathan A" first="Ananth" last="Viswanathan">Ananth Viswanathan</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="1"><nlm:affiliation>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name><affiliation wicri:level="1"><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Centre</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="eISSN">1546-1718</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ABO Blood-Group System (genetics)</term><term>ATP Binding Cassette Transporter 1 (genetics)</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chromosomes, Human, Pair 11 (genetics)</term><term>Chromosomes, Human, Pair 3 (genetics)</term><term>Chromosomes, Human, Pair 9 (genetics)</term><term>Cohort Studies</term><term>Female</term><term>Fibronectins (genetics)</term><term>Genetic Loci (genetics)</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Glaucoma (genetics)</term><term>Glaucoma, Open-Angle (genetics)</term><term>Humans</term><term>Intraocular Pressure (genetics)</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Chromosomes humains de la paire 11 (génétique)</term><term>Chromosomes humains de la paire 3 (génétique)</term><term>Chromosomes humains de la paire 9 (génétique)</term><term>Facteurs de risque</term><term>Femelle</term><term>Fibronectines (génétique)</term><term>Glaucome (génétique)</term><term>Glaucome à angle ouvert (génétique)</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Locus génétiques (génétique)</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Polymorphisme de nucléotide simple</term><term>Pression intraoculaire (génétique)</term><term>Prédisposition génétique à une maladie (génétique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Système ABO de groupes sanguins (génétique)</term><term>Transporteur-1 à cassette liant l'ATP (génétique)</term><term>Étude d'association pangénomique</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>ABO Blood-Group System</term><term>ATP Binding Cassette Transporter 1</term><term>Fibronectins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 11</term><term>Chromosomes, Human, Pair 3</term><term>Chromosomes, Human, Pair 9</term><term>Genetic Loci</term><term>Genetic Predisposition to Disease</term><term>Glaucoma</term><term>Glaucoma, Open-Angle</term><term>Intraocular Pressure</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes humains de la paire 11</term><term>Chromosomes humains de la paire 3</term><term>Chromosomes humains de la paire 9</term><term>Fibronectines</term><term>Glaucome</term><term>Glaucome à angle ouvert</term><term>Locus génétiques</term><term>Pression intraoculaire</term><term>Prédisposition génétique à une maladie</term><term>Système ABO de groupes sanguins</term><term>Transporteur-1 à cassette liant l'ATP</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Polymorphisme de nucléotide simple</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Étude d'association pangénomique</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25173106</PMID><DateCreated><Year>2014</Year><Month>09</Month><Day>26</Day></DateCreated><DateCompleted><Year>2014</Year><Month>12</Month><Day>15</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1546-1718</ISSN><JournalIssue CitedMedium="Internet"><Volume>46</Volume><Issue>10</Issue><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Nature genetics</Title><ISOAbbreviation>Nat. Genet.</ISOAbbreviation></Journal><ArticleTitle>Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.</ArticleTitle><Pagination><MedlinePgn>1126-1130</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ng.3087</ELocationID><Abstract><AbstractText>Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Hysi</LastName><ForeName>Pirro G</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Cheng</LastName><ForeName>Ching-Yu</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Duke-National University of Singapore, Graduate Medical School, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Springelkamp</LastName><ForeName>Henriët</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Macgregor</LastName><ForeName>Stuart</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Bailey</LastName><ForeName>Jessica N Cooke</ForeName><Initials>JNC</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Wojciechowski</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and, Baltimore, MD, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vitart</LastName><ForeName>Veronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nag</LastName><ForeName>Abhishek</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hewitt</LastName><ForeName>Alex W</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Höhn</LastName><ForeName>René</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venturini</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Ophthalmology, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mirshahi</LastName><ForeName>Alireza</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramdas</LastName><ForeName>Wishal D</ForeName><Initials>WD</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thorleifsson</LastName><ForeName>Gudmar</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vithana</LastName><ForeName>Eranga</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Duke-National University of Singapore, Graduate Medical School, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khor</LastName><ForeName>Chiea-Chuen</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stefansson</LastName><ForeName>Arni B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Eye Clinic, 105 Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Jiemin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haines</LastName><ForeName>Jonathan L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin</LastName><ForeName>Najaf</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Ya Xing</ForeName><Initials>YX</Initials><AffiliationInfo><Affiliation>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wild</LastName><ForeName>Philipp S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine II, University Medical Center Mainz, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ozel</LastName><ForeName>Ayse B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jun Z</ForeName><Initials>JZ</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fleck</LastName><ForeName>Brian W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>NHS Princess Alexandra Eye Pavilion, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeller</LastName><ForeName>Tanja</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Staffieri</LastName><ForeName>Sandra E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teo</LastName><ForeName>Yik-Ying</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Statistics and Applied Probability, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuellar-Partida</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Statistical Genetics, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia 4029.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Xiaoyan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Duke University, Duke Eye Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allingham</LastName><ForeName>R Rand</ForeName><Initials>RR</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richards</LastName><ForeName>Julia E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Senft</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karssen</LastName><ForeName>Lennart C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Yingfeng</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellenguez</LastName><ForeName>Céline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Inserm, UMR774, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Lille 2, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Pasteur de Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Liang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China 100730.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iglesias</LastName><ForeName>Adriana I</ForeName><Initials>AI</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>James F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Jae H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Leeuwen</LastName><ForeName>Elisabeth M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jonsson</LastName><ForeName>Vesteinn</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thorsteinsdottir</LastName><ForeName>Unnur</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Despriet</LastName><ForeName>Dominiek D G</ForeName><Initials>DDG</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ennis</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Human Genetics & Genomic Medicine, Faulty of Medicine, University of Southampton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moroi</LastName><ForeName>Sayoko E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Nicholas G</ForeName><Initials>NG</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jansonius</LastName><ForeName>Nomdo M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, University Medical Center Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yazar</LastName><ForeName>Seyhan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tai</LastName><ForeName>E-Shyong</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Duke-National University of Singapore, Graduate Medical School, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amouyel</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, UMR774, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Lille 2, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre Hospitalier Régional Universitaire de Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirwan</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Koolwijk</LastName><ForeName>Leonieke M E</ForeName><Initials>LME</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauser</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jonasson</LastName><ForeName>Fridbert</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leo</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>The University of Queensland, Diamantina Institute, Woollongabba, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loomis</LastName><ForeName>Stephanie J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fogarty</LastName><ForeName>Rhys</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivadeneira</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kearns</LastName><ForeName>Lisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lackner</LastName><ForeName>Karl J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>Institute of Clinical Chemistry and Laboratory Medicine, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Jong</LastName><ForeName>Paulus T V M</ForeName><Initials>PTVM</Initials><AffiliationInfo><Affiliation>Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ophthalmology, Academic Medical Center, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Claire L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pennell</LastName><ForeName>Craig E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>School of Women's and Infants' Health, The University of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oostra</LastName><ForeName>Ben A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitterlinden</LastName><ForeName>André G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saw</LastName><ForeName>Seang-Mei</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Duke-National University of Singapore, Graduate Medical School, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lotery</LastName><ForeName>Andrew J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey-Wilson</LastName><ForeName>Joan E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vingerling</LastName><ForeName>Johannes R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maubaret</LastName><ForeName>Cécilia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfeiffer</LastName><ForeName>Norbert</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolfs</LastName><ForeName>Roger C W</ForeName><Initials>RCW</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemij</LastName><ForeName>Hans G</ForeName><Initials>HG</Initials><AffiliationInfo><Affiliation>Glaucoma Service, the Rotterdam Eye Hospital, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Terri L</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Duke University, Duke Eye Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasquale</LastName><ForeName>Louis R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delcourt</LastName><ForeName>Cécile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm, Centre INSERM U897-Epidemiologie-Biostatistique Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spector</LastName><ForeName>Timothy D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klaver</LastName><ForeName>Caroline C W</ForeName><Initials>CCW</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Small</LastName><ForeName>Kerrin S</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burdon</LastName><ForeName>Kathryn P</ForeName><Initials>KP</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stefansson</LastName><ForeName>Kari</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>deCODE/Amgen, 101 Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Tien-Yin</ForeName><Initials>TY</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>BMES GWAS Group</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>NEIGHBORHOOD Consortium</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>Wellcome Trust Case Control Consortium 2</CollectiveName></Author><Author ValidYN="Y"><LastName>Viswanathan</LastName><ForeName>Ananth</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mackey</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Craig</LastName><ForeName>Jamie E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiggs</LastName><ForeName>Janey L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Dept. Ophthalmology Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Duijn</LastName><ForeName>Cornelia M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hammond</LastName><ForeName>Christopher J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, King's College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aung</LastName><ForeName>Tin</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ophthalmology, National University of Singapore and National University Health System, Singapore.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CZB/4/710</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>CZB/4/438</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>U01 HG004728</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K08 EY022943</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY022124</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY022305</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY015473</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_PC_U127561128</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P30 EY014104</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>SRF/01/010</GrantID><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 EY023512</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nat Genet</MedlineTA><NlmUniqueID>9216904</NlmUniqueID><ISSNLinking>1061-4036</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C577836">ABCA1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000017">ABO Blood-Group System</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064286">ATP Binding Cassette Transporter 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C543006">FNDC3B protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005353">Fibronectins</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C562750">Glaucoma, Primary Open Angle</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2012;8(5):e1002611</RefSource><PMID Version="1">22570627</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 Oct;44(10):1084-9</RefSource><PMID 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UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005353" MajorTopicYN="N">Fibronectins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056426" MajorTopicYN="N">Genetic Loci</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="Y">Genome-Wide Association Study</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005901" MajorTopicYN="N">Glaucoma</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005902" MajorTopicYN="N">Glaucoma, Open-Angle</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007429" MajorTopicYN="N">Intraocular Pressure</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015201" MajorTopicYN="N">Meta-Analysis as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">EMS59965</OtherID><OtherID Source="NLM">PMC4177225</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>09</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>08</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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