Impact of common risk factors of fibrosis progression in chronic hepatitis C.
Identifieur interne : 002852 ( PubMed/Curation ); précédent : 002851; suivant : 002853Impact of common risk factors of fibrosis progression in chronic hepatitis C.
Auteurs : S. Rüeger [Suisse] ; P-Y Bochud [Suisse] ; J-F Dufour [Suisse] ; B. Müllhaupt [Suisse] ; D. Semela [Suisse] ; M H Heim [Suisse] ; D. Moradpour [Suisse] ; A. Cerny [Suisse] ; R. Malinverni [Suisse] ; D R Booth [Australie] ; V. Suppiah [Australie] ; J. George [Australie] ; L. Argiro [France] ; P. Halfon [France] ; M. Bourlière [France] ; A H Talal [États-Unis] ; I M Jacobson [États-Unis] ; E. Patin [France] ; B. Nalpas [France] ; T. Poynard [France] ; S. Pol [France] ; L. Abel [États-Unis] ; Z. Kutalik [Suisse] ; F. Negro [Suisse]Source :
- Gut [ 1468-3288 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Biopsie, Cirrhose du foie (diagnostic), Cirrhose du foie (épidémiologie), Cirrhose du foie (étiologie), Facteurs de risque, Facteurs temps, Femelle, Hepacivirus (génétique), Humains, Hépatite C chronique (), Hépatite C chronique (virologie), Incidence, Mâle, Polymorphisme de nucléotide simple, Suisse (épidémiologie), Étude d'association pangénomique, Études rétrospectives, Évaluation des risques (), Évolution de la maladie.
- MESH :
- analyse : ARN viral.
- diagnostic : Cirrhose du foie.
- génétique : Hepacivirus.
- virologie : Hépatite C chronique.
- épidémiologie : Cirrhose du foie, Suisse.
- étiologie : Cirrhose du foie.
- Biopsie, Facteurs de risque, Facteurs temps, Femelle, Humains, Hépatite C chronique, Incidence, Mâle, Polymorphisme de nucléotide simple, Étude d'association pangénomique, Études rétrospectives, Évaluation des risques, Évolution de la maladie.
- Wicri :
- geographic : Suisse.
English descriptors
- KwdEn :
- Biopsy, Disease Progression, Female, Genome-Wide Association Study, Hepacivirus (genetics), Hepatitis C, Chronic (complications), Hepatitis C, Chronic (virology), Humans, Incidence, Liver Cirrhosis (diagnosis), Liver Cirrhosis (epidemiology), Liver Cirrhosis (etiology), Male, Polymorphism, Single Nucleotide, RNA, Viral (analysis), Retrospective Studies, Risk Assessment (methods), Risk Factors, Switzerland (epidemiology), Time Factors.
- MESH :
- chemical , analysis : RNA, Viral.
- geographic , epidemiology : Switzerland.
- complications : Hepatitis C, Chronic.
- diagnosis : Liver Cirrhosis.
- epidemiology : Liver Cirrhosis.
- etiology : Liver Cirrhosis.
- genetics : Hepacivirus.
- methods : Risk Assessment.
- virology : Hepatitis C, Chronic.
- Biopsy, Disease Progression, Female, Genome-Wide Association Study, Humans, Incidence, Male, Polymorphism, Single Nucleotide, Retrospective Studies, Risk Factors, Time Factors.
Abstract
The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C.
DOI: 10.1136/gutjnl-2014-306997
PubMed: 25214320
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Rüeger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Bochud, P Y" sort="Bochud, P Y" uniqKey="Bochud P" first="P-Y" last="Bochud">P-Y Bochud</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Dufour, J F" sort="Dufour, J F" uniqKey="Dufour J" first="J-F" last="Dufour">J-F Dufour</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hepatology, University of Berne, Berne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Hepatology, University of Berne, Berne</wicri:regionArea></affiliation></author><author><name sortKey="Mullhaupt, B" sort="Mullhaupt, B" uniqKey="Mullhaupt B" first="B" last="Müllhaupt">B. 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Malinverni</name><affiliation wicri:level="1"><nlm:affiliation>Pourtalès Hospital, Neuchatel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pourtalès Hospital, Neuchatel</wicri:regionArea></affiliation></author><author><name sortKey="Booth, D R" sort="Booth, D R" uniqKey="Booth D" first="D R" last="Booth">D R Booth</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Suppiah, V" sort="Suppiah, V" uniqKey="Suppiah V" first="V" last="Suppiah">V. Suppiah</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="George, J" sort="George, J" uniqKey="George J" first="J" last="George">J. George</name><affiliation wicri:level="1"><nlm:affiliation>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Argiro, L" sort="Argiro, L" uniqKey="Argiro L" first="L" last="Argiro">L. Argiro</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles</wicri:regionArea></affiliation></author><author><name sortKey="Halfon, P" sort="Halfon, P" uniqKey="Halfon P" first="P" last="Halfon">P. Halfon</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles</wicri:regionArea></affiliation></author><author><name sortKey="Bourliere, M" sort="Bourliere, M" uniqKey="Bourliere M" first="M" last="Bourlière">M. Bourlière</name><affiliation wicri:level="1"><nlm:affiliation>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles</wicri:regionArea></affiliation></author><author><name sortKey="Talal, A H" sort="Talal, A H" uniqKey="Talal A" first="A H" last="Talal">A H Talal</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea></affiliation></author><author><name sortKey="Jacobson, I M" sort="Jacobson, I M" uniqKey="Jacobson I" first="I M" last="Jacobson">I M Jacobson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea></affiliation></author><author><name sortKey="Patin, E" sort="Patin, E" uniqKey="Patin E" first="E" last="Patin">E. Patin</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Nalpas, B" sort="Nalpas, B" uniqKey="Nalpas B" first="B" last="Nalpas">B. Nalpas</name><affiliation wicri:level="1"><nlm:affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Poynard, T" sort="Poynard, T" uniqKey="Poynard T" first="T" last="Poynard">T. Poynard</name><affiliation wicri:level="1"><nlm:affiliation>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris</wicri:regionArea></affiliation></author><author><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S" last="Pol">S. Pol</name><affiliation wicri:level="1"><nlm:affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Abel, L" sort="Abel, L" uniqKey="Abel L" first="L" last="Abel">L. Abel</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Z" sort="Kutalik, Z" uniqKey="Kutalik Z" first="Z" last="Kutalik">Z. Kutalik</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Negro, F" sort="Negro, F" uniqKey="Negro F" first="F" last="Negro">F. Negro</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25214320</idno><idno type="pmid">25214320</idno><idno type="doi">10.1136/gutjnl-2014-306997</idno><idno type="wicri:Area/PubMed/Corpus">002921</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002921</idno><idno type="wicri:Area/PubMed/Curation">002852</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002852</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of common risk factors of fibrosis progression in chronic hepatitis C.</title><author><name sortKey="Rueger, S" sort="Rueger, S" uniqKey="Rueger S" first="S" last="Rüeger">S. Rüeger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Bochud, P Y" sort="Bochud, P Y" uniqKey="Bochud P" first="P-Y" last="Bochud">P-Y Bochud</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Dufour, J F" sort="Dufour, J F" uniqKey="Dufour J" first="J-F" last="Dufour">J-F Dufour</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hepatology, University of Berne, Berne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Hepatology, University of Berne, Berne</wicri:regionArea></affiliation></author><author><name sortKey="Mullhaupt, B" sort="Mullhaupt, B" uniqKey="Mullhaupt B" first="B" last="Müllhaupt">B. Müllhaupt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Semela, D" sort="Semela, D" uniqKey="Semela D" first="D" last="Semela">D. Semela</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Canton Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology, Canton Hospital St Gallen, St Gallen</wicri:regionArea></affiliation></author><author><name sortKey="Heim, M H" sort="Heim, M H" uniqKey="Heim M" first="M H" last="Heim">M H Heim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, University Hospital of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Hospital of Basel, Basel</wicri:regionArea></affiliation></author><author><name sortKey="Moradpour, D" sort="Moradpour, D" uniqKey="Moradpour D" first="D" last="Moradpour">D. Moradpour</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, University Hospital and University of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Hospital and University of Lausanne, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Cerny, A" sort="Cerny, A" uniqKey="Cerny A" first="A" last="Cerny">A. Cerny</name><affiliation wicri:level="1"><nlm:affiliation>Epatologia, Clinica Moncucco, Lugano, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Epatologia, Clinica Moncucco, Lugano</wicri:regionArea></affiliation></author><author><name sortKey="Malinverni, R" sort="Malinverni, R" uniqKey="Malinverni R" first="R" last="Malinverni">R. Malinverni</name><affiliation wicri:level="1"><nlm:affiliation>Pourtalès Hospital, Neuchatel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pourtalès Hospital, Neuchatel</wicri:regionArea></affiliation></author><author><name sortKey="Booth, D R" sort="Booth, D R" uniqKey="Booth D" first="D R" last="Booth">D R Booth</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Suppiah, V" sort="Suppiah, V" uniqKey="Suppiah V" first="V" last="Suppiah">V. Suppiah</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="George, J" sort="George, J" uniqKey="George J" first="J" last="George">J. George</name><affiliation wicri:level="1"><nlm:affiliation>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Argiro, L" sort="Argiro, L" uniqKey="Argiro L" first="L" last="Argiro">L. Argiro</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles</wicri:regionArea></affiliation></author><author><name sortKey="Halfon, P" sort="Halfon, P" uniqKey="Halfon P" first="P" last="Halfon">P. Halfon</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles</wicri:regionArea></affiliation></author><author><name sortKey="Bourliere, M" sort="Bourliere, M" uniqKey="Bourliere M" first="M" last="Bourlière">M. Bourlière</name><affiliation wicri:level="1"><nlm:affiliation>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles</wicri:regionArea></affiliation></author><author><name sortKey="Talal, A H" sort="Talal, A H" uniqKey="Talal A" first="A H" last="Talal">A H Talal</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea></affiliation></author><author><name sortKey="Jacobson, I M" sort="Jacobson, I M" uniqKey="Jacobson I" first="I M" last="Jacobson">I M Jacobson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea></affiliation></author><author><name sortKey="Patin, E" sort="Patin, E" uniqKey="Patin E" first="E" last="Patin">E. Patin</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Nalpas, B" sort="Nalpas, B" uniqKey="Nalpas B" first="B" last="Nalpas">B. Nalpas</name><affiliation wicri:level="1"><nlm:affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Poynard, T" sort="Poynard, T" uniqKey="Poynard T" first="T" last="Poynard">T. Poynard</name><affiliation wicri:level="1"><nlm:affiliation>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris</wicri:regionArea></affiliation></author><author><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S" last="Pol">S. Pol</name><affiliation wicri:level="1"><nlm:affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Abel, L" sort="Abel, L" uniqKey="Abel L" first="L" last="Abel">L. Abel</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Kutalik, Z" sort="Kutalik, Z" uniqKey="Kutalik Z" first="Z" last="Kutalik">Z. Kutalik</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Negro, F" sort="Negro, F" uniqKey="Negro F" first="F" last="Negro">F. Negro</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva</wicri:regionArea></affiliation></author></analytic><series><title level="j">Gut</title><idno type="eISSN">1468-3288</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biopsy</term><term>Disease Progression</term><term>Female</term><term>Genome-Wide Association Study</term><term>Hepacivirus (genetics)</term><term>Hepatitis C, Chronic (complications)</term><term>Hepatitis C, Chronic (virology)</term><term>Humans</term><term>Incidence</term><term>Liver Cirrhosis (diagnosis)</term><term>Liver Cirrhosis (epidemiology)</term><term>Liver Cirrhosis (etiology)</term><term>Male</term><term>Polymorphism, Single Nucleotide</term><term>RNA, Viral (analysis)</term><term>Retrospective Studies</term><term>Risk Assessment (methods)</term><term>Risk Factors</term><term>Switzerland (epidemiology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Biopsie</term><term>Cirrhose du foie (diagnostic)</term><term>Cirrhose du foie (épidémiologie)</term><term>Cirrhose du foie (étiologie)</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Hepacivirus (génétique)</term><term>Humains</term><term>Hépatite C chronique ()</term><term>Hépatite C chronique (virologie)</term><term>Incidence</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Suisse (épidémiologie)</term><term>Étude d'association pangénomique</term><term>Études rétrospectives</term><term>Évaluation des risques ()</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Switzerland</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Cirrhose du foie</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Cirrhose du foie</term><term>Suisse</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Cirrhose du foie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Disease Progression</term><term>Female</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Polymorphism, Single Nucleotide</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biopsie</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Hépatite C chronique</term><term>Incidence</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Étude d'association pangénomique</term><term>Études rétrospectives</term><term>Évaluation des risques</term><term>Évolution de la maladie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suisse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25214320</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>10</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>01</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-3288</ISSN><JournalIssue CitedMedium="Internet"><Volume>64</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Gut</Title><ISOAbbreviation>Gut</ISOAbbreviation></Journal><ArticleTitle>Impact of common risk factors of fibrosis progression in chronic hepatitis C.</ArticleTitle><Pagination><MedlinePgn>1605-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/gutjnl-2014-306997</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">We analysed 1461 patients with chronic hepatitis C with an estimated date of infection and at least one liver biopsy. Risk factors for accelerated fibrosis progression rate (FPR), defined as ≥ 0.13 Metavir fibrosis units per year, were identified by logistic regression. Examined factors included age at infection, sex, route of infection, HCV genotype, body mass index (BMI), significant alcohol drinking (≥ 20 g/day for ≥ 5 years), HIV coinfection and diabetes. In a subgroup of 575 patients, we assessed the impact of single nucleotide polymorphisms previously associated with fibrosis progression in genome-wide association studies. Results were expressed as attributable fraction (AF) of risk for accelerated FPR.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Age at infection (AF 28.7%), sex (AF 8.2%), route of infection (AF 16.5%) and HCV genotype (AF 7.9%) contributed to accelerated FPR in the Swiss Hepatitis C Cohort Study, whereas significant alcohol drinking, anti-HIV, diabetes and BMI did not. In genotyped patients, variants at rs9380516 (TULP1), rs738409 (PNPLA3), rs4374383 (MERTK) (AF 19.2%) and rs910049 (major histocompatibility complex region) significantly added to the risk of accelerated FPR. Results were replicated in three additional independent cohorts, and a meta-analysis confirmed the role of age at infection, sex, route of infection, HCV genotype, rs738409, rs4374383 and rs910049 in accelerating FPR.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Most factors accelerating liver fibrosis progression in chronic hepatitis C are unmodifiable.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rüeger</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bochud</LastName><ForeName>P-Y</ForeName><Initials>PY</Initials><AffiliationInfo><Affiliation>Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dufour</LastName><ForeName>J-F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Hepatology, University of Berne, Berne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müllhaupt</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Semela</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Canton Hospital St Gallen, St Gallen, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heim</LastName><ForeName>M H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, University Hospital of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moradpour</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, University Hospital and University of Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerny</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Epatologia, Clinica Moncucco, Lugano, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malinverni</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Pourtalès Hospital, Neuchatel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Booth</LastName><ForeName>D R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suppiah</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>George</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Argiro</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratoire d'Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Halfon</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bourlière</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service d'Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Talal</LastName><ForeName>A H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobson</LastName><ForeName>I M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patin</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nalpas</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poynard</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Université Pierre et Marie Curie, Service d'Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pol</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Paris Descartes, Paris, France Département d'Hépatologie, INSERM Unité 1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abel</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, U980, Imagine Institute, Paris, France University Paris Descartes, Paris, France St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kutalik</LastName><ForeName>Z</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Negro</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Clinical Pathology, University Hospitals of Geneva, Geneva, Switzerland Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>09</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Gut</MedlineTA><NlmUniqueID>2985108R</NlmUniqueID><ISSNLinking>0017-5749</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="N">Genome-Wide Association Study</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016174" MajorTopicYN="N">Hepacivirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019698" MajorTopicYN="N">Hepatitis C, Chronic</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008103" MajorTopicYN="N">Liver Cirrhosis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="Y">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013557" MajorTopicYN="N" Type="Geographic">Switzerland</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CIRRHOSIS</Keyword><Keyword MajorTopicYN="N">FIBROSIS</Keyword><Keyword MajorTopicYN="N">HEPATITIS C</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>08</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25214320</ArticleId><ArticleId IdType="pii">gutjnl-2014-306997</ArticleId><ArticleId IdType="doi">10.1136/gutjnl-2014-306997</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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