Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit.
Identifieur interne : 002577 ( PubMed/Curation ); précédent : 002576; suivant : 002578Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit.
Auteurs : M A Bernal [Brésil] ; M C Bordage [France] ; J M C. Brown [Royaume-Uni] ; M. Davídková [République tchèque] ; E. Delage [France] ; Z. El Bitar [France] ; S A Enger [Canada] ; Z. Francis [Liban] ; S. Guatelli [Australie] ; V N Ivanchenko [Russie] ; M. Karamitros [États-Unis] ; I. Kyriakou [Grèce] ; L. Maigne [France] ; S. Meylan [France] ; K. Murakami [Japon] ; S. Okada [Japon] ; H. Payno [France] ; Y. Perrot [France] ; I. Petrovic [Serbie] ; Q T Pham [France] ; A. Ristic-Fira [Serbie] ; T. Sasaki [Japon] ; V. Št Pán [République tchèque] ; H N Tran [Viêt Nam] ; C. Villagrasa [France] ; S. Incerti [France]Source :
- Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [ 1724-191X ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : DNA, Water.
- Chemical Phenomena, Humans, Models, Molecular, Monte Carlo Method.
Abstract
Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of today's radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described.
DOI: 10.1016/j.ejmp.2015.10.087
PubMed: 26653251
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Toulouse III-Paul Sabatier, F-31000 Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CRCT, UMR 1037 INSERM, Université Paul Sabatier, Toulouse, France; UMR 1037, CRCT, Univ. Toulouse III-Paul Sabatier, F-31000 Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Brown, J M C" sort="Brown, J M C" uniqKey="Brown J" first="J M C" last="Brown">J M C. Brown</name><affiliation wicri:level="1"><nlm:affiliation>School of Physics and Astronomy, Monash University, Melbourne, Australia; School of Mathematics and Physics, Queen's University Belfast, Belfast, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Physics and Astronomy, Monash University, Melbourne, Australia; School of Mathematics and Physics, Queen's University Belfast, Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Davidkova, M" sort="Davidkova, M" uniqKey="Davidkova M" first="M" last="Davídková">M. Davídková</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha</wicri:regionArea></affiliation></author><author><name sortKey="Delage, E" sort="Delage, E" uniqKey="Delage E" first="E" last="Delage">E. Delage</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="El Bitar, Z" sort="El Bitar, Z" uniqKey="El Bitar Z" first="Z" last="El Bitar">Z. 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Francis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics, Faculty of Sciences, Université Saint Joseph, Beirut, Lebanon.</nlm:affiliation><country xml:lang="fr">Liban</country><wicri:regionArea>Department of Physics, Faculty of Sciences, Université Saint Joseph, Beirut</wicri:regionArea></affiliation></author><author><name sortKey="Guatelli, S" sort="Guatelli, S" uniqKey="Guatelli S" first="S" last="Guatelli">S. Guatelli</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Ivanchenko, V N" sort="Ivanchenko, V N" uniqKey="Ivanchenko V" first="V N" last="Ivanchenko">V N Ivanchenko</name><affiliation wicri:level="1"><nlm:affiliation>Geant4 Associates International Ltd, United Kingdom; Ecoanalytica, 119899 Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Geant4 Associates International Ltd, United Kingdom; Ecoanalytica, 119899 Moscow</wicri:regionArea></affiliation></author><author><name sortKey="Karamitros, M" sort="Karamitros, M" uniqKey="Karamitros M" first="M" last="Karamitros">M. Karamitros</name><affiliation wicri:level="1"><nlm:affiliation>Notre Dame Radiation Laboratory, University of Notre Dame, Notre Dame, IN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Notre Dame Radiation Laboratory, University of Notre Dame, Notre Dame, IN</wicri:regionArea></affiliation></author><author><name sortKey="Kyriakou, I" sort="Kyriakou, I" uniqKey="Kyriakou I" first="I" last="Kyriakou">I. Kyriakou</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Laboratory, University of Ioannina Medical School, Ioannina 45110, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Medical Physics Laboratory, University of Ioannina Medical School, Ioannina 45110</wicri:regionArea></affiliation></author><author><name sortKey="Maigne, L" sort="Maigne, L" uniqKey="Maigne L" first="L" last="Maigne">L. Maigne</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="Meylan, S" sort="Meylan, S" uniqKey="Meylan S" first="S" last="Meylan">S. Meylan</name><affiliation wicri:level="1"><nlm:affiliation>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses</wicri:regionArea></affiliation></author><author><name sortKey="Murakami, K" sort="Murakami, K" uniqKey="Murakami K" first="K" last="Murakami">K. Murakami</name><affiliation wicri:level="1"><nlm:affiliation>KEK, Tsukuba, Ibaraki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>KEK, Tsukuba, Ibaraki</wicri:regionArea></affiliation></author><author><name sortKey="Okada, S" sort="Okada, S" uniqKey="Okada S" first="S" last="Okada">S. Okada</name><affiliation wicri:level="1"><nlm:affiliation>KEK, Tsukuba, Ibaraki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>KEK, Tsukuba, Ibaraki</wicri:regionArea></affiliation></author><author><name sortKey="Payno, H" sort="Payno, H" uniqKey="Payno H" first="H" last="Payno">H. Payno</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="Perrot, Y" sort="Perrot, Y" uniqKey="Perrot Y" first="Y" last="Perrot">Y. Perrot</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="Petrovic, I" sort="Petrovic, I" uniqKey="Petrovic I" first="I" last="Petrovic">I. Petrovic</name><affiliation wicri:level="1"><nlm:affiliation>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade</wicri:regionArea></affiliation></author><author><name sortKey="Pham, Q T" sort="Pham, Q T" uniqKey="Pham Q" first="Q T" last="Pham">Q T Pham</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="Ristic Fira, A" sort="Ristic Fira, A" uniqKey="Ristic Fira A" first="A" last="Ristic-Fira">A. Ristic-Fira</name><affiliation wicri:level="1"><nlm:affiliation>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade</wicri:regionArea></affiliation></author><author><name sortKey="Sasaki, T" sort="Sasaki, T" uniqKey="Sasaki T" first="T" last="Sasaki">T. Sasaki</name><affiliation wicri:level="1"><nlm:affiliation>KEK, Tsukuba, Ibaraki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>KEK, Tsukuba, Ibaraki</wicri:regionArea></affiliation></author><author><name sortKey="St Pan, V" sort="St Pan, V" uniqKey="St Pan V" first="V" last="Št Pán">V. Št Pán</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha</wicri:regionArea></affiliation></author><author><name sortKey="Tran, H N" sort="Tran, H N" uniqKey="Tran H" first="H N" last="Tran">H N Tran</name><affiliation wicri:level="1"><nlm:affiliation>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City</wicri:regionArea></affiliation></author><author><name sortKey="Villagrasa, C" sort="Villagrasa, C" uniqKey="Villagrasa C" first="C" last="Villagrasa">C. Villagrasa</name><affiliation wicri:level="1"><nlm:affiliation>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses</wicri:regionArea></affiliation></author><author><name sortKey="Incerti, S" sort="Incerti, S" uniqKey="Incerti S" first="S" last="Incerti">S. Incerti</name><affiliation wicri:level="1"><nlm:affiliation>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Univ. Bordeaux, CENBG, UMR 5797, F-33170 Gradignan, France; CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan, France. Electronic address: sebastien.incerti@tdt.edu.vn.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Univ. Bordeaux, CENBG, UMR 5797, F-33170 Gradignan, France; CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26653251</idno><idno type="pmid">26653251</idno><idno type="doi">10.1016/j.ejmp.2015.10.087</idno><idno type="wicri:Area/PubMed/Corpus">002646</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002646</idno><idno type="wicri:Area/PubMed/Curation">002577</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002577</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit.</title><author><name sortKey="Bernal, M A" sort="Bernal, M A" uniqKey="Bernal M" first="M A" last="Bernal">M A Bernal</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, SP</wicri:regionArea></affiliation></author><author><name sortKey="Bordage, M C" sort="Bordage, M C" uniqKey="Bordage M" first="M C" last="Bordage">M C Bordage</name><affiliation wicri:level="1"><nlm:affiliation>CRCT, UMR 1037 INSERM, Université Paul Sabatier, Toulouse, France; UMR 1037, CRCT, Univ. Toulouse III-Paul Sabatier, F-31000 Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CRCT, UMR 1037 INSERM, Université Paul Sabatier, Toulouse, France; UMR 1037, CRCT, Univ. Toulouse III-Paul Sabatier, F-31000 Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Brown, J M C" sort="Brown, J M C" uniqKey="Brown J" first="J M C" last="Brown">J M C. Brown</name><affiliation wicri:level="1"><nlm:affiliation>School of Physics and Astronomy, Monash University, Melbourne, Australia; School of Mathematics and Physics, Queen's University Belfast, Belfast, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Physics and Astronomy, Monash University, Melbourne, Australia; School of Mathematics and Physics, Queen's University Belfast, Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Davidkova, M" sort="Davidkova, M" uniqKey="Davidkova M" first="M" last="Davídková">M. Davídková</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha</wicri:regionArea></affiliation></author><author><name sortKey="Delage, E" sort="Delage, E" uniqKey="Delage E" first="E" last="Delage">E. Delage</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="El Bitar, Z" sort="El Bitar, Z" uniqKey="El Bitar Z" first="Z" last="El Bitar">Z. El Bitar</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pluridisciplinaire Hubert Curien, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pluridisciplinaire Hubert Curien, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Enger, S A" sort="Enger, S A" uniqKey="Enger S" first="S A" last="Enger">S A Enger</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Unit, Department of Oncology, McGill University, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Medical Physics Unit, Department of Oncology, McGill University, Montreal, QC</wicri:regionArea></affiliation></author><author><name sortKey="Francis, Z" sort="Francis, Z" uniqKey="Francis Z" first="Z" last="Francis">Z. Francis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics, Faculty of Sciences, Université Saint Joseph, Beirut, Lebanon.</nlm:affiliation><country xml:lang="fr">Liban</country><wicri:regionArea>Department of Physics, Faculty of Sciences, Université Saint Joseph, Beirut</wicri:regionArea></affiliation></author><author><name sortKey="Guatelli, S" sort="Guatelli, S" uniqKey="Guatelli S" first="S" last="Guatelli">S. Guatelli</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, NSW</wicri:regionArea></affiliation></author><author><name sortKey="Ivanchenko, V N" sort="Ivanchenko, V N" uniqKey="Ivanchenko V" first="V N" last="Ivanchenko">V N Ivanchenko</name><affiliation wicri:level="1"><nlm:affiliation>Geant4 Associates International Ltd, United Kingdom; Ecoanalytica, 119899 Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Geant4 Associates International Ltd, United Kingdom; Ecoanalytica, 119899 Moscow</wicri:regionArea></affiliation></author><author><name sortKey="Karamitros, M" sort="Karamitros, M" uniqKey="Karamitros M" first="M" last="Karamitros">M. Karamitros</name><affiliation wicri:level="1"><nlm:affiliation>Notre Dame Radiation Laboratory, University of Notre Dame, Notre Dame, IN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Notre Dame Radiation Laboratory, University of Notre Dame, Notre Dame, IN</wicri:regionArea></affiliation></author><author><name sortKey="Kyriakou, I" sort="Kyriakou, I" uniqKey="Kyriakou I" first="I" last="Kyriakou">I. Kyriakou</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Laboratory, University of Ioannina Medical School, Ioannina 45110, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Medical Physics Laboratory, University of Ioannina Medical School, Ioannina 45110</wicri:regionArea></affiliation></author><author><name sortKey="Maigne, L" sort="Maigne, L" uniqKey="Maigne L" first="L" last="Maigne">L. Maigne</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="Meylan, S" sort="Meylan, S" uniqKey="Meylan S" first="S" last="Meylan">S. Meylan</name><affiliation wicri:level="1"><nlm:affiliation>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses</wicri:regionArea></affiliation></author><author><name sortKey="Murakami, K" sort="Murakami, K" uniqKey="Murakami K" first="K" last="Murakami">K. Murakami</name><affiliation wicri:level="1"><nlm:affiliation>KEK, Tsukuba, Ibaraki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>KEK, Tsukuba, Ibaraki</wicri:regionArea></affiliation></author><author><name sortKey="Okada, S" sort="Okada, S" uniqKey="Okada S" first="S" last="Okada">S. Okada</name><affiliation wicri:level="1"><nlm:affiliation>KEK, Tsukuba, Ibaraki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>KEK, Tsukuba, Ibaraki</wicri:regionArea></affiliation></author><author><name sortKey="Payno, H" sort="Payno, H" uniqKey="Payno H" first="H" last="Payno">H. Payno</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="Perrot, Y" sort="Perrot, Y" uniqKey="Perrot Y" first="Y" last="Perrot">Y. Perrot</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="Petrovic, I" sort="Petrovic, I" uniqKey="Petrovic I" first="I" last="Petrovic">I. Petrovic</name><affiliation wicri:level="1"><nlm:affiliation>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade</wicri:regionArea></affiliation></author><author><name sortKey="Pham, Q T" sort="Pham, Q T" uniqKey="Pham Q" first="Q T" last="Pham">Q T Pham</name><affiliation wicri:level="1"><nlm:affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière</wicri:regionArea></affiliation></author><author><name sortKey="Ristic Fira, A" sort="Ristic Fira, A" uniqKey="Ristic Fira A" first="A" last="Ristic-Fira">A. Ristic-Fira</name><affiliation wicri:level="1"><nlm:affiliation>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade</wicri:regionArea></affiliation></author><author><name sortKey="Sasaki, T" sort="Sasaki, T" uniqKey="Sasaki T" first="T" last="Sasaki">T. Sasaki</name><affiliation wicri:level="1"><nlm:affiliation>KEK, Tsukuba, Ibaraki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>KEK, Tsukuba, Ibaraki</wicri:regionArea></affiliation></author><author><name sortKey="St Pan, V" sort="St Pan, V" uniqKey="St Pan V" first="V" last="Št Pán">V. Št Pán</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha</wicri:regionArea></affiliation></author><author><name sortKey="Tran, H N" sort="Tran, H N" uniqKey="Tran H" first="H N" last="Tran">H N Tran</name><affiliation wicri:level="1"><nlm:affiliation>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City</wicri:regionArea></affiliation></author><author><name sortKey="Villagrasa, C" sort="Villagrasa, C" uniqKey="Villagrasa C" first="C" last="Villagrasa">C. Villagrasa</name><affiliation wicri:level="1"><nlm:affiliation>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses</wicri:regionArea></affiliation></author><author><name sortKey="Incerti, S" sort="Incerti, S" uniqKey="Incerti S" first="S" last="Incerti">S. Incerti</name><affiliation wicri:level="1"><nlm:affiliation>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Univ. Bordeaux, CENBG, UMR 5797, F-33170 Gradignan, France; CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan, France. Electronic address: sebastien.incerti@tdt.edu.vn.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Univ. Bordeaux, CENBG, UMR 5797, F-33170 Gradignan, France; CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)</title><idno type="eISSN">1724-191X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chemical Phenomena</term><term>DNA (chemistry)</term><term>Humans</term><term>Models, Molecular</term><term>Monte Carlo Method</term><term>Water (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN ()</term><term>Eau ()</term><term>Humains</term><term>Modèles moléculaires</term><term>Méthode de Monte-Carlo</term><term>Phénomènes chimiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term><term>Water</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chemical Phenomena</term><term>Humans</term><term>Models, Molecular</term><term>Monte Carlo Method</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN</term><term>Eau</term><term>Humains</term><term>Modèles moléculaires</term><term>Méthode de Monte-Carlo</term><term>Phénomènes chimiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of today's radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26653251</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>10</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1724-191X</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>8</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)</Title><ISOAbbreviation>Phys Med</ISOAbbreviation></Journal><ArticleTitle>Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit.</ArticleTitle><Pagination><MedlinePgn>861-874</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1120-1797(15)01004-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejmp.2015.10.087</ELocationID><Abstract><AbstractText>Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of today's radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described.</AbstractText><CopyrightInformation>Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bernal</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bordage</LastName><ForeName>M C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>CRCT, UMR 1037 INSERM, Université Paul Sabatier, Toulouse, France; UMR 1037, CRCT, Univ. Toulouse III-Paul Sabatier, F-31000 Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>J M C</ForeName><Initials>JMC</Initials><AffiliationInfo><Affiliation>School of Physics and Astronomy, Monash University, Melbourne, Australia; School of Mathematics and Physics, Queen's University Belfast, Belfast, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davídková</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delage</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El Bitar</LastName><ForeName>Z</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institut Pluridisciplinaire Hubert Curien, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enger</LastName><ForeName>S A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Medical Physics Unit, Department of Oncology, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Francis</LastName><ForeName>Z</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Physics, Faculty of Sciences, Université Saint Joseph, Beirut, Lebanon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guatelli</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ivanchenko</LastName><ForeName>V N</ForeName><Initials>VN</Initials><AffiliationInfo><Affiliation>Geant4 Associates International Ltd, United Kingdom; Ecoanalytica, 119899 Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karamitros</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Notre Dame Radiation Laboratory, University of Notre Dame, Notre Dame, IN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kyriakou</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Medical Physics Laboratory, University of Ioannina Medical School, Ioannina 45110, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maigne</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meylan</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murakami</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>KEK, Tsukuba, Ibaraki, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okada</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>KEK, Tsukuba, Ibaraki, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Payno</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perrot</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrovic</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pham</LastName><ForeName>Q T</ForeName><Initials>QT</Initials><AffiliationInfo><Affiliation>CNRS/IN2P3, Laboratoire de Physique Corpusculaire, Clermont Université, UMR6533 Aubière, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ristic-Fira</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Vinča Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sasaki</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>KEK, Tsukuba, Ibaraki, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Štěpán</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Praha, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tran</LastName><ForeName>H N</ForeName><Initials>HN</Initials><AffiliationInfo><Affiliation>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villagrasa</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>IRSN, Institut de Radioprotection et de Sureté Nucléaire, BP17, 92962 Fontenay-aux-Roses, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Incerti</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Nuclear Physics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Univ. Bordeaux, CENBG, UMR 5797, F-33170 Gradignan, France; CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan, France. Electronic address: sebastien.incerti@tdt.edu.vn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Phys Med</MedlineTA><NlmUniqueID>9302888</NlmUniqueID><ISSNLinking>1120-1797</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>059QF0KO0R</RegistryNumber><NameOfSubstance UI="D014867">Water</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D055598" MajorTopicYN="N">Chemical Phenomena</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008958" MajorTopicYN="Y">Models, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009010" MajorTopicYN="Y">Monte Carlo Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014867" MajorTopicYN="N">Water</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Geant4-DNA</Keyword><Keyword MajorTopicYN="N">Ionizing radiation</Keyword><Keyword MajorTopicYN="N">Monte Carlo</Keyword><Keyword MajorTopicYN="N">Radiobiology</Keyword><Keyword MajorTopicYN="N">Radiolysis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>07</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>09</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>10</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26653251</ArticleId><ArticleId IdType="pii">S1120-1797(15)01004-2</ArticleId><ArticleId IdType="doi">10.1016/j.ejmp.2015.10.087</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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