Drosophila Hrp48 Is Required for Mushroom Body Axon Growth, Branching and Guidance.
Identifieur interne : 002968 ( PubMed/Curation ); précédent : 002967; suivant : 002969Drosophila Hrp48 Is Required for Mushroom Body Axon Growth, Branching and Guidance.
Auteurs : Hélène Bruckert [France] ; Giovanni Marchetti [France] ; Mirana Ramialison [Australie] ; Florence Besse [France]Source :
- PloS one [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Axones (métabolisme), Caractères sexuels, Corps pédonculés (cytologie), Corps pédonculés (embryologie), Drosophila melanogaster, Femelle, Mutation, Mâle, Protéines de Drosophila (génétique), Protéines de Drosophila (métabolisme), Pénétrance, Ribonucléoprotéines nucléaires hétérogènes (génétique), Ribonucléoprotéines nucléaires hétérogènes (métabolisme).
- MESH :
- cytologie : Corps pédonculés.
- embryologie : Corps pédonculés.
- génétique : Protéines de Drosophila, Ribonucléoprotéines nucléaires hétérogènes.
- métabolisme : Axones, Protéines de Drosophila, Ribonucléoprotéines nucléaires hétérogènes.
- Animaux, Caractères sexuels, Drosophila melanogaster, Femelle, Mutation, Mâle, Pénétrance.
English descriptors
- KwdEn :
- Animals, Axons (metabolism), Drosophila Proteins (genetics), Drosophila Proteins (metabolism), Drosophila melanogaster, Female, Heterogeneous-Nuclear Ribonucleoproteins (genetics), Heterogeneous-Nuclear Ribonucleoproteins (metabolism), Male, Mushroom Bodies (cytology), Mushroom Bodies (embryology), Mutation, Penetrance, Sex Characteristics.
- MESH :
- chemical , genetics : Drosophila Proteins, Heterogeneous-Nuclear Ribonucleoproteins.
- cytology : Mushroom Bodies.
- embryology : Mushroom Bodies.
- metabolism : Axons, Drosophila Proteins, Heterogeneous-Nuclear Ribonucleoproteins.
- Animals, Drosophila melanogaster, Female, Male, Mutation, Penetrance, Sex Characteristics.
Abstract
RNA binding proteins assemble on mRNAs to control every single step of their life cycle, from nuclear splicing to cytoplasmic localization, stabilization or translation. Consistent with an essential role of RNA binding proteins in neuronal maturation and function, mutations in this class of proteins, in particular in members of the hnRNP family, have been associated with neurological diseases. To date, however, the physiological function of hnRNPs during in vivo neuronal development has remained poorly explored. Here, we have investigated the role of Drosophila Hrp48, a fly homologue of mammalian hnRNP A2/B1, during central nervous system development. Using a combination of mutant conditions, we showed that hrp48 is required for the formation, growth and guidance of axonal branches in Mushroom Body neurons. Furthermore, our results revealed that hrp48 inactivation induces an overextension of Mushroom Body dorsal axonal branches, with a significantly higher penetrance in females than in males. Finally, as demonstrated by immunolocalization studies, Hrp48 is confined to Mushroom Body neuron cell bodies, where it accumulates in the cytoplasm from larval stages to adulthood. Altogether, our data provide evidence for a crucial in vivo role of the hnRNP Hrp48 in multiple aspects of axon guidance and branching during nervous system development. They also indicate cryptic sex differences in the development of sexually non-dimorphic neuronal structures.
DOI: 10.1371/journal.pone.0136610
PubMed: 26313745
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CNRS UMR7277, Institute of Biology Valrose, Nice, France; INSERM UMR1091, Institute of Biology Valrose, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nice Sophia Antipolis, Institute of Biology Valrose, Nice, France; CNRS UMR7277, Institute of Biology Valrose, Nice, France; INSERM UMR1091, Institute of Biology Valrose, Nice</wicri:regionArea></affiliation></author><author><name sortKey="Marchetti, Giovanni" sort="Marchetti, Giovanni" uniqKey="Marchetti G" first="Giovanni" last="Marchetti">Giovanni Marchetti</name><affiliation wicri:level="1"><nlm:affiliation>University of Nice Sophia Antipolis, Institute of Biology Valrose, Nice, France; CNRS UMR7277, Institute of Biology Valrose, Nice, France; INSERM UMR1091, Institute of Biology Valrose, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nice Sophia Antipolis, Institute of Biology Valrose, Nice, France; CNRS UMR7277, Institute of Biology Valrose, Nice, France; 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CNRS UMR7277, Institute of Biology Valrose, Nice, France; INSERM UMR1091, Institute of Biology Valrose, Nice</wicri:regionArea></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Axons (metabolism)</term><term>Drosophila Proteins (genetics)</term><term>Drosophila Proteins (metabolism)</term><term>Drosophila melanogaster</term><term>Female</term><term>Heterogeneous-Nuclear Ribonucleoproteins (genetics)</term><term>Heterogeneous-Nuclear Ribonucleoproteins (metabolism)</term><term>Male</term><term>Mushroom Bodies (cytology)</term><term>Mushroom Bodies (embryology)</term><term>Mutation</term><term>Penetrance</term><term>Sex Characteristics</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Axones (métabolisme)</term><term>Caractères sexuels</term><term>Corps pédonculés (cytologie)</term><term>Corps pédonculés (embryologie)</term><term>Drosophila melanogaster</term><term>Femelle</term><term>Mutation</term><term>Mâle</term><term>Protéines de Drosophila (génétique)</term><term>Protéines de Drosophila (métabolisme)</term><term>Pénétrance</term><term>Ribonucléoprotéines nucléaires hétérogènes (génétique)</term><term>Ribonucléoprotéines nucléaires hétérogènes (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Drosophila Proteins</term><term>Heterogeneous-Nuclear Ribonucleoproteins</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Corps pédonculés</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mushroom Bodies</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Corps pédonculés</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Mushroom Bodies</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de Drosophila</term><term>Ribonucléoprotéines nucléaires hétérogènes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Axons</term><term>Drosophila Proteins</term><term>Heterogeneous-Nuclear Ribonucleoproteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Axones</term><term>Protéines de Drosophila</term><term>Ribonucléoprotéines nucléaires hétérogènes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drosophila melanogaster</term><term>Female</term><term>Male</term><term>Mutation</term><term>Penetrance</term><term>Sex Characteristics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Caractères sexuels</term><term>Drosophila melanogaster</term><term>Femelle</term><term>Mutation</term><term>Mâle</term><term>Pénétrance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">RNA binding proteins assemble on mRNAs to control every single step of their life cycle, from nuclear splicing to cytoplasmic localization, stabilization or translation. Consistent with an essential role of RNA binding proteins in neuronal maturation and function, mutations in this class of proteins, in particular in members of the hnRNP family, have been associated with neurological diseases. To date, however, the physiological function of hnRNPs during in vivo neuronal development has remained poorly explored. Here, we have investigated the role of Drosophila Hrp48, a fly homologue of mammalian hnRNP A2/B1, during central nervous system development. Using a combination of mutant conditions, we showed that hrp48 is required for the formation, growth and guidance of axonal branches in Mushroom Body neurons. Furthermore, our results revealed that hrp48 inactivation induces an overextension of Mushroom Body dorsal axonal branches, with a significantly higher penetrance in females than in males. Finally, as demonstrated by immunolocalization studies, Hrp48 is confined to Mushroom Body neuron cell bodies, where it accumulates in the cytoplasm from larval stages to adulthood. Altogether, our data provide evidence for a crucial in vivo role of the hnRNP Hrp48 in multiple aspects of axon guidance and branching during nervous system development. They also indicate cryptic sex differences in the development of sexually non-dimorphic neuronal structures.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26313745</PMID><DateCreated><Year>2015</Year><Month>08</Month><Day>28</Day></DateCreated><DateCompleted><Year>2016</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>02</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>8</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Drosophila Hrp48 Is Required for Mushroom Body Axon Growth, Branching and Guidance.</ArticleTitle><Pagination><MedlinePgn>e0136610</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0136610</ELocationID><Abstract><AbstractText>RNA binding proteins assemble on mRNAs to control every single step of their life cycle, from nuclear splicing to cytoplasmic localization, stabilization or translation. Consistent with an essential role of RNA binding proteins in neuronal maturation and function, mutations in this class of proteins, in particular in members of the hnRNP family, have been associated with neurological diseases. To date, however, the physiological function of hnRNPs during in vivo neuronal development has remained poorly explored. Here, we have investigated the role of Drosophila Hrp48, a fly homologue of mammalian hnRNP A2/B1, during central nervous system development. Using a combination of mutant conditions, we showed that hrp48 is required for the formation, growth and guidance of axonal branches in Mushroom Body neurons. Furthermore, our results revealed that hrp48 inactivation induces an overextension of Mushroom Body dorsal axonal branches, with a significantly higher penetrance in females than in males. Finally, as demonstrated by immunolocalization studies, Hrp48 is confined to Mushroom Body neuron cell bodies, where it accumulates in the cytoplasm from larval stages to adulthood. Altogether, our data provide evidence for a crucial in vivo role of the hnRNP Hrp48 in multiple aspects of axon guidance and branching during nervous system development. They also indicate cryptic sex differences in the development of sexually non-dimorphic neuronal structures.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bruckert</LastName><ForeName>Hélène</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University of Nice Sophia Antipolis, Institute of Biology Valrose, Nice, France; CNRS UMR7277, Institute of Biology Valrose, Nice, France; INSERM UMR1091, Institute of Biology Valrose, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marchetti</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>University of Nice Sophia Antipolis, Institute of Biology Valrose, Nice, France; CNRS UMR7277, Institute of Biology Valrose, Nice, France; INSERM UMR1091, Institute of Biology Valrose, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramialison</LastName><ForeName>Mirana</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Besse</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University of Nice Sophia Antipolis, Institute of Biology Valrose, Nice, France; CNRS UMR7277, Institute of Biology Valrose, Nice, France; INSERM UMR1091, Institute of Biology Valrose, Nice, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029721">Drosophila Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D034441">Heterogeneous-Nuclear Ribonucleoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C487485">Hrp48 protein, Drosophila</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Dev Cell. 2004 May;6(5):637-48</RefSource><PMID Version="1">15130489</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Neurobiol. 2004 Oct;14(5):574-81</RefSource><PMID Version="1">15464890</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 1992 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MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004331" MajorTopicYN="N">Drosophila melanogaster</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D034441" MajorTopicYN="N">Heterogeneous-Nuclear Ribonucleoproteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024521" MajorTopicYN="N">Mushroom Bodies</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000196" MajorTopicYN="Y">embryology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019683" MajorTopicYN="Y">Penetrance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012727" MajorTopicYN="Y">Sex Characteristics</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4551846</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>08</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |