Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.
Identifieur interne : 002C27 ( PubMed/Curation ); précédent : 002C26; suivant : 002C28Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.
Auteurs : William H. Goodson ; Leroy Lowe [Royaume-Uni] ; David O. Carpenter [États-Unis] ; Michael Gilbertson [Canada] ; Abdul Manaf Ali [Malaisie] ; Adela Lopez De Cerain Salsamendi [Espagne] ; Ahmed Lasfar [États-Unis] ; Amancio Carnero [Espagne] ; Amaya Azqueta [Espagne] ; Amedeo Amedei [Italie] ; Amelia K. Charles [Royaume-Uni] ; Andrew R. Collins [Norvège] ; Andrew Ward [Royaume-Uni] ; Anna C. Salzberg [États-Unis] ; Annamaria Colacci [Italie] ; Ann-Karin Olsen [Norvège] ; Arthur Berg [États-Unis] ; Barry J. Barclay [Canada] ; Binhua P. Zhou [États-Unis] ; Carmen Blanco-Aparicio [Espagne] ; Carolyn J. Baglole [Canada] ; Chenfang Dong [États-Unis] ; Chiara Mondello [Italie] ; Chia-Wen Hsu [États-Unis] ; Christian C. Naus [Canada] ; Clement Yedjou [États-Unis] ; Colleen S. Curran [États-Unis] ; Dale W. Laird [Canada] ; Daniel C. Koch [États-Unis] ; Danielle J. Carlin [États-Unis] ; Dean W. Felsher [États-Unis] ; Debasish Roy [États-Unis] ; Dustin G. Brown [États-Unis] ; Edward Ratovitski [États-Unis] ; Elizabeth P. Ryan [États-Unis] ; Emanuela Corsini [Italie] ; Emilio Rojas [Mexique] ; Eun-Yi Moon [Corée du Sud] ; Ezio Laconi [Italie] ; Fabio Marongiu [Italie] ; Fahd Al-Mulla [Koweït] ; Ferdinando Chiaradonna [Italie] ; Firouz Darroudi ; Francis L. Martin [Royaume-Uni] ; Frederik J. Van Schooten [Pays-Bas] ; Gary S. Goldberg [États-Unis] ; Gerard Wagemaker [Turquie] ; Gladys N. Nangami [États-Unis] ; Gloria M. Calaf [Chili] ; Graeme Williams [Royaume-Uni] ; Gregory T. Wolf [États-Unis] ; Gudrun Koppen [Belgique] ; Gunnar Brunborg [Norvège] ; H Kim Lyerly [États-Unis] ; Harini Krishnan [États-Unis] ; Hasiah Ab Hamid [Malaisie] ; Hemad Yasaei [Royaume-Uni] ; Hideko Sone [Japon] ; Hiroshi Kondoh [Japon] ; Hosni K. Salem [Égypte] ; Hsue-Yin Hsu [Taïwan] ; Hyun Ho Park [Corée du Sud] ; Igor Koturbash [États-Unis] ; Isabelle R. Miousse [États-Unis] ; A Ivana Scovassi [Italie] ; James E. Klaunig [États-Unis] ; Jan Vondrá Ek [République tchèque] ; Jayadev Raju [Canada] ; Jesse Roman [États-Unis] ; John Pierce Wise [États-Unis] ; Jonathan R. Whitfield [Espagne] ; Jordan Woodrick [États-Unis] ; Joseph A. Christopher [Royaume-Uni] ; Josiah Ochieng [États-Unis] ; Juan Fernando Martinez-Leal [Espagne] ; Judith Weisz [États-Unis] ; Julia Kravchenko [États-Unis] ; Jun Sun [États-Unis] ; Kalan R. Prudhomme [États-Unis] ; Kannan Badri Narayanan [Corée du Sud] ; Karine A. Cohen-Solal [États-Unis] ; Kim Moorwood [Royaume-Uni] ; Laetitia Gonzalez [Belgique] ; Laura Soucek [Espagne] ; Le Jian [États-Unis] ; Leandro S. D'Abronzo [États-Unis] ; Liang-Tzung Lin [Taïwan] ; Lin Li [Hong Kong] ; Linda Gulliver [Nouvelle-Zélande] ; Lisa J. Mccawley [États-Unis] ; Lorenzo Memeo [Italie] ; Louis Vermeulen [Pays-Bas] ; Luc Leyns [Belgique] ; Luoping Zhang [États-Unis] ; Mahara Valverde [Mexique] ; Mahin Khatami [États-Unis] ; Maria Fiammetta Romano [Italie] ; Marion Chapellier [France] ; Marc A. Williams [États-Unis] ; Mark Wade [Italie] ; Masoud H. Manjili [États-Unis] ; Matilde E. Lleonart [Espagne] ; Menghang Xia [États-Unis] ; Michael J. Gonzalez [Porto Rico] ; Michalis V. Karamouzis [Grèce] ; Micheline Kirsch-Volders [Belgique] ; Monica Vaccari [Italie] ; Nancy B. Kuemmerle [États-Unis] ; Neetu Singh [Inde] ; Nichola Cruickshanks [États-Unis] ; Nicole Kleinstreuer [États-Unis] ; Nik Van Larebeke [Belgique] ; Nuzhat Ahmed [Australie] ; Olugbemiga Ogunkua [États-Unis] ; P K Krishnakumar [Arabie saoudite] ; Pankaj Vadgama [Royaume-Uni] ; Paola A. Marignani [Canada] ; Paramita M. Ghosh [États-Unis] ; Patricia Ostrosky-Wegman [Mexique] ; Patricia A. Thompson [États-Unis] ; Paul Dent [États-Unis] ; Petr Heneberg [République tchèque] ; Philippa Darbre [Royaume-Uni] ; Po Sing Leung [Hong Kong] ; Pratima Nangia-Makker [États-Unis] ; Qiang Shawn Cheng [États-Unis] ; R Brooks Robey [États-Unis] ; Rabeah Al-Temaimi [Koweït] ; Rabindra Roy [États-Unis] ; Rafaela Andrade-Vieira [Canada] ; Ranjeet K. Sinha [États-Unis] ; Rekha Mehta [Canada] ; Renza Vento [États-Unis] ; Riccardo Di Fiore [Italie] ; Richard Ponce-Cusi [Chili] ; Rita Dornetshuber-Fleiss [Autriche] ; Rita Nahta [États-Unis] ; Robert C. Castellino [États-Unis] ; Roberta Palorini [Italie] ; Roslida Abd Hamid [Malaisie] ; Sabine A S. Langie [Belgique] ; Sakina E. Eltom [États-Unis] ; Samira A. Brooks [États-Unis] ; Sandra Ryeom [États-Unis] ; Sandra S. Wise [États-Unis] ; Sarah N. Bay [États-Unis] ; Shelley A. Harris [Canada] ; Silvana Papagerakis [États-Unis] ; Simona Romano [Italie] ; Sofia Pavanello [Italie] ; Staffan Eriksson [Suède] ; Stefano Forte [Italie] ; Stephanie C. Casey [États-Unis] ; Sudjit Luanpitpong [Thaïlande] ; Tae-Jin Lee [Corée du Sud] ; Takemi Otsuki [Japon] ; Tao Chen [États-Unis] ; Thierry Massfelder [France] ; Thomas Sanderson [Canada] ; Tiziana Guarnieri [Italie] ; Tove Hultman [Suède] ; Valérian Dormoy [États-Unis] ; Valerie Odero-Marah [États-Unis] ; Venkata Sabbisetti [États-Unis] ; Veronique Maguer-Satta [États-Unis] ; W Kimryn Rathmell [États-Unis] ; Wilhelm Engström [Suède] ; William K. Decker [États-Unis] ; William H. Bisson [États-Unis] ; Yon Rojanasakul [États-Unis] ; Yunus Luqmani ; Zhenbang Chen [États-Unis] ; Zhiwei Hu [États-Unis]Source :
- Carcinogenesis [ 1460-2180 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Cancérogènes environnementaux, Exposition environnementale, Produits dangereux.
- étiologie : Tumeurs.
- Animaux, Carcinogenèse, Humains, Tumeurs.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Carcinogens, Environmental, Hazardous Substances.
- adverse effects : Environmental Exposure.
- chemically induced : Carcinogenesis, Neoplasms.
- etiology : Neoplasms.
- Animals, Humans.
Abstract
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.
DOI: 10.1093/carcin/bgv039
PubMed: 26106142
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William H. Goodson<affiliation><nlm:affiliation>California Pacific Medical Center Research Institute, 2100 Webster Street #401, San Francisco, CA 94115, USA, Getting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK, Institute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144, USA, Getting to Know Cancer, Guelph N1G 1E4, Canada, School of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu, Malaysia, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA, Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla, Spain, Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy, School of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK, Department of Nutrition, University of Oslo, Oslo, Norway, Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK, Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy, Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway, Planet Biotechnologies Inc., St Albert, Alberta T8N 5K4, Canada, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA, Spanish National Cancer Research Centre, CNI</nlm:affiliation>
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<affiliation><nlm:affiliation>Human Safety and Environmental Research, Department of Health Sciences, College of North Atlantic, Doha 24449, State of Qatar.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait and.</nlm:affiliation>
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Le document en format XML
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<author><name sortKey="Lasfar, Ahmed" sort="Lasfar, Ahmed" uniqKey="Lasfar A" first="Ahmed" last="Lasfar">Ahmed Lasfar</name>
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<author><name sortKey="Amedei, Amedeo" sort="Amedei, Amedeo" uniqKey="Amedei A" first="Amedeo" last="Amedei">Amedeo Amedei</name>
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<wicri:regionArea>Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134</wicri:regionArea>
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<author><name sortKey="Charles, Amelia K" sort="Charles, Amelia K" uniqKey="Charles A" first="Amelia K" last="Charles">Amelia K. Charles</name>
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<author><name sortKey="Collins, Andrew R" sort="Collins, Andrew R" uniqKey="Collins A" first="Andrew R" last="Collins">Andrew R. Collins</name>
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<author><name sortKey="Ward, Andrew" sort="Ward, Andrew" uniqKey="Ward A" first="Andrew" last="Ward">Andrew Ward</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY</wicri:regionArea>
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<author><name sortKey="Salzberg, Anna C" sort="Salzberg, Anna C" uniqKey="Salzberg A" first="Anna C" last="Salzberg">Anna C. Salzberg</name>
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<author><name sortKey="Colacci, Annamaria" sort="Colacci, Annamaria" uniqKey="Colacci A" first="Annamaria" last="Colacci">Annamaria Colacci</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Olsen, Ann Karin" sort="Olsen, Ann Karin" uniqKey="Olsen A" first="Ann-Karin" last="Olsen">Ann-Karin Olsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403</wicri:regionArea>
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<author><name sortKey="Berg, Arthur" sort="Berg, Arthur" uniqKey="Berg A" first="Arthur" last="Berg">Arthur Berg</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033</wicri:regionArea>
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<author><name sortKey="Barclay, Barry J" sort="Barclay, Barry J" uniqKey="Barclay B" first="Barry J" last="Barclay">Barry J. Barclay</name>
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<country xml:lang="fr">Canada</country>
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<author><name sortKey="Zhou, Binhua P" sort="Zhou, Binhua P" uniqKey="Zhou B" first="Binhua P" last="Zhou">Binhua P. Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508</wicri:regionArea>
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<author><name sortKey="Blanco Aparicio, Carmen" sort="Blanco Aparicio, Carmen" uniqKey="Blanco Aparicio C" first="Carmen" last="Blanco-Aparicio">Carmen Blanco-Aparicio</name>
<affiliation wicri:level="1"><nlm:affiliation>Spanish National Cancer Research Centre, CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Research Centre, CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea>
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<author><name sortKey="Baglole, Carolyn J" sort="Baglole, Carolyn J" uniqKey="Baglole C" first="Carolyn J" last="Baglole">Carolyn J. Baglole</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, McGill University, Montreal, Quebec H4A 3J1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, McGill University, Montreal, Quebec H4A 3J1</wicri:regionArea>
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<author><name sortKey="Dong, Chenfang" sort="Dong, Chenfang" uniqKey="Dong C" first="Chenfang" last="Dong">Chenfang Dong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508</wicri:regionArea>
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<author><name sortKey="Mondello, Chiara" sort="Mondello, Chiara" uniqKey="Mondello C" first="Chiara" last="Mondello">Chiara Mondello</name>
<affiliation wicri:level="1"><nlm:affiliation>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia</wicri:regionArea>
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</author>
<author><name sortKey="Hsu, Chia Wen" sort="Hsu, Chia Wen" uniqKey="Hsu C" first="Chia-Wen" last="Hsu">Chia-Wen Hsu</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Naus, Christian C" sort="Naus, Christian C" uniqKey="Naus C" first="Christian C" last="Naus">Christian C. Naus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cellular and Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Cellular and Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V5Z 1M9</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yedjou, Clement" sort="Yedjou, Clement" uniqKey="Yedjou C" first="Clement" last="Yedjou">Clement Yedjou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Jackson State University, Jackson, MS 39217, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Jackson State University, Jackson, MS 39217</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Curran, Colleen S" sort="Curran, Colleen S" uniqKey="Curran C" first="Colleen S" last="Curran">Colleen S. Curran</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Environmental Toxicology, University of Wisconsin-Madison, Madison, WI 53706, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Environmental Toxicology, University of Wisconsin-Madison, Madison, WI 53706</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laird, Dale W" sort="Laird, Dale W" uniqKey="Laird D" first="Dale W" last="Laird">Dale W. Laird</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 3K7, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 3K7</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koch, Daniel C" sort="Koch, Daniel C" uniqKey="Koch D" first="Daniel C" last="Koch">Daniel C. Koch</name>
<affiliation wicri:level="1"><nlm:affiliation>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carlin, Danielle J" sort="Carlin, Danielle J" uniqKey="Carlin D" first="Danielle J" last="Carlin">Danielle J. Carlin</name>
<affiliation wicri:level="1"><nlm:affiliation>Superfund Research Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27560, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Superfund Research Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27560</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Felsher, Dean W" sort="Felsher, Dean W" uniqKey="Felsher D" first="Dean W" last="Felsher">Dean W. Felsher</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Oncology and Pathology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Oncology and Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roy, Debasish" sort="Roy, Debasish" uniqKey="Roy D" first="Debasish" last="Roy">Debasish Roy</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brown, Dustin G" sort="Brown, Dustin G" uniqKey="Brown D" first="Dustin G" last="Brown">Dustin G. Brown</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ratovitski, Edward" sort="Ratovitski, Edward" uniqKey="Ratovitski E" first="Edward" last="Ratovitski">Edward Ratovitski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Head and Neck Surgery/Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Head and Neck Surgery/Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ryan, Elizabeth P" sort="Ryan, Elizabeth P" uniqKey="Ryan E" first="Elizabeth P" last="Ryan">Elizabeth P. Ryan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Corsini, Emanuela" sort="Corsini, Emanuela" uniqKey="Corsini E" first="Emanuela" last="Corsini">Emanuela Corsini</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rojas, Emilio" sort="Rojas, Emilio" uniqKey="Rojas E" first="Emilio" last="Rojas">Emilio Rojas</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moon, Eun Yi" sort="Moon, Eun Yi" uniqKey="Moon E" first="Eun-Yi" last="Moon">Eun-Yi Moon</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laconi, Ezio" sort="Laconi, Ezio" uniqKey="Laconi E" first="Ezio" last="Laconi">Ezio Laconi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marongiu, Fabio" sort="Marongiu, Fabio" uniqKey="Marongiu F" first="Fabio" last="Marongiu">Fabio Marongiu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Mulla, Fahd" sort="Al Mulla, Fahd" uniqKey="Al Mulla F" first="Fahd" last="Al-Mulla">Fahd Al-Mulla</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Kuwait University, Safat 13110, Kuwait.</nlm:affiliation>
<country xml:lang="fr">Koweït</country>
<wicri:regionArea>Department of Pathology, Kuwait University, Safat 13110</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chiaradonna, Ferdinando" sort="Chiaradonna, Ferdinando" uniqKey="Chiaradonna F" first="Ferdinando" last="Chiaradonna">Ferdinando Chiaradonna</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Darroudi, Firouz" sort="Darroudi, Firouz" uniqKey="Darroudi F" first="Firouz" last="Darroudi">Firouz Darroudi</name>
<affiliation><nlm:affiliation>Human Safety and Environmental Research, Department of Health Sciences, College of North Atlantic, Doha 24449, State of Qatar.</nlm:affiliation>
<wicri:noCountry code="subField">State of Qatar</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Martin, Francis L" sort="Martin, Francis L" uniqKey="Martin F" first="Francis L" last="Martin">Francis L. Martin</name>
<affiliation wicri:level="1"><nlm:affiliation>Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Schooten, Frederik J" sort="Van Schooten, Frederik J" uniqKey="Van Schooten F" first="Frederik J" last="Van Schooten">Frederik J. Van Schooten</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht 6200, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht 6200</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goldberg, Gary S" sort="Goldberg, Gary S" uniqKey="Goldberg G" first="Gary S" last="Goldberg">Gary S. Goldberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wagemaker, Gerard" sort="Wagemaker, Gerard" uniqKey="Wagemaker G" first="Gerard" last="Wagemaker">Gerard Wagemaker</name>
<affiliation wicri:level="1"><nlm:affiliation>Hacettepe University, Center for Stem Cell Research and Development, Ankara 06640, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Hacettepe University, Center for Stem Cell Research and Development, Ankara 06640</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nangami, Gladys N" sort="Nangami, Gladys N" uniqKey="Nangami G" first="Gladys N" last="Nangami">Gladys N. Nangami</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Calaf, Gloria M" sort="Calaf, Gloria M" uniqKey="Calaf G" first="Gloria M" last="Calaf">Gloria M. Calaf</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica, Chile.</nlm:affiliation>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Williams, Graeme" sort="Williams, Graeme" uniqKey="Williams G" first="Graeme" last="Williams">Graeme Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, University of Reading, Reading, RG6 6UB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biological Sciences, University of Reading, Reading, RG6 6UB</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolf, Gregory T" sort="Wolf, Gregory T" uniqKey="Wolf G" first="Gregory T" last="Wolf">Gregory T. Wolf</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koppen, Gudrun" sort="Koppen, Gudrun" uniqKey="Koppen G" first="Gudrun" last="Koppen">Gudrun Koppen</name>
<affiliation wicri:level="1"><nlm:affiliation>Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brunborg, Gunnar" sort="Brunborg, Gunnar" uniqKey="Brunborg G" first="Gunnar" last="Brunborg">Gunnar Brunborg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lyerly, H Kim" sort="Lyerly, H Kim" uniqKey="Lyerly H" first="H Kim" last="Lyerly">H Kim Lyerly</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krishnan, Harini" sort="Krishnan, Harini" uniqKey="Krishnan H" first="Harini" last="Krishnan">Harini Krishnan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ab Hamid, Hasiah" sort="Ab Hamid, Hasiah" uniqKey="Ab Hamid H" first="Hasiah" last="Ab Hamid">Hasiah Ab Hamid</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yasaei, Hemad" sort="Yasaei, Hemad" uniqKey="Yasaei H" first="Hemad" last="Yasaei">Hemad Yasaei</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, College of Health and Life Sciences and the Health and Environment Theme, Institute of Environment, Health and Societies, Brunel University Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Life Sciences, College of Health and Life Sciences and the Health and Environment Theme, Institute of Environment, Health and Societies, Brunel University Kingston Lane, Uxbridge, Middlesex UB8 3PH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sone, Hideko" sort="Sone, Hideko" uniqKey="Sone H" first="Hideko" last="Sone">Hideko Sone</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibraki 3058506, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibraki 3058506</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kondoh, Hiroshi" sort="Kondoh, Hiroshi" uniqKey="Kondoh H" first="Hiroshi" last="Kondoh">Hiroshi Kondoh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Geriatric Medicine, Kyoto University Hospital 54 Kawaharacho, Shogoin, Sakyo-ku Kyoto, 606-8507, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Geriatric Medicine, Kyoto University Hospital 54 Kawaharacho, Shogoin, Sakyo-ku Kyoto, 606-8507</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Salem, Hosni K" sort="Salem, Hosni K" uniqKey="Salem H" first="Hosni K" last="Salem">Hosni K. Salem</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Urology, Kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 11559, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Urology, Kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 11559</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsu, Hsue Yin" sort="Hsu, Hsue Yin" uniqKey="Hsu H" first="Hsue-Yin" last="Hsu">Hsue-Yin Hsu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, Tzu-Chi University, Hualien 970, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Life Sciences, Tzu-Chi University, Hualien 970</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Hyun Ho" sort="Park, Hyun Ho" uniqKey="Park H" first="Hyun Ho" last="Park">Hyun Ho Park</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koturbash, Igor" sort="Koturbash, Igor" uniqKey="Koturbash I" first="Igor" last="Koturbash">Igor Koturbash</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miousse, Isabelle R" sort="Miousse, Isabelle R" uniqKey="Miousse I" first="Isabelle R" last="Miousse">Isabelle R. Miousse</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scovassi, A Ivana" sort="Scovassi, A Ivana" uniqKey="Scovassi A" first="A Ivana" last="Scovassi">A Ivana Scovassi</name>
<affiliation wicri:level="1"><nlm:affiliation>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klaunig, James E" sort="Klaunig, James E" uniqKey="Klaunig J" first="James E" last="Klaunig">James E. Klaunig</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental Health, Indiana University, School of Public Health, Bloomington, IN 47405, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, Indiana University, School of Public Health, Bloomington, IN 47405</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vondra Ek, Jan" sort="Vondra Ek, Jan" uniqKey="Vondra Ek J" first="Jan" last="Vondrá Ek">Jan Vondrá Ek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cytokinetics, Institute of Biophysics Academy of Sciences of the Czech Republic, Brno, CZ-61265, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Cytokinetics, Institute of Biophysics Academy of Sciences of the Czech Republic, Brno, CZ-61265</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Raju, Jayadev" sort="Raju, Jayadev" uniqKey="Raju J" first="Jayadev" last="Raju">Jayadev Raju</name>
<affiliation wicri:level="1"><nlm:affiliation>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roman, Jesse" sort="Roman, Jesse" uniqKey="Roman J" first="Jesse" last="Roman">Jesse Roman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Louisville, Louisville, KY 40202, USA, Robley Rex VA Medical Center, Louisville, KY 40202, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Louisville, Louisville, KY 40202, USA, Robley Rex VA Medical Center, Louisville, KY 40202</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wise, John Pierce" sort="Wise, John Pierce" uniqKey="Wise J" first="John Pierce" last="Wise">John Pierce Wise</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Whitfield, Jonathan R" sort="Whitfield, Jonathan R" uniqKey="Whitfield J" first="Jonathan R" last="Whitfield">Jonathan R. Whitfield</name>
<affiliation wicri:level="1"><nlm:affiliation>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Woodrick, Jordan" sort="Woodrick, Jordan" uniqKey="Woodrick J" first="Jordan" last="Woodrick">Jordan Woodrick</name>
<affiliation wicri:level="1"><nlm:affiliation>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Christopher, Joseph A" sort="Christopher, Joseph A" uniqKey="Christopher J" first="Joseph A" last="Christopher">Joseph A. Christopher</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK. Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK. Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ochieng, Josiah" sort="Ochieng, Josiah" uniqKey="Ochieng J" first="Josiah" last="Ochieng">Josiah Ochieng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martinez Leal, Juan Fernando" sort="Martinez Leal, Juan Fernando" uniqKey="Martinez Leal J" first="Juan Fernando" last="Martinez-Leal">Juan Fernando Martinez-Leal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, Pharmamar-SAU, Avda. De los Reyes, 1. 28770-Colmenar Viejo, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Cell Biology, Pharmamar-SAU, Avda. De los Reyes, 1. 28770-Colmenar Viejo, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weisz, Judith" sort="Weisz, Judith" uniqKey="Weisz J" first="Judith" last="Weisz">Judith Weisz</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Obstetrics and Gynecology and Pathology, Pennsylvania State University College of Medicine, Hershey PA 17033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Obstetrics and Gynecology and Pathology, Pennsylvania State University College of Medicine, Hershey PA 17033</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kravchenko, Julia" sort="Kravchenko, Julia" uniqKey="Kravchenko J" first="Julia" last="Kravchenko">Julia Kravchenko</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sun, Jun" sort="Sun, Jun" uniqKey="Sun J" first="Jun" last="Sun">Jun Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Rush University, Chicago, IL 60612, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Rush University, Chicago, IL 60612</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prudhomme, Kalan R" sort="Prudhomme, Kalan R" uniqKey="Prudhomme K" first="Kalan R" last="Prudhomme">Kalan R. Prudhomme</name>
<affiliation wicri:level="1"><nlm:affiliation>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Narayanan, Kannan Badri" sort="Narayanan, Kannan Badri" uniqKey="Narayanan K" first="Kannan Badri" last="Narayanan">Kannan Badri Narayanan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cohen Solal, Karine A" sort="Cohen Solal, Karine A" uniqKey="Cohen Solal K" first="Karine A" last="Cohen-Solal">Karine A. Cohen-Solal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moorwood, Kim" sort="Moorwood, Kim" uniqKey="Moorwood K" first="Kim" last="Moorwood">Kim Moorwood</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Laetitia" sort="Gonzalez, Laetitia" uniqKey="Gonzalez L" first="Laetitia" last="Gonzalez">Laetitia Gonzalez</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soucek, Laura" sort="Soucek, Laura" uniqKey="Soucek L" first="Laura" last="Soucek">Laura Soucek</name>
<affiliation wicri:level="1"><nlm:affiliation>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jian, Le" sort="Jian, Le" uniqKey="Jian L" first="Le" last="Jian">Le Jian</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Curtin University, Bentley, WA 6102, Australia, Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, Curtin University, Bentley, WA 6102, Australia, Department of Urology, University of California Davis, Sacramento, CA 95817</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="D Abronzo, Leandro S" sort="D Abronzo, Leandro S" uniqKey="D Abronzo L" first="Leandro S" last="D'Abronzo">Leandro S. D'Abronzo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of California Davis, Sacramento, CA 95817</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lin, Liang Tzung" sort="Lin, Liang Tzung" uniqKey="Lin L" first="Liang-Tzung" last="Lin">Liang-Tzung Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Lin" sort="Li, Lin" uniqKey="Li L" first="Lin" last="Li">Lin Li</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.</nlm:affiliation>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gulliver, Linda" sort="Gulliver, Linda" uniqKey="Gulliver L" first="Linda" last="Gulliver">Linda Gulliver</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Otago, Dunedin 9054, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Faculty of Medicine, University of Otago, Dunedin 9054</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mccawley, Lisa J" sort="Mccawley, Lisa J" uniqKey="Mccawley L" first="Lisa J" last="Mccawley">Lisa J. Mccawley</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Engineering and Cancer Biology, Vanderbilt University, Nashville, TN 37235, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering and Cancer Biology, Vanderbilt University, Nashville, TN 37235</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Memeo, Lorenzo" sort="Memeo, Lorenzo" uniqKey="Memeo L" first="Lorenzo" last="Memeo">Lorenzo Memeo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vermeulen, Louis" sort="Vermeulen, Louis" uniqKey="Vermeulen L" first="Louis" last="Vermeulen">Louis Vermeulen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leyns, Luc" sort="Leyns, Luc" uniqKey="Leyns L" first="Luc" last="Leyns">Luc Leyns</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Luoping" sort="Zhang, Luoping" uniqKey="Zhang L" first="Luoping" last="Zhang">Luoping Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Valverde, Mahara" sort="Valverde, Mahara" uniqKey="Valverde M" first="Mahara" last="Valverde">Mahara Valverde</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khatami, Mahin" sort="Khatami, Mahin" uniqKey="Khatami M" first="Mahin" last="Khatami">Mahin Khatami</name>
<affiliation wicri:level="1"><nlm:affiliation>Inflammation and Cancer Research, National Cancer Institute (NCI) (Retired), National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Inflammation and Cancer Research, National Cancer Institute (NCI) (Retired), National Institutes of Health, Bethesda, MD 20892</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Romano, Maria Fiammetta" sort="Romano, Maria Fiammetta" uniqKey="Romano M" first="Maria Fiammetta" last="Romano">Maria Fiammetta Romano</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chapellier, Marion" sort="Chapellier, Marion" uniqKey="Chapellier M" first="Marion" last="Chapellier">Marion Chapellier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre De Recherche En Cancerologie, De Lyon, Lyon, U1052-UMR5286, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre De Recherche En Cancerologie, De Lyon, Lyon, U1052-UMR5286</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Williams, Marc A" sort="Williams, Marc A" uniqKey="Williams M" first="Marc A" last="Williams">Marc A. Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wade, Mark" sort="Wade, Mark" uniqKey="Wade M" first="Mark" last="Wade">Mark Wade</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milano, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milano</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manjili, Masoud H" sort="Manjili, Masoud H" uniqKey="Manjili M" first="Masoud H" last="Manjili">Masoud H. Manjili</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lleonart, Matilde E" sort="Lleonart, Matilde E" uniqKey="Lleonart M" first="Matilde E" last="Lleonart">Matilde E. Lleonart</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut De Recerca Hospital Vall D'Hebron, Passeig Vall d'Hebron, 119-129, 08035 Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut De Recerca Hospital Vall D'Hebron, Passeig Vall d'Hebron, 119-129, 08035 Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xia, Menghang" sort="Xia, Menghang" uniqKey="Xia M" first="Menghang" last="Xia">Menghang Xia</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Michael J" sort="Gonzalez, Michael J" uniqKey="Gonzalez M" first="Michael J" last="Gonzalez">Michael J. Gonzalez</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan 00921, Puerto Rico.</nlm:affiliation>
<country xml:lang="fr">Porto Rico</country>
<wicri:regionArea>University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan 00921</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karamouzis, Michalis V" sort="Karamouzis, Michalis V" uniqKey="Karamouzis M" first="Michalis V" last="Karamouzis">Michalis V. Karamouzis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Chemistry, Medical School, University of Athens, Institute of Molecular Medicine and Biomedical Research, 10676 Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Biological Chemistry, Medical School, University of Athens, Institute of Molecular Medicine and Biomedical Research, 10676 Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kirsch Volders, Micheline" sort="Kirsch Volders, Micheline" uniqKey="Kirsch Volders M" first="Micheline" last="Kirsch-Volders">Micheline Kirsch-Volders</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vaccari, Monica" sort="Vaccari, Monica" uniqKey="Vaccari M" first="Monica" last="Vaccari">Monica Vaccari</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuemmerle, Nancy B" sort="Kuemmerle, Nancy B" uniqKey="Kuemmerle N" first="Nancy B" last="Kuemmerle">Nancy B. Kuemmerle</name>
<affiliation wicri:level="1"><nlm:affiliation>Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Singh, Neetu" sort="Singh, Neetu" uniqKey="Singh N" first="Neetu" last="Singh">Neetu Singh</name>
<affiliation wicri:level="1"><nlm:affiliation>Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh 226 003, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh 226 003</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cruickshanks, Nichola" sort="Cruickshanks, Nichola" uniqKey="Cruickshanks N" first="Nichola" last="Cruickshanks">Nichola Cruickshanks</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kleinstreuer, Nicole" sort="Kleinstreuer, Nicole" uniqKey="Kleinstreuer N" first="Nicole" last="Kleinstreuer">Nicole Kleinstreuer</name>
<affiliation wicri:level="1"><nlm:affiliation>Integrated Laboratory Systems Inc., in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, RTP, NC 27709, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Laboratory Systems Inc., in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, RTP, NC 27709</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Larebeke, Nik" sort="Van Larebeke, Nik" uniqKey="Van Larebeke N" first="Nik" last="Van Larebeke">Nik Van Larebeke</name>
<affiliation wicri:level="1"><nlm:affiliation>Analytische, Milieu en Geochemie, Vrije Universiteit Brussel, Brussel B1050, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Analytische, Milieu en Geochemie, Vrije Universiteit Brussel, Brussel B1050</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahmed, Nuzhat" sort="Ahmed, Nuzhat" uniqKey="Ahmed N" first="Nuzhat" last="Ahmed">Nuzhat Ahmed</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Melbourne, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Melbourne, Victoria 3052</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ogunkua, Olugbemiga" sort="Ogunkua, Olugbemiga" uniqKey="Ogunkua O" first="Olugbemiga" last="Ogunkua">Olugbemiga Ogunkua</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krishnakumar, P K" sort="Krishnakumar, P K" uniqKey="Krishnakumar P" first="P K" last="Krishnakumar">P K Krishnakumar</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 3126, Saudi Arabia .</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 3126</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vadgama, Pankaj" sort="Vadgama, Pankaj" uniqKey="Vadgama P" first="Pankaj" last="Vadgama">Pankaj Vadgama</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marignani, Paola A" sort="Marignani, Paola A" uniqKey="Marignani P" first="Paola A" last="Marignani">Paola A. Marignani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghosh, Paramita M" sort="Ghosh, Paramita M" uniqKey="Ghosh P" first="Paramita M" last="Ghosh">Paramita M. Ghosh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of California Davis, Sacramento, CA 95817</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ostrosky Wegman, Patricia" sort="Ostrosky Wegman, Patricia" uniqKey="Ostrosky Wegman P" first="Patricia" last="Ostrosky-Wegman">Patricia Ostrosky-Wegman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thompson, Patricia A" sort="Thompson, Patricia A" uniqKey="Thompson P" first="Patricia A" last="Thompson">Patricia A. Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stony Brook School of Medicine, Stony Brook University, The State University of New York, Stony Brook, NY 11794-8691, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stony Brook School of Medicine, Stony Brook University, The State University of New York, Stony Brook, NY 11794-8691</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dent, Paul" sort="Dent, Paul" uniqKey="Dent P" first="Paul" last="Dent">Paul Dent</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heneberg, Petr" sort="Heneberg, Petr" uniqKey="Heneberg P" first="Petr" last="Heneberg">Petr Heneberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Charles University in Prague, Third Faculty of Medicine, CZ-100 00 Prague 10, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Charles University in Prague, Third Faculty of Medicine, CZ-100 00 Prague 10</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Darbre, Philippa" sort="Darbre, Philippa" uniqKey="Darbre P" first="Philippa" last="Darbre">Philippa Darbre</name>
<affiliation wicri:level="2"><nlm:affiliation>School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6UB, England.</nlm:affiliation>
<country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6UB</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sing Leung, Po" sort="Sing Leung, Po" uniqKey="Sing Leung P" first="Po" last="Sing Leung">Po Sing Leung</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.</nlm:affiliation>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nangia Makker, Pratima" sort="Nangia Makker, Pratima" uniqKey="Nangia Makker P" first="Pratima" last="Nangia-Makker">Pratima Nangia-Makker</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Wayne State University, Detroit, MI 48201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Wayne State University, Detroit, MI 48201</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cheng, Qiang Shawn" sort="Cheng, Qiang Shawn" uniqKey="Cheng Q" first="Qiang Shawn" last="Cheng">Qiang Shawn Cheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Computer Science Department, Southern Illinois University, Carbondale, IL 62901</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robey, R Brooks" sort="Robey, R Brooks" uniqKey="Robey R" first="R Brooks" last="Robey">R Brooks Robey</name>
<affiliation wicri:level="1"><nlm:affiliation>White River Junction Veterans Affairs Medical Center, White River Junction, VT 05009, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>White River Junction Veterans Affairs Medical Center, White River Junction, VT 05009, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Temaimi, Rabeah" sort="Al Temaimi, Rabeah" uniqKey="Al Temaimi R" first="Rabeah" last="Al-Temaimi">Rabeah Al-Temaimi</name>
<affiliation wicri:level="1"><nlm:affiliation>Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya 13110, Kuwait.</nlm:affiliation>
<country xml:lang="fr">Koweït</country>
<wicri:regionArea>Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya 13110</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roy, Rabindra" sort="Roy, Rabindra" uniqKey="Roy R" first="Rabindra" last="Roy">Rabindra Roy</name>
<affiliation wicri:level="1"><nlm:affiliation>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrade Vieira, Rafaela" sort="Andrade Vieira, Rafaela" uniqKey="Andrade Vieira R" first="Rafaela" last="Andrade-Vieira">Rafaela Andrade-Vieira</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sinha, Ranjeet K" sort="Sinha, Ranjeet K" uniqKey="Sinha R" first="Ranjeet K" last="Sinha">Ranjeet K. Sinha</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mehta, Rekha" sort="Mehta, Rekha" uniqKey="Mehta R" first="Rekha" last="Mehta">Rekha Mehta</name>
<affiliation wicri:level="1"><nlm:affiliation>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vento, Renza" sort="Vento, Renza" uniqKey="Vento R" first="Renza" last="Vento">Renza Vento</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy , Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy , Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Di Fiore, Riccardo" sort="Di Fiore, Riccardo" uniqKey="Di Fiore R" first="Riccardo" last="Di Fiore">Riccardo Di Fiore</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy .</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ponce Cusi, Richard" sort="Ponce Cusi, Richard" uniqKey="Ponce Cusi R" first="Richard" last="Ponce-Cusi">Richard Ponce-Cusi</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Alta Investigacion, Universidad de Tarapaca, Arica, Chile.</nlm:affiliation>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Instituto de Alta Investigacion, Universidad de Tarapaca, Arica</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dornetshuber Fleiss, Rita" sort="Dornetshuber Fleiss, Rita" uniqKey="Dornetshuber Fleiss R" first="Rita" last="Dornetshuber-Fleiss">Rita Dornetshuber-Fleiss</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, University of Vienna, Vienna A-1090, Austria, Institute of Cancer Research, Department of Medicine, Medical University of Vienna, Wien 1090, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Pharmacology and Toxicology, University of Vienna, Vienna A-1090, Austria, Institute of Cancer Research, Department of Medicine, Medical University of Vienna, Wien 1090</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nahta, Rita" sort="Nahta, Rita" uniqKey="Nahta R" first="Rita" last="Nahta">Rita Nahta</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Pharmacology and Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacology and Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Castellino, Robert C" sort="Castellino, Robert C" uniqKey="Castellino R" first="Robert C" last="Castellino">Robert C. Castellino</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta, GA 30322, USA, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta, GA 30322, USA, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Palorini, Roberta" sort="Palorini, Roberta" uniqKey="Palorini R" first="Roberta" last="Palorini">Roberta Palorini</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abd Hamid, Roslida" sort="Abd Hamid, Roslida" uniqKey="Abd Hamid R" first="Roslida" last="Abd Hamid">Roslida Abd Hamid</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langie, Sabine A S" sort="Langie, Sabine A S" uniqKey="Langie S" first="Sabine A S" last="Langie">Sabine A S. Langie</name>
<affiliation wicri:level="1"><nlm:affiliation>Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eltom, Sakina E" sort="Eltom, Sakina E" uniqKey="Eltom S" first="Sakina E" last="Eltom">Sakina E. Eltom</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brooks, Samira A" sort="Brooks, Samira A" uniqKey="Brooks S" first="Samira A" last="Brooks">Samira A. Brooks</name>
<affiliation wicri:level="1"><nlm:affiliation>Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ryeom, Sandra" sort="Ryeom, Sandra" uniqKey="Ryeom S" first="Sandra" last="Ryeom">Sandra Ryeom</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wise, Sandra S" sort="Wise, Sandra S" uniqKey="Wise S" first="Sandra S" last="Wise">Sandra S. Wise</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bay, Sarah N" sort="Bay, Sarah N" uniqKey="Bay S" first="Sarah N" last="Bay">Sarah N. Bay</name>
<affiliation wicri:level="1"><nlm:affiliation>Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harris, Shelley A" sort="Harris, Shelley A" uniqKey="Harris S" first="Shelley A" last="Harris">Shelley A. Harris</name>
<affiliation wicri:level="1"><nlm:affiliation>Population Health and Prevention, Research, Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada, Departments of Epidemiology and Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7, Canada .</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Population Health and Prevention, Research, Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada, Departments of Epidemiology and Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Papagerakis, Silvana" sort="Papagerakis, Silvana" uniqKey="Papagerakis S" first="Silvana" last="Papagerakis">Silvana Papagerakis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Romano, Simona" sort="Romano, Simona" uniqKey="Romano S" first="Simona" last="Romano">Simona Romano</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pavanello, Sofia" sort="Pavanello, Sofia" uniqKey="Pavanello S" first="Sofia" last="Pavanello">Sofia Pavanello</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiac, Thoracic and Vascular Sciences, Unit of Occupational Medicine, University of Padova, Padova 35128, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiac, Thoracic and Vascular Sciences, Unit of Occupational Medicine, University of Padova, Padova 35128</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eriksson, Staffan" sort="Eriksson, Staffan" uniqKey="Eriksson S" first="Staffan" last="Eriksson">Staffan Eriksson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy, Physiology and Biochemistry, The Swedish University of Agricultural Sciences, PO Box 7011, VHC, Almas Allé 4, SE-756 51, Uppsala, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Anatomy, Physiology and Biochemistry, The Swedish University of Agricultural Sciences, PO Box 7011, VHC, Almas Allé 4, SE-756 51, Uppsala</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Forte, Stefano" sort="Forte, Stefano" uniqKey="Forte S" first="Stefano" last="Forte">Stefano Forte</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Casey, Stephanie C" sort="Casey, Stephanie C" uniqKey="Casey S" first="Stephanie C" last="Casey">Stephanie C. Casey</name>
<affiliation wicri:level="1"><nlm:affiliation>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luanpitpong, Sudjit" sort="Luanpitpong, Sudjit" uniqKey="Luanpitpong S" first="Sudjit" last="Luanpitpong">Sudjit Luanpitpong</name>
<affiliation wicri:level="1"><nlm:affiliation>Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Tae Jin" sort="Lee, Tae Jin" uniqKey="Lee T" first="Tae-Jin" last="Lee">Tae-Jin Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy, College of Medicine, Yeungnam University, Daegu 705-717, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Anatomy, College of Medicine, Yeungnam University, Daegu 705-717</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Otsuki, Takemi" sort="Otsuki, Takemi" uniqKey="Otsuki T" first="Takemi" last="Otsuki">Takemi Otsuki</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Hygiene, Kawasaki Medical School, Matsushima Kurashiki, Okayama 701-0192, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Hygiene, Kawasaki Medical School, Matsushima Kurashiki, Okayama 701-0192</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Tao" sort="Chen, Tao" uniqKey="Chen T" first="Tao" last="Chen">Tao Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Massfelder, Thierry" sort="Massfelder, Thierry" uniqKey="Massfelder T" first="Thierry" last="Massfelder">Thierry Massfelder</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sanderson, Thomas" sort="Sanderson, Thomas" uniqKey="Sanderson T" first="Thomas" last="Sanderson">Thomas Sanderson</name>
<affiliation wicri:level="1"><nlm:affiliation>INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval, QC H7V 1B7</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guarnieri, Tiziana" sort="Guarnieri, Tiziana" uniqKey="Guarnieri T" first="Tiziana" last="Guarnieri">Tiziana Guarnieri</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Geology and Environmental Sciences, Alma Mater Studiorum Università di Bologna, Via Francesco Selmi, 3, 40126 Bologna, Italy, Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Via Massarenti, 9, 40126 Bologna, Italy, National Institute of Biostructures and Biosystems, Viale Medaglie d' Oro, 305, 00136 Roma, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biology, Geology and Environmental Sciences, Alma Mater Studiorum Università di Bologna, Via Francesco Selmi, 3, 40126 Bologna, Italy, Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Via Massarenti, 9, 40126 Bologna, Italy, National Institute of Biostructures and Biosystems, Viale Medaglie d' Oro, 305, 00136 Roma</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hultman, Tove" sort="Hultman, Tove" uniqKey="Hultman T" first="Tove" last="Hultman">Tove Hultman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dormoy, Valerian" sort="Dormoy, Valerian" uniqKey="Dormoy V" first="Valérian" last="Dormoy">Valérian Dormoy</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France, Department of Cell and Developmental Biology, University of California, Irvine, CA 92697, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France, Department of Cell and Developmental Biology, University of California, Irvine, CA 92697</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Odero Marah, Valerie" sort="Odero Marah, Valerie" uniqKey="Odero Marah V" first="Valerie" last="Odero-Marah">Valerie Odero-Marah</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology/Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology/Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sabbisetti, Venkata" sort="Sabbisetti, Venkata" uniqKey="Sabbisetti V" first="Venkata" last="Sabbisetti">Venkata Sabbisetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Harvard Medical School/Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School/Brigham and Women's Hospital, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maguer Satta, Veronique" sort="Maguer Satta, Veronique" uniqKey="Maguer Satta V" first="Veronique" last="Maguer-Satta">Veronique Maguer-Satta</name>
<affiliation wicri:level="1"><nlm:affiliation>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rathmell, W Kimryn" sort="Rathmell, W Kimryn" uniqKey="Rathmell W" first="W Kimryn" last="Rathmell">W Kimryn Rathmell</name>
<affiliation wicri:level="1"><nlm:affiliation>Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Engstrom, Wilhelm" sort="Engstrom, Wilhelm" uniqKey="Engstrom W" first="Wilhelm" last="Engström">Wilhelm Engström</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Decker, William K" sort="Decker, William K" uniqKey="Decker W" first="William K" last="Decker">William K. Decker</name>
<affiliation wicri:level="1"><nlm:affiliation>Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Baylor College of Medicine, Houston, TX 77030</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bisson, William H" sort="Bisson, William H" uniqKey="Bisson W" first="William H" last="Bisson">William H. Bisson</name>
<affiliation wicri:level="1"><nlm:affiliation>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rojanasakul, Yon" sort="Rojanasakul, Yon" uniqKey="Rojanasakul Y" first="Yon" last="Rojanasakul">Yon Rojanasakul</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luqmani, Yunus" sort="Luqmani, Yunus" uniqKey="Luqmani Y" first="Yunus" last="Luqmani">Yunus Luqmani</name>
<affiliation><nlm:affiliation>Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait and.</nlm:affiliation>
<wicri:noCountry code="subField">Kuwait and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chen, Zhenbang" sort="Chen, Zhenbang" uniqKey="Chen Z" first="Zhenbang" last="Chen">Zhenbang Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hu, Zhiwei" sort="Hu, Zhiwei" uniqKey="Hu Z" first="Zhiwei" last="Hu">Zhiwei Hu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.</title>
<author><name sortKey="Goodson, William H" sort="Goodson, William H" uniqKey="Goodson W" first="William H" last="Goodson">William H. Goodson</name>
<affiliation><nlm:affiliation>California Pacific Medical Center Research Institute, 2100 Webster Street #401, San Francisco, CA 94115, USA, Getting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK, Institute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144, USA, Getting to Know Cancer, Guelph N1G 1E4, Canada, School of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu, Malaysia, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA, Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla, Spain, Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy, School of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK, Department of Nutrition, University of Oslo, Oslo, Norway, Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK, Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy, Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway, Planet Biotechnologies Inc., St Albert, Alberta T8N 5K4, Canada, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA, Spanish National Cancer Research Centre, CNI</nlm:affiliation>
<wicri:noCountry>no dot</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lowe, Leroy" sort="Lowe, Leroy" uniqKey="Lowe L" first="Leroy" last="Lowe">Leroy Lowe</name>
<affiliation wicri:level="1"><nlm:affiliation>Getting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Getting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carpenter, David O" sort="Carpenter, David O" uniqKey="Carpenter D" first="David O" last="Carpenter">David O. Carpenter</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gilbertson, Michael" sort="Gilbertson, Michael" uniqKey="Gilbertson M" first="Michael" last="Gilbertson">Michael Gilbertson</name>
<affiliation wicri:level="1"><nlm:affiliation>Getting to Know Cancer, Guelph N1G 1E4, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Getting to Know Cancer, Guelph N1G 1E4</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manaf Ali, Abdul" sort="Manaf Ali, Abdul" uniqKey="Manaf Ali A" first="Abdul" last="Manaf Ali">Abdul Manaf Ali</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>School of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lopez De Cerain Salsamendi, Adela" sort="Lopez De Cerain Salsamendi, Adela" uniqKey="Lopez De Cerain Salsamendi A" first="Adela" last="Lopez De Cerain Salsamendi">Adela Lopez De Cerain Salsamendi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lasfar, Ahmed" sort="Lasfar, Ahmed" uniqKey="Lasfar A" first="Ahmed" last="Lasfar">Ahmed Lasfar</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carnero, Amancio" sort="Carnero, Amancio" uniqKey="Carnero A" first="Amancio" last="Carnero">Amancio Carnero</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Azqueta, Amaya" sort="Azqueta, Amaya" uniqKey="Azqueta A" first="Amaya" last="Azqueta">Amaya Azqueta</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Amedei, Amedeo" sort="Amedei, Amedeo" uniqKey="Amedei A" first="Amedeo" last="Amedei">Amedeo Amedei</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Charles, Amelia K" sort="Charles, Amelia K" uniqKey="Charles A" first="Amelia K" last="Charles">Amelia K. Charles</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Collins, Andrew R" sort="Collins, Andrew R" uniqKey="Collins A" first="Andrew R" last="Collins">Andrew R. Collins</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Nutrition, University of Oslo, Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ward, Andrew" sort="Ward, Andrew" uniqKey="Ward A" first="Andrew" last="Ward">Andrew Ward</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Salzberg, Anna C" sort="Salzberg, Anna C" uniqKey="Salzberg A" first="Anna C" last="Salzberg">Anna C. Salzberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colacci, Annamaria" sort="Colacci, Annamaria" uniqKey="Colacci A" first="Annamaria" last="Colacci">Annamaria Colacci</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olsen, Ann Karin" sort="Olsen, Ann Karin" uniqKey="Olsen A" first="Ann-Karin" last="Olsen">Ann-Karin Olsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berg, Arthur" sort="Berg, Arthur" uniqKey="Berg A" first="Arthur" last="Berg">Arthur Berg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barclay, Barry J" sort="Barclay, Barry J" uniqKey="Barclay B" first="Barry J" last="Barclay">Barry J. Barclay</name>
<affiliation wicri:level="1"><nlm:affiliation>Planet Biotechnologies Inc., St Albert, Alberta T8N 5K4, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Planet Biotechnologies Inc., St Albert, Alberta T8N 5K4</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhou, Binhua P" sort="Zhou, Binhua P" uniqKey="Zhou B" first="Binhua P" last="Zhou">Binhua P. Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanco Aparicio, Carmen" sort="Blanco Aparicio, Carmen" uniqKey="Blanco Aparicio C" first="Carmen" last="Blanco-Aparicio">Carmen Blanco-Aparicio</name>
<affiliation wicri:level="1"><nlm:affiliation>Spanish National Cancer Research Centre, CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Research Centre, CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baglole, Carolyn J" sort="Baglole, Carolyn J" uniqKey="Baglole C" first="Carolyn J" last="Baglole">Carolyn J. Baglole</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, McGill University, Montreal, Quebec H4A 3J1, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, McGill University, Montreal, Quebec H4A 3J1</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dong, Chenfang" sort="Dong, Chenfang" uniqKey="Dong C" first="Chenfang" last="Dong">Chenfang Dong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mondello, Chiara" sort="Mondello, Chiara" uniqKey="Mondello C" first="Chiara" last="Mondello">Chiara Mondello</name>
<affiliation wicri:level="1"><nlm:affiliation>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsu, Chia Wen" sort="Hsu, Chia Wen" uniqKey="Hsu C" first="Chia-Wen" last="Hsu">Chia-Wen Hsu</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Naus, Christian C" sort="Naus, Christian C" uniqKey="Naus C" first="Christian C" last="Naus">Christian C. Naus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cellular and Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Cellular and Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V5Z 1M9</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yedjou, Clement" sort="Yedjou, Clement" uniqKey="Yedjou C" first="Clement" last="Yedjou">Clement Yedjou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Jackson State University, Jackson, MS 39217, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, Jackson State University, Jackson, MS 39217</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Curran, Colleen S" sort="Curran, Colleen S" uniqKey="Curran C" first="Colleen S" last="Curran">Colleen S. Curran</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Environmental Toxicology, University of Wisconsin-Madison, Madison, WI 53706, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Environmental Toxicology, University of Wisconsin-Madison, Madison, WI 53706</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laird, Dale W" sort="Laird, Dale W" uniqKey="Laird D" first="Dale W" last="Laird">Dale W. Laird</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 3K7, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 3K7</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koch, Daniel C" sort="Koch, Daniel C" uniqKey="Koch D" first="Daniel C" last="Koch">Daniel C. Koch</name>
<affiliation wicri:level="1"><nlm:affiliation>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carlin, Danielle J" sort="Carlin, Danielle J" uniqKey="Carlin D" first="Danielle J" last="Carlin">Danielle J. Carlin</name>
<affiliation wicri:level="1"><nlm:affiliation>Superfund Research Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27560, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Superfund Research Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27560</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Felsher, Dean W" sort="Felsher, Dean W" uniqKey="Felsher D" first="Dean W" last="Felsher">Dean W. Felsher</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Oncology and Pathology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Oncology and Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roy, Debasish" sort="Roy, Debasish" uniqKey="Roy D" first="Debasish" last="Roy">Debasish Roy</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brown, Dustin G" sort="Brown, Dustin G" uniqKey="Brown D" first="Dustin G" last="Brown">Dustin G. Brown</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ratovitski, Edward" sort="Ratovitski, Edward" uniqKey="Ratovitski E" first="Edward" last="Ratovitski">Edward Ratovitski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Head and Neck Surgery/Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Head and Neck Surgery/Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ryan, Elizabeth P" sort="Ryan, Elizabeth P" uniqKey="Ryan E" first="Elizabeth P" last="Ryan">Elizabeth P. Ryan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Corsini, Emanuela" sort="Corsini, Emanuela" uniqKey="Corsini E" first="Emanuela" last="Corsini">Emanuela Corsini</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rojas, Emilio" sort="Rojas, Emilio" uniqKey="Rojas E" first="Emilio" last="Rojas">Emilio Rojas</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moon, Eun Yi" sort="Moon, Eun Yi" uniqKey="Moon E" first="Eun-Yi" last="Moon">Eun-Yi Moon</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Laconi, Ezio" sort="Laconi, Ezio" uniqKey="Laconi E" first="Ezio" last="Laconi">Ezio Laconi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marongiu, Fabio" sort="Marongiu, Fabio" uniqKey="Marongiu F" first="Fabio" last="Marongiu">Fabio Marongiu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Mulla, Fahd" sort="Al Mulla, Fahd" uniqKey="Al Mulla F" first="Fahd" last="Al-Mulla">Fahd Al-Mulla</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Kuwait University, Safat 13110, Kuwait.</nlm:affiliation>
<country xml:lang="fr">Koweït</country>
<wicri:regionArea>Department of Pathology, Kuwait University, Safat 13110</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chiaradonna, Ferdinando" sort="Chiaradonna, Ferdinando" uniqKey="Chiaradonna F" first="Ferdinando" last="Chiaradonna">Ferdinando Chiaradonna</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Darroudi, Firouz" sort="Darroudi, Firouz" uniqKey="Darroudi F" first="Firouz" last="Darroudi">Firouz Darroudi</name>
<affiliation><nlm:affiliation>Human Safety and Environmental Research, Department of Health Sciences, College of North Atlantic, Doha 24449, State of Qatar.</nlm:affiliation>
<wicri:noCountry code="subField">State of Qatar</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Martin, Francis L" sort="Martin, Francis L" uniqKey="Martin F" first="Francis L" last="Martin">Francis L. Martin</name>
<affiliation wicri:level="1"><nlm:affiliation>Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Schooten, Frederik J" sort="Van Schooten, Frederik J" uniqKey="Van Schooten F" first="Frederik J" last="Van Schooten">Frederik J. Van Schooten</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht 6200, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht 6200</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goldberg, Gary S" sort="Goldberg, Gary S" uniqKey="Goldberg G" first="Gary S" last="Goldberg">Gary S. Goldberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wagemaker, Gerard" sort="Wagemaker, Gerard" uniqKey="Wagemaker G" first="Gerard" last="Wagemaker">Gerard Wagemaker</name>
<affiliation wicri:level="1"><nlm:affiliation>Hacettepe University, Center for Stem Cell Research and Development, Ankara 06640, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Hacettepe University, Center for Stem Cell Research and Development, Ankara 06640</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nangami, Gladys N" sort="Nangami, Gladys N" uniqKey="Nangami G" first="Gladys N" last="Nangami">Gladys N. Nangami</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Calaf, Gloria M" sort="Calaf, Gloria M" uniqKey="Calaf G" first="Gloria M" last="Calaf">Gloria M. Calaf</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica, Chile.</nlm:affiliation>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Williams, Graeme" sort="Williams, Graeme" uniqKey="Williams G" first="Graeme" last="Williams">Graeme Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, University of Reading, Reading, RG6 6UB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biological Sciences, University of Reading, Reading, RG6 6UB</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolf, Gregory T" sort="Wolf, Gregory T" uniqKey="Wolf G" first="Gregory T" last="Wolf">Gregory T. Wolf</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koppen, Gudrun" sort="Koppen, Gudrun" uniqKey="Koppen G" first="Gudrun" last="Koppen">Gudrun Koppen</name>
<affiliation wicri:level="1"><nlm:affiliation>Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brunborg, Gunnar" sort="Brunborg, Gunnar" uniqKey="Brunborg G" first="Gunnar" last="Brunborg">Gunnar Brunborg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lyerly, H Kim" sort="Lyerly, H Kim" uniqKey="Lyerly H" first="H Kim" last="Lyerly">H Kim Lyerly</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krishnan, Harini" sort="Krishnan, Harini" uniqKey="Krishnan H" first="Harini" last="Krishnan">Harini Krishnan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ab Hamid, Hasiah" sort="Ab Hamid, Hasiah" uniqKey="Ab Hamid H" first="Hasiah" last="Ab Hamid">Hasiah Ab Hamid</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yasaei, Hemad" sort="Yasaei, Hemad" uniqKey="Yasaei H" first="Hemad" last="Yasaei">Hemad Yasaei</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, College of Health and Life Sciences and the Health and Environment Theme, Institute of Environment, Health and Societies, Brunel University Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Life Sciences, College of Health and Life Sciences and the Health and Environment Theme, Institute of Environment, Health and Societies, Brunel University Kingston Lane, Uxbridge, Middlesex UB8 3PH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sone, Hideko" sort="Sone, Hideko" uniqKey="Sone H" first="Hideko" last="Sone">Hideko Sone</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibraki 3058506, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibraki 3058506</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kondoh, Hiroshi" sort="Kondoh, Hiroshi" uniqKey="Kondoh H" first="Hiroshi" last="Kondoh">Hiroshi Kondoh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Geriatric Medicine, Kyoto University Hospital 54 Kawaharacho, Shogoin, Sakyo-ku Kyoto, 606-8507, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Geriatric Medicine, Kyoto University Hospital 54 Kawaharacho, Shogoin, Sakyo-ku Kyoto, 606-8507</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Salem, Hosni K" sort="Salem, Hosni K" uniqKey="Salem H" first="Hosni K" last="Salem">Hosni K. Salem</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Urology, Kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 11559, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Urology, Kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 11559</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hsu, Hsue Yin" sort="Hsu, Hsue Yin" uniqKey="Hsu H" first="Hsue-Yin" last="Hsu">Hsue-Yin Hsu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, Tzu-Chi University, Hualien 970, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Life Sciences, Tzu-Chi University, Hualien 970</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Hyun Ho" sort="Park, Hyun Ho" uniqKey="Park H" first="Hyun Ho" last="Park">Hyun Ho Park</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koturbash, Igor" sort="Koturbash, Igor" uniqKey="Koturbash I" first="Igor" last="Koturbash">Igor Koturbash</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miousse, Isabelle R" sort="Miousse, Isabelle R" uniqKey="Miousse I" first="Isabelle R" last="Miousse">Isabelle R. Miousse</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scovassi, A Ivana" sort="Scovassi, A Ivana" uniqKey="Scovassi A" first="A Ivana" last="Scovassi">A Ivana Scovassi</name>
<affiliation wicri:level="1"><nlm:affiliation>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klaunig, James E" sort="Klaunig, James E" uniqKey="Klaunig J" first="James E" last="Klaunig">James E. Klaunig</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental Health, Indiana University, School of Public Health, Bloomington, IN 47405, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, Indiana University, School of Public Health, Bloomington, IN 47405</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vondra Ek, Jan" sort="Vondra Ek, Jan" uniqKey="Vondra Ek J" first="Jan" last="Vondrá Ek">Jan Vondrá Ek</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cytokinetics, Institute of Biophysics Academy of Sciences of the Czech Republic, Brno, CZ-61265, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Cytokinetics, Institute of Biophysics Academy of Sciences of the Czech Republic, Brno, CZ-61265</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Raju, Jayadev" sort="Raju, Jayadev" uniqKey="Raju J" first="Jayadev" last="Raju">Jayadev Raju</name>
<affiliation wicri:level="1"><nlm:affiliation>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roman, Jesse" sort="Roman, Jesse" uniqKey="Roman J" first="Jesse" last="Roman">Jesse Roman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Louisville, Louisville, KY 40202, USA, Robley Rex VA Medical Center, Louisville, KY 40202, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Louisville, Louisville, KY 40202, USA, Robley Rex VA Medical Center, Louisville, KY 40202</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wise, John Pierce" sort="Wise, John Pierce" uniqKey="Wise J" first="John Pierce" last="Wise">John Pierce Wise</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Whitfield, Jonathan R" sort="Whitfield, Jonathan R" uniqKey="Whitfield J" first="Jonathan R" last="Whitfield">Jonathan R. Whitfield</name>
<affiliation wicri:level="1"><nlm:affiliation>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Woodrick, Jordan" sort="Woodrick, Jordan" uniqKey="Woodrick J" first="Jordan" last="Woodrick">Jordan Woodrick</name>
<affiliation wicri:level="1"><nlm:affiliation>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Christopher, Joseph A" sort="Christopher, Joseph A" uniqKey="Christopher J" first="Joseph A" last="Christopher">Joseph A. Christopher</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Research UK. Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Research UK. Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ochieng, Josiah" sort="Ochieng, Josiah" uniqKey="Ochieng J" first="Josiah" last="Ochieng">Josiah Ochieng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martinez Leal, Juan Fernando" sort="Martinez Leal, Juan Fernando" uniqKey="Martinez Leal J" first="Juan Fernando" last="Martinez-Leal">Juan Fernando Martinez-Leal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, Pharmamar-SAU, Avda. De los Reyes, 1. 28770-Colmenar Viejo, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Cell Biology, Pharmamar-SAU, Avda. De los Reyes, 1. 28770-Colmenar Viejo, Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weisz, Judith" sort="Weisz, Judith" uniqKey="Weisz J" first="Judith" last="Weisz">Judith Weisz</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Obstetrics and Gynecology and Pathology, Pennsylvania State University College of Medicine, Hershey PA 17033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Obstetrics and Gynecology and Pathology, Pennsylvania State University College of Medicine, Hershey PA 17033</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kravchenko, Julia" sort="Kravchenko, Julia" uniqKey="Kravchenko J" first="Julia" last="Kravchenko">Julia Kravchenko</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sun, Jun" sort="Sun, Jun" uniqKey="Sun J" first="Jun" last="Sun">Jun Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Rush University, Chicago, IL 60612, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Rush University, Chicago, IL 60612</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prudhomme, Kalan R" sort="Prudhomme, Kalan R" uniqKey="Prudhomme K" first="Kalan R" last="Prudhomme">Kalan R. Prudhomme</name>
<affiliation wicri:level="1"><nlm:affiliation>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Narayanan, Kannan Badri" sort="Narayanan, Kannan Badri" uniqKey="Narayanan K" first="Kannan Badri" last="Narayanan">Kannan Badri Narayanan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cohen Solal, Karine A" sort="Cohen Solal, Karine A" uniqKey="Cohen Solal K" first="Karine A" last="Cohen-Solal">Karine A. Cohen-Solal</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moorwood, Kim" sort="Moorwood, Kim" uniqKey="Moorwood K" first="Kim" last="Moorwood">Kim Moorwood</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Laetitia" sort="Gonzalez, Laetitia" uniqKey="Gonzalez L" first="Laetitia" last="Gonzalez">Laetitia Gonzalez</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soucek, Laura" sort="Soucek, Laura" uniqKey="Soucek L" first="Laura" last="Soucek">Laura Soucek</name>
<affiliation wicri:level="1"><nlm:affiliation>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jian, Le" sort="Jian, Le" uniqKey="Jian L" first="Le" last="Jian">Le Jian</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Curtin University, Bentley, WA 6102, Australia, Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, Curtin University, Bentley, WA 6102, Australia, Department of Urology, University of California Davis, Sacramento, CA 95817</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="D Abronzo, Leandro S" sort="D Abronzo, Leandro S" uniqKey="D Abronzo L" first="Leandro S" last="D'Abronzo">Leandro S. D'Abronzo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of California Davis, Sacramento, CA 95817</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lin, Liang Tzung" sort="Lin, Liang Tzung" uniqKey="Lin L" first="Liang-Tzung" last="Lin">Liang-Tzung Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Lin" sort="Li, Lin" uniqKey="Li L" first="Lin" last="Li">Lin Li</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.</nlm:affiliation>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gulliver, Linda" sort="Gulliver, Linda" uniqKey="Gulliver L" first="Linda" last="Gulliver">Linda Gulliver</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Otago, Dunedin 9054, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Faculty of Medicine, University of Otago, Dunedin 9054</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mccawley, Lisa J" sort="Mccawley, Lisa J" uniqKey="Mccawley L" first="Lisa J" last="Mccawley">Lisa J. Mccawley</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Engineering and Cancer Biology, Vanderbilt University, Nashville, TN 37235, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering and Cancer Biology, Vanderbilt University, Nashville, TN 37235</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Memeo, Lorenzo" sort="Memeo, Lorenzo" uniqKey="Memeo L" first="Lorenzo" last="Memeo">Lorenzo Memeo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vermeulen, Louis" sort="Vermeulen, Louis" uniqKey="Vermeulen L" first="Louis" last="Vermeulen">Louis Vermeulen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leyns, Luc" sort="Leyns, Luc" uniqKey="Leyns L" first="Luc" last="Leyns">Luc Leyns</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Luoping" sort="Zhang, Luoping" uniqKey="Zhang L" first="Luoping" last="Zhang">Luoping Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Valverde, Mahara" sort="Valverde, Mahara" uniqKey="Valverde M" first="Mahara" last="Valverde">Mahara Valverde</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khatami, Mahin" sort="Khatami, Mahin" uniqKey="Khatami M" first="Mahin" last="Khatami">Mahin Khatami</name>
<affiliation wicri:level="1"><nlm:affiliation>Inflammation and Cancer Research, National Cancer Institute (NCI) (Retired), National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Inflammation and Cancer Research, National Cancer Institute (NCI) (Retired), National Institutes of Health, Bethesda, MD 20892</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Romano, Maria Fiammetta" sort="Romano, Maria Fiammetta" uniqKey="Romano M" first="Maria Fiammetta" last="Romano">Maria Fiammetta Romano</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chapellier, Marion" sort="Chapellier, Marion" uniqKey="Chapellier M" first="Marion" last="Chapellier">Marion Chapellier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre De Recherche En Cancerologie, De Lyon, Lyon, U1052-UMR5286, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre De Recherche En Cancerologie, De Lyon, Lyon, U1052-UMR5286</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Williams, Marc A" sort="Williams, Marc A" uniqKey="Williams M" first="Marc A" last="Williams">Marc A. Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wade, Mark" sort="Wade, Mark" uniqKey="Wade M" first="Mark" last="Wade">Mark Wade</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milano, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milano</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manjili, Masoud H" sort="Manjili, Masoud H" uniqKey="Manjili M" first="Masoud H" last="Manjili">Masoud H. Manjili</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lleonart, Matilde E" sort="Lleonart, Matilde E" uniqKey="Lleonart M" first="Matilde E" last="Lleonart">Matilde E. Lleonart</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut De Recerca Hospital Vall D'Hebron, Passeig Vall d'Hebron, 119-129, 08035 Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut De Recerca Hospital Vall D'Hebron, Passeig Vall d'Hebron, 119-129, 08035 Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xia, Menghang" sort="Xia, Menghang" uniqKey="Xia M" first="Menghang" last="Xia">Menghang Xia</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Michael J" sort="Gonzalez, Michael J" uniqKey="Gonzalez M" first="Michael J" last="Gonzalez">Michael J. Gonzalez</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan 00921, Puerto Rico.</nlm:affiliation>
<country xml:lang="fr">Porto Rico</country>
<wicri:regionArea>University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan 00921</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karamouzis, Michalis V" sort="Karamouzis, Michalis V" uniqKey="Karamouzis M" first="Michalis V" last="Karamouzis">Michalis V. Karamouzis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Chemistry, Medical School, University of Athens, Institute of Molecular Medicine and Biomedical Research, 10676 Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Biological Chemistry, Medical School, University of Athens, Institute of Molecular Medicine and Biomedical Research, 10676 Athens</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kirsch Volders, Micheline" sort="Kirsch Volders, Micheline" uniqKey="Kirsch Volders M" first="Micheline" last="Kirsch-Volders">Micheline Kirsch-Volders</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vaccari, Monica" sort="Vaccari, Monica" uniqKey="Vaccari M" first="Monica" last="Vaccari">Monica Vaccari</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuemmerle, Nancy B" sort="Kuemmerle, Nancy B" uniqKey="Kuemmerle N" first="Nancy B" last="Kuemmerle">Nancy B. Kuemmerle</name>
<affiliation wicri:level="1"><nlm:affiliation>Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Singh, Neetu" sort="Singh, Neetu" uniqKey="Singh N" first="Neetu" last="Singh">Neetu Singh</name>
<affiliation wicri:level="1"><nlm:affiliation>Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh 226 003, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh 226 003</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cruickshanks, Nichola" sort="Cruickshanks, Nichola" uniqKey="Cruickshanks N" first="Nichola" last="Cruickshanks">Nichola Cruickshanks</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kleinstreuer, Nicole" sort="Kleinstreuer, Nicole" uniqKey="Kleinstreuer N" first="Nicole" last="Kleinstreuer">Nicole Kleinstreuer</name>
<affiliation wicri:level="1"><nlm:affiliation>Integrated Laboratory Systems Inc., in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, RTP, NC 27709, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Laboratory Systems Inc., in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, RTP, NC 27709</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Larebeke, Nik" sort="Van Larebeke, Nik" uniqKey="Van Larebeke N" first="Nik" last="Van Larebeke">Nik Van Larebeke</name>
<affiliation wicri:level="1"><nlm:affiliation>Analytische, Milieu en Geochemie, Vrije Universiteit Brussel, Brussel B1050, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Analytische, Milieu en Geochemie, Vrije Universiteit Brussel, Brussel B1050</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahmed, Nuzhat" sort="Ahmed, Nuzhat" uniqKey="Ahmed N" first="Nuzhat" last="Ahmed">Nuzhat Ahmed</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Melbourne, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Melbourne, Victoria 3052</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ogunkua, Olugbemiga" sort="Ogunkua, Olugbemiga" uniqKey="Ogunkua O" first="Olugbemiga" last="Ogunkua">Olugbemiga Ogunkua</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krishnakumar, P K" sort="Krishnakumar, P K" uniqKey="Krishnakumar P" first="P K" last="Krishnakumar">P K Krishnakumar</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 3126, Saudi Arabia .</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 3126</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vadgama, Pankaj" sort="Vadgama, Pankaj" uniqKey="Vadgama P" first="Pankaj" last="Vadgama">Pankaj Vadgama</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marignani, Paola A" sort="Marignani, Paola A" uniqKey="Marignani P" first="Paola A" last="Marignani">Paola A. Marignani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghosh, Paramita M" sort="Ghosh, Paramita M" uniqKey="Ghosh P" first="Paramita M" last="Ghosh">Paramita M. Ghosh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of California Davis, Sacramento, CA 95817</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ostrosky Wegman, Patricia" sort="Ostrosky Wegman, Patricia" uniqKey="Ostrosky Wegman P" first="Patricia" last="Ostrosky-Wegman">Patricia Ostrosky-Wegman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Mexique</country>
<wicri:regionArea>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thompson, Patricia A" sort="Thompson, Patricia A" uniqKey="Thompson P" first="Patricia A" last="Thompson">Patricia A. Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stony Brook School of Medicine, Stony Brook University, The State University of New York, Stony Brook, NY 11794-8691, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stony Brook School of Medicine, Stony Brook University, The State University of New York, Stony Brook, NY 11794-8691</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dent, Paul" sort="Dent, Paul" uniqKey="Dent P" first="Paul" last="Dent">Paul Dent</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heneberg, Petr" sort="Heneberg, Petr" uniqKey="Heneberg P" first="Petr" last="Heneberg">Petr Heneberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Charles University in Prague, Third Faculty of Medicine, CZ-100 00 Prague 10, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Charles University in Prague, Third Faculty of Medicine, CZ-100 00 Prague 10</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Darbre, Philippa" sort="Darbre, Philippa" uniqKey="Darbre P" first="Philippa" last="Darbre">Philippa Darbre</name>
<affiliation wicri:level="2"><nlm:affiliation>School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6UB, England.</nlm:affiliation>
<country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6UB</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sing Leung, Po" sort="Sing Leung, Po" uniqKey="Sing Leung P" first="Po" last="Sing Leung">Po Sing Leung</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.</nlm:affiliation>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<country>Hong Kong</country>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nangia Makker, Pratima" sort="Nangia Makker, Pratima" uniqKey="Nangia Makker P" first="Pratima" last="Nangia-Makker">Pratima Nangia-Makker</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Wayne State University, Detroit, MI 48201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Wayne State University, Detroit, MI 48201</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cheng, Qiang Shawn" sort="Cheng, Qiang Shawn" uniqKey="Cheng Q" first="Qiang Shawn" last="Cheng">Qiang Shawn Cheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Computer Science Department, Southern Illinois University, Carbondale, IL 62901</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robey, R Brooks" sort="Robey, R Brooks" uniqKey="Robey R" first="R Brooks" last="Robey">R Brooks Robey</name>
<affiliation wicri:level="1"><nlm:affiliation>White River Junction Veterans Affairs Medical Center, White River Junction, VT 05009, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>White River Junction Veterans Affairs Medical Center, White River Junction, VT 05009, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Temaimi, Rabeah" sort="Al Temaimi, Rabeah" uniqKey="Al Temaimi R" first="Rabeah" last="Al-Temaimi">Rabeah Al-Temaimi</name>
<affiliation wicri:level="1"><nlm:affiliation>Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya 13110, Kuwait.</nlm:affiliation>
<country xml:lang="fr">Koweït</country>
<wicri:regionArea>Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya 13110</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roy, Rabindra" sort="Roy, Rabindra" uniqKey="Roy R" first="Rabindra" last="Roy">Rabindra Roy</name>
<affiliation wicri:level="1"><nlm:affiliation>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrade Vieira, Rafaela" sort="Andrade Vieira, Rafaela" uniqKey="Andrade Vieira R" first="Rafaela" last="Andrade-Vieira">Rafaela Andrade-Vieira</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sinha, Ranjeet K" sort="Sinha, Ranjeet K" uniqKey="Sinha R" first="Ranjeet K" last="Sinha">Ranjeet K. Sinha</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mehta, Rekha" sort="Mehta, Rekha" uniqKey="Mehta R" first="Rekha" last="Mehta">Rekha Mehta</name>
<affiliation wicri:level="1"><nlm:affiliation>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vento, Renza" sort="Vento, Renza" uniqKey="Vento R" first="Renza" last="Vento">Renza Vento</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy , Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy , Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Di Fiore, Riccardo" sort="Di Fiore, Riccardo" uniqKey="Di Fiore R" first="Riccardo" last="Di Fiore">Riccardo Di Fiore</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy .</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ponce Cusi, Richard" sort="Ponce Cusi, Richard" uniqKey="Ponce Cusi R" first="Richard" last="Ponce-Cusi">Richard Ponce-Cusi</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto de Alta Investigacion, Universidad de Tarapaca, Arica, Chile.</nlm:affiliation>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Instituto de Alta Investigacion, Universidad de Tarapaca, Arica</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dornetshuber Fleiss, Rita" sort="Dornetshuber Fleiss, Rita" uniqKey="Dornetshuber Fleiss R" first="Rita" last="Dornetshuber-Fleiss">Rita Dornetshuber-Fleiss</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Toxicology, University of Vienna, Vienna A-1090, Austria, Institute of Cancer Research, Department of Medicine, Medical University of Vienna, Wien 1090, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Pharmacology and Toxicology, University of Vienna, Vienna A-1090, Austria, Institute of Cancer Research, Department of Medicine, Medical University of Vienna, Wien 1090</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nahta, Rita" sort="Nahta, Rita" uniqKey="Nahta R" first="Rita" last="Nahta">Rita Nahta</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Pharmacology and Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacology and Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Castellino, Robert C" sort="Castellino, Robert C" uniqKey="Castellino R" first="Robert C" last="Castellino">Robert C. Castellino</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta, GA 30322, USA, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta, GA 30322, USA, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Palorini, Roberta" sort="Palorini, Roberta" uniqKey="Palorini R" first="Roberta" last="Palorini">Roberta Palorini</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abd Hamid, Roslida" sort="Abd Hamid, Roslida" uniqKey="Abd Hamid R" first="Roslida" last="Abd Hamid">Roslida Abd Hamid</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langie, Sabine A S" sort="Langie, Sabine A S" uniqKey="Langie S" first="Sabine A S" last="Langie">Sabine A S. Langie</name>
<affiliation wicri:level="1"><nlm:affiliation>Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eltom, Sakina E" sort="Eltom, Sakina E" uniqKey="Eltom S" first="Sakina E" last="Eltom">Sakina E. Eltom</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brooks, Samira A" sort="Brooks, Samira A" uniqKey="Brooks S" first="Samira A" last="Brooks">Samira A. Brooks</name>
<affiliation wicri:level="1"><nlm:affiliation>Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ryeom, Sandra" sort="Ryeom, Sandra" uniqKey="Ryeom S" first="Sandra" last="Ryeom">Sandra Ryeom</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wise, Sandra S" sort="Wise, Sandra S" uniqKey="Wise S" first="Sandra S" last="Wise">Sandra S. Wise</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bay, Sarah N" sort="Bay, Sarah N" uniqKey="Bay S" first="Sarah N" last="Bay">Sarah N. Bay</name>
<affiliation wicri:level="1"><nlm:affiliation>Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harris, Shelley A" sort="Harris, Shelley A" uniqKey="Harris S" first="Shelley A" last="Harris">Shelley A. Harris</name>
<affiliation wicri:level="1"><nlm:affiliation>Population Health and Prevention, Research, Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada, Departments of Epidemiology and Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7, Canada .</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Population Health and Prevention, Research, Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada, Departments of Epidemiology and Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Papagerakis, Silvana" sort="Papagerakis, Silvana" uniqKey="Papagerakis S" first="Silvana" last="Papagerakis">Silvana Papagerakis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Romano, Simona" sort="Romano, Simona" uniqKey="Romano S" first="Simona" last="Romano">Simona Romano</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pavanello, Sofia" sort="Pavanello, Sofia" uniqKey="Pavanello S" first="Sofia" last="Pavanello">Sofia Pavanello</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiac, Thoracic and Vascular Sciences, Unit of Occupational Medicine, University of Padova, Padova 35128, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiac, Thoracic and Vascular Sciences, Unit of Occupational Medicine, University of Padova, Padova 35128</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eriksson, Staffan" sort="Eriksson, Staffan" uniqKey="Eriksson S" first="Staffan" last="Eriksson">Staffan Eriksson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy, Physiology and Biochemistry, The Swedish University of Agricultural Sciences, PO Box 7011, VHC, Almas Allé 4, SE-756 51, Uppsala, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Anatomy, Physiology and Biochemistry, The Swedish University of Agricultural Sciences, PO Box 7011, VHC, Almas Allé 4, SE-756 51, Uppsala</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Forte, Stefano" sort="Forte, Stefano" uniqKey="Forte S" first="Stefano" last="Forte">Stefano Forte</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Casey, Stephanie C" sort="Casey, Stephanie C" uniqKey="Casey S" first="Stephanie C" last="Casey">Stephanie C. Casey</name>
<affiliation wicri:level="1"><nlm:affiliation>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luanpitpong, Sudjit" sort="Luanpitpong, Sudjit" uniqKey="Luanpitpong S" first="Sudjit" last="Luanpitpong">Sudjit Luanpitpong</name>
<affiliation wicri:level="1"><nlm:affiliation>Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Tae Jin" sort="Lee, Tae Jin" uniqKey="Lee T" first="Tae-Jin" last="Lee">Tae-Jin Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy, College of Medicine, Yeungnam University, Daegu 705-717, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Anatomy, College of Medicine, Yeungnam University, Daegu 705-717</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Otsuki, Takemi" sort="Otsuki, Takemi" uniqKey="Otsuki T" first="Takemi" last="Otsuki">Takemi Otsuki</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Hygiene, Kawasaki Medical School, Matsushima Kurashiki, Okayama 701-0192, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Hygiene, Kawasaki Medical School, Matsushima Kurashiki, Okayama 701-0192</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Tao" sort="Chen, Tao" uniqKey="Chen T" first="Tao" last="Chen">Tao Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Massfelder, Thierry" sort="Massfelder, Thierry" uniqKey="Massfelder T" first="Thierry" last="Massfelder">Thierry Massfelder</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sanderson, Thomas" sort="Sanderson, Thomas" uniqKey="Sanderson T" first="Thomas" last="Sanderson">Thomas Sanderson</name>
<affiliation wicri:level="1"><nlm:affiliation>INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval, QC H7V 1B7</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guarnieri, Tiziana" sort="Guarnieri, Tiziana" uniqKey="Guarnieri T" first="Tiziana" last="Guarnieri">Tiziana Guarnieri</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Geology and Environmental Sciences, Alma Mater Studiorum Università di Bologna, Via Francesco Selmi, 3, 40126 Bologna, Italy, Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Via Massarenti, 9, 40126 Bologna, Italy, National Institute of Biostructures and Biosystems, Viale Medaglie d' Oro, 305, 00136 Roma, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biology, Geology and Environmental Sciences, Alma Mater Studiorum Università di Bologna, Via Francesco Selmi, 3, 40126 Bologna, Italy, Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Via Massarenti, 9, 40126 Bologna, Italy, National Institute of Biostructures and Biosystems, Viale Medaglie d' Oro, 305, 00136 Roma</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hultman, Tove" sort="Hultman, Tove" uniqKey="Hultman T" first="Tove" last="Hultman">Tove Hultman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dormoy, Valerian" sort="Dormoy, Valerian" uniqKey="Dormoy V" first="Valérian" last="Dormoy">Valérian Dormoy</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France, Department of Cell and Developmental Biology, University of California, Irvine, CA 92697, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France, Department of Cell and Developmental Biology, University of California, Irvine, CA 92697</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Odero Marah, Valerie" sort="Odero Marah, Valerie" uniqKey="Odero Marah V" first="Valerie" last="Odero-Marah">Valerie Odero-Marah</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology/Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology/Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sabbisetti, Venkata" sort="Sabbisetti, Venkata" uniqKey="Sabbisetti V" first="Venkata" last="Sabbisetti">Venkata Sabbisetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Harvard Medical School/Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School/Brigham and Women's Hospital, Boston, MA 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maguer Satta, Veronique" sort="Maguer Satta, Veronique" uniqKey="Maguer Satta V" first="Veronique" last="Maguer-Satta">Veronique Maguer-Satta</name>
<affiliation wicri:level="1"><nlm:affiliation>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rathmell, W Kimryn" sort="Rathmell, W Kimryn" uniqKey="Rathmell W" first="W Kimryn" last="Rathmell">W Kimryn Rathmell</name>
<affiliation wicri:level="1"><nlm:affiliation>Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Engstrom, Wilhelm" sort="Engstrom, Wilhelm" uniqKey="Engstrom W" first="Wilhelm" last="Engström">Wilhelm Engström</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Decker, William K" sort="Decker, William K" uniqKey="Decker W" first="William K" last="Decker">William K. Decker</name>
<affiliation wicri:level="1"><nlm:affiliation>Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Baylor College of Medicine, Houston, TX 77030</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bisson, William H" sort="Bisson, William H" uniqKey="Bisson W" first="William H" last="Bisson">William H. Bisson</name>
<affiliation wicri:level="1"><nlm:affiliation>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rojanasakul, Yon" sort="Rojanasakul, Yon" uniqKey="Rojanasakul Y" first="Yon" last="Rojanasakul">Yon Rojanasakul</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506</wicri:regionArea>
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<author><name sortKey="Luqmani, Yunus" sort="Luqmani, Yunus" uniqKey="Luqmani Y" first="Yunus" last="Luqmani">Yunus Luqmani</name>
<affiliation><nlm:affiliation>Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait and.</nlm:affiliation>
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</affiliation>
</author>
<author><name sortKey="Chen, Zhenbang" sort="Chen, Zhenbang" uniqKey="Chen Z" first="Zhenbang" last="Chen">Zhenbang Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208</wicri:regionArea>
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</author>
<author><name sortKey="Hu, Zhiwei" sort="Hu, Zhiwei" uniqKey="Hu Z" first="Zhiwei" last="Hu">Zhiwei Hu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210</wicri:regionArea>
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<series><title level="j">Carcinogenesis</title>
<idno type="eISSN">1460-2180</idno>
<imprint><date when="2015" type="published">2015</date>
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<term>Carcinogenesis (chemically induced)</term>
<term>Carcinogens, Environmental (adverse effects)</term>
<term>Environmental Exposure (adverse effects)</term>
<term>Hazardous Substances (adverse effects)</term>
<term>Humans</term>
<term>Neoplasms (chemically induced)</term>
<term>Neoplasms (etiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cancérogènes environnementaux (effets indésirables)</term>
<term>Carcinogenèse ()</term>
<term>Exposition environnementale (effets indésirables)</term>
<term>Humains</term>
<term>Produits dangereux (effets indésirables)</term>
<term>Tumeurs ()</term>
<term>Tumeurs (étiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Carcinogens, Environmental</term>
<term>Hazardous Substances</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Carcinogenesis</term>
<term>Neoplasms</term>
</keywords>
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<term>Exposition environnementale</term>
<term>Produits dangereux</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26106142</PMID>
<DateCreated><Year>2015</Year>
<Month>06</Month>
<Day>24</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>09</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>05</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1460-2180</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>36 Suppl 1</Volume>
<PubDate><Year>2015</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Carcinogenesis</Title>
<ISOAbbreviation>Carcinogenesis</ISOAbbreviation>
</Journal>
<ArticleTitle>Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.</ArticleTitle>
<Pagination><MedlinePgn>S254-96</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/carcin/bgv039</ELocationID>
<Abstract><AbstractText>Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.</AbstractText>
<CopyrightInformation>© The Author 2015. Published by Oxford University Press.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Goodson</LastName>
<ForeName>William H</ForeName>
<Initials>WH</Initials>
<Suffix>3rd</Suffix>
<AffiliationInfo><Affiliation>California Pacific Medical Center Research Institute, 2100 Webster Street #401, San Francisco, CA 94115, USA, Getting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK, Institute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144, USA, Getting to Know Cancer, Guelph N1G 1E4, Canada, School of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu, Malaysia, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA, Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla, Spain, Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy, School of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK, Department of Nutrition, University of Oslo, Oslo, Norway, Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK, Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy, Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway, Planet Biotechnologies Inc., St Albert, Alberta T8N 5K4, Canada, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA, Spanish National Cancer Research Centre, CNI</Affiliation>
</AffiliationInfo>
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<ForeName>Leroy</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Getting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK.</Affiliation>
</AffiliationInfo>
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<ForeName>David O</ForeName>
<Initials>DO</Initials>
<AffiliationInfo><Affiliation>Institute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144, USA.</Affiliation>
</AffiliationInfo>
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<ForeName>Michael</ForeName>
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<AffiliationInfo><Affiliation>Getting to Know Cancer, Guelph N1G 1E4, Canada.</Affiliation>
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<ForeName>Abdul</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>School of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu, Malaysia.</Affiliation>
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<Author ValidYN="Y"><LastName>Lopez de Cerain Salsamendi</LastName>
<ForeName>Adela</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Lasfar</LastName>
<ForeName>Ahmed</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA.</Affiliation>
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<ForeName>Amancio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Azqueta</LastName>
<ForeName>Amaya</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Amedei</LastName>
<ForeName>Amedeo</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Charles</LastName>
<ForeName>Amelia K</ForeName>
<Initials>AK</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Collins</LastName>
<ForeName>Andrew R</ForeName>
<Initials>AR</Initials>
<AffiliationInfo><Affiliation>Department of Nutrition, University of Oslo, Oslo, Norway.</Affiliation>
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<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.</Affiliation>
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<ForeName>Anna C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA.</Affiliation>
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<ForeName>Annamaria</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy.</Affiliation>
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<Initials>AK</Initials>
<AffiliationInfo><Affiliation>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway.</Affiliation>
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<ForeName>Arthur</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA.</Affiliation>
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<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>Planet Biotechnologies Inc., St Albert, Alberta T8N 5K4, Canada.</Affiliation>
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<Initials>BP</Initials>
<AffiliationInfo><Affiliation>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.</Affiliation>
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<ForeName>Carmen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Spanish National Cancer Research Centre, CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid, Spain.</Affiliation>
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<ForeName>Carolyn J</ForeName>
<Initials>CJ</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, McGill University, Montreal, Quebec H4A 3J1, Canada.</Affiliation>
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<ForeName>Chenfang</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.</Affiliation>
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<ForeName>Chiara</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.</Affiliation>
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<Initials>CW</Initials>
<AffiliationInfo><Affiliation>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.</Affiliation>
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<Initials>CC</Initials>
<AffiliationInfo><Affiliation>Department of Cellular and Physiological Sciences, Life Sciences Institute, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.</Affiliation>
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<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Biology, Jackson State University, Jackson, MS 39217, USA.</Affiliation>
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<ForeName>Colleen S</ForeName>
<Initials>CS</Initials>
<AffiliationInfo><Affiliation>Department of Molecular and Environmental Toxicology, University of Wisconsin-Madison, Madison, WI 53706, USA.</Affiliation>
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<ForeName>Dale W</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 3K7, Canada.</Affiliation>
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<ForeName>Daniel C</ForeName>
<Initials>DC</Initials>
<AffiliationInfo><Affiliation>Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305, USA.</Affiliation>
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<ForeName>Danielle J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Superfund Research Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27560, USA.</Affiliation>
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<ForeName>Dean W</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Oncology and Pathology, Stanford University, Stanford, CA 94305, USA.</Affiliation>
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<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Natural Science, The City University of New York at Hostos Campus, Bronx, NY 10451, USA.</Affiliation>
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<Initials>DG</Initials>
<AffiliationInfo><Affiliation>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.</Affiliation>
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<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Head and Neck Surgery/Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</Affiliation>
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<Initials>EP</Initials>
<AffiliationInfo><Affiliation>Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA.</Affiliation>
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<ForeName>Emanuela</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.</Affiliation>
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<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</Affiliation>
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<Initials>EY</Initials>
<AffiliationInfo><Affiliation>Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.</Affiliation>
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<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.</Affiliation>
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<ForeName>Fabio</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.</Affiliation>
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<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Kuwait University, Safat 13110, Kuwait.</Affiliation>
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<ForeName>Ferdinando</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.</Affiliation>
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<AffiliationInfo><Affiliation>Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Hacettepe University, Center for Stem Cell Research and Development, Ankara 06640, Turkey.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Molecular Biology, School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</Affiliation>
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<Author ValidYN="Y"><LastName>Yasaei</LastName>
<ForeName>Hemad</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Life Sciences, College of Health and Life Sciences and the Health and Environment Theme, Institute of Environment, Health and Societies, Brunel University Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Sone</LastName>
<ForeName>Hideko</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibraki 3058506, Japan.</Affiliation>
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<Author ValidYN="Y"><LastName>Kondoh</LastName>
<ForeName>Hiroshi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Geriatric Medicine, Kyoto University Hospital 54 Kawaharacho, Shogoin, Sakyo-ku Kyoto, 606-8507, Japan.</Affiliation>
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<Author ValidYN="Y"><LastName>Salem</LastName>
<ForeName>Hosni K</ForeName>
<Initials>HK</Initials>
<AffiliationInfo><Affiliation>Department of Urology, Kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 11559, Egypt.</Affiliation>
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<Author ValidYN="Y"><LastName>Hsu</LastName>
<ForeName>Hsue-Yin</ForeName>
<Initials>HY</Initials>
<AffiliationInfo><Affiliation>Department of Life Sciences, Tzu-Chi University, Hualien 970, Taiwan.</Affiliation>
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<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Hyun Ho</ForeName>
<Initials>HH</Initials>
<AffiliationInfo><Affiliation>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749, South Korea.</Affiliation>
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<Author ValidYN="Y"><LastName>Koturbash</LastName>
<ForeName>Igor</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Miousse</LastName>
<ForeName>Isabelle R</ForeName>
<Initials>IR</Initials>
<AffiliationInfo><Affiliation>Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Scovassi</LastName>
<ForeName>A Ivana</ForeName>
<Initials>AI</Initials>
<AffiliationInfo><Affiliation>Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Klaunig</LastName>
<ForeName>James E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Department of Environmental Health, Indiana University, School of Public Health, Bloomington, IN 47405, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Vondráček</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Cytokinetics, Institute of Biophysics Academy of Sciences of the Czech Republic, Brno, CZ-61265, Czech Republic.</Affiliation>
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<ForeName>Jayadev</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Roman</LastName>
<ForeName>Jesse</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Louisville, Louisville, KY 40202, USA, Robley Rex VA Medical Center, Louisville, KY 40202, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Wise</LastName>
<ForeName>John Pierce</ForeName>
<Initials>JP</Initials>
<Suffix>Sr</Suffix>
<AffiliationInfo><Affiliation>Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, USA.</Affiliation>
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<ForeName>Jonathan R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain.</Affiliation>
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<Initials>J</Initials>
<AffiliationInfo><Affiliation>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.</Affiliation>
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<ForeName>Joseph A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Cancer Research UK. Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Ochieng</LastName>
<ForeName>Josiah</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Martinez-Leal</LastName>
<ForeName>Juan Fernando</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology, Pharmamar-SAU, Avda. De los Reyes, 1. 28770-Colmenar Viejo, Madrid, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Weisz</LastName>
<ForeName>Judith</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Departments of Obstetrics and Gynecology and Pathology, Pennsylvania State University College of Medicine, Hershey PA 17033, USA.</Affiliation>
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<ForeName>Julia</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Surgery, Pathology, Immunology, Duke University Medical Center, Durham, NC 27710, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Rush University, Chicago, IL 60612, USA.</Affiliation>
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<ForeName>Kalan R</ForeName>
<Initials>KR</Initials>
<AffiliationInfo><Affiliation>Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Narayanan</LastName>
<ForeName>Kannan Badri</ForeName>
<Initials>KB</Initials>
<AffiliationInfo><Affiliation>School of Biotechnology, Yeungnam University, Gyeongbuk 712-749, South Korea.</Affiliation>
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<Author ValidYN="Y"><LastName>Cohen-Solal</LastName>
<ForeName>Karine A</ForeName>
<Initials>KA</Initials>
<AffiliationInfo><Affiliation>Department of Medicine/Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Moorwood</LastName>
<ForeName>Kim</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.</Affiliation>
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<ForeName>Laetitia</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</Affiliation>
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<Author ValidYN="Y"><LastName>Soucek</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Jian</LastName>
<ForeName>Le</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Curtin University, Bentley, WA 6102, Australia, Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>D'Abronzo</LastName>
<ForeName>Leandro S</ForeName>
<Initials>LS</Initials>
<AffiliationInfo><Affiliation>Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Liang-Tzung</ForeName>
<Initials>LT</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.</Affiliation>
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<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Lin</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.</Affiliation>
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<ForeName>Linda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Faculty of Medicine, University of Otago, Dunedin 9054, New Zealand.</Affiliation>
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<Author ValidYN="Y"><LastName>McCawley</LastName>
<ForeName>Lisa J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Engineering and Cancer Biology, Vanderbilt University, Nashville, TN 37235, USA.</Affiliation>
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<ForeName>Lorenzo</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.</Affiliation>
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<ForeName>Louis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.</Affiliation>
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<ForeName>Luc</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</Affiliation>
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<ForeName>Luoping</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.</Affiliation>
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<ForeName>Mahara</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</Affiliation>
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<ForeName>Mahin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Inflammation and Cancer Research, National Cancer Institute (NCI) (Retired), National Institutes of Health, Bethesda, MD 20892, USA.</Affiliation>
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<ForeName>Maria Fiammetta</ForeName>
<Initials>MF</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.</Affiliation>
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<ForeName>Marion</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre De Recherche En Cancerologie, De Lyon, Lyon, U1052-UMR5286, France.</Affiliation>
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<Initials>MA</Initials>
<AffiliationInfo><Affiliation>United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.</Affiliation>
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<Initials>M</Initials>
<AffiliationInfo><Affiliation>Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milano, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Manjili</LastName>
<ForeName>Masoud H</ForeName>
<Initials>MH</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298, USA.</Affiliation>
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<ForeName>Matilde E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Institut De Recerca Hospital Vall D'Hebron, Passeig Vall d'Hebron, 119-129, 08035 Barcelona, Spain.</Affiliation>
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<ForeName>Menghang</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Gonzalez</LastName>
<ForeName>Michael J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan 00921, Puerto Rico.</Affiliation>
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<Author ValidYN="Y"><LastName>Karamouzis</LastName>
<ForeName>Michalis V</ForeName>
<Initials>MV</Initials>
<AffiliationInfo><Affiliation>Department of Biological Chemistry, Medical School, University of Athens, Institute of Molecular Medicine and Biomedical Research, 10676 Athens, Greece.</Affiliation>
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<Author ValidYN="Y"><LastName>Kirsch-Volders</LastName>
<ForeName>Micheline</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.</Affiliation>
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<ForeName>Monica</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Kuemmerle</LastName>
<ForeName>Nancy B</ForeName>
<Initials>NB</Initials>
<AffiliationInfo><Affiliation>Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Singh</LastName>
<ForeName>Neetu</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh 226 003, India.</Affiliation>
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<Author ValidYN="Y"><LastName>Cruickshanks</LastName>
<ForeName>Nichola</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Kleinstreuer</LastName>
<ForeName>Nicole</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Integrated Laboratory Systems Inc., in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, RTP, NC 27709, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>van Larebeke</LastName>
<ForeName>Nik</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Analytische, Milieu en Geochemie, Vrije Universiteit Brussel, Brussel B1050, Belgium.</Affiliation>
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<Author ValidYN="Y"><LastName>Ahmed</LastName>
<ForeName>Nuzhat</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University of Melbourne, Victoria 3052, Australia.</Affiliation>
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<Author ValidYN="Y"><LastName>Ogunkua</LastName>
<ForeName>Olugbemiga</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Krishnakumar</LastName>
<ForeName>P K</ForeName>
<Initials>PK</Initials>
<AffiliationInfo><Affiliation>Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 3126, Saudi Arabia .</Affiliation>
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<Author ValidYN="Y"><LastName>Vadgama</LastName>
<ForeName>Pankaj</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Marignani</LastName>
<ForeName>Paola A</ForeName>
<Initials>PA</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Ghosh</LastName>
<ForeName>Paramita M</ForeName>
<Initials>PM</Initials>
<AffiliationInfo><Affiliation>Department of Urology, University of California Davis, Sacramento, CA 95817, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Ostrosky-Wegman</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.</Affiliation>
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<Author ValidYN="Y"><LastName>Thompson</LastName>
<ForeName>Patricia A</ForeName>
<Initials>PA</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Stony Brook School of Medicine, Stony Brook University, The State University of New York, Stony Brook, NY 11794-8691, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Dent</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Heneberg</LastName>
<ForeName>Petr</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Charles University in Prague, Third Faculty of Medicine, CZ-100 00 Prague 10, Czech Republic.</Affiliation>
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<Author ValidYN="Y"><LastName>Darbre</LastName>
<ForeName>Philippa</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6UB, England.</Affiliation>
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<Author ValidYN="Y"><LastName>Sing Leung</LastName>
<ForeName>Po</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.</Affiliation>
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<Author ValidYN="Y"><LastName>Nangia-Makker</LastName>
<ForeName>Pratima</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Wayne State University, Detroit, MI 48201, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Cheng</LastName>
<ForeName>Qiang Shawn</ForeName>
<Initials>QS</Initials>
<AffiliationInfo><Affiliation>Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Robey</LastName>
<ForeName>R Brooks</ForeName>
<Initials>RB</Initials>
<AffiliationInfo><Affiliation>White River Junction Veterans Affairs Medical Center, White River Junction, VT 05009, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Al-Temaimi</LastName>
<ForeName>Rabeah</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya 13110, Kuwait.</Affiliation>
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<Author ValidYN="Y"><LastName>Roy</LastName>
<ForeName>Rabindra</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Andrade-Vieira</LastName>
<ForeName>Rafaela</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Sinha</LastName>
<ForeName>Ranjeet K</ForeName>
<Initials>RK</Initials>
<AffiliationInfo><Affiliation>Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Mehta</LastName>
<ForeName>Rekha</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Vento</LastName>
<ForeName>Renza</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy , Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Di Fiore</LastName>
<ForeName>Riccardo</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy .</Affiliation>
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<Author ValidYN="Y"><LastName>Ponce-Cusi</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Instituto de Alta Investigacion, Universidad de Tarapaca, Arica, Chile.</Affiliation>
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<Author ValidYN="Y"><LastName>Dornetshuber-Fleiss</LastName>
<ForeName>Rita</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology and Toxicology, University of Vienna, Vienna A-1090, Austria, Institute of Cancer Research, Department of Medicine, Medical University of Vienna, Wien 1090, Austria.</Affiliation>
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<Author ValidYN="Y"><LastName>Nahta</LastName>
<ForeName>Rita</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Departments of Pharmacology and Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Castellino</LastName>
<ForeName>Robert C</ForeName>
<Initials>RC</Initials>
<AffiliationInfo><Affiliation>Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta, GA 30322, USA, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Palorini</LastName>
<ForeName>Roberta</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Abd Hamid</LastName>
<ForeName>Roslida</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</Affiliation>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
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