A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.
Identifieur interne : 002207 ( PubMed/Curation ); précédent : 002206; suivant : 002208A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.
Auteurs : Eric A. Hungate [États-Unis] ; Sapana R. Vora [États-Unis] ; Eric R. Gamazon [États-Unis] ; Takaya Moriyama [États-Unis] ; Timothy Best [États-Unis] ; Imge Hulur [États-Unis] ; Younghee Lee [États-Unis] ; Tiffany-Jane Evans [Australie] ; Eva Ellinghaus [Allemagne] ; Martin Stanulla [Allemagne] ; Jéremie Rudant [France] ; Laurent Orsi [France] ; Jacqueline Clavel [France] ; Elizabeth Milne [Australie] ; Rodney J. Scott [Australie] ; Ching-Hon Pui [États-Unis] ; Nancy J. Cox [États-Unis] ; Mignon L. Loh [États-Unis] ; Jun J. Yang [États-Unis] ; Andrew D. Skol [États-Unis] ; Kenan Onel [États-Unis]Source :
- Nature communications [ 2041-1723 ] ; 2016.
Descripteurs français
- KwdFr :
- Afro-Américains (génétique), Cartographie chromosomique, Chromosomes humains de la paire 9 (génétique), Enfant, Enfant d'âge préscolaire, Femelle, Hispano-américain (génétique), Humains, Inhibiteur p15 de kinase cycline-dépendante (génétique), Leucémie-lymphome lymphoblastique à précurseurs B (génétique), Mâle, Nourrisson, Polymorphisme de nucléotide simple, Population d'origine européenne (génétique), Prédisposition génétique à une maladie, Variation génétique, Étude d'association pangénomique, Études cas-témoins.
- MESH :
- génétique : Afro-Américains, Chromosomes humains de la paire 9, Hispano-américain, Inhibiteur p15 de kinase cycline-dépendante, Leucémie-lymphome lymphoblastique à précurseurs B, Population d'origine européenne.
- Cartographie chromosomique, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Nourrisson, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Variation génétique, Étude d'association pangénomique, Études cas-témoins.
English descriptors
- KwdEn :
- African Americans (genetics), Case-Control Studies, Child, Child, Preschool, Chromosome Mapping, Chromosomes, Human, Pair 9 (genetics), Cyclin-Dependent Kinase Inhibitor p15 (genetics), European Continental Ancestry Group (genetics), Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Hispanic Americans (genetics), Humans, Infant, Male, Polymorphism, Single Nucleotide, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (genetics).
- MESH :
- chemical , genetics : Cyclin-Dependent Kinase Inhibitor p15.
- genetics : African Americans, Chromosomes, Human, Pair 9, European Continental Ancestry Group, Hispanic Americans, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma.
- Case-Control Studies, Child, Child, Preschool, Chromosome Mapping, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Infant, Male, Polymorphism, Single Nucleotide.
Abstract
Paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little is known about BCP-ALL predisposition. In this study, in 2,187 cases of European ancestry and 5,543 controls, we discover and replicate a locus indexed by rs77728904 at 9p21.3 associated with BCP-ALL susceptibility (Pcombined=3.32 × 10(-15), OR=1.72) and independent from rs3731217, the previously reported ALL-associated variant in this region. Of correlated SNPs tagged by this locus, only rs662463 is significant in African Americans, suggesting it is a plausible causative variant. Functional analysis shows that rs662463 is a cis-eQTL for CDKN2B, with the risk allele associated with lower expression, and suggests that rs662463 influences BCP-ALL risk by regulating CDKN2B expression through CEBPB signalling. Functional analysis of rs3731217 suggests it is associated with BCP-ALL by acting within a splicing regulatory element determining CDKN2A exon 3 usage (P=0.01). These findings provide new insights into the critical role of the CDKN2 locus in BCP-ALL aetiology.
DOI: 10.1038/ncomms10635
PubMed: 26868379
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Hungate</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637</wicri:regionArea></affiliation></author><author><name sortKey="Vora, Sapana R" sort="Vora, Sapana R" uniqKey="Vora S" first="Sapana R" last="Vora">Sapana R. Vora</name><affiliation wicri:level="1"><nlm:affiliation>Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637</wicri:regionArea></affiliation></author><author><name sortKey="Gamazon, Eric R" sort="Gamazon, Eric R" uniqKey="Gamazon E" first="Eric R" last="Gamazon">Eric R. Gamazon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232</wicri:regionArea></affiliation></author><author><name sortKey="Moriyama, Takaya" sort="Moriyama, Takaya" uniqKey="Moriyama T" first="Takaya" last="Moriyama">Takaya Moriyama</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105</wicri:regionArea></affiliation></author><author><name sortKey="Best, Timothy" sort="Best, Timothy" uniqKey="Best T" first="Timothy" last="Best">Timothy Best</name><affiliation wicri:level="1"><nlm:affiliation>Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637</wicri:regionArea></affiliation></author><author><name sortKey="Hulur, Imge" sort="Hulur, Imge" uniqKey="Hulur I" first="Imge" last="Hulur">Imge Hulur</name><affiliation wicri:level="1"><nlm:affiliation>Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60637</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Younghee" sort="Lee, Younghee" uniqKey="Lee Y" first="Younghee" last="Lee">Younghee Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232</wicri:regionArea></affiliation></author><author><name sortKey="Evans, Tiffany Jane" sort="Evans, Tiffany Jane" uniqKey="Evans T" first="Tiffany-Jane" last="Evans">Tiffany-Jane Evans</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine and Health, Information Based Medicine, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton, New South Wales 2305, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Medicine and Health, Information Based Medicine, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton, New South Wales 2305</wicri:regionArea></affiliation></author><author><name sortKey="Ellinghaus, Eva" sort="Ellinghaus, Eva" uniqKey="Ellinghaus E" first="Eva" last="Ellinghaus">Eva Ellinghaus</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel 24118, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel 24118</wicri:regionArea></affiliation></author><author><name sortKey="Stanulla, Martin" sort="Stanulla, Martin" uniqKey="Stanulla M" first="Martin" last="Stanulla">Martin Stanulla</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel 24105, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel 24105</wicri:regionArea></affiliation></author><author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jéremie" last="Rudant">Jéremie Rudant</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807</wicri:regionArea></affiliation></author><author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807</wicri:regionArea></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name><affiliation wicri:level="1"><nlm:affiliation>Telethon Kids Institute, University of Western Australia, Crawley, Western Australia 6872, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Telethon Kids Institute, University of Western Australia, Crawley, Western Australia 6872</wicri:regionArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine and Health, Information Based Medicine, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton, New South Wales 2305, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Medicine and Health, Information Based Medicine, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton, New South Wales 2305</wicri:regionArea></affiliation></author><author><name sortKey="Pui, Ching Hon" sort="Pui, Ching Hon" uniqKey="Pui C" first="Ching-Hon" last="Pui">Ching-Hon Pui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J" last="Cox">Nancy J. Cox</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232</wicri:regionArea></affiliation></author><author><name sortKey="Loh, Mignon L" sort="Loh, Mignon L" uniqKey="Loh M" first="Mignon L" last="Loh">Mignon L. Loh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of California-San Francisco, San Francisco, California 94143, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of California-San Francisco, San Francisco, California 94143</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Jun J" sort="Yang, Jun J" uniqKey="Yang J" first="Jun J" last="Yang">Jun J. Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105</wicri:regionArea></affiliation></author><author><name sortKey="Skol, Andrew D" sort="Skol, Andrew D" uniqKey="Skol A" first="Andrew D" last="Skol">Andrew D. Skol</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637</wicri:regionArea></affiliation></author><author><name sortKey="Onel, Kenan" sort="Onel, Kenan" uniqKey="Onel K" first="Kenan" last="Onel">Kenan Onel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African Americans (genetics)</term><term>Case-Control Studies</term><term>Child</term><term>Child, Preschool</term><term>Chromosome Mapping</term><term>Chromosomes, Human, Pair 9 (genetics)</term><term>Cyclin-Dependent Kinase Inhibitor p15 (genetics)</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Hispanic Americans (genetics)</term><term>Humans</term><term>Infant</term><term>Male</term><term>Polymorphism, Single Nucleotide</term><term>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Afro-Américains (génétique)</term><term>Cartographie chromosomique</term><term>Chromosomes humains de la paire 9 (génétique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Hispano-américain (génétique)</term><term>Humains</term><term>Inhibiteur p15 de kinase cycline-dépendante (génétique)</term><term>Leucémie-lymphome lymphoblastique à précurseurs B (génétique)</term><term>Mâle</term><term>Nourrisson</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine européenne (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Variation génétique</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclin-Dependent Kinase Inhibitor p15</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>African Americans</term><term>Chromosomes, Human, Pair 9</term><term>European Continental Ancestry Group</term><term>Hispanic Americans</term><term>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Afro-Américains</term><term>Chromosomes humains de la paire 9</term><term>Hispano-américain</term><term>Inhibiteur p15 de kinase cycline-dépendante</term><term>Leucémie-lymphome lymphoblastique à précurseurs B</term><term>Population d'origine européenne</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Child</term><term>Child, Preschool</term><term>Chromosome Mapping</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Infant</term><term>Male</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cartographie chromosomique</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Variation génétique</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little is known about BCP-ALL predisposition. In this study, in 2,187 cases of European ancestry and 5,543 controls, we discover and replicate a locus indexed by rs77728904 at 9p21.3 associated with BCP-ALL susceptibility (Pcombined=3.32 × 10(-15), OR=1.72) and independent from rs3731217, the previously reported ALL-associated variant in this region. Of correlated SNPs tagged by this locus, only rs662463 is significant in African Americans, suggesting it is a plausible causative variant. Functional analysis shows that rs662463 is a cis-eQTL for CDKN2B, with the risk allele associated with lower expression, and suggests that rs662463 influences BCP-ALL risk by regulating CDKN2B expression through CEBPB signalling. Functional analysis of rs3731217 suggests it is associated with BCP-ALL by acting within a splicing regulatory element determining CDKN2A exon 3 usage (P=0.01). These findings provide new insights into the critical role of the CDKN2 locus in BCP-ALL aetiology.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26868379</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>12</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>28</Day></DateCompleted><DateRevised><Year>2017</Year><Month>04</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><PubDate><Year>2016</Year><Month>Feb</Month><Day>12</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.</ArticleTitle><Pagination><MedlinePgn>10635</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms10635</ELocationID><Abstract><AbstractText>Paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little is known about BCP-ALL predisposition. In this study, in 2,187 cases of European ancestry and 5,543 controls, we discover and replicate a locus indexed by rs77728904 at 9p21.3 associated with BCP-ALL susceptibility (Pcombined=3.32 × 10(-15), OR=1.72) and independent from rs3731217, the previously reported ALL-associated variant in this region. Of correlated SNPs tagged by this locus, only rs662463 is significant in African Americans, suggesting it is a plausible causative variant. Functional analysis shows that rs662463 is a cis-eQTL for CDKN2B, with the risk allele associated with lower expression, and suggests that rs662463 influences BCP-ALL risk by regulating CDKN2B expression through CEBPB signalling. Functional analysis of rs3731217 suggests it is associated with BCP-ALL by acting within a splicing regulatory element determining CDKN2A exon 3 usage (P=0.01). These findings provide new insights into the critical role of the CDKN2 locus in BCP-ALL aetiology.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hungate</LastName><ForeName>Eric A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vora</LastName><ForeName>Sapana R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gamazon</LastName><ForeName>Eric R</ForeName><Initials>ER</Initials><AffiliationInfo><Affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moriyama</LastName><ForeName>Takaya</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Best</LastName><ForeName>Timothy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hulur</LastName><ForeName>Imge</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60637, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Younghee</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evans</LastName><ForeName>Tiffany-Jane</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Faculty of Medicine and Health, Information Based Medicine, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton, New South Wales 2305, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ellinghaus</LastName><ForeName>Eva</ForeName><Initials>E</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2914-3382</Identifier><AffiliationInfo><Affiliation>Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel 24118, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stanulla</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel 24105, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rudant</LastName><ForeName>Jéremie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris-Descartes University, Paris 75270, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orsi</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris-Descartes University, Paris 75270, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clavel</LastName><ForeName>Jacqueline</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif 94807, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris-Descartes University, Paris 75270, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>French National Registry of Childhood Hematopoietic Malignancies (RNHE), Villejuif 94807, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milne</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Telethon Kids Institute, University of Western Australia, Crawley, Western Australia 6872, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Rodney J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Faculty of Medicine and Health, Information Based Medicine, Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton, New South Wales 2305, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales 2305, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pui</LastName><ForeName>Ching-Hon</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cox</LastName><ForeName>Nancy J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loh</LastName><ForeName>Mignon L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University of California-San Francisco, San Francisco, California 94143, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Jun J</ForeName><Initials>JJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0770-9659</Identifier><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skol</LastName><ForeName>Andrew D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Onel</LastName><ForeName>Kenan</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University of Chicago, 900 East 57th Street, Room 5140, MC 4060, Chicago, Illinois 60637, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UL1 TR000430</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA40046</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA040046</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HD0433871</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 CA129045</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 CA114766</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA021765</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01GM92666</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 CA098543</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH101820</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA129045</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01CA176063</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 CA98543</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 GM092666</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 GM115279</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA176063</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Commun</MedlineTA><NlmUniqueID>101528555</NlmUniqueID><ISSNLinking>2041-1723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C493966">CDKN2B protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050762">Cyclin-Dependent Kinase Inhibitor p15</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nature. 2011 Oct 6;478(7367):103-9</RefSource><PMID Version="1">21909115</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2012;8(4):e1002639</RefSource><PMID Version="1">22532805</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 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