A Transcriptomic Signature of Mouse Liver Progenitor Cells.
Identifieur interne : 002404 ( PubMed/Curation ); précédent : 002403; suivant : 002405A Transcriptomic Signature of Mouse Liver Progenitor Cells.
Auteurs : Adam M. Passman [Australie] ; Jasmine Low [Australie] ; Roslyn London [Australie] ; Janina E E. Tirnitz-Parker [Australie] ; Atsushi Miyajima [Japon] ; Minoru Tanaka [Japon] ; Helene Strick-Marchand [France] ; Gretchen J. Darlington [États-Unis] ; Megan Finch-Edmondson [Singapour] ; Scott Ochsner [États-Unis] ; Cornelia Zhu [Australie] ; James Whelan [Australie] ; Bernard A. Callus [Australie] ; George C T. Yeoh [Australie]Source :
- Stem cells international [ 1687-966X ] ; 2016.
Abstract
Liver progenitor cells (LPCs) can proliferate extensively, are able to differentiate into hepatocytes and cholangiocytes, and contribute to liver regeneration. The presence of LPCs, however, often accompanies liver disease and hepatocellular carcinoma (HCC), indicating that they may be a cancer stem cell. Understanding LPC biology and establishing a sensitive, rapid, and reliable method to detect their presence in the liver will assist diagnosis and facilitate monitoring of treatment outcomes in patients with liver pathologies. A transcriptomic meta-analysis of over 400 microarrays was undertaken to compare LPC lines against datasets of muscle and embryonic stem cell lines, embryonic and developed liver (DL), and HCC. Three gene clusters distinguishing LPCs from other liver cell types were identified. Pathways overrepresented in these clusters denote the proliferative nature of LPCs and their association with HCC. Our analysis also revealed 26 novel markers, LPC markers, including Mcm2 and Ltbp3, and eight known LPC markers, including M2pk and Ncam. These markers specified the presence of LPCs in pathological liver tissue by qPCR and correlated with LPC abundance determined using immunohistochemistry. These results showcase the value of global transcript profiling to identify pathways and markers that may be used to detect LPCs in injured or diseased liver.
DOI: 10.1155/2016/5702873
PubMed: 27777588
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002450
Links to Exploration step
pubmed:27777588Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Transcriptomic Signature of Mouse Liver Progenitor Cells.</title><author><name sortKey="Passman, Adam M" sort="Passman, Adam M" uniqKey="Passman A" first="Adam M" last="Passman">Adam M. Passman</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="Low, Jasmine" sort="Low, Jasmine" uniqKey="Low J" first="Jasmine" last="Low">Jasmine Low</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="London, Roslyn" sort="London, Roslyn" uniqKey="London R" first="Roslyn" last="London">Roslyn London</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="Tirnitz Parker, Janina E E" sort="Tirnitz Parker, Janina E E" uniqKey="Tirnitz Parker J" first="Janina E E" last="Tirnitz-Parker">Janina E E. Tirnitz-Parker</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia; School of Medicine and Pharmacology, The University of Western Australia, Fremantle, WA 6160, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia; School of Medicine and Pharmacology, The University of Western Australia, Fremantle, WA 6160</wicri:regionArea></affiliation></author><author><name sortKey="Miyajima, Atsushi" sort="Miyajima, Atsushi" uniqKey="Miyajima A" first="Atsushi" last="Miyajima">Atsushi Miyajima</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654</wicri:regionArea></affiliation></author><author><name sortKey="Tanaka, Minoru" sort="Tanaka, Minoru" uniqKey="Tanaka M" first="Minoru" last="Tanaka">Minoru Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654</wicri:regionArea></affiliation></author><author><name sortKey="Strick Marchand, Helene" sort="Strick Marchand, Helene" uniqKey="Strick Marchand H" first="Helene" last="Strick-Marchand">Helene Strick-Marchand</name><affiliation wicri:level="1"><nlm:affiliation>Unité de Génétique de la Différenciation, Institut Pasteur, 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Génétique de la Différenciation, Institut Pasteur, 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Darlington, Gretchen J" sort="Darlington, Gretchen J" uniqKey="Darlington G" first="Gretchen J" last="Darlington">Gretchen J. Darlington</name><affiliation wicri:level="1"><nlm:affiliation>Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea></affiliation></author><author><name sortKey="Finch Edmondson, Megan" sort="Finch Edmondson, Megan" uniqKey="Finch Edmondson M" first="Megan" last="Finch-Edmondson">Megan Finch-Edmondson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore 117411; Mechanobiology Institute (MBI), National University of Singapore, Singapore 117411.</nlm:affiliation><orgName type="university">Université nationale de Singapour</orgName><country>Singapour</country></affiliation></author><author><name sortKey="Ochsner, Scott" sort="Ochsner, Scott" uniqKey="Ochsner S" first="Scott" last="Ochsner">Scott Ochsner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Cornelia" sort="Zhu, Cornelia" uniqKey="Zhu C" first="Cornelia" last="Zhu">Cornelia Zhu</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="Whelan, James" sort="Whelan, James" uniqKey="Whelan J" first="James" last="Whelan">James Whelan</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia; Department of Animal, Plant and Soil Sciences, La Trobe University, Melbourne, VIC 3086, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia; Department of Animal, Plant and Soil Sciences, La Trobe University, Melbourne, VIC 3086</wicri:regionArea></affiliation></author><author><name sortKey="Callus, Bernard A" sort="Callus, Bernard A" uniqKey="Callus B" first="Bernard A" last="Callus">Bernard A. Callus</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia; School of Health Sciences, The University of Notre Dame Australia, Fremantle, WA 6959, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia; School of Health Sciences, The University of Notre Dame Australia, Fremantle, WA 6959</wicri:regionArea></affiliation></author><author><name sortKey="Yeoh, George C T" sort="Yeoh, George C T" uniqKey="Yeoh G" first="George C T" last="Yeoh">George C T. Yeoh</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27777588</idno><idno type="pmid">27777588</idno><idno type="doi">10.1155/2016/5702873</idno><idno type="wicri:Area/PubMed/Corpus">002450</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002450</idno><idno type="wicri:Area/PubMed/Curation">002404</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002404</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Transcriptomic Signature of Mouse Liver Progenitor Cells.</title><author><name sortKey="Passman, Adam M" sort="Passman, Adam M" uniqKey="Passman A" first="Adam M" last="Passman">Adam M. Passman</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="Low, Jasmine" sort="Low, Jasmine" uniqKey="Low J" first="Jasmine" last="Low">Jasmine Low</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="London, Roslyn" sort="London, Roslyn" uniqKey="London R" first="Roslyn" last="London">Roslyn London</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="Tirnitz Parker, Janina E E" sort="Tirnitz Parker, Janina E E" uniqKey="Tirnitz Parker J" first="Janina E E" last="Tirnitz-Parker">Janina E E. Tirnitz-Parker</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia; School of Medicine and Pharmacology, The University of Western Australia, Fremantle, WA 6160, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia; School of Medicine and Pharmacology, The University of Western Australia, Fremantle, WA 6160</wicri:regionArea></affiliation></author><author><name sortKey="Miyajima, Atsushi" sort="Miyajima, Atsushi" uniqKey="Miyajima A" first="Atsushi" last="Miyajima">Atsushi Miyajima</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654</wicri:regionArea></affiliation></author><author><name sortKey="Tanaka, Minoru" sort="Tanaka, Minoru" uniqKey="Tanaka M" first="Minoru" last="Tanaka">Minoru Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654</wicri:regionArea></affiliation></author><author><name sortKey="Strick Marchand, Helene" sort="Strick Marchand, Helene" uniqKey="Strick Marchand H" first="Helene" last="Strick-Marchand">Helene Strick-Marchand</name><affiliation wicri:level="1"><nlm:affiliation>Unité de Génétique de la Différenciation, Institut Pasteur, 75015 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Génétique de la Différenciation, Institut Pasteur, 75015 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Darlington, Gretchen J" sort="Darlington, Gretchen J" uniqKey="Darlington G" first="Gretchen J" last="Darlington">Gretchen J. Darlington</name><affiliation wicri:level="1"><nlm:affiliation>Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea></affiliation></author><author><name sortKey="Finch Edmondson, Megan" sort="Finch Edmondson, Megan" uniqKey="Finch Edmondson M" first="Megan" last="Finch-Edmondson">Megan Finch-Edmondson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore 117411; Mechanobiology Institute (MBI), National University of Singapore, Singapore 117411.</nlm:affiliation><orgName type="university">Université nationale de Singapour</orgName><country>Singapour</country></affiliation></author><author><name sortKey="Ochsner, Scott" sort="Ochsner, Scott" uniqKey="Ochsner S" first="Scott" last="Ochsner">Scott Ochsner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Cornelia" sort="Zhu, Cornelia" uniqKey="Zhu C" first="Cornelia" last="Zhu">Cornelia Zhu</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009</wicri:regionArea></affiliation></author><author><name sortKey="Whelan, James" sort="Whelan, James" uniqKey="Whelan J" first="James" last="Whelan">James Whelan</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia; Department of Animal, Plant and Soil Sciences, La Trobe University, Melbourne, VIC 3086, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia; Department of Animal, Plant and Soil Sciences, La Trobe University, Melbourne, VIC 3086</wicri:regionArea></affiliation></author><author><name sortKey="Callus, Bernard A" sort="Callus, Bernard A" uniqKey="Callus B" first="Bernard A" last="Callus">Bernard A. Callus</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia; School of Health Sciences, The University of Notre Dame Australia, Fremantle, WA 6959, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia; School of Health Sciences, The University of Notre Dame Australia, Fremantle, WA 6959</wicri:regionArea></affiliation></author><author><name sortKey="Yeoh, George C T" sort="Yeoh, George C T" uniqKey="Yeoh G" first="George C T" last="Yeoh">George C T. Yeoh</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009</wicri:regionArea></affiliation></author></analytic><series><title level="j">Stem cells international</title><idno type="ISSN">1687-966X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Liver progenitor cells (LPCs) can proliferate extensively, are able to differentiate into hepatocytes and cholangiocytes, and contribute to liver regeneration. The presence of LPCs, however, often accompanies liver disease and hepatocellular carcinoma (HCC), indicating that they may be a cancer stem cell. Understanding LPC biology and establishing a sensitive, rapid, and reliable method to detect their presence in the liver will assist diagnosis and facilitate monitoring of treatment outcomes in patients with liver pathologies. A transcriptomic meta-analysis of over 400 microarrays was undertaken to compare LPC lines against datasets of muscle and embryonic stem cell lines, embryonic and developed liver (DL), and HCC. Three gene clusters distinguishing LPCs from other liver cell types were identified. Pathways overrepresented in these clusters denote the proliferative nature of LPCs and their association with HCC. Our analysis also revealed 26 novel markers, LPC markers, including Mcm2 and Ltbp3, and eight known LPC markers, including M2pk and Ncam. These markers specified the presence of LPCs in pathological liver tissue by qPCR and correlated with LPC abundance determined using immunohistochemistry. These results showcase the value of global transcript profiling to identify pathways and markers that may be used to detect LPCs in injured or diseased liver.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27777588</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>25</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1687-966X</ISSN><JournalIssue CitedMedium="Print"><Volume>2016</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Stem cells international</Title><ISOAbbreviation>Stem Cells Int</ISOAbbreviation></Journal><ArticleTitle>A Transcriptomic Signature of Mouse Liver Progenitor Cells.</ArticleTitle><Pagination><MedlinePgn>5702873</MedlinePgn></Pagination><Abstract><AbstractText>Liver progenitor cells (LPCs) can proliferate extensively, are able to differentiate into hepatocytes and cholangiocytes, and contribute to liver regeneration. The presence of LPCs, however, often accompanies liver disease and hepatocellular carcinoma (HCC), indicating that they may be a cancer stem cell. Understanding LPC biology and establishing a sensitive, rapid, and reliable method to detect their presence in the liver will assist diagnosis and facilitate monitoring of treatment outcomes in patients with liver pathologies. A transcriptomic meta-analysis of over 400 microarrays was undertaken to compare LPC lines against datasets of muscle and embryonic stem cell lines, embryonic and developed liver (DL), and HCC. Three gene clusters distinguishing LPCs from other liver cell types were identified. Pathways overrepresented in these clusters denote the proliferative nature of LPCs and their association with HCC. Our analysis also revealed 26 novel markers, LPC markers, including Mcm2 and Ltbp3, and eight known LPC markers, including M2pk and Ncam. These markers specified the presence of LPCs in pathological liver tissue by qPCR and correlated with LPC abundance determined using immunohistochemistry. These results showcase the value of global transcript profiling to identify pathways and markers that may be used to detect LPCs in injured or diseased liver.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Passman</LastName><ForeName>Adam M</ForeName><Initials>AM</Initials><Identifier Source="ORCID">0000-0003-3212-6938</Identifier><AffiliationInfo><Affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Low</LastName><ForeName>Jasmine</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>London</LastName><ForeName>Roslyn</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0002-7032-2756</Identifier><AffiliationInfo><Affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tirnitz-Parker</LastName><ForeName>Janina E E</ForeName><Initials>JE</Initials><Identifier Source="ORCID">0000-0002-3558-5892</Identifier><AffiliationInfo><Affiliation>School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA 6102, Australia; School of Medicine and Pharmacology, The University of Western Australia, Fremantle, WA 6160, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyajima</LastName><ForeName>Atsushi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Minoru</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-8654, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strick-Marchand</LastName><ForeName>Helene</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Unité de Génétique de la Différenciation, Institut Pasteur, 75015 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Darlington</LastName><ForeName>Gretchen J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Finch-Edmondson</LastName><ForeName>Megan</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-9628-5842</Identifier><AffiliationInfo><Affiliation>Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore 117411; Mechanobiology Institute (MBI), National University of Singapore, Singapore 117411.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ochsner</LastName><ForeName>Scott</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Cornelia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whelan</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, WA 6009, Australia; Department of Animal, Plant and Soil Sciences, La Trobe University, Melbourne, VIC 3086, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Callus</LastName><ForeName>Bernard A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia; School of Health Sciences, The University of Notre Dame Australia, Fremantle, WA 6959, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeoh</LastName><ForeName>George C T</ForeName><Initials>GC</Initials><Identifier Source="ORCID">0000-0002-4740-4702</Identifier><AffiliationInfo><Affiliation>School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins Institute of Medical Research, Nedlands, WA 6009, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>09-0084</GrantID><Agency>Worldwide Cancer Research</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Stem Cells Int</MedlineTA><NlmUniqueID>101535822</NlmUniqueID></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int J Biochem Cell Biol. 2007;39(12):2226-39</RefSource><PMID Version="1">17693121</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8360-5</RefSource><PMID Version="1">15155906</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Oncogene. 2005 Mar 10;24(11):1809-19</RefSource><PMID Version="1">15674348</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2007 Dec;39(12 ):1500-6</RefSource><PMID Version="1">18026104</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2007 Aug 6;204(8):1973-87</RefSource><PMID Version="1">17664288</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2014 Jun 5;157(6):1324-38</RefSource><PMID Version="1">24906150</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Liver Int. 2010 Jan;30(1):126-38</RefSource><PMID Version="1">19889080</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gastroenterology. 2001 Feb;120(2):534-44</RefSource><PMID Version="1">11159894</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Biol. 2007 Dec 4;17(23):2054-60</RefSource><PMID Version="1">17980593</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gastroenterology. 2012 Dec;143(6):1564-1575.e7</RefSource><PMID Version="1">22922013</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Liver Int. 2010 Jan;30(1):102-11</RefSource><PMID Version="1">19793197</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Biol. 2002 Jun 18;3(7):RESEARCH0034</RefSource><PMID Version="1">12184808</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stem Cells. 2007 Oct;25(10):2476-87</RefSource><PMID Version="1">17641245</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Cancer. 2010 May 1;126(9):2067-78</RefSource><PMID Version="1">19711346</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 1997 Feb;25(2):329-34</RefSource><PMID Version="1">9021943</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Stem Cell. 2014 Sep 4;15(3):340-9</RefSource><PMID Version="1">25130492</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2011 Jun 1;25(11):1193-203</RefSource><PMID Version="1">21632826</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1998 Jul;153(1):319-29</RefSource><PMID Version="1">9665494</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biotechniques. 2004 Aug;37(2):173-5, 177</RefSource><PMID Version="1">15335204</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2002 Oct;36(4 Pt 1):794-804</RefSource><PMID Version="1">12297826</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2008 Jan;47(1):288-95</RefSource><PMID Version="1">17929301</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2000 Jan 7;100(1):57-70</RefSource><PMID Version="1">10647931</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circulation. 2001 Jun 5;103(22):2731-8</RefSource><PMID Version="1">11390345</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dis Model Mech. 2015 Dec;8(12):1635-41</RefSource><PMID Version="1">26496771</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anticancer Res. 2003 Sep-Oct;23(5A):3783-94</RefSource><PMID Version="1">14666678</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gastroenterology. 2005 Jul;129(1):285-302</RefSource><PMID Version="1">16012954</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Ophthalmol. 2006 Jul;90(7):889-93</RefSource><PMID Version="1">16556617</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2001 Sep;34(3):519-22</RefSource><PMID Version="1">11526537</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Commun. 2015 Oct 06;6:8070</RefSource><PMID Version="1">26437858</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2009 Sep 11;284(37):25160-9</RefSource><PMID Version="1">19592488</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Carcinogenesis. 2002 Mar;23(3):435-45</RefSource><PMID Version="1">11895858</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioessays. 2005 Nov;27(11):1192-202</RefSource><PMID Version="1">16237666</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 May 4;107(18):8248-53</RefSource><PMID Version="1">20404163</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1437-42</RefSource><PMID Version="1">20080689</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2004 Mar;39(3):617-27</RefSource><PMID Version="1">14999680</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Cancer. 2001 May 18;84(10):1377-83</RefSource><PMID Version="1">11355950</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2012 Mar 04;18(4):572-9</RefSource><PMID Version="1">22388089</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gastroenterology. 2009 Mar;136(3):1012-24</RefSource><PMID Version="1">19150350</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2006 Sep;6(9):674-87</RefSource><PMID Version="1">16929323</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2008 Nov;22(11):3813-22</RefSource><PMID Version="1">18653765</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Comput Methods Programs Biomed. 2003 Feb;70(2):107-19</RefSource><PMID Version="1">12507787</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Development. 2009 Jun;136(11):1951-60</RefSource><PMID Version="1">19429791</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2006 Jun 30;125(7):1253-67</RefSource><PMID Version="1">16814713</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Semin Cell Dev Biol. 2002 Dec;13(6):389-96</RefSource><PMID Version="1">12468238</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gastroenterology. 2011 May;140(5):1501-12.e2</RefSource><PMID Version="1">21320499</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2008 Dec 9;14(6):471-84</RefSource><PMID Version="1">19061838</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Semin Liver Dis. 2003 Nov;23(4):337-48</RefSource><PMID Version="1">14722811</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2004 Oct 28;431(7012):1112-7</RefSource><PMID Version="1">15475948</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Biol. 2003;4(5):P3</RefSource><PMID Version="1">12734009</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Stem Cell. 2014 Sep 4;15(3):257-8</RefSource><PMID Version="1">25192457</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2005 Apr 15;19(8):877-90</RefSource><PMID Version="1">15833914</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1999 Feb;154(2):537-41</RefSource><PMID Version="1">10027411</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cells. 2012 Dec 13;1(4):1261-92</RefSource><PMID Version="1">24710554</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Leukemia. 2009 Sep;23(9):1650-7</RefSource><PMID Version="1">19369964</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Oncol. 2004 May;24(5):1077-83</RefSource><PMID Version="1">15067328</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gut. 2005 Jul;54(7):972-9</RefSource><PMID Version="1">15951545</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gastroenterology. 2015 Jan;148(1):192-202.e3</RefSource><PMID Version="1">25286440</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Rep. 2014 Aug 21;8(4):933-9</RefSource><PMID Version="1">25131204</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1988 Jul;85(14):5126-30</RefSource><PMID Version="1">3164865</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2009 Jan;49(1):227-39</RefSource><PMID Version="1">19111021</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Transplant. 2005;14(1):41-7</RefSource><PMID Version="1">15789661</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Viral Hepat. 2003 Sep;10(5):345-50</RefSource><PMID Version="1">12969185</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genomics. 2005 Sep;86(3):352-64</RefSource><PMID Version="1">15993033</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Protoc. 2009;4(1):44-57</RefSource><PMID Version="1">19131956</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2009 Jan;49(1):318-29</RefSource><PMID Version="1">19111019</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Oncogene. 2006 Jun 15;25(25):3528-36</RefSource><PMID Version="1">16607285</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1984 Mar;114(3):418-30</RefSource><PMID Version="1">6198921</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2009 Aug;9(8):537-49</RefSource><PMID Version="1">19629069</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2006 Apr;12(4):410-6</RefSource><PMID Version="1">16532004</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2008 Aug 22;134(4):657-67</RefSource><PMID Version="1">18724938</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Sci. 2004 Dec 15;117(Pt 26):6425-34</RefSource><PMID Version="1">15572411</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>OMICS. 2003 Fall;7(3):235-52</RefSource><PMID Version="1">14583114</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2011 Nov;54(5):1707-17</RefSource><PMID Version="1">22045674</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11881-8</RefSource><PMID Version="1">12902545</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 1978 Sep;61(3):813-7</RefSource><PMID Version="1">278859</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cancer Res. 2007 Nov;5(11):1159-70</RefSource><PMID Version="1">18025261</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2014 Oct;60(4):1367-77</RefSource><PMID Version="1">24700364</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2008 Jun 1;68(11):4287-95</RefSource><PMID Version="1">18519688</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>08</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>08</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27777588</ArticleId><ArticleId IdType="doi">10.1155/2016/5702873</ArticleId><ArticleId IdType="pmc">PMC5061959</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002404 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 002404 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:27777588
|texte= A Transcriptomic Signature of Mouse Liver Progenitor Cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27777588" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |