Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration.
Identifieur interne : 002291 ( PubMed/Curation ); précédent : 002290; suivant : 002292Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration.
Auteurs : C. Roger [France] ; L. Muller [France] ; S C Wallis [Australie] ; B. Louart [France] ; G. Saissi [France] ; J. Lipman [Australie] ; J Y Lefrant [France] ; J A Roberts [Royaume-Uni]Source :
- The Journal of antimicrobial chemotherapy [ 1460-2091 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacokinetics : Anti-Bacterial Agents, Linezolid.
- Aged, Blood Chemical Analysis, Chromatography, Critical Illness, Female, Hemodiafiltration, Hemofiltration, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Prospective Studies.
Abstract
Few data are available to guide linezolid dosing during renal replacement therapy. The objective of this study was to compare the population pharmacokinetics of linezolid during continuous venovenous haemofiltration (CVVHF, 30 mL/kg/h) and continuous venovenous haemodiafiltration (CVVHDF, 15 mL/kg/h + 15 mL/kg/h).
DOI: 10.1093/jac/dkv349
PubMed: 26538503
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Roger</name><affiliation wicri:level="1"><nlm:affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France claire.roger@chu-nimes.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes</wicri:regionArea></affiliation></author><author><name sortKey="Muller, L" sort="Muller, L" uniqKey="Muller L" first="L" last="Muller">L. 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Roger</name><affiliation wicri:level="1"><nlm:affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France claire.roger@chu-nimes.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes</wicri:regionArea></affiliation></author><author><name sortKey="Muller, L" sort="Muller, L" uniqKey="Muller L" first="L" last="Muller">L. Muller</name><affiliation wicri:level="1"><nlm:affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes</wicri:regionArea></affiliation></author><author><name sortKey="Wallis, S C" sort="Wallis, S C" uniqKey="Wallis S" first="S C" last="Wallis">S C Wallis</name><affiliation wicri:level="1"><nlm:affiliation>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Louart, B" sort="Louart, B" uniqKey="Louart B" first="B" last="Louart">B. Louart</name><affiliation wicri:level="1"><nlm:affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes</wicri:regionArea></affiliation></author><author><name sortKey="Saissi, G" sort="Saissi, G" uniqKey="Saissi G" first="G" last="Saissi">G. Saissi</name><affiliation wicri:level="1"><nlm:affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes</wicri:regionArea></affiliation></author><author><name sortKey="Lipman, J" sort="Lipman, J" uniqKey="Lipman J" first="J" last="Lipman">J. Lipman</name><affiliation wicri:level="1"><nlm:affiliation>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Lefrant, J Y" sort="Lefrant, J Y" uniqKey="Lefrant J" first="J Y" last="Lefrant">J Y Lefrant</name><affiliation wicri:level="1"><nlm:affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes</wicri:regionArea></affiliation></author><author><name sortKey="Roberts, J A" sort="Roberts, J A" uniqKey="Roberts J" first="J A" last="Roberts">J A Roberts</name><affiliation wicri:level="1"><nlm:affiliation>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of antimicrobial chemotherapy</title><idno type="eISSN">1460-2091</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anti-Bacterial Agents (pharmacokinetics)</term><term>Blood Chemical Analysis</term><term>Chromatography</term><term>Critical Illness</term><term>Female</term><term>Hemodiafiltration</term><term>Hemofiltration</term><term>Humans</term><term>Linezolid (pharmacokinetics)</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Prospective Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse chimique du sang</term><term>Antibactériens (pharmacocinétique)</term><term>Chromatographie</term><term>Femelle</term><term>Humains</term><term>Hémodiafiltration</term><term>Hémofiltration</term><term>Linézolide (pharmacocinétique)</term><term>Maladie grave</term><term>Mâle</term><term>Sujet âgé</term><term>Tests de sensibilité microbienne</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Linezolid</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Antibactériens</term><term>Linézolide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Blood Chemical Analysis</term><term>Chromatography</term><term>Critical Illness</term><term>Female</term><term>Hemodiafiltration</term><term>Hemofiltration</term><term>Humans</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse chimique du sang</term><term>Chromatographie</term><term>Femelle</term><term>Humains</term><term>Hémodiafiltration</term><term>Hémofiltration</term><term>Maladie grave</term><term>Mâle</term><term>Sujet âgé</term><term>Tests de sensibilité microbienne</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Few data are available to guide linezolid dosing during renal replacement therapy. The objective of this study was to compare the population pharmacokinetics of linezolid during continuous venovenous haemofiltration (CVVHF, 30 mL/kg/h) and continuous venovenous haemodiafiltration (CVVHDF, 15 mL/kg/h + 15 mL/kg/h).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26538503</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>13</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2091</ISSN><JournalIssue CitedMedium="Internet"><Volume>71</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The Journal of antimicrobial chemotherapy</Title><ISOAbbreviation>J. Antimicrob. Chemother.</ISOAbbreviation></Journal><ArticleTitle>Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration.</ArticleTitle><Pagination><MedlinePgn>464-70</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/jac/dkv349</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Few data are available to guide linezolid dosing during renal replacement therapy. The objective of this study was to compare the population pharmacokinetics of linezolid during continuous venovenous haemofiltration (CVVHF, 30 mL/kg/h) and continuous venovenous haemodiafiltration (CVVHDF, 15 mL/kg/h + 15 mL/kg/h).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients requiring linezolid 600 mg iv every 12 h and CVVHF or CVVHDF were eligible for this prospective study. Seven blood samples were collected over one dosing interval and analysed by a validated chromatographic method. Population pharmacokinetic analysis was undertaken using Pmetrics. Monte Carlo simulations evaluated achievement of a pharmacodynamics target of an AUC from 0-24 h to MIC (AUC0-24/MIC) of 80.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Nine CVVHDF and eight CVVHF treatments were performed in 13 patients. Regimens of CVVHDF and CVVHF were similar. A two-compartment linear model best described the data. CVVHDF was associated with a 20.5% higher mean linezolid clearance than CVVHF, without statistical significance (P = 0.39). Increasing patient weight and decreasing SOFA score were associated with increasing linezolid clearance. The mean (SD) parameter estimates were: clearance (CL), 3.8 (2.2) L/h; volume of the central compartment, 26.5 (10.3) L; intercompartmental clearance constants from central to peripheral, 8.1 (12.1) L/h; and peripheral to central compartments, 3.6 (4.0) L/h. Achievement of pharmacodynamic targets was poor for an MIC of 2 mg/L with the studied dose.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">During CVVHF and CVVHDF, there is profound pharmacokinetic variability of linezolid. Suboptimal achievement of therapeutic targets occurs at the EUCAST breakpoint MIC of 2 mg/L using 600 mg iv every 12 h.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Roger</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France claire.roger@chu-nimes.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muller</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallis</LastName><ForeName>S C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Louart</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saissi</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lipman</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lefrant</LastName><ForeName>J Y</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Service des réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Place du Professeur Robert Debré, 30 029 Nîmes cedex 9, France Equipe d'Accueil 2992, Faculté de Médecine de Nîmes, Université de Montpellier, Chemin du Carreau de Lanes, Nimes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>J A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>11</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Antimicrob Chemother</MedlineTA><NlmUniqueID>7513617</NlmUniqueID><ISSNLinking>0305-7453</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>ISQ9I6J12J</RegistryNumber><NameOfSubstance UI="D000069349">Linezolid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001774" MajorTopicYN="N">Blood Chemical Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002845" MajorTopicYN="N">Chromatography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017583" MajorTopicYN="Y">Hemodiafiltration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006440" MajorTopicYN="Y">Hemofiltration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000069349" MajorTopicYN="N">Linezolid</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" 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