Epigenetics and depressive disorders: a review of current progress and future directions.
Identifieur interne : 002A49 ( PubMed/Curation ); précédent : 002A48; suivant : 002A50Epigenetics and depressive disorders: a review of current progress and future directions.
Auteurs : Vania Januar [Australie] ; Richard Saffery [Australie] ; Joanne Ryan [Australie]Source :
- International journal of epidemiology [ 1464-3685 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Dépression (génétique), Facteur neurotrophique dérivé du cerveau (génétique), Humains, Interaction entre gènes et environnement, Marqueurs biologiques (analyse), Modèles animaux de maladie humaine, Méthylation de l'ADN, Récepteurs aux glucocorticoïdes (génétique), Transporteurs de la sérotonine (génétique), Trouble dépressif majeur (génétique), Épigenèse génétique.
- MESH :
- analyse : Marqueurs biologiques.
- génétique : Dépression, Facteur neurotrophique dérivé du cerveau, Récepteurs aux glucocorticoïdes, Transporteurs de la sérotonine, Trouble dépressif majeur.
- Animaux, Humains, Interaction entre gènes et environnement, Modèles animaux de maladie humaine, Méthylation de l'ADN, Épigenèse génétique.
English descriptors
- KwdEn :
- Animals, Biomarkers (analysis), Brain-Derived Neurotrophic Factor (genetics), DNA Methylation, Depression (genetics), Depressive Disorder, Major (genetics), Disease Models, Animal, Epigenesis, Genetic, Gene-Environment Interaction, Humans, Receptors, Glucocorticoid (genetics), Serotonin Plasma Membrane Transport Proteins (genetics).
- MESH :
- chemical , analysis : Biomarkers.
- chemical , genetics : Brain-Derived Neurotrophic Factor, Receptors, Glucocorticoid, Serotonin Plasma Membrane Transport Proteins.
- genetics : Depression, Depressive Disorder, Major.
- Animals, DNA Methylation, Disease Models, Animal, Epigenesis, Genetic, Gene-Environment Interaction, Humans.
Abstract
Several broad lines of evidence support the involvement of epigenetic processes in neurodevelopment and psychiatric disorders. Epigenetic disruption also provides a potential mechanism to account for the numerous gene-environment interactions that have been reported in association with neuropsychiatric phenotypes.
DOI: 10.1093/ije/dyu273
PubMed: 25716985
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Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="1"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and Inserm U1061, Hopital La Colombiere & Universite Montpellier, Montpellier, France joanne.ryan@mcri.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia 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Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and joanne.ryan@mcri.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC</wicri:regionArea></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="4"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="1"><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and Inserm U1061, Hopital La Colombiere & Universite Montpellier, Montpellier, France joanne.ryan@mcri.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and Inserm U1061, Hopital La Colombiere & Universite Montpellier, Montpellier</wicri:regionArea></affiliation></author></analytic><series><title level="j">International journal of epidemiology</title><idno type="eISSN">1464-3685</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biomarkers (analysis)</term><term>Brain-Derived Neurotrophic Factor (genetics)</term><term>DNA Methylation</term><term>Depression (genetics)</term><term>Depressive Disorder, Major (genetics)</term><term>Disease Models, Animal</term><term>Epigenesis, Genetic</term><term>Gene-Environment Interaction</term><term>Humans</term><term>Receptors, Glucocorticoid (genetics)</term><term>Serotonin Plasma Membrane Transport Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Dépression (génétique)</term><term>Facteur neurotrophique dérivé du cerveau (génétique)</term><term>Humains</term><term>Interaction entre gènes et environnement</term><term>Marqueurs biologiques (analyse)</term><term>Modèles animaux de maladie humaine</term><term>Méthylation de l'ADN</term><term>Récepteurs aux glucocorticoïdes (génétique)</term><term>Transporteurs de la sérotonine (génétique)</term><term>Trouble dépressif majeur (génétique)</term><term>Épigenèse génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term><term>Receptors, Glucocorticoid</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depression</term><term>Depressive Disorder, Major</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Dépression</term><term>Facteur neurotrophique dérivé du cerveau</term><term>Récepteurs aux glucocorticoïdes</term><term>Transporteurs de la sérotonine</term><term>Trouble dépressif majeur</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>DNA Methylation</term><term>Disease Models, Animal</term><term>Epigenesis, Genetic</term><term>Gene-Environment Interaction</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Interaction entre gènes et environnement</term><term>Modèles animaux de maladie humaine</term><term>Méthylation de l'ADN</term><term>Épigenèse génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several broad lines of evidence support the involvement of epigenetic processes in neurodevelopment and psychiatric disorders. Epigenetic disruption also provides a potential mechanism to account for the numerous gene-environment interactions that have been reported in association with neuropsychiatric phenotypes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25716985</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>01</Day></DateCreated><DateCompleted><Year>2016</Year><Month>07</Month><Day>25</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1464-3685</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>International journal of epidemiology</Title><ISOAbbreviation>Int J Epidemiol</ISOAbbreviation></Journal><ArticleTitle>Epigenetics and depressive disorders: a review of current progress and future directions.</ArticleTitle><Pagination><MedlinePgn>1364-87</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/ije/dyu273</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several broad lines of evidence support the involvement of epigenetic processes in neurodevelopment and psychiatric disorders. Epigenetic disruption also provides a potential mechanism to account for the numerous gene-environment interactions that have been reported in association with neuropsychiatric phenotypes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A review of the literature was performed with keywords 'depression', 'depressive disorder' or 'antidepressants' and 'DNA methylation', or 'epigenetics' in humans. Citations were limited to those written in English and published prior to July 2014.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We present a summary of results to date. Most studies have focused on DNA methylation in various CNS or peripheral tissue, with almost universally small sample sizes. Although seven epigenome-wide association studies have now been reported, the majority of studies have used a candidate-gene approach. Three genes (SLC6A4, BDNF, NR3C1) have been investigated in more than one study, but replication of findings is generally lacking.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Recent evidence provides insights to epigenetic processes in psychiatric disorders; however, replication is lacking and care must be taken in the interpretation of current findings. This applies to epigenetic epidemiology generally, which is subject to various limitations that no single approach can address in isolation. Due to limited focus of most depression studies to date, placing the findings within the broader context of mood disorder pathophysiology may prove challenging. However, identifying peripheral biomarkers for depressive disorder remains a tantalising possibility, especially given the potential for carefully-designed longitudinal studies with multiple biospecimens and ongoing advances in epigenetic technologies.</AbstractText><CopyrightInformation>© The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Januar</LastName><ForeName>Vania</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and joanne.ryan@mcri.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saffery</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryan</LastName><ForeName>Joanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, & Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia and Inserm U1061, Hopital La Colombiere & Universite Montpellier, Montpellier, France joanne.ryan@mcri.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Int J Epidemiol</MedlineTA><NlmUniqueID>7802871</NlmUniqueID><ISSNLinking>0300-5771</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019208">Brain-Derived Neurotrophic Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C497713">NR3C1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011965">Receptors, Glucocorticoid</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C493230">SLC6A4 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050486">Serotonin Plasma Membrane Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C579455">brain-derived neurotrophic factor, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019208" MajorTopicYN="N">Brain-Derived Neurotrophic Factor</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019175" MajorTopicYN="Y">DNA Methylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003865" MajorTopicYN="N">Depressive Disorder, Major</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044127" MajorTopicYN="Y">Epigenesis, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059647" MajorTopicYN="N">Gene-Environment Interaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011965" MajorTopicYN="N">Receptors, Glucocorticoid</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050486" MajorTopicYN="N">Serotonin Plasma Membrane Transport Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CNS tissue</Keyword><Keyword MajorTopicYN="N">DNA methylation</Keyword><Keyword MajorTopicYN="N">Epigenetics</Keyword><Keyword MajorTopicYN="N">biomarker</Keyword><Keyword MajorTopicYN="N">causation</Keyword><Keyword MajorTopicYN="N">confounding</Keyword><Keyword MajorTopicYN="N">depression</Keyword><Keyword MajorTopicYN="N">gene-environment</Keyword><Keyword MajorTopicYN="N">major depressive disorder</Keyword><Keyword MajorTopicYN="N">tissue heterogeneity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25716985</ArticleId><ArticleId IdType="pii">dyu273</ArticleId><ArticleId 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