Patterns and factors associated with low adherence to psychotropic medications during pregnancy--a cross-sectional, multinational web-based study.
Identifieur interne : 002C60 ( PubMed/Curation ); précédent : 002C59; suivant : 002C61Patterns and factors associated with low adherence to psychotropic medications during pregnancy--a cross-sectional, multinational web-based study.
Auteurs : Angela Lupattelli [Norvège] ; Olav Spigset [Norvège] ; Ingunn Björnsd Ttir [Norvège] ; Katri H Meen-Anttila [Finlande] ; Ann-Charlotte M Rdby [Suède] ; Alice Panchaud [Suisse] ; Romana Gjergja Juraski [Croatie] ; Gorazd Rudolf [Slovénie] ; Marina Odalovic [Serbie] ; Mariola Drozd [Pologne] ; Michael J. Twigg [Royaume-Uni] ; Herbert Juch [Autriche] ; Myla E. Moretti [Canada] ; Debra Kennedy [Australie] ; Andre Rieutord [France] ; Ksenia Zagorodnikova [Russie] ; Anneke Passier [Pays-Bas] ; Hedvig Nordeng [Norvège]Source :
- Depression and anxiety [ 1520-6394 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Comparaison interculturelle, Complications de la grossesse (psychologie), Complications de la grossesse (traitement médicamenteux), Culture (sociologie), Enquêtes et questionnaires, Femelle, Grossesse, Humains, Internet, Jeune adulte, Observance du traitement médicamenteux, Psychoanaleptiques (effets indésirables), Psychoanaleptiques (usage thérapeutique), Trouble dépressif (psychologie), Trouble dépressif (traitement médicamenteux), Troubles anxieux (psychologie), Troubles anxieux (traitement médicamenteux), Troubles mentaux (psychologie), Troubles mentaux (traitement médicamenteux), Études transversales.
- MESH :
- effets indésirables : Psychoanaleptiques.
- psychologie : Complications de la grossesse, Trouble dépressif, Troubles anxieux, Troubles mentaux.
- traitement médicamenteux : Complications de la grossesse, Trouble dépressif, Troubles anxieux, Troubles mentaux.
- usage thérapeutique : Psychoanaleptiques.
- Adulte, Comparaison interculturelle, Culture (sociologie), Enquêtes et questionnaires, Femelle, Grossesse, Humains, Internet, Jeune adulte, Observance du traitement médicamenteux, Études transversales.
English descriptors
- KwdEn :
- Adult, Anxiety Disorders (drug therapy), Anxiety Disorders (psychology), Cross-Cultural Comparison, Cross-Sectional Studies, Culture, Depressive Disorder (drug therapy), Depressive Disorder (psychology), Female, Humans, Internet, Medication Adherence, Mental Disorders (drug therapy), Mental Disorders (psychology), Pregnancy, Pregnancy Complications (drug therapy), Pregnancy Complications (psychology), Psychotropic Drugs (adverse effects), Psychotropic Drugs (therapeutic use), Surveys and Questionnaires, Young Adult.
- MESH :
- chemical , adverse effects : Psychotropic Drugs.
- drug therapy : Anxiety Disorders, Depressive Disorder, Mental Disorders, Pregnancy Complications.
- psychology : Anxiety Disorders, Depressive Disorder, Mental Disorders, Pregnancy Complications.
- chemical , therapeutic use : Psychotropic Drugs.
- Adult, Cross-Cultural Comparison, Cross-Sectional Studies, Culture, Female, Humans, Internet, Medication Adherence, Pregnancy, Surveys and Questionnaires, Young Adult.
Abstract
No previous studies have explored how closely women follow their psychotropic drug regimens during pregnancy. This study aimed to explore patterns of and factors associated with low adherence to psychotropic medication during pregnancy.
DOI: 10.1002/da.22352
PubMed: 25703355
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Petersburg</wicri:regionArea></affiliation></author><author><name sortKey="Passier, Anneke" sort="Passier, Anneke" uniqKey="Passier A" first="Anneke" last="Passier">Anneke Passier</name><affiliation wicri:level="1"><nlm:affiliation>Teratology Information Service (TIS), Netherlands Pharmacovigilance Centre Lareb, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Teratology Information Service (TIS), Netherlands Pharmacovigilance Centre Lareb</wicri:regionArea></affiliation></author><author><name sortKey="Nordeng, Hedvig" sort="Nordeng, Hedvig" uniqKey="Nordeng H" first="Hedvig" last="Nordeng">Hedvig Nordeng</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, University of Oslo, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>School of Pharmacy, University of Oslo, Oslo</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date 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Pharmacy, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Spigset, Olav" sort="Spigset, Olav" uniqKey="Spigset O" first="Olav" last="Spigset">Olav Spigset</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Pharmacology, St. Olav's University Hospital, Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Pharmacology, St. Olav's University Hospital, Trondheim</wicri:regionArea></affiliation></author><author><name sortKey="Bjornsd Ttir, Ingunn" sort="Bjornsd Ttir, Ingunn" uniqKey="Bjornsd Ttir I" first="Ingunn" last="Björnsd Ttir">Ingunn Björnsd Ttir</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, University of Oslo, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>School of Pharmacy, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="H Meen Anttila, Katri" sort="H Meen Anttila, Katri" uniqKey="H Meen Anttila K" first="Katri" last="H Meen-Anttila">Katri H Meen-Anttila</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Medicines Agency, Kuopio, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Medicines Agency, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="M Rdby, Ann Charlotte" sort="M Rdby, Ann Charlotte" uniqKey="M Rdby A" first="Ann-Charlotte" last="M Rdby">Ann-Charlotte M Rdby</name><affiliation wicri:level="1"><nlm:affiliation>Research and Development, Sahlgrenska University Hospital, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Research and Development, Sahlgrenska University Hospital, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Panchaud, Alice" sort="Panchaud, Alice" uniqKey="Panchaud A" first="Alice" last="Panchaud">Alice Panchaud</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmaceutical Sciences, University of Geneva and Lausanne, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>School of Pharmaceutical Sciences, University of Geneva and Lausanne, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Juraski, Romana Gjergja" sort="Juraski, Romana Gjergja" uniqKey="Juraski R" first="Romana Gjergja" last="Juraski">Romana Gjergja Juraski</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital Srebrnjak, Neuropediatric Unit, Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Children's Hospital Srebrnjak, Neuropediatric Unit, Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Rudolf, Gorazd" sort="Rudolf, Gorazd" uniqKey="Rudolf G" first="Gorazd" last="Rudolf">Gorazd Rudolf</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Clinical Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Odalovic, Marina" sort="Odalovic, Marina" uniqKey="Odalovic M" first="Marina" last="Odalovic">Marina Odalovic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of Pharmacy, University of Belgrade, Belgrade</wicri:regionArea></affiliation></author><author><name sortKey="Drozd, Mariola" sort="Drozd, Mariola" uniqKey="Drozd M" first="Mariola" last="Drozd">Mariola Drozd</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Pharmacy, Medical University of Lublin, Lublin</wicri:regionArea></affiliation></author><author><name sortKey="Twigg, Michael J" sort="Twigg, Michael J" uniqKey="Twigg M" first="Michael J" last="Twigg">Michael J. Twigg</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, University of East Anglia, Norwich Research Park, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Pharmacy, University of East Anglia, Norwich Research Park</wicri:regionArea></affiliation></author><author><name sortKey="Juch, Herbert" sort="Juch, Herbert" uniqKey="Juch H" first="Herbert" last="Juch">Herbert Juch</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit Human Teratogens, Institute for Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit Human Teratogens, Institute for Cell Biology, Histology and Embryology, Medical University of Graz, Graz</wicri:regionArea></affiliation></author><author><name sortKey="Moretti, Myla E" sort="Moretti, Myla E" uniqKey="Moretti M" first="Myla E" last="Moretti">Myla E. Moretti</name><affiliation wicri:level="1"><nlm:affiliation>The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Kennedy, Debra" sort="Kennedy, Debra" uniqKey="Kennedy D" first="Debra" last="Kennedy">Debra Kennedy</name><affiliation wicri:level="1"><nlm:affiliation>MotherSafe, Royal Hospital for Women and University of NSW, Randwick, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>MotherSafe, Royal Hospital for Women and University of NSW, Randwick</wicri:regionArea></affiliation></author><author><name sortKey="Rieutord, Andre" sort="Rieutord, Andre" uniqKey="Rieutord A" first="Andre" last="Rieutord">Andre Rieutord</name><affiliation wicri:level="1"><nlm:affiliation>APHP, GH HUPS, Hop Antoine Béclère, Service Pharmacie, Clamart France and Européenne de Formation pour les Pharmaciens, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHP, GH HUPS, Hop Antoine Béclère, Service Pharmacie, Clamart France and Européenne de Formation pour les Pharmaciens</wicri:regionArea></affiliation></author><author><name sortKey="Zagorodnikova, Ksenia" sort="Zagorodnikova, Ksenia" uniqKey="Zagorodnikova K" first="Ksenia" last="Zagorodnikova">Ksenia Zagorodnikova</name><affiliation wicri:level="1"><nlm:affiliation>Northwest Medical Center for Drug Safety in Pregnancy & Lactation, Northwest State Medical University n.a.I.I.Mechnikov, St. Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Northwest Medical Center for Drug Safety in Pregnancy & Lactation, Northwest State Medical University n.a.I.I.Mechnikov, St. Petersburg</wicri:regionArea></affiliation></author><author><name sortKey="Passier, Anneke" sort="Passier, Anneke" uniqKey="Passier A" first="Anneke" last="Passier">Anneke Passier</name><affiliation wicri:level="1"><nlm:affiliation>Teratology Information Service (TIS), Netherlands Pharmacovigilance Centre Lareb, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Teratology Information Service (TIS), Netherlands Pharmacovigilance Centre Lareb</wicri:regionArea></affiliation></author><author><name sortKey="Nordeng, Hedvig" sort="Nordeng, Hedvig" uniqKey="Nordeng H" first="Hedvig" last="Nordeng">Hedvig Nordeng</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, University of Oslo, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>School of Pharmacy, University of Oslo, Oslo</wicri:regionArea></affiliation></author></analytic><series><title level="j">Depression and anxiety</title><idno type="eISSN">1520-6394</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anxiety Disorders (drug therapy)</term><term>Anxiety Disorders (psychology)</term><term>Cross-Cultural Comparison</term><term>Cross-Sectional Studies</term><term>Culture</term><term>Depressive Disorder (drug therapy)</term><term>Depressive Disorder (psychology)</term><term>Female</term><term>Humans</term><term>Internet</term><term>Medication Adherence</term><term>Mental Disorders (drug therapy)</term><term>Mental Disorders (psychology)</term><term>Pregnancy</term><term>Pregnancy Complications (drug therapy)</term><term>Pregnancy Complications (psychology)</term><term>Psychotropic Drugs (adverse effects)</term><term>Psychotropic Drugs (therapeutic use)</term><term>Surveys and Questionnaires</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Comparaison interculturelle</term><term>Complications de la grossesse (psychologie)</term><term>Complications de la grossesse (traitement médicamenteux)</term><term>Culture (sociologie)</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Internet</term><term>Jeune adulte</term><term>Observance du traitement médicamenteux</term><term>Psychoanaleptiques (effets indésirables)</term><term>Psychoanaleptiques (usage thérapeutique)</term><term>Trouble dépressif (psychologie)</term><term>Trouble dépressif (traitement médicamenteux)</term><term>Troubles anxieux (psychologie)</term><term>Troubles anxieux (traitement médicamenteux)</term><term>Troubles mentaux (psychologie)</term><term>Troubles mentaux (traitement médicamenteux)</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Psychotropic Drugs</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anxiety Disorders</term><term>Depressive Disorder</term><term>Mental Disorders</term><term>Pregnancy Complications</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Psychoanaleptiques</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Complications de la grossesse</term><term>Trouble dépressif</term><term>Troubles anxieux</term><term>Troubles mentaux</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Anxiety Disorders</term><term>Depressive Disorder</term><term>Mental Disorders</term><term>Pregnancy Complications</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Psychotropic Drugs</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications de la grossesse</term><term>Trouble dépressif</term><term>Troubles anxieux</term><term>Troubles mentaux</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Psychoanaleptiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Cultural Comparison</term><term>Cross-Sectional Studies</term><term>Culture</term><term>Female</term><term>Humans</term><term>Internet</term><term>Medication Adherence</term><term>Pregnancy</term><term>Surveys and Questionnaires</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Comparaison interculturelle</term><term>Culture (sociologie)</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Internet</term><term>Jeune adulte</term><term>Observance du traitement médicamenteux</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">No previous studies have explored how closely women follow their psychotropic drug regimens during pregnancy. This study aimed to explore patterns of and factors associated with low adherence to psychotropic medication during pregnancy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25703355</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>18</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>18</Day></DateCompleted><DateRevised><Year>2015</Year><Month>05</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-6394</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Depression and anxiety</Title><ISOAbbreviation>Depress Anxiety</ISOAbbreviation></Journal><ArticleTitle>Patterns and factors associated with low adherence to psychotropic medications during pregnancy--a cross-sectional, multinational web-based study.</ArticleTitle><Pagination><MedlinePgn>426-36</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/da.22352</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">No previous studies have explored how closely women follow their psychotropic drug regimens during pregnancy. This study aimed to explore patterns of and factors associated with low adherence to psychotropic medication during pregnancy.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Multinational web-based study was performed in 18 countries in Europe, North America, and Australia. Uniform data collection was ensured via an electronic questionnaire. Pregnant women were eligible to participate. Adherence was measured via the 8-item Morisky Medication Adherence Scale (MMAS-8). The Beliefs about Prescribed Medicines Questionnaire (BMQ-specific), the Edinburgh Postnatal Depression Scale (EPDS), and a numeric rating scale were utilized to measure women's beliefs, depressive symptoms, and antidepressant risk perception, respectively. Participants reporting use of psychotropic medication during pregnancy (n = 160) were included in the analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">On the basis of the MMAS-8, 78 of 160 women (48.8%, 95% CI: 41.1-56.4%) demonstrated low adherence during pregnancy. The rates of low adherence were 51.3% for medication for anxiety, 47.2% for depression, and 42.9% for other psychiatric disorders. Smoking during pregnancy, elevated antidepressant risk perception (risk≥6), and depressive symptoms were associated with a significant 3.9-, 2.3-, and 2.5-fold increased likelihood of low medication adherence, respectively. Women on psychotropic polytherapy were less likely to demonstrate low adherence. The belief that the benefit of pharmacotherapy outweighed the risks positively correlated (r = .282) with higher medication adherence.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Approximately one of two pregnant women using psychotropic medication demonstrated low adherence in pregnancy. Life-style factors, risk perception, depressive symptoms, and individual beliefs are important factors related to adherence to psychotropic medication in pregnancy.</AbstractText><CopyrightInformation>© 2015 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lupattelli</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Pharmacy, University of Oslo, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spigset</LastName><ForeName>Olav</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacology, St. Olav's University Hospital, Trondheim, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Björnsdóttir</LastName><ForeName>Ingunn</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>School of Pharmacy, University of Oslo, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hämeen-Anttila</LastName><ForeName>Katri</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Finnish Medicines Agency, Kuopio, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mårdby</LastName><ForeName>Ann-Charlotte</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Research and Development, Sahlgrenska University Hospital, Gothenburg, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panchaud</LastName><ForeName>Alice</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Pharmaceutical Sciences, University of Geneva and Lausanne, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Juraski</LastName><ForeName>Romana Gjergja</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Children's Hospital Srebrnjak, Neuropediatric Unit, Zagreb, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rudolf</LastName><ForeName>Gorazd</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Clinical Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Odalovic</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drozd</LastName><ForeName>Mariola</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Twigg</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>School of Pharmacy, University of East Anglia, Norwich Research Park, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Juch</LastName><ForeName>Herbert</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Research Unit Human Teratogens, Institute for Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moretti</LastName><ForeName>Myla E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kennedy</LastName><ForeName>Debra</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>MotherSafe, Royal Hospital for Women and University of NSW, Randwick, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rieutord</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>APHP, GH HUPS, Hop Antoine Béclère, Service Pharmacie, Clamart France and Européenne de Formation pour les Pharmaciens, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zagorodnikova</LastName><ForeName>Ksenia</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Northwest Medical Center for Drug Safety in Pregnancy & Lactation, Northwest State Medical University n.a.I.I.Mechnikov, St. Petersburg, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Passier</LastName><ForeName>Anneke</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Teratology Information Service (TIS), Netherlands Pharmacovigilance Centre Lareb, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nordeng</LastName><ForeName>Hedvig</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>School of Pharmacy, University of Oslo, Oslo, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Depress Anxiety</MedlineTA><NlmUniqueID>9708816</NlmUniqueID><ISSNLinking>1091-4269</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011619">Psychotropic Drugs</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001008" MajorTopicYN="N">Anxiety Disorders</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003431" MajorTopicYN="N">Cross-Cultural Comparison</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003469" MajorTopicYN="N">Culture</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003866" MajorTopicYN="N">Depressive Disorder</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020407" MajorTopicYN="N">Internet</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055118" MajorTopicYN="Y">Medication Adherence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001523" MajorTopicYN="N">Mental Disorders</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011248" MajorTopicYN="N">Pregnancy Complications</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011619" MajorTopicYN="N">Psychotropic Drugs</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">adherence</Keyword><Keyword MajorTopicYN="N">antidepressants</Keyword><Keyword MajorTopicYN="N">anxiety</Keyword><Keyword MajorTopicYN="N">depression</Keyword><Keyword MajorTopicYN="N">pharmacotherapy</Keyword><Keyword MajorTopicYN="N">pregnancy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>06</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25703355</ArticleId><ArticleId 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