The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies.
Identifieur interne : 002704 ( PubMed/Curation ); précédent : 002703; suivant : 002705The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies.
Auteurs : Aziz Bousfiha [Maroc] ; Leïla Jeddane [Maroc] ; Waleed Al-Herz [Koweït] ; Fatima Ailal [Maroc] ; Jean-Laurent Casanova [États-Unis] ; Talal Chatila [États-Unis] ; Mary Ellen Conley [États-Unis] ; Charlotte Cunningham-Rundles [États-Unis] ; Amos Etzioni [Israël] ; Jose Luis Franco [Colombie] ; H Bobby Gaspar [Royaume-Uni] ; Steven M. Holland [États-Unis] ; Christoph Klein [Allemagne] ; Shigeaki Nonoyama [Japon] ; Hans D. Ochs [États-Unis] ; Eric Oksenhendler [France] ; Capucine Picard [États-Unis] ; Jennifer M. Puck [États-Unis] ; Kathleen E. Sullivan [États-Unis] ; Mimi L K. Tang [Australie]Source :
- Journal of clinical immunology [ 1573-2592 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Immunité.
- immunologie : Déficits immunitaires, Hypersensibilité, Infection, Inflammation, Tumeurs.
- Auto-immunité, Déficits immunitaires, Expertise, Humains, Phénotype.
English descriptors
- KwdEn :
- MESH :
- classification : Immunologic Deficiency Syndromes.
- genetics : Immunity.
- immunology : Hypersensitivity, Immunologic Deficiency Syndromes, Infection, Inflammation, Neoplasms.
- Autoimmunity, Expert Testimony, Humans, Phenotype.
Abstract
There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of these five categories, a growing variety of phenotypes are ascribed to Primary Immunodeficiency Diseases (PID), making PIDs a rapidly expanding field of medicine. The International Union of Immunological Societies (IUIS) PID expert committee (EC) has published every other year a classification of these disorders into tables, defined by shared pathogenesis and/or clinical consequences. In 2013, the IUIS committee also proposed a more user-friendly, phenotypic classification, based on the selection of key phenotypes at the bedside. We herein propose the revised figures, based on the accompanying 2015 IUIS PID EC classification.
DOI: 10.1007/s10875-015-0198-5
PubMed: 26445875
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<author><name sortKey="Bousfiha, Aziz" sort="Bousfiha, Aziz" uniqKey="Bousfiha A" first="Aziz" last="Bousfiha">Aziz Bousfiha</name>
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<author><name sortKey="Jeddane, Leila" sort="Jeddane, Leila" uniqKey="Jeddane L" first="Leïla" last="Jeddane">Leïla Jeddane</name>
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<author><name sortKey="Al Herz, Waleed" sort="Al Herz, Waleed" uniqKey="Al Herz W" first="Waleed" last="Al-Herz">Waleed Al-Herz</name>
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<author><name sortKey="Ailal, Fatima" sort="Ailal, Fatima" uniqKey="Ailal F" first="Fatima" last="Ailal">Fatima Ailal</name>
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<author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
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<author><name sortKey="Chatila, Talal" sort="Chatila, Talal" uniqKey="Chatila T" first="Talal" last="Chatila">Talal Chatila</name>
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<author><name sortKey="Conley, Mary Ellen" sort="Conley, Mary Ellen" uniqKey="Conley M" first="Mary Ellen" last="Conley">Mary Ellen Conley</name>
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<author><name sortKey="Cunningham Rundles, Charlotte" sort="Cunningham Rundles, Charlotte" uniqKey="Cunningham Rundles C" first="Charlotte" last="Cunningham-Rundles">Charlotte Cunningham-Rundles</name>
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<author><name sortKey="Etzioni, Amos" sort="Etzioni, Amos" uniqKey="Etzioni A" first="Amos" last="Etzioni">Amos Etzioni</name>
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<author><name sortKey="Franco, Jose Luis" sort="Franco, Jose Luis" uniqKey="Franco J" first="Jose Luis" last="Franco">Jose Luis Franco</name>
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<author><name sortKey="Gaspar, H Bobby" sort="Gaspar, H Bobby" uniqKey="Gaspar H" first="H Bobby" last="Gaspar">H Bobby Gaspar</name>
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<author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M" last="Holland">Steven M. Holland</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Klein, Christoph" sort="Klein, Christoph" uniqKey="Klein C" first="Christoph" last="Klein">Christoph Klein</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Nonoyama, Shigeaki" sort="Nonoyama, Shigeaki" uniqKey="Nonoyama S" first="Shigeaki" last="Nonoyama">Shigeaki Nonoyama</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pediatrics, National Defense Medical College, Saitama</wicri:regionArea>
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<author><name sortKey="Ochs, Hans D" sort="Ochs, Hans D" uniqKey="Ochs H" first="Hans D" last="Ochs">Hans D. Ochs</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Oksenhendler, Eric" sort="Oksenhendler, Eric" uniqKey="Oksenhendler E" first="Eric" last="Oksenhendler">Eric Oksenhendler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Immunology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris</wicri:regionArea>
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<author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Howard Hughes Medical Institute, New York, NY</wicri:regionArea>
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<author><name sortKey="Puck, Jennifer M" sort="Puck, Jennifer M" uniqKey="Puck J" first="Jennifer M" last="Puck">Jennifer M. Puck</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of California San Francisco and UCSF Benioff Children's Hospital, San Francisco, CA</wicri:regionArea>
</affiliation>
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<author><name sortKey="Sullivan, Kathleen E" sort="Sullivan, Kathleen E" uniqKey="Sullivan K" first="Kathleen E" last="Sullivan">Kathleen E. Sullivan</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
</affiliation>
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<author><name sortKey="Tang, Mimi L K" sort="Tang, Mimi L K" uniqKey="Tang M" first="Mimi L K" last="Tang">Mimi L K. Tang</name>
<affiliation wicri:level="1"><nlm:affiliation>Murdoch Childrens Research Institute, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Murdoch Childrens Research Institute, Melbourne, VIC</wicri:regionArea>
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<author><name sortKey="Bousfiha, Aziz" sort="Bousfiha, Aziz" uniqKey="Bousfiha A" first="Aziz" last="Bousfiha">Aziz Bousfiha</name>
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<author><name sortKey="Jeddane, Leila" sort="Jeddane, Leila" uniqKey="Jeddane L" first="Leïla" last="Jeddane">Leïla Jeddane</name>
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<author><name sortKey="Al Herz, Waleed" sort="Al Herz, Waleed" uniqKey="Al Herz W" first="Waleed" last="Al-Herz">Waleed Al-Herz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Faculty of Medicine Kuwait University, Jabriya, Kuwait.</nlm:affiliation>
<country xml:lang="fr">Koweït</country>
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<author><name sortKey="Ailal, Fatima" sort="Ailal, Fatima" uniqKey="Ailal F" first="Fatima" last="Ailal">Fatima Ailal</name>
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<country xml:lang="fr">Maroc</country>
<wicri:regionArea>Clinical Immunology Unit, A. Harouchi Hospital, Ibn Roshd Medical School, King Hassan II University, Casablanca</wicri:regionArea>
</affiliation>
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<author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<affiliation wicri:level="1"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY</wicri:regionArea>
</affiliation>
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<author><name sortKey="Chatila, Talal" sort="Chatila, Talal" uniqKey="Chatila T" first="Talal" last="Chatila">Talal Chatila</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Immunology, Children's Hospital Boston, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Immunology, Children's Hospital Boston, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Conley, Mary Ellen" sort="Conley, Mary Ellen" uniqKey="Conley M" first="Mary Ellen" last="Conley">Mary Ellen Conley</name>
<affiliation wicri:level="1"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cunningham Rundles, Charlotte" sort="Cunningham Rundles, Charlotte" uniqKey="Cunningham Rundles C" first="Charlotte" last="Cunningham-Rundles">Charlotte Cunningham-Rundles</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Etzioni, Amos" sort="Etzioni, Amos" uniqKey="Etzioni A" first="Amos" last="Etzioni">Amos Etzioni</name>
<affiliation wicri:level="1"><nlm:affiliation>Meyer Children's Hospital-Technion, Haifa, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Meyer Children's Hospital-Technion, Haifa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Franco, Jose Luis" sort="Franco, Jose Luis" uniqKey="Franco J" first="Jose Luis" last="Franco">Jose Luis Franco</name>
<affiliation wicri:level="1"><nlm:affiliation>Group of Primary Immunodeficiencies, University of Antioquia, Medellin, Colombia.</nlm:affiliation>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Group of Primary Immunodeficiencies, University of Antioquia, Medellin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaspar, H Bobby" sort="Gaspar, H Bobby" uniqKey="Gaspar H" first="H Bobby" last="Gaspar">H Bobby Gaspar</name>
<affiliation wicri:level="1"><nlm:affiliation>UCL Institute of Child Health, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Child Health, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holland, Steven M" sort="Holland, Steven M" uniqKey="Holland S" first="Steven M" last="Holland">Steven M. Holland</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klein, Christoph" sort="Klein, Christoph" uniqKey="Klein C" first="Christoph" last="Klein">Christoph Klein</name>
<affiliation wicri:level="1"><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig-Maximilians University Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr von Hauner Children's Hospital, Ludwig-Maximilians University Munich, Munich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nonoyama, Shigeaki" sort="Nonoyama, Shigeaki" uniqKey="Nonoyama S" first="Shigeaki" last="Nonoyama">Shigeaki Nonoyama</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, National Defense Medical College, Saitama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pediatrics, National Defense Medical College, Saitama</wicri:regionArea>
</affiliation>
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<author><name sortKey="Ochs, Hans D" sort="Ochs, Hans D" uniqKey="Ochs H" first="Hans D" last="Ochs">Hans D. Ochs</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oksenhendler, Eric" sort="Oksenhendler, Eric" uniqKey="Oksenhendler E" first="Eric" last="Oksenhendler">Eric Oksenhendler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Immunology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Immunology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name>
<affiliation wicri:level="1"><nlm:affiliation>Howard Hughes Medical Institute, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Howard Hughes Medical Institute, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Puck, Jennifer M" sort="Puck, Jennifer M" uniqKey="Puck J" first="Jennifer M" last="Puck">Jennifer M. Puck</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of California San Francisco and UCSF Benioff Children's Hospital, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of California San Francisco and UCSF Benioff Children's Hospital, San Francisco, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sullivan, Kathleen E" sort="Sullivan, Kathleen E" uniqKey="Sullivan K" first="Kathleen E" last="Sullivan">Kathleen E. Sullivan</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tang, Mimi L K" sort="Tang, Mimi L K" uniqKey="Tang M" first="Mimi L K" last="Tang">Mimi L K. Tang</name>
<affiliation wicri:level="1"><nlm:affiliation>Murdoch Childrens Research Institute, Melbourne, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Murdoch Childrens Research Institute, Melbourne, VIC</wicri:regionArea>
</affiliation>
</author>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autoimmunity</term>
<term>Expert Testimony</term>
<term>Humans</term>
<term>Hypersensitivity (immunology)</term>
<term>Immunity (genetics)</term>
<term>Immunologic Deficiency Syndromes (classification)</term>
<term>Immunologic Deficiency Syndromes (immunology)</term>
<term>Infection (immunology)</term>
<term>Inflammation (immunology)</term>
<term>Neoplasms (immunology)</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Auto-immunité</term>
<term>Déficits immunitaires ()</term>
<term>Déficits immunitaires (immunologie)</term>
<term>Expertise</term>
<term>Humains</term>
<term>Hypersensibilité (immunologie)</term>
<term>Immunité (génétique)</term>
<term>Infection (immunologie)</term>
<term>Inflammation (immunologie)</term>
<term>Phénotype</term>
<term>Tumeurs (immunologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Immunologic Deficiency Syndromes</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Immunity</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Immunité</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Déficits immunitaires</term>
<term>Hypersensibilité</term>
<term>Infection</term>
<term>Inflammation</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hypersensitivity</term>
<term>Immunologic Deficiency Syndromes</term>
<term>Infection</term>
<term>Inflammation</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Autoimmunity</term>
<term>Expert Testimony</term>
<term>Humans</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Auto-immunité</term>
<term>Déficits immunitaires</term>
<term>Expertise</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en">There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of these five categories, a growing variety of phenotypes are ascribed to Primary Immunodeficiency Diseases (PID), making PIDs a rapidly expanding field of medicine. The International Union of Immunological Societies (IUIS) PID expert committee (EC) has published every other year a classification of these disorders into tables, defined by shared pathogenesis and/or clinical consequences. In 2013, the IUIS committee also proposed a more user-friendly, phenotypic classification, based on the selection of key phenotypes at the bedside. We herein propose the revised figures, based on the accompanying 2015 IUIS PID EC classification.</div>
</front>
</TEI>
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<DateCreated><Year>2015</Year>
<Month>11</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>09</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-2592</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>35</Volume>
<Issue>8</Issue>
<PubDate><Year>2015</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical immunology</Title>
<ISOAbbreviation>J. Clin. Immunol.</ISOAbbreviation>
</Journal>
<ArticleTitle>The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies.</ArticleTitle>
<Pagination><MedlinePgn>727-38</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s10875-015-0198-5</ELocationID>
<Abstract><AbstractText>There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of these five categories, a growing variety of phenotypes are ascribed to Primary Immunodeficiency Diseases (PID), making PIDs a rapidly expanding field of medicine. The International Union of Immunological Societies (IUIS) PID expert committee (EC) has published every other year a classification of these disorders into tables, defined by shared pathogenesis and/or clinical consequences. In 2013, the IUIS committee also proposed a more user-friendly, phenotypic classification, based on the selection of key phenotypes at the bedside. We herein propose the revised figures, based on the accompanying 2015 IUIS PID EC classification.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bousfiha</LastName>
<ForeName>Aziz</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Clinical Immunology Unit, A. Harouchi Hospital, Ibn Roshd Medical School, King Hassan II University, Casablanca, Morocco. profbousfiha@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jeddane</LastName>
<ForeName>Leïla</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Clinical Immunology Unit, A. Harouchi Hospital, Ibn Roshd Medical School, King Hassan II University, Casablanca, Morocco.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Herz</LastName>
<ForeName>Waleed</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Faculty of Medicine Kuwait University, Jabriya, Kuwait.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Allergy and Clinical Immunology Unit, Department of Pediatrics, Al-Sabah Hospital, Kuwait City, Kuwait.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ailal</LastName>
<ForeName>Fatima</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Clinical Immunology Unit, A. Harouchi Hospital, Ibn Roshd Medical School, King Hassan II University, Casablanca, Morocco.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Casanova</LastName>
<ForeName>Jean-Laurent</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Howard Hughes Medical Institute, New York, NY, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Necker Hospital for Sick Children, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Imagine Institute, University Paris Descartes, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Pediatric Hematology & Immunology Unit, Necker Hospital for Sick Children, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chatila</LastName>
<ForeName>Talal</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Division of Immunology, Children's Hospital Boston, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Conley</LastName>
<ForeName>Mary Ellen</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cunningham-Rundles</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Etzioni</LastName>
<ForeName>Amos</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Meyer Children's Hospital-Technion, Haifa, Israel.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Franco</LastName>
<ForeName>Jose Luis</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Group of Primary Immunodeficiencies, University of Antioquia, Medellin, Colombia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gaspar</LastName>
<ForeName>H Bobby</ForeName>
<Initials>HB</Initials>
<AffiliationInfo><Affiliation>UCL Institute of Child Health, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holland</LastName>
<ForeName>Steven M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klein</LastName>
<ForeName>Christoph</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Dr von Hauner Children's Hospital, Ludwig-Maximilians University Munich, Munich, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nonoyama</LastName>
<ForeName>Shigeaki</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, National Defense Medical College, Saitama, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ochs</LastName>
<ForeName>Hans D</ForeName>
<Initials>HD</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, WA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oksenhendler</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Immunology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Université Paris Diderot, Sorbonne Paris Cité, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Picard</LastName>
<ForeName>Capucine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Howard Hughes Medical Institute, New York, NY, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre d'étude des déficits immunitaires (CEDI), Hôpital Necker-Enfants Malades, AP-HP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Puck</LastName>
<ForeName>Jennifer M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, University of California San Francisco and UCSF Benioff Children's Hospital, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sullivan</LastName>
<ForeName>Kathleen E</ForeName>
<Initials>KE</Initials>
<AffiliationInfo><Affiliation>Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Mimi L K</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Murdoch Childrens Research Institute, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R18 AI048693</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>10</Month>
<Day>07</Day>
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</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>J Clin Immunol</MedlineTA>
<NlmUniqueID>8102137</NlmUniqueID>
<ISSNLinking>0271-9142</ISSNLinking>
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<CitationSubset>IM</CitationSubset>
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</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D015551" MajorTopicYN="N">Autoimmunity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005104" MajorTopicYN="N">Expert Testimony</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006967" MajorTopicYN="N">Hypersensitivity</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007109" MajorTopicYN="N">Immunity</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007153" MajorTopicYN="N">Immunologic Deficiency Syndromes</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007239" MajorTopicYN="N">Infection</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC4659854</OtherID>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">IUIS PID expert committee</Keyword>
<Keyword MajorTopicYN="N">Primary immunodeficiencies</Keyword>
<Keyword MajorTopicYN="N">classification</Keyword>
</KeywordList>
</MedlineCitation>
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<Month>08</Month>
<Day>11</Day>
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