Prenatal management of the fetus with isolated congenital diaphragmatic hernia in the era of the TOTAL trial.
Identifieur interne : 003138 ( PubMed/Curation ); précédent : 003137; suivant : 003139Prenatal management of the fetus with isolated congenital diaphragmatic hernia in the era of the TOTAL trial.
Auteurs : Jan Deprest [Belgique] ; Paul Brady [Belgique] ; Kypros Nicolaides [Royaume-Uni] ; Alexandra Benachi [France] ; Christoph Berg [Allemagne] ; Joris Vermeesch [Belgique] ; Glenn Gardener [Australie] ; Eduard Gratacos [Espagne]Source :
- Seminars in fetal & neonatal medicine [ 1878-0946 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Hernies diaphragmatiques congénitales.
- malformations : Poumon.
- Femelle, Foetoscopie, Foetus, Grossesse, Hernies diaphragmatiques congénitales, Humains, Prise en charge de la maladie, Résultat thérapeutique, Échographie prénatale.
English descriptors
- KwdEn :
- MESH :
- abnormalities : Lung.
- diagnosis : Hernias, Diaphragmatic, Congenital.
- surgery : Fetus, Hernias, Diaphragmatic, Congenital.
- Disease Management, Female, Fetoscopy, Humans, Pregnancy, Treatment Outcome, Ultrasonography, Prenatal.
Abstract
Congenital diaphragmatic hernia (CDH) may be isolated or associated with other structural anomalies, the latter with poor prognosis. The defect allows viscera to herniate through the defect into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. When isolated, survival chances can be predicted by antenatal measurement of lung size and liver herniation. Chromosomal microarrays and exome sequencing contribute to understanding genetic factors underlying isolated CDH. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia. The Tracheal Occlusion To Accelerate Lung growth trial (www.totaltrial.eu) is an international randomized trial investigating the role of fetal therapy for severe and moderate pulmonary hypoplasia. Despite an apparent increase in survival following FETO, the search for lesser invasive and more potent prenatal interventions must continue.
DOI: 10.1016/j.siny.2014.09.006
PubMed: 25447987
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BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25447987</idno><idno type="pmid">25447987</idno><idno type="doi">10.1016/j.siny.2014.09.006</idno><idno type="wicri:Area/PubMed/Corpus">003248</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003248</idno><idno type="wicri:Area/PubMed/Curation">003138</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003138</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prenatal management of the fetus with isolated congenital diaphragmatic hernia in the era of the TOTAL trial.</title><author><name sortKey="Deprest, Jan" sort="Deprest, Jan" uniqKey="Deprest J" first="Jan" last="Deprest">Jan Deprest</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynaecology, University Hospitals Leuven, and Academic Department of Development and Regeneration, Organ System Cluster, Leuven, Belgium; TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial). Electronic address: Jan.Deprest@uzleuven.be.</nlm:affiliation><country wicri:rule="url">Belgique</country></affiliation></author><author><name sortKey="Brady, Paul" sort="Brady, Paul" uniqKey="Brady P" first="Paul" last="Brady">Paul Brady</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, University Hospitals Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Genetics, University Hospitals Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Nicolaides, Kypros" sort="Nicolaides, Kypros" uniqKey="Nicolaides K" first="Kypros" last="Nicolaides">Kypros Nicolaides</name><affiliation wicri:level="1"><nlm:affiliation>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Harris Birthright Centre, King's College Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Harris Birthright Centre, King's College Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Benachi, Alexandra" sort="Benachi, Alexandra" uniqKey="Benachi A" first="Alexandra" last="Benachi">Alexandra Benachi</name><affiliation wicri:level="1"><nlm:affiliation>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Department of Obstetrics, Gynaecology and Reproductive Medicine, Hôpital Antoine Beclere, University Paris Sud, Clamart, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Department of Obstetrics, Gynaecology and Reproductive Medicine, Hôpital Antoine Beclere, University Paris Sud, Clamart</wicri:regionArea></affiliation></author><author><name sortKey="Berg, Christoph" sort="Berg, Christoph" uniqKey="Berg C" first="Christoph" last="Berg">Christoph Berg</name><affiliation wicri:level="1"><nlm:affiliation>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Division of Fetal Surgery, Department of Obstetrics and Prenatal Medicine, University of Bonn, and Department of Obstetrics and Gynecology, University of Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Division of Fetal Surgery, Department of Obstetrics and Prenatal Medicine, University of Bonn, and Department of Obstetrics and Gynecology, University of Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Vermeesch, Joris" sort="Vermeesch, Joris" uniqKey="Vermeesch J" first="Joris" last="Vermeesch">Joris Vermeesch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Human Genetics, University Hospitals Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Genetics, University Hospitals Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Gardener, Glenn" sort="Gardener, Glenn" uniqKey="Gardener G" first="Glenn" last="Gardener">Glenn Gardener</name><affiliation wicri:level="1"><nlm:affiliation>Mater Health Services, Mater Research UQ, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Mater Health Services, Mater Research UQ, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Gratacos, Eduard" sort="Gratacos, Eduard" uniqKey="Gratacos E" first="Eduard" last="Gratacos">Eduard Gratacos</name><affiliation wicri:level="1"><nlm:affiliation>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona</wicri:regionArea></affiliation></author></analytic><series><title level="j">Seminars in fetal & neonatal medicine</title><idno type="eISSN">1878-0946</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease Management</term><term>Female</term><term>Fetoscopy</term><term>Fetus (surgery)</term><term>Hernias, Diaphragmatic, Congenital (diagnosis)</term><term>Hernias, Diaphragmatic, Congenital (surgery)</term><term>Humans</term><term>Lung (abnormalities)</term><term>Pregnancy</term><term>Treatment Outcome</term><term>Ultrasonography, Prenatal</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Foetoscopie</term><term>Foetus ()</term><term>Grossesse</term><term>Hernies diaphragmatiques congénitales ()</term><term>Hernies diaphragmatiques congénitales (diagnostic)</term><term>Humains</term><term>Poumon (malformations)</term><term>Prise en charge de la maladie</term><term>Résultat thérapeutique</term><term>Échographie prénatale</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hernias, Diaphragmatic, Congenital</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hernies diaphragmatiques congénitales</term></keywords><keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Fetus</term><term>Hernias, Diaphragmatic, Congenital</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Management</term><term>Female</term><term>Fetoscopy</term><term>Humans</term><term>Pregnancy</term><term>Treatment Outcome</term><term>Ultrasonography, Prenatal</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Foetoscopie</term><term>Foetus</term><term>Grossesse</term><term>Hernies diaphragmatiques congénitales</term><term>Humains</term><term>Prise en charge de la maladie</term><term>Résultat thérapeutique</term><term>Échographie prénatale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Congenital diaphragmatic hernia (CDH) may be isolated or associated with other structural anomalies, the latter with poor prognosis. The defect allows viscera to herniate through the defect into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. When isolated, survival chances can be predicted by antenatal measurement of lung size and liver herniation. Chromosomal microarrays and exome sequencing contribute to understanding genetic factors underlying isolated CDH. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia. The Tracheal Occlusion To Accelerate Lung growth trial (www.totaltrial.eu) is an international randomized trial investigating the role of fetal therapy for severe and moderate pulmonary hypoplasia. Despite an apparent increase in survival following FETO, the search for lesser invasive and more potent prenatal interventions must continue.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25447987</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>08</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>07</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-0946</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Seminars in fetal & neonatal medicine</Title><ISOAbbreviation>Semin Fetal Neonatal Med</ISOAbbreviation></Journal><ArticleTitle>Prenatal management of the fetus with isolated congenital diaphragmatic hernia in the era of the TOTAL trial.</ArticleTitle><Pagination><MedlinePgn>338-48</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.siny.2014.09.006</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1744-165X(14)00076-6</ELocationID><Abstract><AbstractText>Congenital diaphragmatic hernia (CDH) may be isolated or associated with other structural anomalies, the latter with poor prognosis. The defect allows viscera to herniate through the defect into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. When isolated, survival chances can be predicted by antenatal measurement of lung size and liver herniation. Chromosomal microarrays and exome sequencing contribute to understanding genetic factors underlying isolated CDH. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia. The Tracheal Occlusion To Accelerate Lung growth trial (www.totaltrial.eu) is an international randomized trial investigating the role of fetal therapy for severe and moderate pulmonary hypoplasia. Despite an apparent increase in survival following FETO, the search for lesser invasive and more potent prenatal interventions must continue.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deprest</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynaecology, University Hospitals Leuven, and Academic Department of Development and Regeneration, Organ System Cluster, Leuven, Belgium; TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial). Electronic address: Jan.Deprest@uzleuven.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brady</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, University Hospitals Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicolaides</LastName><ForeName>Kypros</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Harris Birthright Centre, King's College Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benachi</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Department of Obstetrics, Gynaecology and Reproductive Medicine, Hôpital Antoine Beclere, University Paris Sud, Clamart, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berg</LastName><ForeName>Christoph</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); Division of Fetal Surgery, Department of Obstetrics and Prenatal Medicine, University of Bonn, and Department of Obstetrics and Gynecology, University of Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vermeesch</LastName><ForeName>Joris</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, University Hospitals Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gardener</LastName><ForeName>Glenn</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Mater Health Services, Mater Research UQ, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gratacos</LastName><ForeName>Eduard</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>TOTAL Consortium (Tracheal Occlusion To Accelerate Lung Growth Trial); BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Semin Fetal Neonatal Med</MedlineTA><NlmUniqueID>101240003</NlmUniqueID><ISSNLinking>1744-165X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019468" MajorTopicYN="N">Disease Management</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005332" MajorTopicYN="Y">Fetoscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005333" MajorTopicYN="N">Fetus</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065630" MajorTopicYN="N">Hernias, Diaphragmatic, Congenital</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000002" MajorTopicYN="Y">abnormalities</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016216" MajorTopicYN="N">Ultrasonography, Prenatal</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chromosomal microarrays</Keyword><Keyword MajorTopicYN="N">Congenital diaphragmatic hernia</Keyword><Keyword MajorTopicYN="N">Exome sequencing</Keyword><Keyword MajorTopicYN="N">Fetal surgery</Keyword><Keyword MajorTopicYN="N">Pulmonary hypoplasia</Keyword><Keyword MajorTopicYN="N">Tracheal occlusion</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25447987</ArticleId><ArticleId IdType="pii">S1744-165X(14)00076-6</ArticleId><ArticleId IdType="doi">10.1016/j.siny.2014.09.006</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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