A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis.
Identifieur interne : 002D28 ( PubMed/Curation ); précédent : 002D27; suivant : 002D29A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis.
Auteurs : Lavinia Palamiuc [France] ; Anna Schlagowski [France] ; Shyuan T. Ngo [Australie] ; Aurelia Vernay [France] ; Sylvie Dirrig-Grosch [France] ; Alexandre Henriques [France] ; Anne-Laurence Boutillier [France] ; Joffrey Zoll [France] ; Andoni Echaniz-Laguna [France] ; Jean-Philippe Loeffler [France] ; Frédérique René [France]Source :
- EMBO molecular medicine [ 1757-4684 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Sclérose latérale amyotrophique.
- métabolisme : Muscles.
- physiologie : Muscles.
- physiopathologie : Sclérose latérale amyotrophique.
- Animaux, Glycolyse, Modèles animaux de maladie humaine, Métabolisme des lipides, Souris.
English descriptors
- KwdEn :
- MESH :
- metabolism : Muscles.
- pathology : Amyotrophic Lateral Sclerosis.
- physiology : Muscles.
- physiopathology : Amyotrophic Lateral Sclerosis.
- Animals, Disease Models, Animal, Glycolysis, Lipid Metabolism, Mice.
Abstract
Amyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease in adults. Numerous studies indicate that ALS is a systemic disease that affects whole body physiology and metabolic homeostasis. Using a mouse model of the disease (SOD1(G86R)), we investigated muscle physiology and motor behavior with respect to muscle metabolic capacity. We found that at 65 days of age, an age described as asymptomatic, SOD1(G86R) mice presented with improved endurance capacity associated with an early inhibition in the capacity for glycolytic muscle to use glucose as a source of energy and a switch in fuel preference toward lipids. Indeed, in glycolytic muscles we showed progressive induction of pyruvate dehydrogenase kinase 4 expression. Phosphofructokinase 1 was inhibited, and the expression of lipid handling molecules was increased. This mechanism represents a chronic pathologic alteration in muscle metabolism that is exacerbated with disease progression. Further, inhibition of pyruvate dehydrogenase kinase 4 activity with dichloroacetate delayed symptom onset while improving mitochondrial dysfunction and ameliorating muscle denervation. In this study, we provide the first molecular basis for the particular sensitivity of glycolytic muscles to ALS pathology.
DOI: 10.15252/emmm.201404433
PubMed: 25820275
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Ngo</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, The University of Queensland, St Lucia, Qld, Australia University of Queensland Centre for Clinical Research, The University of Queensland, Herston, Qld, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences, The University of Queensland, St Lucia, Qld, Australia University of Queensland Centre for Clinical Research, The University of Queensland, Herston, Qld</wicri:regionArea></affiliation></author><author><name sortKey="Vernay, Aurelia" sort="Vernay, Aurelia" uniqKey="Vernay A" first="Aurelia" last="Vernay">Aurelia Vernay</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Dirrig Grosch, Sylvie" sort="Dirrig Grosch, Sylvie" uniqKey="Dirrig Grosch S" first="Sylvie" last="Dirrig-Grosch">Sylvie Dirrig-Grosch</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Henriques, Alexandre" sort="Henriques, Alexandre" uniqKey="Henriques A" first="Alexandre" last="Henriques">Alexandre Henriques</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Boutillier, Anne Laurence" sort="Boutillier, Anne Laurence" uniqKey="Boutillier A" first="Anne-Laurence" last="Boutillier">Anne-Laurence Boutillier</name><affiliation wicri:level="1"><nlm:affiliation>UMR7364 Laboratoire de Neurosciences Cognitives et Adaptatives, Faculté de Psychologie, Université de Strasbourg-CNRS, GDR CNRS 2905, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR7364 Laboratoire de Neurosciences Cognitives et Adaptatives, Faculté de Psychologie, Université de Strasbourg-CNRS, GDR CNRS 2905, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Zoll, Joffrey" sort="Zoll, Joffrey" uniqKey="Zoll J" first="Joffrey" last="Zoll">Joffrey Zoll</name><affiliation wicri:level="1"><nlm:affiliation>Equipe d'Accueil 3072, Mitochondrie, Stress oxydant et Protection Musculaire, Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France Service de Physiologie et d'Explorations Fonctionnelles, Pôle de Pathologie Thoracique Hôpitaux Universitaires, CHRU de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe d'Accueil 3072, Mitochondrie, Stress oxydant et Protection Musculaire, Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France Service de Physiologie et d'Explorations Fonctionnelles, Pôle de Pathologie Thoracique Hôpitaux Universitaires, CHRU de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Echaniz Laguna, Andoni" sort="Echaniz Laguna, Andoni" uniqKey="Echaniz Laguna A" first="Andoni" last="Echaniz-Laguna">Andoni Echaniz-Laguna</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France Département de Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France Département de Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Loeffler, Jean Philippe" sort="Loeffler, Jean Philippe" uniqKey="Loeffler J" first="Jean-Philippe" last="Loeffler">Jean-Philippe Loeffler</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France loeffler@unistra.fr frederique.rene@unistra.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Rene, Frederique" sort="Rene, Frederique" uniqKey="Rene F" first="Frédérique" last="René">Frédérique René</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France loeffler@unistra.fr frederique.rene@unistra.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM, U1118 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first="Lavinia" last="Palamiuc">Lavinia Palamiuc</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Schlagowski, Anna" sort="Schlagowski, Anna" uniqKey="Schlagowski A" first="Anna" last="Schlagowski">Anna Schlagowski</name><affiliation wicri:level="1"><nlm:affiliation>Equipe d'Accueil 3072, Mitochondrie, Stress oxydant et Protection Musculaire, Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France Service de Physiologie et d'Explorations Fonctionnelles, Pôle de Pathologie Thoracique Hôpitaux Universitaires, CHRU de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe d'Accueil 3072, Mitochondrie, Stress oxydant et Protection Musculaire, Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France Service de Physiologie et d'Explorations Fonctionnelles, Pôle de Pathologie Thoracique Hôpitaux Universitaires, CHRU de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Ngo, Shyuan T" sort="Ngo, Shyuan T" uniqKey="Ngo S" first="Shyuan T" last="Ngo">Shyuan T. Ngo</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, The University of Queensland, St Lucia, Qld, Australia University of Queensland Centre for Clinical Research, The University of Queensland, Herston, Qld, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences, The University of Queensland, St Lucia, Qld, Australia University of Queensland Centre for Clinical Research, The University of Queensland, Herston, Qld</wicri:regionArea></affiliation></author><author><name sortKey="Vernay, Aurelia" sort="Vernay, Aurelia" uniqKey="Vernay A" first="Aurelia" last="Vernay">Aurelia Vernay</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Dirrig Grosch, Sylvie" sort="Dirrig Grosch, Sylvie" uniqKey="Dirrig Grosch S" first="Sylvie" last="Dirrig-Grosch">Sylvie Dirrig-Grosch</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Henriques, Alexandre" sort="Henriques, Alexandre" uniqKey="Henriques A" first="Alexandre" last="Henriques">Alexandre Henriques</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Boutillier, Anne Laurence" sort="Boutillier, Anne Laurence" uniqKey="Boutillier A" first="Anne-Laurence" last="Boutillier">Anne-Laurence Boutillier</name><affiliation wicri:level="1"><nlm:affiliation>UMR7364 Laboratoire de Neurosciences Cognitives et Adaptatives, Faculté de Psychologie, Université de Strasbourg-CNRS, GDR CNRS 2905, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR7364 Laboratoire de Neurosciences Cognitives et Adaptatives, Faculté de Psychologie, Université de Strasbourg-CNRS, GDR CNRS 2905, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Zoll, Joffrey" sort="Zoll, Joffrey" uniqKey="Zoll J" first="Joffrey" last="Zoll">Joffrey Zoll</name><affiliation wicri:level="1"><nlm:affiliation>Equipe d'Accueil 3072, Mitochondrie, Stress oxydant et Protection Musculaire, Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France Service de Physiologie et d'Explorations Fonctionnelles, Pôle de Pathologie Thoracique Hôpitaux Universitaires, CHRU de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe d'Accueil 3072, Mitochondrie, Stress oxydant et Protection Musculaire, Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France Service de Physiologie et d'Explorations Fonctionnelles, Pôle de Pathologie Thoracique Hôpitaux Universitaires, CHRU de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Echaniz Laguna, Andoni" sort="Echaniz Laguna, Andoni" uniqKey="Echaniz Laguna A" first="Andoni" last="Echaniz-Laguna">Andoni Echaniz-Laguna</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France Département de Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France Département de Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Loeffler, Jean Philippe" sort="Loeffler, Jean Philippe" uniqKey="Loeffler J" first="Jean-Philippe" last="Loeffler">Jean-Philippe Loeffler</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France loeffler@unistra.fr frederique.rene@unistra.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Rene, Frederique" sort="Rene, Frederique" uniqKey="Rene F" first="Frédérique" last="René">Frédérique René</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France loeffler@unistra.fr frederique.rene@unistra.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg</wicri:regionArea></affiliation></author></analytic><series><title level="j">EMBO molecular medicine</title><idno type="eISSN">1757-4684</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amyotrophic Lateral Sclerosis (pathology)</term><term>Amyotrophic Lateral Sclerosis (physiopathology)</term><term>Animals</term><term>Disease Models, Animal</term><term>Glycolysis</term><term>Lipid Metabolism</term><term>Mice</term><term>Muscles (metabolism)</term><term>Muscles (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Glycolyse</term><term>Modèles animaux de maladie humaine</term><term>Muscles (métabolisme)</term><term>Muscles (physiologie)</term><term>Métabolisme des lipides</term><term>Sclérose latérale amyotrophique (anatomopathologie)</term><term>Sclérose latérale amyotrophique (physiopathologie)</term><term>Souris</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Sclérose latérale amyotrophique</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Sclérose latérale amyotrophique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Glycolysis</term><term>Lipid Metabolism</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Glycolyse</term><term>Modèles animaux de maladie humaine</term><term>Métabolisme des lipides</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Amyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease in adults. Numerous studies indicate that ALS is a systemic disease that affects whole body physiology and metabolic homeostasis. Using a mouse model of the disease (SOD1(G86R)), we investigated muscle physiology and motor behavior with respect to muscle metabolic capacity. We found that at 65 days of age, an age described as asymptomatic, SOD1(G86R) mice presented with improved endurance capacity associated with an early inhibition in the capacity for glycolytic muscle to use glucose as a source of energy and a switch in fuel preference toward lipids. Indeed, in glycolytic muscles we showed progressive induction of pyruvate dehydrogenase kinase 4 expression. Phosphofructokinase 1 was inhibited, and the expression of lipid handling molecules was increased. This mechanism represents a chronic pathologic alteration in muscle metabolism that is exacerbated with disease progression. Further, inhibition of pyruvate dehydrogenase kinase 4 activity with dichloroacetate delayed symptom onset while improving mitochondrial dysfunction and ameliorating muscle denervation. In this study, we provide the first molecular basis for the particular sensitivity of glycolytic muscles to ALS pathology.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25820275</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>05</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>25</Day></DateCompleted><DateRevised><Year>2017</Year><Month>03</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1757-4684</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>EMBO molecular medicine</Title><ISOAbbreviation>EMBO Mol Med</ISOAbbreviation></Journal><ArticleTitle>A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis.</ArticleTitle><Pagination><MedlinePgn>526-46</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.15252/emmm.201404433</ELocationID><Abstract><AbstractText>Amyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease in adults. Numerous studies indicate that ALS is a systemic disease that affects whole body physiology and metabolic homeostasis. Using a mouse model of the disease (SOD1(G86R)), we investigated muscle physiology and motor behavior with respect to muscle metabolic capacity. We found that at 65 days of age, an age described as asymptomatic, SOD1(G86R) mice presented with improved endurance capacity associated with an early inhibition in the capacity for glycolytic muscle to use glucose as a source of energy and a switch in fuel preference toward lipids. Indeed, in glycolytic muscles we showed progressive induction of pyruvate dehydrogenase kinase 4 expression. Phosphofructokinase 1 was inhibited, and the expression of lipid handling molecules was increased. This mechanism represents a chronic pathologic alteration in muscle metabolism that is exacerbated with disease progression. Further, inhibition of pyruvate dehydrogenase kinase 4 activity with dichloroacetate delayed symptom onset while improving mitochondrial dysfunction and ameliorating muscle denervation. In this study, we provide the first molecular basis for the particular sensitivity of glycolytic muscles to ALS pathology.</AbstractText><CopyrightInformation>© 2015 The Authors. Published under the terms of the CC BY 4.0 license.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Palamiuc</LastName><ForeName>Lavinia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schlagowski</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Equipe d'Accueil 3072, Mitochondrie, Stress oxydant et Protection Musculaire, Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France Service de Physiologie et d'Explorations Fonctionnelles, Pôle de Pathologie Thoracique Hôpitaux Universitaires, CHRU de Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ngo</LastName><ForeName>Shyuan T</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences, The University of Queensland, St Lucia, Qld, Australia University of Queensland Centre for Clinical Research, The University of Queensland, Herston, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vernay</LastName><ForeName>Aurelia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dirrig-Grosch</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henriques</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boutillier</LastName><ForeName>Anne-Laurence</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>UMR7364 Laboratoire de Neurosciences Cognitives et Adaptatives, Faculté de Psychologie, Université de Strasbourg-CNRS, GDR CNRS 2905, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zoll</LastName><ForeName>Joffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Equipe d'Accueil 3072, Mitochondrie, Stress oxydant et Protection Musculaire, Fédération de Médecine Translationelle de Strasbourg, Université de Strasbourg, Strasbourg, France Service de Physiologie et d'Explorations Fonctionnelles, Pôle de Pathologie Thoracique Hôpitaux Universitaires, CHRU de Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Echaniz-Laguna</LastName><ForeName>Andoni</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France Département de Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loeffler</LastName><ForeName>Jean-Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France loeffler@unistra.fr frederique.rene@unistra.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>René</LastName><ForeName>Frédérique</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM, U1118 Mécanismes Centraux et Périphériques de la Neurodégénérescence, Strasbourg, France Université de Strasbourg UMRS1118, Strasbourg, France loeffler@unistra.fr frederique.rene@unistra.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>EMBO Mol Med</MedlineTA><NlmUniqueID>101487380</NlmUniqueID><ISSNLinking>1757-4676</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Front Physiol. 2014 Jul 31;5:282</RefSource><PMID Version="1">25132820</PMID></CommentsCorrections><CommentsCorrections 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Version="1">24021858</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000690" MajorTopicYN="N">Amyotrophic Lateral Sclerosis</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006019" MajorTopicYN="Y">Glycolysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050356" MajorTopicYN="Y">Lipid Metabolism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009132" MajorTopicYN="N">Muscles</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4492815</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">amyotrophic lateral sclerosis</Keyword><Keyword MajorTopicYN="N">exercise</Keyword><Keyword MajorTopicYN="N">glucose</Keyword><Keyword MajorTopicYN="N">lipids</Keyword><Keyword MajorTopicYN="N">muscle</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25820275</ArticleId><ArticleId IdType="pii">emmm.201404433</ArticleId><ArticleId IdType="doi">10.15252/emmm.201404433</ArticleId><ArticleId IdType="pmc">PMC4492815</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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