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Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.

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Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.

Auteurs : Carolina Bonilla [Royaume-Uni] ; Sarah J. Lewis [Royaume-Uni] ; Richard M. Martin [Royaume-Uni] ; Jenny L. Donovan [Royaume-Uni] ; Freddie C. Hamdy [Royaume-Uni] ; David E. Neal [Royaume-Uni] ; Rosalind Eeles [Royaume-Uni] ; Doug Easton [Royaume-Uni] ; Zsofia Kote-Jarai [Royaume-Uni] ; Ali Amin Al Olama [Royaume-Uni] ; Sara Benlloch [Royaume-Uni] ; Kenneth Muir [Royaume-Uni] ; Graham G. Giles [Australie] ; Fredrik Wiklund [Suède] ; Henrik Gronberg [Suède] ; Christopher A. Haiman [États-Unis] ; Johanna Schleutker [Finlande] ; B Rge G. Nordestgaard [Danemark] ; Ruth C. Travis [Royaume-Uni] ; Nora Pashayan [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Janet L. Stanford [États-Unis] ; William J. Blot [États-Unis] ; Stephen Thibodeau [États-Unis] ; Christiane Maier [Allemagne] ; Adam S. Kibel [États-Unis] ; Cezary Cybulski [Pologne] ; Lisa Cannon-Albright [États-Unis] ; Hermann Brenner [Allemagne] ; Jong Park [États-Unis] ; Radka Kaneva [Bulgarie] ; Jyotsna Batra [Australie] ; Manuel R. Teixeira [Portugal] ; Hardev Pandha [Royaume-Uni] ; Mark Lathrop [France] ; George Davey Smith [Royaume-Uni]

Source :

BMC medicine [ 1741-7015 ] ; 2016.

RBID : pubmed:27044414

Descripteurs français

KwdFr :
- Adolescent, Adulte d'âge moyen, Analyse de randomisation mendélienne (), Analyse de régression, Analyse de survie, Attribution aléatoire, Facteurs de risque, Humains, Maturation sexuelle (génétique), Mâle, Odds ratio, Polymorphisme de nucléotide simple, Puberté (physiologie), Royaume-Uni (épidémiologie), Stade de la tumeur, Sujet âgé, Tumeurs de la prostate (anatomopathologie), Tumeurs de la prostate (génétique), Tumeurs de la prostate (physiopathologie), Tumeurs de la prostate (épidémiologie), Âge de début, Étude d'association pangénomique, Études cas-témoins.
MESH :
- anatomopathologie : Tumeurs de la prostate.
- génétique : Maturation sexuelle, Tumeurs de la prostate.
- physiologie : Puberté.
- physiopathologie : Tumeurs de la prostate.
- épidémiologie : Royaume-Uni, Tumeurs de la prostate.
- Adolescent, Adulte d'âge moyen, Analyse de randomisation mendélienne, Analyse de régression, Analyse de survie, Attribution aléatoire, Facteurs de risque, Humains, Mâle, Odds ratio, Polymorphisme de nucléotide simple, Stade de la tumeur, Sujet âgé, Âge de début, Étude d'association pangénomique, Études cas-témoins.

English descriptors

KwdEn :
- Adolescent, Age of Onset, Aged, Case-Control Studies, Genome-Wide Association Study, Humans, Male, Mendelian Randomization Analysis (methods), Middle Aged, Neoplasm Staging, Odds Ratio, Polymorphism, Single Nucleotide, Prostatic Neoplasms (epidemiology), Prostatic Neoplasms (genetics), Prostatic Neoplasms (pathology), Prostatic Neoplasms (physiopathology), Puberty (physiology), Random Allocation, Regression Analysis, Risk Factors, Sexual Maturation (genetics), Survival Analysis, United Kingdom (epidemiology).
MESH :
- epidemiology : Prostatic Neoplasms, United Kingdom.
- genetics : Prostatic Neoplasms, Sexual Maturation.
- methods : Mendelian Randomization Analysis.
- pathology : Prostatic Neoplasms.
- physiology : Puberty.
- physiopathology : Prostatic Neoplasms.
- Adolescent, Age of Onset, Aged, Case-Control Studies, Genome-Wide Association Study, Humans, Male, Middle Aged, Neoplasm Staging, Odds Ratio, Polymorphism, Single Nucleotide, Random Allocation, Regression Analysis, Risk Factors, Survival Analysis.

Abstract

Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely to suffer from a degree of uncontrolled confounding. To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated with Tanner stage in adolescent boys in a Mendelian randomization (MR) approach.

DOI: 10.1186/s12916-016-0602-x
PubMed: 27044414

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<author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name>
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<author><name sortKey="Kibel, Adam S" sort="Kibel, Adam S" uniqKey="Kibel A" first="Adam S" last="Kibel">Adam S. Kibel</name>
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<author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
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<wicri:regionArea>Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT</wicri:regionArea>
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<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
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<author><name sortKey="Park, Jong" sort="Park, Jong" uniqKey="Park J" first="Jong" last="Park">Jong Park</name>
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<wicri:regionArea>Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL</wicri:regionArea>
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<author><name sortKey="Kaneva, Radka" sort="Kaneva, Radka" uniqKey="Kaneva R" first="Radka" last="Kaneva">Radka Kaneva</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave St., Sofia, 1431, Bulgaria.</nlm:affiliation>
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<author><name sortKey="Batra, Jyotsna" sort="Batra, Jyotsna" uniqKey="Batra J" first="Jyotsna" last="Batra">Jyotsna Batra</name>
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<author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Genetics, Portuguese Oncology Institute, Porto</wicri:regionArea>
</affiliation>
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<author><name sortKey="Pandha, Hardev" sort="Pandha, Hardev" uniqKey="Pandha H" first="Hardev" last="Pandha">Hardev Pandha</name>
<affiliation wicri:level="1"><nlm:affiliation>The University of Surrey, Guildford, Surrey, GU2 7XH, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The University of Surrey, Guildford, Surrey, GU2 7XH</wicri:regionArea>
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<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="1"><nlm:affiliation>Commissariat à l'Energie Atomique, Center National de Génotypage, Evry, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Commissariat à l'Energie Atomique, Center National de Génotypage, Evry</wicri:regionArea>
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<author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name>
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<author><name sortKey="Bonilla, Carolina" sort="Bonilla, Carolina" uniqKey="Bonilla C" first="Carolina" last="Bonilla">Carolina Bonilla</name>
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<author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M" last="Martin">Richard M. Martin</name>
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<country xml:lang="fr">Royaume-Uni</country>
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</author>
<author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C" last="Hamdy">Freddie C. Hamdy</name>
<affiliation wicri:level="1"><nlm:affiliation>Nuffield Department of Surgery, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Surgery, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E" last="Neal">David E. Neal</name>
<affiliation wicri:level="1"><nlm:affiliation>Nuffield Department of Surgery, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Nuffield Department of Surgery, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, Doug" sort="Easton, Doug" uniqKey="Easton D" first="Doug" last="Easton">Doug Easton</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benlloch, Sara" sort="Benlloch, Sara" uniqKey="Benlloch S" first="Sara" last="Benlloch">Sara Benlloch</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Warwick, Coventry, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Warwick, Coventry</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1"><nlm:affiliation>The Cancer Council Victoria, 615 St. Kilda Road, Melbourne, Victoria, 3004, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Cancer Council Victoria, 615 St. Kilda Road, Melbourne, Victoria, 3004</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Gronberg">Henrik Gronberg</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Biochemistry and Genetics, University of Turku, Turku</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, DK-2730, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, DK-2730</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name>
<affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pashayan, Nora" sort="Pashayan, Nora" uniqKey="Pashayan N" first="Nora" last="Pashayan">Nora Pashayan</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation wicri:level="1"><nlm:affiliation>Cambridge Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0SR</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L" last="Stanford">Janet L. Stanford</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blot, William J" sort="Blot, William J" uniqKey="Blot W" first="William J" last="Blot">William J. Blot</name>
<affiliation wicri:level="1"><nlm:affiliation>International Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville, MD, 20850, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>International Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville, MD, 20850</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name>
<affiliation wicri:level="1"><nlm:affiliation>Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic, Rochester, MN</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Urology, University Hospital Ulm, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Urology, University Hospital Ulm, Ulm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kibel, Adam S" sort="Kibel, Adam S" uniqKey="Kibel A" first="Adam S" last="Kibel">Adam S. Kibel</name>
<affiliation wicri:level="1"><nlm:affiliation>Brigham and Women's Hospital/Dana-Farber Cancer Institute, 45 Francis Street - ASB II-3, Boston, MA, 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women's Hospital/Dana-Farber Cancer Institute, 45 Francis Street - ASB II-3, Boston, MA, 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
<affiliation wicri:level="1"><nlm:affiliation>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Jong" sort="Park, Jong" uniqKey="Park J" first="Jong" last="Park">Jong Park</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaneva, Radka" sort="Kaneva, Radka" uniqKey="Kaneva R" first="Radka" last="Kaneva">Radka Kaneva</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave St., Sofia, 1431, Bulgaria.</nlm:affiliation>
<country xml:lang="fr">Bulgarie</country>
<wicri:regionArea>Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave St., Sofia, 1431</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Batra, Jyotsna" sort="Batra, Jyotsna" uniqKey="Batra J" first="Jyotsna" last="Batra">Jyotsna Batra</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian Prostate Cancer Research Centre - Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian Prostate Cancer Research Centre - Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Genetics, Portuguese Oncology Institute, Porto</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pandha, Hardev" sort="Pandha, Hardev" uniqKey="Pandha H" first="Hardev" last="Pandha">Hardev Pandha</name>
<affiliation wicri:level="1"><nlm:affiliation>The University of Surrey, Guildford, Surrey, GU2 7XH, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The University of Surrey, Guildford, Surrey, GU2 7XH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="1"><nlm:affiliation>Commissariat à l'Energie Atomique, Center National de Génotypage, Evry, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Commissariat à l'Energie Atomique, Center National de Génotypage, Evry</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC medicine</title>
<idno type="eISSN">1741-7015</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Male</term>
<term>Mendelian Randomization Analysis (methods)</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Odds Ratio</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Prostatic Neoplasms (epidemiology)</term>
<term>Prostatic Neoplasms (genetics)</term>
<term>Prostatic Neoplasms (pathology)</term>
<term>Prostatic Neoplasms (physiopathology)</term>
<term>Puberty (physiology)</term>
<term>Random Allocation</term>
<term>Regression Analysis</term>
<term>Risk Factors</term>
<term>Sexual Maturation (genetics)</term>
<term>Survival Analysis</term>
<term>United Kingdom (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de randomisation mendélienne ()</term>
<term>Analyse de régression</term>
<term>Analyse de survie</term>
<term>Attribution aléatoire</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Maturation sexuelle (génétique)</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Puberté (physiologie)</term>
<term>Royaume-Uni (épidémiologie)</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Tumeurs de la prostate (anatomopathologie)</term>
<term>Tumeurs de la prostate (génétique)</term>
<term>Tumeurs de la prostate (physiopathologie)</term>
<term>Tumeurs de la prostate (épidémiologie)</term>
<term>Âge de début</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la prostate</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Prostatic Neoplasms</term>
<term>United Kingdom</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Prostatic Neoplasms</term>
<term>Sexual Maturation</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Maturation sexuelle</term>
<term>Tumeurs de la prostate</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mendelian Randomization Analysis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Puberté</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Puberty</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Tumeurs de la prostate</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Royaume-Uni</term>
<term>Tumeurs de la prostate</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Odds Ratio</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Random Allocation</term>
<term>Regression Analysis</term>
<term>Risk Factors</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de randomisation mendélienne</term>
<term>Analyse de régression</term>
<term>Analyse de survie</term>
<term>Attribution aléatoire</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Âge de début</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
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<front><div type="abstract" xml:lang="en">Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely to suffer from a degree of uncontrolled confounding. To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated with Tanner stage in adolescent boys in a Mendelian randomization (MR) approach.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27044414</PMID>
<DateCreated><Year>2016</Year>
<Month>04</Month>
<Day>05</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>11</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1741-7015</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<PubDate><Year>2016</Year>
<Month>Apr</Month>
<Day>04</Day>
</PubDate>
</JournalIssue>
<Title>BMC medicine</Title>
<ISOAbbreviation>BMC Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.</ArticleTitle>
<Pagination><MedlinePgn>66</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12916-016-0602-x</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely to suffer from a degree of uncontrolled confounding. To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated with Tanner stage in adolescent boys in a Mendelian randomization (MR) approach.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We derived a weighted genetic risk score for pubertal development, combining 13 SNPs associated with male Tanner stage. A higher score indicated a later puberty onset. We examined the association of this score with prostate cancer risk, stage and grade in the UK-based ProtecT case-control study (n = 2,927), and used the PRACTICAL consortium (n = 43,737) as a replication sample.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In ProtecT, the puberty genetic score was inversely associated with prostate cancer grade (odds ratio (OR) of high- vs. low-grade cancer, per tertile of the score: 0.76; 95 % CI, 0.64-0.89). In an instrumental variable estimation of the causal OR, later physical development in adolescence (equivalent to a difference of one Tanner stage between pubertal boys of the same age) was associated with a 77 % (95 % CI, 43-91 %) reduced odds of high Gleason prostate cancer. In PRACTICAL, the puberty genetic score was associated with prostate cancer stage (OR of advanced vs. localized cancer, per tertile: 0.95; 95 % CI, 0.91-1.00) and prostate cancer-specific mortality (hazard ratio amongst cases, per tertile: 0.94; 95 % CI, 0.90-0.98), but not with disease grade.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Older age at sexual maturation is causally linked to a reduced risk of later prostate cancer, especially aggressive disease.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bonilla</LastName>
<ForeName>Carolina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.</Affiliation>
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<AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Eeles</LastName>
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<AffiliationInfo><Affiliation>The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey, UK.</Affiliation>
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<AffiliationInfo><Affiliation>The Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Kote-Jarai</LastName>
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<AffiliationInfo><Affiliation>The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Institute of Population Health, The University of Manchester, Manchester, M13 9PL, UK.</Affiliation>
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<Initials>F</Initials>
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<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Applied Health Research, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Cambridge Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Brigham and Women's Hospital/Dana-Farber Cancer Institute, 45 Francis Street - ASB II-3, Boston, MA, 02115, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Washington University, St Louis, MO, USA.</Affiliation>
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<Initials>H</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation>
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<Initials>MR</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal.</Affiliation>
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<Initials>H</Initials>
<AffiliationInfo><Affiliation>The University of Surrey, Guildford, Surrey, GU2 7XH, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Davey Smith</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.</Affiliation>
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<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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   |texte=   Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.

Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.

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