Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: The ATLANTIC-H²⁴ Analysis.
Identifieur interne : 001F71 ( PubMed/Curation ); précédent : 001F70; suivant : 001F72Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: The ATLANTIC-H²⁴ Analysis.
Auteurs : Gilles Montalescot [France] ; Arnoud W. Van T Hof [Pays-Bas] ; Leonardo Bolognese [Italie] ; Warren J. Cantor [Canada] ; Angel Cequier [Espagne] ; Mohamed Chettibi [Algérie] ; Jean-Philippe Collet [France] ; Shaun G. Goodman [Canada] ; Christopher J. Hammett [Australie] ; Kurt Huber [Autriche] ; Magnus Janzon [Suède] ; Frédéric Lapostolle [France] ; Jens Flensted Lassen [Danemark] ; Muriel Licour [France] ; Béla Merkely [Hongrie] ; Néjoua Salhi [Royaume-Uni] ; Johanne Silvain [France] ; Robert F. Storey [Royaume-Uni] ; Jurriën M. Ten Berg [Pays-Bas] ; Anne Tsatsaris [France] ; Uwe Zeymer [Allemagne] ; Eric Vicaut [France] ; Christian W. Hamm [Allemagne]Source :
- JACC. Cardiovascular interventions [ 1876-7605 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Adénosine (administration et posologie), Adénosine (analogues et dérivés), Adénosine (effets indésirables), Agrégation plaquettaire (), Ambulances, Antiagrégants plaquettaires (administration et posologie), Antiagrégants plaquettaires (effets indésirables), Délai jusqu'au traitement, Facteurs temps, Femelle, Humains, Infarctus du myocarde avec sus-décalage du segment ST (), Infarctus du myocarde avec sus-décalage du segment ST (imagerie diagnostique), Infarctus du myocarde avec sus-décalage du segment ST (mortalité), Infarctus du myocarde avec sus-décalage du segment ST (sang), Intervention coronarienne percutanée (effets indésirables), Intervention coronarienne percutanée (mortalité), Mâle, Méthode en double aveugle, Récidive, Résultat thérapeutique, Services des urgences médicales (), Sujet âgé, Tests fonctionnels plaquettaires, Thrombose coronarienne (), Thrombose coronarienne (étiologie).
- MESH :
- administration et posologie : Adénosine, Antiagrégants plaquettaires.
- analogues et dérivés : Adénosine.
- effets indésirables : Adénosine, Antiagrégants plaquettaires, Intervention coronarienne percutanée.
- imagerie diagnostique : Infarctus du myocarde avec sus-décalage du segment ST.
- mortalité : Infarctus du myocarde avec sus-décalage du segment ST, Intervention coronarienne percutanée.
- sang : Infarctus du myocarde avec sus-décalage du segment ST.
- étiologie : Thrombose coronarienne.
- Adulte, Adulte d'âge moyen, Agrégation plaquettaire, Ambulances, Délai jusqu'au traitement, Facteurs temps, Femelle, Humains, Infarctus du myocarde avec sus-décalage du segment ST, Mâle, Méthode en double aveugle, Récidive, Résultat thérapeutique, Services des urgences médicales, Sujet âgé, Tests fonctionnels plaquettaires, Thrombose coronarienne.
English descriptors
- KwdEn :
- Adenosine (administration & dosage), Adenosine (adverse effects), Adenosine (analogs & derivatives), Adult, Aged, Ambulances, Coronary Thrombosis (etiology), Coronary Thrombosis (prevention & control), Double-Blind Method, Emergency Medical Services (methods), Female, Humans, Male, Middle Aged, Percutaneous Coronary Intervention (adverse effects), Percutaneous Coronary Intervention (mortality), Platelet Aggregation (drug effects), Platelet Aggregation Inhibitors (administration & dosage), Platelet Aggregation Inhibitors (adverse effects), Platelet Function Tests, Recurrence, ST Elevation Myocardial Infarction (blood), ST Elevation Myocardial Infarction (diagnostic imaging), ST Elevation Myocardial Infarction (mortality), ST Elevation Myocardial Infarction (therapy), Time Factors, Time-to-Treatment, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Adenosine, Platelet Aggregation Inhibitors.
- chemical , adverse effects : Adenosine, Platelet Aggregation Inhibitors.
- chemical , analogs & derivatives : Adenosine.
- adverse effects : Percutaneous Coronary Intervention.
- blood : ST Elevation Myocardial Infarction.
- diagnostic imaging : ST Elevation Myocardial Infarction.
- drug effects : Platelet Aggregation.
- etiology : Coronary Thrombosis.
- methods : Emergency Medical Services.
- mortality : Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction.
- prevention & control : Coronary Thrombosis.
- therapy : ST Elevation Myocardial Infarction.
- Adult, Aged, Ambulances, Double-Blind Method, Female, Humans, Male, Middle Aged, Platelet Function Tests, Recurrence, Time Factors, Time-to-Treatment, Treatment Outcome.
Abstract
The aim of this landmark exploratory analysis, ATLANTIC-H(24), was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study.
DOI: 10.1016/j.jcin.2015.12.024
PubMed: 26952907
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Goodman</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Heart Research Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Heart Research Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Hammett, Christopher J" sort="Hammett, Christopher J" uniqKey="Hammett C" first="Christopher J" last="Hammett">Christopher J. Hammett</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Huber, Kurt" sort="Huber, Kurt" uniqKey="Huber K" first="Kurt" last="Huber">Kurt Huber</name><affiliation wicri:level="1"><nlm:affiliation>3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Janzon, Magnus" sort="Janzon, Magnus" uniqKey="Janzon M" first="Magnus" last="Janzon">Magnus Janzon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping</wicri:regionArea></affiliation></author><author><name sortKey="Lapostolle, Frederic" sort="Lapostolle, Frederic" uniqKey="Lapostolle F" first="Frédéric" last="Lapostolle">Frédéric Lapostolle</name><affiliation wicri:level="1"><nlm:affiliation>SAMU 93 Hôpital Avicenne, Bobigny, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>SAMU 93 Hôpital Avicenne, Bobigny</wicri:regionArea></affiliation></author><author><name sortKey="Lassen, Jens Flensted" sort="Lassen, Jens Flensted" uniqKey="Lassen J" first="Jens Flensted" last="Lassen">Jens Flensted Lassen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology B, Aarhus University Hospital, Aarhus N, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Cardiology B, Aarhus University Hospital, Aarhus N</wicri:regionArea></affiliation></author><author><name sortKey="Licour, Muriel" sort="Licour, Muriel" uniqKey="Licour M" first="Muriel" last="Licour">Muriel Licour</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca, Rueil Malmaison, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AstraZeneca, Rueil Malmaison</wicri:regionArea></affiliation></author><author><name sortKey="Merkely, Bela" sort="Merkely, Bela" uniqKey="Merkely B" first="Béla" last="Merkely">Béla Merkely</name><affiliation wicri:level="1"><nlm:affiliation>Heart and Vascular Center, Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heart and Vascular Center, Semmelweis University, Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Salhi, Nejoua" sort="Salhi, Nejoua" uniqKey="Salhi N" first="Néjoua" last="Salhi">Néjoua Salhi</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca, Luton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>AstraZeneca, Luton</wicri:regionArea></affiliation></author><author><name sortKey="Silvain, Johanne" sort="Silvain, Johanne" uniqKey="Silvain J" first="Johanne" last="Silvain">Johanne Silvain</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Storey, Robert F" sort="Storey, Robert F" uniqKey="Storey R" first="Robert F" last="Storey">Robert F. Storey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Science, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Ten Berg, Jurrien M" sort="Ten Berg, Jurrien M" uniqKey="Ten Berg J" first="Jurriën M" last="Ten Berg">Jurriën M. Ten Berg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein</wicri:regionArea></affiliation></author><author><name sortKey="Tsatsaris, Anne" sort="Tsatsaris, Anne" uniqKey="Tsatsaris A" first="Anne" last="Tsatsaris">Anne Tsatsaris</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca, Rueil Malmaison, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AstraZeneca, Rueil Malmaison</wicri:regionArea></affiliation></author><author><name sortKey="Zeymer, Uwe" sort="Zeymer, Uwe" uniqKey="Zeymer U" first="Uwe" last="Zeymer">Uwe Zeymer</name><affiliation wicri:level="1"><nlm:affiliation>Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen</wicri:regionArea></affiliation></author><author><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name><affiliation wicri:level="1"><nlm:affiliation>Unite de Recherche Clinique, Université Paris 7, Hôpital Lariboisière, ACTION Study Group, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unite de Recherche Clinique, Université Paris 7, Hôpital Lariboisière, ACTION Study Group, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Hamm, Christian W" sort="Hamm, Christian W" uniqKey="Hamm C" first="Christian W" last="Hamm">Christian W. Hamm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26952907</idno><idno type="pmid">26952907</idno><idno type="doi">10.1016/j.jcin.2015.12.024</idno><idno type="wicri:Area/PubMed/Corpus">001F96</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F96</idno><idno type="wicri:Area/PubMed/Curation">001F71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: The ATLANTIC-H²⁴ Analysis.</title><author><name sortKey="Montalescot, Gilles" sort="Montalescot, Gilles" uniqKey="Montalescot G" first="Gilles" last="Montalescot">Gilles Montalescot</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris, France. Electronic address: gilles.montalescot@psl.aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Van T Hof, Arnoud W" sort="Van T Hof, Arnoud W" uniqKey="Van T Hof A" first="Arnoud W" last="Van T Hof">Arnoud W. Van T Hof</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Isala Clinics, Zwolle, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Isala Clinics, Zwolle</wicri:regionArea></affiliation></author><author><name sortKey="Bolognese, Leonardo" sort="Bolognese, Leonardo" uniqKey="Bolognese L" first="Leonardo" last="Bolognese">Leonardo Bolognese</name><affiliation wicri:level="1"><nlm:affiliation>Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo</wicri:regionArea></affiliation></author><author><name sortKey="Cantor, Warren J" sort="Cantor, Warren J" uniqKey="Cantor W" first="Warren J" last="Cantor">Warren J. Cantor</name><affiliation wicri:level="1"><nlm:affiliation>Southlake Regional Health Centre, University of Toronto, Newmarket, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Southlake Regional Health Centre, University of Toronto, Newmarket, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Cequier, Angel" sort="Cequier, Angel" uniqKey="Cequier A" first="Angel" last="Cequier">Angel Cequier</name><affiliation wicri:level="1"><nlm:affiliation>Heart Disease Institute, Hospital Universitario de Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Heart Disease Institute, Hospital Universitario de Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Chettibi, Mohamed" sort="Chettibi, Mohamed" uniqKey="Chettibi M" first="Mohamed" last="Chettibi">Mohamed Chettibi</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospito-universitaire Frantz Fanon, Blida, Algeria.</nlm:affiliation><country xml:lang="fr">Algérie</country><wicri:regionArea>Centre Hospito-universitaire Frantz Fanon, Blida</wicri:regionArea></affiliation></author><author><name sortKey="Collet, Jean Philippe" sort="Collet, Jean Philippe" uniqKey="Collet J" first="Jean-Philippe" last="Collet">Jean-Philippe Collet</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Goodman, Shaun G" sort="Goodman, Shaun G" uniqKey="Goodman S" first="Shaun G" last="Goodman">Shaun G. Goodman</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Heart Research Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Heart Research Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Hammett, Christopher J" sort="Hammett, Christopher J" uniqKey="Hammett C" first="Christopher J" last="Hammett">Christopher J. Hammett</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Huber, Kurt" sort="Huber, Kurt" uniqKey="Huber K" first="Kurt" last="Huber">Kurt Huber</name><affiliation wicri:level="1"><nlm:affiliation>3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Janzon, Magnus" sort="Janzon, Magnus" uniqKey="Janzon M" first="Magnus" last="Janzon">Magnus Janzon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping</wicri:regionArea></affiliation></author><author><name sortKey="Lapostolle, Frederic" sort="Lapostolle, Frederic" uniqKey="Lapostolle F" first="Frédéric" last="Lapostolle">Frédéric Lapostolle</name><affiliation wicri:level="1"><nlm:affiliation>SAMU 93 Hôpital Avicenne, Bobigny, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>SAMU 93 Hôpital Avicenne, Bobigny</wicri:regionArea></affiliation></author><author><name sortKey="Lassen, Jens Flensted" sort="Lassen, Jens Flensted" uniqKey="Lassen J" first="Jens Flensted" last="Lassen">Jens Flensted Lassen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology B, Aarhus University Hospital, Aarhus N, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Cardiology B, Aarhus University Hospital, Aarhus N</wicri:regionArea></affiliation></author><author><name sortKey="Licour, Muriel" sort="Licour, Muriel" uniqKey="Licour M" first="Muriel" last="Licour">Muriel Licour</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca, Rueil Malmaison, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AstraZeneca, Rueil Malmaison</wicri:regionArea></affiliation></author><author><name sortKey="Merkely, Bela" sort="Merkely, Bela" uniqKey="Merkely B" first="Béla" last="Merkely">Béla Merkely</name><affiliation wicri:level="1"><nlm:affiliation>Heart and Vascular Center, Semmelweis University, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Heart and Vascular Center, Semmelweis University, Budapest</wicri:regionArea></affiliation></author><author><name sortKey="Salhi, Nejoua" sort="Salhi, Nejoua" uniqKey="Salhi N" first="Néjoua" last="Salhi">Néjoua Salhi</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca, Luton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>AstraZeneca, Luton</wicri:regionArea></affiliation></author><author><name sortKey="Silvain, Johanne" sort="Silvain, Johanne" uniqKey="Silvain J" first="Johanne" last="Silvain">Johanne Silvain</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Storey, Robert F" sort="Storey, Robert F" uniqKey="Storey R" first="Robert F" last="Storey">Robert F. Storey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Science, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Ten Berg, Jurrien M" sort="Ten Berg, Jurrien M" uniqKey="Ten Berg J" first="Jurriën M" last="Ten Berg">Jurriën M. Ten Berg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein</wicri:regionArea></affiliation></author><author><name sortKey="Tsatsaris, Anne" sort="Tsatsaris, Anne" uniqKey="Tsatsaris A" first="Anne" last="Tsatsaris">Anne Tsatsaris</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca, Rueil Malmaison, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AstraZeneca, Rueil Malmaison</wicri:regionArea></affiliation></author><author><name sortKey="Zeymer, Uwe" sort="Zeymer, Uwe" uniqKey="Zeymer U" first="Uwe" last="Zeymer">Uwe Zeymer</name><affiliation wicri:level="1"><nlm:affiliation>Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen</wicri:regionArea></affiliation></author><author><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name><affiliation wicri:level="1"><nlm:affiliation>Unite de Recherche Clinique, Université Paris 7, Hôpital Lariboisière, ACTION Study Group, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unite de Recherche Clinique, Université Paris 7, Hôpital Lariboisière, ACTION Study Group, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Hamm, Christian W" sort="Hamm, Christian W" uniqKey="Hamm C" first="Christian W" last="Hamm">Christian W. Hamm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim</wicri:regionArea></affiliation></author></analytic><series><title level="j">JACC. Cardiovascular interventions</title><idno type="eISSN">1876-7605</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine (administration & dosage)</term><term>Adenosine (adverse effects)</term><term>Adenosine (analogs & derivatives)</term><term>Adult</term><term>Aged</term><term>Ambulances</term><term>Coronary Thrombosis (etiology)</term><term>Coronary Thrombosis (prevention & control)</term><term>Double-Blind Method</term><term>Emergency Medical Services (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Percutaneous Coronary Intervention (adverse effects)</term><term>Percutaneous Coronary Intervention (mortality)</term><term>Platelet Aggregation (drug effects)</term><term>Platelet Aggregation Inhibitors (administration & dosage)</term><term>Platelet Aggregation Inhibitors (adverse effects)</term><term>Platelet Function Tests</term><term>Recurrence</term><term>ST Elevation Myocardial Infarction (blood)</term><term>ST Elevation Myocardial Infarction (diagnostic imaging)</term><term>ST Elevation Myocardial Infarction (mortality)</term><term>ST Elevation Myocardial Infarction (therapy)</term><term>Time Factors</term><term>Time-to-Treatment</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénosine (administration et posologie)</term><term>Adénosine (analogues et dérivés)</term><term>Adénosine (effets indésirables)</term><term>Agrégation plaquettaire ()</term><term>Ambulances</term><term>Antiagrégants plaquettaires (administration et posologie)</term><term>Antiagrégants plaquettaires (effets indésirables)</term><term>Délai jusqu'au traitement</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Infarctus du myocarde avec sus-décalage du segment ST ()</term><term>Infarctus du myocarde avec sus-décalage du segment ST (imagerie diagnostique)</term><term>Infarctus du myocarde avec sus-décalage du segment ST (mortalité)</term><term>Infarctus du myocarde avec sus-décalage du segment ST (sang)</term><term>Intervention coronarienne percutanée (effets indésirables)</term><term>Intervention coronarienne percutanée (mortalité)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Récidive</term><term>Résultat thérapeutique</term><term>Services des urgences médicales ()</term><term>Sujet âgé</term><term>Tests fonctionnels plaquettaires</term><term>Thrombose coronarienne ()</term><term>Thrombose coronarienne (étiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adenosine</term><term>Platelet Aggregation Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Adenosine</term><term>Platelet Aggregation Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adénosine</term><term>Antiagrégants plaquettaires</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Percutaneous Coronary Intervention</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénosine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>ST Elevation Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>ST Elevation Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Platelet Aggregation</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Adénosine</term><term>Antiagrégants plaquettaires</term><term>Intervention coronarienne percutanée</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Coronary Thrombosis</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Infarctus du myocarde avec sus-décalage du segment ST</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Emergency Medical Services</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Percutaneous Coronary Intervention</term><term>ST Elevation Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infarctus du myocarde avec sus-décalage du segment ST</term><term>Intervention coronarienne percutanée</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronary Thrombosis</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Infarctus du myocarde avec sus-décalage du segment ST</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>ST Elevation Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Thrombose coronarienne</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Ambulances</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Platelet Function Tests</term><term>Recurrence</term><term>Time Factors</term><term>Time-to-Treatment</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agrégation plaquettaire</term><term>Ambulances</term><term>Délai jusqu'au traitement</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Infarctus du myocarde avec sus-décalage du segment ST</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Récidive</term><term>Résultat thérapeutique</term><term>Services des urgences médicales</term><term>Sujet âgé</term><term>Tests fonctionnels plaquettaires</term><term>Thrombose coronarienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this landmark exploratory analysis, ATLANTIC-H(24), was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26952907</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>08</Day></DateCreated><DateCompleted><Year>2017</Year><Month>01</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1876-7605</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>7</Issue><PubDate><Year>2016</Year><Month>Apr</Month><Day>11</Day></PubDate></JournalIssue><Title>JACC. Cardiovascular interventions</Title><ISOAbbreviation>JACC Cardiovasc Interv</ISOAbbreviation></Journal><ArticleTitle>Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: The ATLANTIC-H²⁴ Analysis.</ArticleTitle><Pagination><MedlinePgn>646-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcin.2015.12.024</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1936-8798(15)02005-1</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The aim of this landmark exploratory analysis, ATLANTIC-H(24), was to evaluate the effects of pre-hospital ticagrelor during the first 24 h after primary percutaneous coronary intervention (PCI) in the ATLANTIC (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery) study.</AbstractText><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The ATLANTIC trial in patients with ongoing ST-segment elevation myocardial infarction showed that pre-hospital ticagrelor was safe but did not improve pre-PCI coronary reperfusion compared with in-hospital ticagrelor. We hypothesized that the effect of pre-hospital ticagrelor may not have manifested until after PCI due to the rapid transfer time (31 min).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The ATLANTIC-H(24) analysis included 1,629 patients who underwent PCI, evaluating platelet reactivity, Thrombolysis In Myocardial Infarction flow grade 3, ≥ 70% ST-segment elevation resolution, and clinical endpoints over the first 24 h.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Following PCI, largest between-group differences in platelet reactivity occurred at 1 to 6 h; coronary reperfusion rates numerically favored pre-hospital ticagrelor, and the degree of ST-segment elevation resolution was significantly greater in the pre-hospital group (median, 75.0% vs. 71.4%; p = 0.049). At 24 h, the composite ischemic endpoint was lower with pre-hospital ticagrelor (10.4% vs. 13.7%; p = 0.039), as were individual endpoints of definite stent thrombosis (p = 0.0078) and myocardial infarction (p = 0.031). All endpoints except death (1.1% vs. 0.2%; p = 0.048) favored pre-hospital ticagrelor, with no differences in bleeding events.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The effects of pre-hospital ticagrelor became apparent after PCI, with numerical differences in platelet reactivity and immediate post-PCI reperfusion, associated with reductions in ischemic endpoints, over the first 24 h, whereas there was a small excess of mortality. (Administration of Ticagrelor in the cath Lab or in the Ambulance for New ST elevation myocardial infarction to open the Coronary artery [ATLANTIC, NCT01347580]).</AbstractText><CopyrightInformation>Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Montalescot</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris, France. Electronic address: gilles.montalescot@psl.aphp.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van 't Hof</LastName><ForeName>Arnoud W</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Isala Clinics, Zwolle, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bolognese</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cantor</LastName><ForeName>Warren J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Southlake Regional Health Centre, University of Toronto, Newmarket, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cequier</LastName><ForeName>Angel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Heart Disease Institute, Hospital Universitario de Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chettibi</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre Hospito-universitaire Frantz Fanon, Blida, Algeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Collet</LastName><ForeName>Jean-Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goodman</LastName><ForeName>Shaun G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Canadian Heart Research Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hammett</LastName><ForeName>Christopher J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huber</LastName><ForeName>Kurt</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janzon</LastName><ForeName>Magnus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lapostolle</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>SAMU 93 Hôpital Avicenne, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lassen</LastName><ForeName>Jens Flensted</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Cardiology B, Aarhus University Hospital, Aarhus N, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Licour</LastName><ForeName>Muriel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>AstraZeneca, Rueil Malmaison, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merkely</LastName><ForeName>Béla</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Heart and Vascular Center, Semmelweis University, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salhi</LastName><ForeName>Néjoua</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>AstraZeneca, Luton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silvain</LastName><ForeName>Johanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Université Paris 6, ACTION Study Group, Institut de Cardiologie (AP-HP), Centre Hospitalier Universitaire Pitié-Salpêtrière, INSERM UMRS 1166, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Storey</LastName><ForeName>Robert F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ten Berg</LastName><ForeName>Jurriën M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsatsaris</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>AstraZeneca, Rueil Malmaison, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeymer</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vicaut</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Unite de Recherche Clinique, Université Paris 7, Hôpital Lariboisière, ACTION Study Group, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamm</LastName><ForeName>Christian W</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>ATLANTIC Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01347580</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JACC Cardiovasc Interv</MedlineTA><NlmUniqueID>101467004</NlmUniqueID><ISSNLinking>1936-8798</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010975">Platelet Aggregation Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>GLH0314RVC</RegistryNumber><NameOfSubstance UI="C503700">Ticagrelor</NameOfSubstance></Chemical><Chemical><RegistryNumber>K72T3FS567</RegistryNumber><NameOfSubstance UI="D000241">Adenosine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>JACC Cardiovasc Interv. 2016 Apr 11;9(7):657-9</RefSource><PMID Version="1">26952912</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000241" MajorTopicYN="N">Adenosine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" 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ValidYN="Y"><LastName>Huber</LastName><ForeName>Kurt</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Neunteufl</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brussee</LastName><ForeName>Helmut</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alber</LastName><ForeName>Hannes</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Weidinger</LastName><ForeName>Franz</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brunner</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sipoetz</LastName><ForeName>Johann</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prause</LastName><ForeName>Gerhard</ForeName><Initials>G</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Livarek</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Berthier</LastName><ForeName>Romain</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hovasse</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Garot</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Payot</LastName><ForeName>Laurent</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Benamer</LastName><ForeName>Hakim</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Esteve</LastName><ForeName>Jean Baptiste</ForeName><Initials>JB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Elhadad</LastName><ForeName>Simon</ForeName><Initials>S</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Varenne</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>El Mahmoud</LastName><ForeName>Rami</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Filippi-Codaccioni</LastName><ForeName>Emmanuelle</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Angoulvant</LastName><ForeName>Denis</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Peycher</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Poitrineau</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tabone</LastName><ForeName>Xavier</ForeName><Initials>X</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ecollan</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Broche</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lambert</LastName><ForeName>Yves</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Briole</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Beruben</LastName><ForeName>Arielle</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Porcher</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Auffray</LastName><ForeName>Jean-Pierre</ForeName><Initials>JP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Freysz</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Depardieu</LastName><ForeName>Franck</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Poubel</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>De La Cousaye</LastName><ForeName>Jean-Emmanuel</ForeName><Initials>JE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bartier</LastName><ForeName>Jean-Claude</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jardel</LastName><ForeName>Benoît</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Boulanger</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Labourel</LastName><ForeName>Hervé</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Soulat</LastName><ForeName>Louis-Christophe</ForeName><Initials>LC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lapostolle</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Julie</LastName><ForeName>Véronique</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Thicoipe</LastName><ForeName>Michel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Capel</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stibbe</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carli</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tazarourte</LastName><ForeName>Karim</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alcouffe</LastName><ForeName>Fabrice</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aboucaya</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aubert</LastName><ForeName>Gaële</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kierzek</LastName><ForeName>Gérald</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cahun-Giraud</LastName><ForeName>Séverine</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zeymer</LastName><ForeName>Uwe</ForeName><Initials>U</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hamm</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dengler</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prondzinsky</LastName><ForeName>Roland</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Biever</LastName><ForeName>Paul Marc</ForeName><Initials>PM</Initials></Investigator><Investigator 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de Pas</LastName><ForeName>Harm</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fillat</LastName><ForeName>Ángel Cequier</ForeName><Initials>ÁC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tenas</LastName><ForeName>Manel Sabaté</ForeName><Initials>MS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferrer</LastName><ForeName>Josepa Mauri</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Peñaranda</LastName><ForeName>Antoni Serra</ForeName><Initials>AS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferrer</LastName><ForeName>Joan Ángel</ForeName><Initials>JÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Del Blanco</LastName><ForeName>Bruno García</ForeName><Initials>BG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guardiola</LastName><ForeName>Faustino Miranda</ForeName><Initials>FM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ruiz Nodar</LastName><ForeName>Juan Miguel</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Romo</LastName><ForeName>Andrés Íñiguez</ForeName><Initials>AÍ</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Nicolás Vázquez</ForeName><Initials>NV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nouche</LastName><ForeName>Ramiro Trillo</ForeName><Initials>RT</Initials></Investigator><Investigator ValidYN="Y"><LastName>De La Llera</LastName><ForeName>Luis Díaz</ForeName><Initials>LD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernández García</LastName><ForeName>José María</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rivero-Crespo</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernández</LastName><ForeName>Felipe Hernández</ForeName><Initials>FH</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zamorano Gómez</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fárega</LastName><ForeName>Xavier Jiménez</ForeName><Initials>XJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Gilberto Alonso</ForeName><Initials>GA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Toboso</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carrasco</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barreiro</LastName><ForeName>Victoria</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Iglesias Vázquez</LastName><ForeName>José Antonio</ForeName><Initials>JA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Montero</LastName><ForeName>María Del Mar Ruiz</ForeName><Initials>Mdel 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