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Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.

Identifieur interne : 003142 ( PubMed/Curation ); précédent : 003141; suivant : 003143

Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.

Auteurs : Brenna J. Hill [États-Unis] ; Patricia A. Darrah [États-Unis] ; Zachary Ende [États-Unis] ; David R. Ambrozak [États-Unis] ; Kylie M. Quinn [États-Unis] ; Sam Darko [États-Unis] ; Emma Gostick [Royaume-Uni] ; Linda Wooldridge [Royaume-Uni] ; Hugo A. Van Den Berg [Royaume-Uni] ; Vanessa Venturi [Australie] ; Martin Larsen [France] ; Miles P. Davenport [Australie] ; Robert A. Seder [États-Unis] ; David A. Price [Royaume-Uni] ; Daniel C. Douek [Royaume-Uni]

Source :

Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2014.

RBID : pubmed:25348625

Descripteurs français

English descriptors

KwdEn :
- AIDS Vaccines, Adenoviridae (genetics), Animals, CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (virology), Cells, Cultured, Cytotoxicity, Immunologic, Female, Genetic Vectors, H-2 Antigens (metabolism), Histocompatibility Antigen H-2D (metabolism), Humans, Immunodominant Epitopes (genetics), Immunodominant Epitopes (metabolism), Immunologic Memory, Mice, Mice, Inbred BALB C, Vaccination, gag Gene Products, Human Immunodeficiency Virus (genetics), gag Gene Products, Human Immunodeficiency Virus (metabolism), pol Gene Products, Human Immunodeficiency Virus (genetics), pol Gene Products, Human Immunodeficiency Virus (metabolism).
MESH :
- chemical , genetics : Immunodominant Epitopes, gag Gene Products, Human Immunodeficiency Virus, pol Gene Products, Human Immunodeficiency Virus.
- chemical , metabolism : H-2 Antigens, Histocompatibility Antigen H-2D, Immunodominant Epitopes, gag Gene Products, Human Immunodeficiency Virus, pol Gene Products, Human Immunodeficiency Virus.
- chemical : AIDS Vaccines.
- genetics : Adenoviridae.
- immunology : CD8-Positive T-Lymphocytes.
- virology : CD8-Positive T-Lymphocytes.
- Animals, Cells, Cultured, Cytotoxicity, Immunologic, Female, Genetic Vectors, Humans, Immunologic Memory, Mice, Mice, Inbred BALB C, Vaccination.

Abstract

Despite progress toward understanding the correlates of protective T cell immunity in HIV infection, the optimal approach to Ag delivery by vaccination remains uncertain. We characterized two immunodominant CD8 T cell populations generated in response to immunization of BALB/c mice with a replication-deficient adenovirus serotype 5 vector expressing the HIV-derived Gag and Pol proteins at equivalent levels. The Gag-AI9/H-2K(d) epitope elicited high-avidity CD8 T cell populations with architecturally diverse clonotypic repertoires that displayed potent lytic activity in vivo. In contrast, the Pol-LI9/H-2D(d) epitope elicited motif-constrained CD8 T cell repertoires that displayed lower levels of physical avidity and lytic activity despite equivalent measures of overall clonality. Although low-dose vaccination enhanced the functional profiles of both epitope-specific CD8 T cell populations, greater polyfunctionality was apparent within the Pol-LI9/H-2D(d) specificity. Higher proportions of central memory-like cells were present after low-dose vaccination and at later time points. However, there were no noteworthy phenotypic differences between epitope-specific CD8 T cell populations across vaccine doses or time points. Collectively, these data indicate that the functional and phenotypic properties of vaccine-induced CD8 T cell populations are sensitive to dose manipulation, yet constrained by epitope specificity in a clonotype-dependent manner.

DOI: 10.4049/jimmunol.1401017
PubMed: 25348625

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<author><name sortKey="Price, David A" sort="Price, David A" uniqKey="Price D" first="David A" last="Price">David A. Price</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.</title>
<author><name sortKey="Hill, Brenna J" sort="Hill, Brenna J" uniqKey="Hill B" first="Brenna J" last="Hill">Brenna J. Hill</name>
<affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
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<author><name sortKey="Darrah, Patricia A" sort="Darrah, Patricia A" uniqKey="Darrah P" first="Patricia A" last="Darrah">Patricia A. Darrah</name>
<affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
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<author><name sortKey="Ende, Zachary" sort="Ende, Zachary" uniqKey="Ende Z" first="Zachary" last="Ende">Zachary Ende</name>
<affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
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<author><name sortKey="Ambrozak, David R" sort="Ambrozak, David R" uniqKey="Ambrozak D" first="David R" last="Ambrozak">David R. Ambrozak</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Quinn, Kylie M" sort="Quinn, Kylie M" uniqKey="Quinn K" first="Kylie M" last="Quinn">Kylie M. Quinn</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
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</affiliation>
</author>
<author><name sortKey="Darko, Sam" sort="Darko, Sam" uniqKey="Darko S" first="Sam" last="Darko">Sam Darko</name>
<affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gostick, Emma" sort="Gostick, Emma" uniqKey="Gostick E" first="Emma" last="Gostick">Emma Gostick</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wooldridge, Linda" sort="Wooldridge, Linda" uniqKey="Wooldridge L" first="Linda" last="Wooldridge">Linda Wooldridge</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medical and Veterinary Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Faculty of Medical and Veterinary Sciences, University of Bristol, Bristol BS8 1TD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Berg, Hugo A" sort="Van Den Berg, Hugo A" uniqKey="Van Den Berg H" first="Hugo A" last="Van Den Berg">Hugo A. Van Den Berg</name>
<affiliation wicri:level="1"><nlm:affiliation>Mathematics Institute, University of Warwick, Coventry CV4 7AL, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Mathematics Institute, University of Warwick, Coventry CV4 7AL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Venturi, Vanessa" sort="Venturi, Vanessa" uniqKey="Venturi V" first="Vanessa" last="Venturi">Vanessa Venturi</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Biology Group, Centre for Vascular Research, University of New South Wales, Kensington 2052, New South Wales, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Computational Biology Group, Centre for Vascular Research, University of New South Wales, Kensington 2052, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Larsen, Martin" sort="Larsen, Martin" uniqKey="Larsen M" first="Martin" last="Larsen">Martin Larsen</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM, U1135, Centre d'Immunologie et des Maladies Infectieuses, F-75013 Paris, France; and Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, Université Pierre et Marie Curie (Université Paris 06), CR7, F-75013 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1135, Centre d'Immunologie et des Maladies Infectieuses, F-75013 Paris, France; and Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, Université Pierre et Marie Curie (Université Paris 06), CR7, F-75013 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davenport, Miles P" sort="Davenport, Miles P" uniqKey="Davenport M" first="Miles P" last="Davenport">Miles P. Davenport</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Biology Group, Centre for Vascular Research, University of New South Wales, Kensington 2052, New South Wales, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Computational Biology Group, Centre for Vascular Research, University of New South Wales, Kensington 2052, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seder, Robert A" sort="Seder, Robert A" uniqKey="Seder R" first="Robert A" last="Seder">Robert A. Seder</name>
<affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Price, David A" sort="Price, David A" uniqKey="Price D" first="David A" last="Price">David A. Price</name>
<affiliation wicri:level="1"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom; ddouek@mail.nih.gov priced6@cardiff.ac.uk.</nlm:affiliation>
<country wicri:rule="url">Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Douek, Daniel C" sort="Douek, Daniel C" uniqKey="Douek D" first="Daniel C" last="Douek">Daniel C. Douek</name>
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<country wicri:rule="url">Royaume-Uni</country>
</affiliation>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS Vaccines</term>
<term>Adenoviridae (genetics)</term>
<term>Animals</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (virology)</term>
<term>Cells, Cultured</term>
<term>Cytotoxicity, Immunologic</term>
<term>Female</term>
<term>Genetic Vectors</term>
<term>H-2 Antigens (metabolism)</term>
<term>Histocompatibility Antigen H-2D (metabolism)</term>
<term>Humans</term>
<term>Immunodominant Epitopes (genetics)</term>
<term>Immunodominant Epitopes (metabolism)</term>
<term>Immunologic Memory</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Vaccination</term>
<term>gag Gene Products, Human Immunodeficiency Virus (genetics)</term>
<term>gag Gene Products, Human Immunodeficiency Virus (metabolism)</term>
<term>pol Gene Products, Human Immunodeficiency Virus (genetics)</term>
<term>pol Gene Products, Human Immunodeficiency Virus (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term>
<term>Animaux</term>
<term>Antigène d'histocompatibilité H2-D (métabolisme)</term>
<term>Antigènes H-2 (métabolisme)</term>
<term>Cellules cultivées</term>
<term>Cytotoxicité immunologique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Lymphocytes T CD8+ (virologie)</term>
<term>Mémoire immunologique</term>
<term>Produits du gène gag du virus de l'immunodéficience humaine (génétique)</term>
<term>Produits du gène gag du virus de l'immunodéficience humaine (métabolisme)</term>
<term>Produits du gène pol du virus de l'immunodéficience humaine (génétique)</term>
<term>Produits du gène pol du virus de l'immunodéficience humaine (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Vaccination</term>
<term>Vaccins contre le SIDA</term>
<term>Vecteurs génétiques</term>
<term>Épitopes immunodominants (génétique)</term>
<term>Épitopes immunodominants (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Immunodominant Epitopes</term>
<term>gag Gene Products, Human Immunodeficiency Virus</term>
<term>pol Gene Products, Human Immunodeficiency Virus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>H-2 Antigens</term>
<term>Histocompatibility Antigen H-2D</term>
<term>Immunodominant Epitopes</term>
<term>gag Gene Products, Human Immunodeficiency Virus</term>
<term>pol Gene Products, Human Immunodeficiency Virus</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>AIDS Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term>
<term>Produits du gène gag du virus de l'immunodéficience humaine</term>
<term>Produits du gène pol du virus de l'immunodéficience humaine</term>
<term>Épitopes immunodominants</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigène d'histocompatibilité H2-D</term>
<term>Antigènes H-2</term>
<term>Produits du gène gag du virus de l'immunodéficience humaine</term>
<term>Produits du gène pol du virus de l'immunodéficience humaine</term>
<term>Épitopes immunodominants</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Cytotoxicity, Immunologic</term>
<term>Female</term>
<term>Genetic Vectors</term>
<term>Humans</term>
<term>Immunologic Memory</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cytotoxicité immunologique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mémoire immunologique</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Vaccination</term>
<term>Vaccins contre le SIDA</term>
<term>Vecteurs génétiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Despite progress toward understanding the correlates of protective T cell immunity in HIV infection, the optimal approach to Ag delivery by vaccination remains uncertain. We characterized two immunodominant CD8 T cell populations generated in response to immunization of BALB/c mice with a replication-deficient adenovirus serotype 5 vector expressing the HIV-derived Gag and Pol proteins at equivalent levels. The Gag-AI9/H-2K(d) epitope elicited high-avidity CD8 T cell populations with architecturally diverse clonotypic repertoires that displayed potent lytic activity in vivo. In contrast, the Pol-LI9/H-2D(d) epitope elicited motif-constrained CD8 T cell repertoires that displayed lower levels of physical avidity and lytic activity despite equivalent measures of overall clonality. Although low-dose vaccination enhanced the functional profiles of both epitope-specific CD8 T cell populations, greater polyfunctionality was apparent within the Pol-LI9/H-2D(d) specificity. Higher proportions of central memory-like cells were present after low-dose vaccination and at later time points. However, there were no noteworthy phenotypic differences between epitope-specific CD8 T cell populations across vaccine doses or time points. Collectively, these data indicate that the functional and phenotypic properties of vaccine-induced CD8 T cell populations are sensitive to dose manipulation, yet constrained by epitope specificity in a clonotype-dependent manner.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25348625</PMID>
<DateCreated><Year>2014</Year>
<Month>11</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>04</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1550-6606</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>193</Volume>
<Issue>11</Issue>
<PubDate><Year>2014</Year>
<Month>Dec</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Journal of immunology (Baltimore, Md. : 1950)</Title>
<ISOAbbreviation>J. Immunol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.</ArticleTitle>
<Pagination><MedlinePgn>5626-36</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.4049/jimmunol.1401017</ELocationID>
<Abstract><AbstractText>Despite progress toward understanding the correlates of protective T cell immunity in HIV infection, the optimal approach to Ag delivery by vaccination remains uncertain. We characterized two immunodominant CD8 T cell populations generated in response to immunization of BALB/c mice with a replication-deficient adenovirus serotype 5 vector expressing the HIV-derived Gag and Pol proteins at equivalent levels. The Gag-AI9/H-2K(d) epitope elicited high-avidity CD8 T cell populations with architecturally diverse clonotypic repertoires that displayed potent lytic activity in vivo. In contrast, the Pol-LI9/H-2D(d) epitope elicited motif-constrained CD8 T cell repertoires that displayed lower levels of physical avidity and lytic activity despite equivalent measures of overall clonality. Although low-dose vaccination enhanced the functional profiles of both epitope-specific CD8 T cell populations, greater polyfunctionality was apparent within the Pol-LI9/H-2D(d) specificity. Higher proportions of central memory-like cells were present after low-dose vaccination and at later time points. However, there were no noteworthy phenotypic differences between epitope-specific CD8 T cell populations across vaccine doses or time points. Collectively, these data indicate that the functional and phenotypic properties of vaccine-induced CD8 T cell populations are sensitive to dose manipulation, yet constrained by epitope specificity in a clonotype-dependent manner.</AbstractText>
<CopyrightInformation>Copyright © 2014 by The American Association of Immunologists, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hill</LastName>
<ForeName>Brenna J</ForeName>
<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Darrah</LastName>
<ForeName>Patricia A</ForeName>
<Initials>PA</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ende</LastName>
<ForeName>Zachary</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ambrozak</LastName>
<ForeName>David R</ForeName>
<Initials>DR</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Quinn</LastName>
<ForeName>Kylie M</ForeName>
<Initials>KM</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Darko</LastName>
<ForeName>Sam</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gostick</LastName>
<ForeName>Emma</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wooldridge</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Faculty of Medical and Veterinary Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van den Berg</LastName>
<ForeName>Hugo A</ForeName>
<Initials>HA</Initials>
<AffiliationInfo><Affiliation>Mathematics Institute, University of Warwick, Coventry CV4 7AL, United Kingdom;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Venturi</LastName>
<ForeName>Vanessa</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Computational Biology Group, Centre for Vascular Research, University of New South Wales, Kensington 2052, New South Wales, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Larsen</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>INSERM, U1135, Centre d'Immunologie et des Maladies Infectieuses, F-75013 Paris, France; and Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, Université Pierre et Marie Curie (Université Paris 06), CR7, F-75013 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davenport</LastName>
<ForeName>Miles P</ForeName>
<Initials>MP</Initials>
<AffiliationInfo><Affiliation>Computational Biology Group, Centre for Vascular Research, University of New South Wales, Kensington 2052, New South Wales, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seder</LastName>
<ForeName>Robert A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Price</LastName>
<ForeName>David A</ForeName>
<Initials>DA</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom; ddouek@mail.nih.gov priced6@cardiff.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Douek</LastName>
<ForeName>Daniel C</ForeName>
<Initials>DC</Initials>
<AffiliationInfo><Affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ddouek@mail.nih.gov priced6@cardiff.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>100326</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>10</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Immunol</MedlineTA>
<NlmUniqueID>2985117R</NlmUniqueID>
<ISSNLinking>0022-1767</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016915">AIDS Vaccines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006183">H-2 Antigens</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C024755">H-2K(K) antigen</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064532">Histocompatibility Antigen H-2D</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016056">Immunodominant Epitopes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054301">gag Gene Products, Human Immunodeficiency Virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054302">pol Gene Products, Human Immunodeficiency Virus</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.

Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.

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