AustralieFrV1, PubMed, Curation, bibRecord, 002C77

Neuregulin 1 expression and electrophysiological abnormalities in the Neuregulin 1 transmembrane domain heterozygous mutant mouse.

Identifieur interne : 002C77 ( PubMed/Curation ); précédent : 002C76; suivant : 002C78

Neuregulin 1 expression and electrophysiological abnormalities in the Neuregulin 1 transmembrane domain heterozygous mutant mouse.

Auteurs : Leonora E. Long [Australie] ; Paul Anderson [Australie] ; Elisabeth Frank [Australie] ; Alex Shaw [Australie] ; Shijie Liu [Australie] ; Xu-Feng Huang [Australie] ; Didier Pinault [France] ; Tim Karl [Australie] ; Terence J. O'Brien [Australie] ; Cynthia Shannon Weickert [Australie] ; Nigel C. Jones [Australie]

Source :

PloS one [ 1932-6203 ] ; 2015.

RBID : pubmed:25992564

Descripteurs français

KwdFr :
- ARN messager (génétique), Animaux, Encéphale (métabolisme), Encéphale (physiologie), Femelle, Hétérozygote, Locomotion, Mâle, Neuréguline-1 (génétique), Neuréguline-1 (physiologie), Phosphorylation, Récepteurs du N-méthyl-D-aspartate (génétique), Récepteurs du N-méthyl-D-aspartate (métabolisme), Souches mutantes de souris, Souris, Électroencéphalographie.
MESH :
- génétique : ARN messager, Neuréguline-1, Récepteurs du N-méthyl-D-aspartate.
- métabolisme : Encéphale, Récepteurs du N-méthyl-D-aspartate.
- physiologie : Encéphale, Neuréguline-1.
- Animaux, Femelle, Hétérozygote, Locomotion, Mâle, Phosphorylation, Souches mutantes de souris, Souris, Électroencéphalographie.

English descriptors

KwdEn :
- Animals, Brain (metabolism), Brain (physiology), Electroencephalography, Female, Heterozygote, Locomotion, Male, Mice, Mice, Mutant Strains, Neuregulin-1 (genetics), Neuregulin-1 (physiology), Phosphorylation, RNA, Messenger (genetics), Receptors, N-Methyl-D-Aspartate (genetics), Receptors, N-Methyl-D-Aspartate (metabolism).
MESH :
- chemical , genetics : Neuregulin-1, RNA, Messenger, Receptors, N-Methyl-D-Aspartate.
- metabolism : Brain, Receptors, N-Methyl-D-Aspartate.
- physiology : Brain, Neuregulin-1.
- Animals, Electroencephalography, Female, Heterozygote, Locomotion, Male, Mice, Mice, Mutant Strains, Phosphorylation.

Abstract

The Neuregulin 1 transmembrane domain heterozygous mutant (Nrg1 TM HET) mouse is used to investigate the role of Nrg1 in brain function and schizophrenia-like behavioural phenotypes. However, the molecular alterations in brain Nrg1 expression that underpin the behavioural observations have been assumed, but not directly determined. Here we comprehensively characterise mRNA Nrg1 transcripts throughout development of the Nrg1 TM HET mouse. In addition, we investigate the regulation of high-frequency (gamma) electrophysiological oscillations in this mutant mouse to associate molecular changes in Nrg1 with a schizophrenia-relevant neurophysiological profile.

DOI: 10.1371/journal.pone.0124114
PubMed: 25992564

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<term>Brain (metabolism)</term>
<term>Brain (physiology)</term>
<term>Electroencephalography</term>
<term>Female</term>
<term>Heterozygote</term>
<term>Locomotion</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Mutant Strains</term>
<term>Neuregulin-1 (genetics)</term>
<term>Neuregulin-1 (physiology)</term>
<term>Phosphorylation</term>
<term>RNA, Messenger (genetics)</term>
<term>Receptors, N-Methyl-D-Aspartate (genetics)</term>
<term>Receptors, N-Methyl-D-Aspartate (metabolism)</term>
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<term>Hétérozygote</term>
<term>Locomotion</term>
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<term>Récepteurs du N-méthyl-D-aspartate (métabolisme)</term>
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<term>Souris</term>
<term>Électroencéphalographie</term>
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<term>Receptors, N-Methyl-D-Aspartate</term>
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<term>Mice, Mutant Strains</term>
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<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">The Neuregulin 1 transmembrane domain heterozygous mutant (Nrg1 TM HET) mouse is used to investigate the role of Nrg1 in brain function and schizophrenia-like behavioural phenotypes. However, the molecular alterations in brain Nrg1 expression that underpin the behavioural observations have been assumed, but not directly determined. Here we comprehensively characterise mRNA Nrg1 transcripts throughout development of the Nrg1 TM HET mouse. In addition, we investigate the regulation of high-frequency (gamma) electrophysiological oscillations in this mutant mouse to associate molecular changes in Nrg1 with a schizophrenia-relevant neurophysiological profile.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25992564</PMID>
<DateCreated><Year>2015</Year>
<Month>05</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>04</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>5</Issue>
<PubDate><Year>2015</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Neuregulin 1 expression and electrophysiological abnormalities in the Neuregulin 1 transmembrane domain heterozygous mutant mouse.</ArticleTitle>
<Pagination><MedlinePgn>e0124114</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0124114</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The Neuregulin 1 transmembrane domain heterozygous mutant (Nrg1 TM HET) mouse is used to investigate the role of Nrg1 in brain function and schizophrenia-like behavioural phenotypes. However, the molecular alterations in brain Nrg1 expression that underpin the behavioural observations have been assumed, but not directly determined. Here we comprehensively characterise mRNA Nrg1 transcripts throughout development of the Nrg1 TM HET mouse. In addition, we investigate the regulation of high-frequency (gamma) electrophysiological oscillations in this mutant mouse to associate molecular changes in Nrg1 with a schizophrenia-relevant neurophysiological profile.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Using exonic probes spanning the cysteine-rich, epidermal growth factor (EGF)-like, transmembrane and intracellular domain encoding regions of Nrg1, mRNA levels were measured using qPCR in hippocampus and frontal cortex from male and female Nrg1 TM HET and wild type-like (WT) mice throughout development. We also performed electrophysiological recordings in adult mice and analysed gamma oscillatory at baseline, in responses to auditory stimuli and to ketamine.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In both hippocampus and cortex, Nrg1 TM HET mice show significantly reduced expression of the exon encoding the transmembrane domain of Nrg1 compared with WT, but unaltered mRNA expression encoding the extracellular bioactive EGF-like and the cysteine-rich (type III) domains, and development-specific and region-specific reductions in the mRNA encoding the intracellular domain. Hippocampal Nrg1 protein expression was not altered, but NMDA receptor NR2B subunit phosphorylation was lower in Nrg1 TM HET mice. We identified elevated ongoing and reduced sensory-evoked gamma power in Nrg1 TM HET mice.</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">We found no evidence to support the claim that the Nrg1 TM HET mouse represents a simple haploinsufficient model. Further research is required to explore the possibility that mutation results in a gain of Nrg1 function.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Long</LastName>
<ForeName>Leonora E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Schizophrenia Research Institute, Sydney, New South Wales, Australia; Neuroscience Research Australia, Randwick, New South Wales, Australia; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anderson</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frank</LastName>
<ForeName>Elisabeth</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Schizophrenia Research Institute, Sydney, New South Wales, Australia; University of Wollongong, Wollongong, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shaw</LastName>
<ForeName>Alex</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Schizophrenia Research Institute, Sydney, New South Wales, Australia; Neuroscience Research Australia, Randwick, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Shijie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Xu-Feng</ForeName>
<Initials>XF</Initials>
<AffiliationInfo><Affiliation>Schizophrenia Research Institute, Sydney, New South Wales, Australia; University of Wollongong, Wollongong, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pinault</LastName>
<ForeName>Didier</ForeName>
<Initials>D</Initials>
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Neuregulin 1 expression and electrophysiological abnormalities in the Neuregulin 1 transmembrane domain heterozygous mutant mouse.

Neuregulin 1 expression and electrophysiological abnormalities in the Neuregulin 1 transmembrane domain heterozygous mutant mouse.

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