X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.
Identifieur interne : 001F32 ( PubMed/Curation ); précédent : 001F31; suivant : 001F33X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.
Auteurs : Ke Liu [États-Unis] ; Biji T. Kurien [États-Unis] ; Sarah L. Zimmerman [États-Unis] ; Kenneth M. Kaufman [États-Unis] ; Diana H. Taft [États-Unis] ; Leah C. Kottyan [États-Unis] ; Sara Lazaro [États-Unis] ; Carrie A. Weaver [États-Unis] ; John A. Ice [États-Unis] ; Adam J. Adler [États-Unis] ; James Chodosh [États-Unis] ; Lida Radfar [États-Unis] ; Astrid Rasmussen [États-Unis] ; Donald U. Stone [États-Unis] ; David M. Lewis [États-Unis] ; Shibo Li [États-Unis] ; Kristi A. Koelsch [États-Unis] ; Ann Igoe [États-Unis] ; Mitali Talsania [États-Unis] ; Jay Kumar [États-Unis] ; Jacen S. Maier-Moore [États-Unis] ; Valerie M. Harris [États-Unis] ; Rajaram Gopalakrishnan [États-Unis] ; Roland Jonsson [Norvège] ; James A. Lessard [États-Unis] ; Xianglan Lu [États-Unis] ; Jacques-Eric Gottenberg [France] ; Juan-Manuel Anaya [Colombie] ; Deborah S. Cunninghame-Graham [Royaume-Uni] ; Andrew J W. Huang [États-Unis] ; Michael T. Brennan [États-Unis] ; Pamela Hughes [États-Unis] ; Gabor G. Illei [États-Unis] ; Corinne Miceli-Richard [France] ; Edward C. Keystone [Canada] ; Vivian P. Bykerk [États-Unis] ; Gideon Hirschfield [Royaume-Uni] ; Gang Xie [Canada] ; Wan-Fai Ng [Royaume-Uni] ; Gunnel Nordmark [Suède] ; Per Eriksson [Suède] ; Roald Omdal [Norvège] ; Nelson L. Rhodus [États-Unis] ; Maureen Rischmueller [Australie] ; Michael Rohrer [États-Unis] ; Barbara M. Segal [États-Unis] ; Timothy J. Vyse [Royaume-Uni] ; Marie Wahren-Herlenius [Suède] ; Torsten Witte [Allemagne] ; Bernardo Pons-Estel [Argentine] ; Marta E. Alarcon-Riquelme [États-Unis] ; Joel M. Guthridge [États-Unis] ; Judith A. James [États-Unis] ; Christopher J. Lessard [États-Unis] ; Jennifer A. Kelly [États-Unis] ; Susan D. Thompson [États-Unis] ; Patrick M. Gaffney [États-Unis] ; Courtney G. Montgomery [États-Unis] ; Jeffrey C. Edberg [États-Unis] ; Robert P. Kimberly [États-Unis] ; Graciela S. Alarc N [États-Unis] ; Carl L. Langefeld [États-Unis] ; Gary S. Gilkeson [États-Unis] ; Diane L. Kamen [États-Unis] ; Betty P. Tsao ; W Joseph Mccune [États-Unis] ; Jane E. Salmon [États-Unis] ; Joan T. Merrill [États-Unis] ; Michael H. Weisman [États-Unis] ; Daniel J. Wallace [États-Unis] ; Tammy O. Utset [États-Unis] ; Erwin P. Bottinger [États-Unis] ; Christopher I. Amos [États-Unis] ; Katherine A. Siminovitch [Canada] ; Xavier Mariette ; Kathy L. Sivils [États-Unis] ; John B. Harley [États-Unis] ; R Hal Scofield [États-Unis]Source :
- Arthritis & rheumatology (Hoboken, N.J.) [ 2326-5205 ] ; 2016.
Descripteurs français
- KwdFr :
- Aberrations des chromosomes sexuels, Chromosomes X humains, Cirrhose biliaire (épidémiologie), Dosage génique, Femelle, Humains, Lupus érythémateux disséminé (épidémiologie), Maladies auto-immunes (épidémiologie), Polyarthrite rhumatoïde (épidémiologie), Prévalence, Répartition par sexe, Sarcoïdose (épidémiologie), Syndrome de Gougerot-Sjögren (épidémiologie), Technique FISH, Trisomie, Troubles du développement sexuel avec anomalie des gonosomes (épidémiologie), Études cas-témoins.
- MESH :
- épidémiologie : Cirrhose biliaire, Lupus érythémateux disséminé, Maladies auto-immunes, Polyarthrite rhumatoïde, Sarcoïdose, Syndrome de Gougerot-Sjögren, Troubles du développement sexuel avec anomalie des gonosomes.
- Aberrations des chromosomes sexuels, Chromosomes X humains, Dosage génique, Femelle, Humains, Prévalence, Répartition par sexe, Technique FISH, Trisomie, Études cas-témoins.
English descriptors
- KwdEn :
- Arthritis, Rheumatoid (epidemiology), Autoimmune Diseases (epidemiology), Case-Control Studies, Chromosomes, Human, X, Female, Gene Dosage, Humans, In Situ Hybridization, Fluorescence, Liver Cirrhosis, Biliary (epidemiology), Lupus Erythematosus, Systemic (epidemiology), Prevalence, Sarcoidosis (epidemiology), Sex Chromosome Aberrations, Sex Chromosome Disorders of Sex Development (epidemiology), Sex Distribution, Sjogren's Syndrome (epidemiology), Trisomy.
- MESH :
- epidemiology : Arthritis, Rheumatoid, Autoimmune Diseases, Liver Cirrhosis, Biliary, Lupus Erythematosus, Systemic, Sarcoidosis, Sex Chromosome Disorders of Sex Development, Sjogren's Syndrome.
- Case-Control Studies, Chromosomes, Human, X, Female, Gene Dosage, Humans, In Situ Hybridization, Fluorescence, Prevalence, Sex Chromosome Aberrations, Sex Distribution, Trisomy.
Abstract
More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ∼1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls.
DOI: 10.1002/art.39560
PubMed: 26713507
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Betty P. Tsao<affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine, UCLA School of Medicine.</nlm:affiliation><wicri:noCountry code="subField">UCLA School of Medicine</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Rhumatologie, Responsable de l'Unité de Recherche Clinique Hôpitaux Universitaire Paris-Sud Université Paris-Sud, INSERM U1184 Head of Autoimmunity team, IMVA : Immunology of viral Infections and Autoimmune Diseases.</nlm:affiliation><wicri:noCountry code="subField">IMVA : Immunology of viral Infections and Autoimmune Diseases</wicri:noCountry></affiliation>Le document en format XML
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Stone</name><affiliation wicri:level="1"><nlm:affiliation>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK</wicri:regionArea></affiliation></author><author><name sortKey="Lewis, David M" sort="Lewis, David M" uniqKey="Lewis D" first="David M" last="Lewis">David M. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea></affiliation></author><author><name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A" last="Koelsch">Kristi A. Koelsch</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Igoe, Ann" sort="Igoe, Ann" uniqKey="Igoe A" first="Ann" last="Igoe">Ann Igoe</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Talsania, Mitali" sort="Talsania, Mitali" uniqKey="Talsania M" first="Mitali" last="Talsania">Mitali Talsania</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Kumar, Jay" sort="Kumar, Jay" uniqKey="Kumar J" first="Jay" last="Kumar">Jay Kumar</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Maier Moore, Jacen S" sort="Maier Moore, Jacen S" uniqKey="Maier Moore J" first="Jacen S" last="Maier-Moore">Jacen S. Maier-Moore</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M" last="Harris">Valerie M. Harris</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Gopalakrishnan, Rajaram" sort="Gopalakrishnan, Rajaram" uniqKey="Gopalakrishnan R" first="Rajaram" last="Gopalakrishnan">Rajaram Gopalakrishnan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name><affiliation wicri:level="1"><nlm:affiliation>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021</wicri:regionArea></affiliation></author><author><name sortKey="Lessard, James A" sort="Lessard, James A" uniqKey="Lessard J" first="James A" last="Lessard">James A. Lessard</name><affiliation wicri:level="1"><nlm:affiliation>Valley Bone & Joint Clinic, 3035 DeMers Avenue, Grand Forks, ND 58201, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Valley Bone & Joint Clinic, 3035 DeMers Avenue, Grand Forks, ND 58201</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation wicri:level="1"><nlm:affiliation>Strasbourg University, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Strasbourg University, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota</wicri:regionArea></affiliation></author><author><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S" last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name><affiliation wicri:level="3"><nlm:affiliation>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London</wicri:orgArea></affiliation></author><author><name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J W" last="Huang">Andrew J W. Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T" last="Brennan">Michael T. Brennan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232</wicri:regionArea></affiliation></author><author><name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Illei, Gabor G" sort="Illei, Gabor G" uniqKey="Illei G" first="Gabor G" last="Illei">Gabor G. Illei</name><affiliation wicri:level="1"><nlm:affiliation>Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Molecular Physiology and Therapeutics Branch, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Molecular Physiology and Therapeutics Branch, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea></affiliation></author><author><name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea></affiliation></author><author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C" last="Keystone">Edward C. Keystone</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P" last="Bykerk">Vivian P. Bykerk</name><affiliation wicri:level="1"><nlm:affiliation>Hospital for Special Surgery, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hospital for Special Surgery, New York</wicri:regionArea></affiliation></author><author><name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Biomedical Research Unit, University of Birmingham, Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld Tanenbaum and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name><affiliation wicri:level="1"><nlm:affiliation>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea></affiliation></author><author><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name><affiliation wicri:level="1"><nlm:affiliation>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping</wicri:regionArea></affiliation></author><author><name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea></affiliation></author><author><name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L" last="Rhodus">Nelson L. Rhodus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis</wicri:regionArea></affiliation></author><author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011</wicri:regionArea></affiliation></author><author><name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Segal, Barbara M" sort="Segal, Barbara M" uniqKey="Segal B" first="Barbara M" last="Segal">Barbara M. Segal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Vyse, Timothy J" sort="Vyse, Timothy J" uniqKey="Vyse T" first="Timothy J" last="Vyse">Timothy J. Vyse</name><affiliation wicri:level="3"><nlm:affiliation>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London</wicri:orgArea></affiliation></author><author><name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name><affiliation wicri:level="1"><nlm:affiliation>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name><affiliation wicri:level="1"><nlm:affiliation>Sanatorio Parque, Rosario, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Sanatorio Parque, Rosario</wicri:regionArea></affiliation></author><author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E" last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Guthridge, Joel M" sort="Guthridge, Joel M" uniqKey="Guthridge J" first="Joel M" last="Guthridge">Joel M. Guthridge</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="James, Judith A" sort="James, Judith A" uniqKey="James J" first="Judith A" last="James">Judith A. James</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J" last="Lessard">Christopher J. Lessard</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A" last="Kelly">Jennifer A. Kelly</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Susan D" sort="Thompson, Susan D" uniqKey="Thompson S" first="Susan D" last="Thompson">Susan D. Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Gaffney, Patrick M" sort="Gaffney, Patrick M" uniqKey="Gaffney P" first="Patrick M" last="Gaffney">Patrick M. Gaffney</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Montgomery, Courtney G" sort="Montgomery, Courtney G" uniqKey="Montgomery C" first="Courtney G" last="Montgomery">Courtney G. Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Edberg, Jeffrey C" sort="Edberg, Jeffrey C" uniqKey="Edberg J" first="Jeffrey C" last="Edberg">Jeffrey C. Edberg</name><affiliation wicri:level="2"><nlm:affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Kimberly, Robert P" sort="Kimberly, Robert P" uniqKey="Kimberly R" first="Robert P" last="Kimberly">Robert P. Kimberly</name><affiliation wicri:level="2"><nlm:affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Alarc N, Graciela S" sort="Alarc N, Graciela S" uniqKey="Alarc N G" first="Graciela S" last="Alarc N">Graciela S. Alarc N</name><affiliation wicri:level="2"><nlm:affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Langefeld, Carl L" sort="Langefeld, Carl L" uniqKey="Langefeld C" first="Carl L" last="Langefeld">Carl L. Langefeld</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics and Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Center for Public Health Genomics and Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Gilkeson, Gary S" sort="Gilkeson, Gary S" uniqKey="Gilkeson G" first="Gary S" last="Gilkeson">Gary S. Gilkeson</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Kamen, Diane L" sort="Kamen, Diane L" uniqKey="Kamen D" first="Diane L" last="Kamen">Diane L. Kamen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Tsao, Betty P" sort="Tsao, Betty P" uniqKey="Tsao B" first="Betty P" last="Tsao">Betty P. Tsao</name><affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine, UCLA School of Medicine.</nlm:affiliation><wicri:noCountry code="subField">UCLA School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Mccune, W Joseph" sort="Mccune, W Joseph" uniqKey="Mccune W" first="W Joseph" last="Mccune">W Joseph Mccune</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Medicine, University of Michigan College of Medicine, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Division of Rheumatology, Department of Medicine, University of Michigan College of Medicine, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Salmon, Jane E" sort="Salmon, Jane E" uniqKey="Salmon J" first="Jane E" last="Salmon">Jane E. Salmon</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Rheumatology, Hospital for Special Surgery and Weill Cornell Medical College, New York</wicri:cityArea></affiliation></author><author><name sortKey="Merrill, Joan T" sort="Merrill, Joan T" uniqKey="Merrill J" first="Joan T" last="Merrill">Joan T. Merrill</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Utset, Tammy O" sort="Utset, Tammy O" uniqKey="Utset T" first="Tammy O" last="Utset">Tammy O. Utset</name><affiliation wicri:level="2"><nlm:affiliation>University of Chicago Pritzker School of Medicine, Chicago, IL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago Pritzker School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Bottinger, Erwin P" sort="Bottinger, Erwin P" uniqKey="Bottinger E" first="Erwin P" last="Bottinger">Erwin P. Bottinger</name><affiliation wicri:level="2"><nlm:affiliation>Charles R. Bronfman Institute for personalized medicine, Mount Sinai Hospital, 1468 Madison Avenue, New York, NY 10029.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Charles R. Bronfman Institute for personalized medicine, Mount Sinai Hospital, 1468 Madison Avenue, New York</wicri:cityArea></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH</wicri:regionArea></affiliation></author><author><name sortKey="Siminovitch, Katherine A" sort="Siminovitch, Katherine A" uniqKey="Siminovitch K" first="Katherine A" last="Siminovitch">Katherine A. Siminovitch</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld Tanenbaum and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:affiliation>Rhumatologie, Responsable de l'Unité de Recherche Clinique Hôpitaux Universitaire Paris-Sud Université Paris-Sud, INSERM U1184 Head of Autoimmunity team, IMVA : Immunology of viral Infections and Autoimmune Diseases.</nlm:affiliation><wicri:noCountry code="subField">IMVA : Immunology of viral Infections and Autoimmune Diseases</wicri:noCountry></affiliation></author><author><name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R Hal" last="Scofield">R Hal Scofield</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26713507</idno><idno type="pmid">26713507</idno><idno type="doi">10.1002/art.39560</idno><idno type="wicri:Area/PubMed/Corpus">001F56</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F56</idno><idno type="wicri:Area/PubMed/Curation">001F32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.</title><author><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T" last="Kurien">Biji T. Kurien</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Zimmerman, Sarah L" sort="Zimmerman, Sarah L" uniqKey="Zimmerman S" first="Sarah L" last="Zimmerman">Sarah L. Zimmerman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH</wicri:regionArea></affiliation></author><author><name sortKey="Kaufman, Kenneth M" sort="Kaufman, Kenneth M" uniqKey="Kaufman K" first="Kenneth M" last="Kaufman">Kenneth M. Kaufman</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Taft, Diana H" sort="Taft, Diana H" uniqKey="Taft D" first="Diana H" last="Taft">Diana H. Taft</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Kottyan, Leah C" sort="Kottyan, Leah C" uniqKey="Kottyan L" first="Leah C" last="Kottyan">Leah C. Kottyan</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Lazaro, Sara" sort="Lazaro, Sara" uniqKey="Lazaro S" first="Sara" last="Lazaro">Sara Lazaro</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Weaver, Carrie A" sort="Weaver, Carrie A" uniqKey="Weaver C" first="Carrie A" last="Weaver">Carrie A. Weaver</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Ice, John A" sort="Ice, John A" uniqKey="Ice J" first="John A" last="Ice">John A. Ice</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Adler, Adam J" sort="Adler, Adam J" uniqKey="Adler A" first="Adam J" last="Adler">Adam J. Adler</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Chodosh, James" sort="Chodosh, James" uniqKey="Chodosh J" first="James" last="Chodosh">James Chodosh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts</wicri:regionArea></affiliation></author><author><name sortKey="Radfar, Lida" sort="Radfar, Lida" uniqKey="Radfar L" first="Lida" last="Radfar">Lida Radfar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea></affiliation></author><author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Stone, Donald U" sort="Stone, Donald U" uniqKey="Stone D" first="Donald U" last="Stone">Donald U. Stone</name><affiliation wicri:level="1"><nlm:affiliation>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK</wicri:regionArea></affiliation></author><author><name sortKey="Lewis, David M" sort="Lewis, David M" uniqKey="Lewis D" first="David M" last="Lewis">David M. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea></affiliation></author><author><name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A" last="Koelsch">Kristi A. Koelsch</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Igoe, Ann" sort="Igoe, Ann" uniqKey="Igoe A" first="Ann" last="Igoe">Ann Igoe</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Talsania, Mitali" sort="Talsania, Mitali" uniqKey="Talsania M" first="Mitali" last="Talsania">Mitali Talsania</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Kumar, Jay" sort="Kumar, Jay" uniqKey="Kumar J" first="Jay" last="Kumar">Jay Kumar</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Maier Moore, Jacen S" sort="Maier Moore, Jacen S" uniqKey="Maier Moore J" first="Jacen S" last="Maier-Moore">Jacen S. Maier-Moore</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M" last="Harris">Valerie M. Harris</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Gopalakrishnan, Rajaram" sort="Gopalakrishnan, Rajaram" uniqKey="Gopalakrishnan R" first="Rajaram" last="Gopalakrishnan">Rajaram Gopalakrishnan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name><affiliation wicri:level="1"><nlm:affiliation>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021</wicri:regionArea></affiliation></author><author><name sortKey="Lessard, James A" sort="Lessard, James A" uniqKey="Lessard J" first="James A" last="Lessard">James A. Lessard</name><affiliation wicri:level="1"><nlm:affiliation>Valley Bone & Joint Clinic, 3035 DeMers Avenue, Grand Forks, ND 58201, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Valley Bone & Joint Clinic, 3035 DeMers Avenue, Grand Forks, ND 58201</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation wicri:level="1"><nlm:affiliation>Strasbourg University, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Strasbourg University, Strasbourg</wicri:regionArea></affiliation></author><author><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota</wicri:regionArea></affiliation></author><author><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S" last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name><affiliation wicri:level="3"><nlm:affiliation>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London</wicri:orgArea></affiliation></author><author><name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J W" last="Huang">Andrew J W. Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T" last="Brennan">Michael T. Brennan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232</wicri:regionArea></affiliation></author><author><name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Illei, Gabor G" sort="Illei, Gabor G" uniqKey="Illei G" first="Gabor G" last="Illei">Gabor G. Illei</name><affiliation wicri:level="1"><nlm:affiliation>Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Molecular Physiology and Therapeutics Branch, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Molecular Physiology and Therapeutics Branch, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea></affiliation></author><author><name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea></affiliation></author><author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C" last="Keystone">Edward C. Keystone</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P" last="Bykerk">Vivian P. Bykerk</name><affiliation wicri:level="1"><nlm:affiliation>Hospital for Special Surgery, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hospital for Special Surgery, New York</wicri:regionArea></affiliation></author><author><name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Biomedical Research Unit, University of Birmingham, Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld Tanenbaum and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name><affiliation wicri:level="1"><nlm:affiliation>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea></affiliation></author><author><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name><affiliation wicri:level="1"><nlm:affiliation>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping</wicri:regionArea></affiliation></author><author><name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea></affiliation></author><author><name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L" last="Rhodus">Nelson L. Rhodus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis</wicri:regionArea></affiliation></author><author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011</wicri:regionArea></affiliation></author><author><name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Segal, Barbara M" sort="Segal, Barbara M" uniqKey="Segal B" first="Barbara M" last="Segal">Barbara M. Segal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN</wicri:regionArea></affiliation></author><author><name sortKey="Vyse, Timothy J" sort="Vyse, Timothy J" uniqKey="Vyse T" first="Timothy J" last="Vyse">Timothy J. Vyse</name><affiliation wicri:level="3"><nlm:affiliation>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London</wicri:orgArea></affiliation></author><author><name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name><affiliation wicri:level="1"><nlm:affiliation>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name><affiliation wicri:level="1"><nlm:affiliation>Sanatorio Parque, Rosario, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Sanatorio Parque, Rosario</wicri:regionArea></affiliation></author><author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E" last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Guthridge, Joel M" sort="Guthridge, Joel M" uniqKey="Guthridge J" first="Joel M" last="Guthridge">Joel M. Guthridge</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="James, Judith A" sort="James, Judith A" uniqKey="James J" first="Judith A" last="James">Judith A. James</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J" last="Lessard">Christopher J. Lessard</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A" last="Kelly">Jennifer A. Kelly</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Susan D" sort="Thompson, Susan D" uniqKey="Thompson S" first="Susan D" last="Thompson">Susan D. Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Gaffney, Patrick M" sort="Gaffney, Patrick M" uniqKey="Gaffney P" first="Patrick M" last="Gaffney">Patrick M. Gaffney</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Montgomery, Courtney G" sort="Montgomery, Courtney G" uniqKey="Montgomery C" first="Courtney G" last="Montgomery">Courtney G. Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Edberg, Jeffrey C" sort="Edberg, Jeffrey C" uniqKey="Edberg J" first="Jeffrey C" last="Edberg">Jeffrey C. Edberg</name><affiliation wicri:level="2"><nlm:affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Kimberly, Robert P" sort="Kimberly, Robert P" uniqKey="Kimberly R" first="Robert P" last="Kimberly">Robert P. Kimberly</name><affiliation wicri:level="2"><nlm:affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Alarc N, Graciela S" sort="Alarc N, Graciela S" uniqKey="Alarc N G" first="Graciela S" last="Alarc N">Graciela S. Alarc N</name><affiliation wicri:level="2"><nlm:affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Langefeld, Carl L" sort="Langefeld, Carl L" uniqKey="Langefeld C" first="Carl L" last="Langefeld">Carl L. Langefeld</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics and Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Center for Public Health Genomics and Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Gilkeson, Gary S" sort="Gilkeson, Gary S" uniqKey="Gilkeson G" first="Gary S" last="Gilkeson">Gary S. Gilkeson</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Kamen, Diane L" sort="Kamen, Diane L" uniqKey="Kamen D" first="Diane L" last="Kamen">Diane L. Kamen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Tsao, Betty P" sort="Tsao, Betty P" uniqKey="Tsao B" first="Betty P" last="Tsao">Betty P. Tsao</name><affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine, UCLA School of Medicine.</nlm:affiliation><wicri:noCountry code="subField">UCLA School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Mccune, W Joseph" sort="Mccune, W Joseph" uniqKey="Mccune W" first="W Joseph" last="Mccune">W Joseph Mccune</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Department of Medicine, University of Michigan College of Medicine, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Division of Rheumatology, Department of Medicine, University of Michigan College of Medicine, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Salmon, Jane E" sort="Salmon, Jane E" uniqKey="Salmon J" first="Jane E" last="Salmon">Jane E. Salmon</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Rheumatology, Hospital for Special Surgery and Weill Cornell Medical College, New York</wicri:cityArea></affiliation></author><author><name sortKey="Merrill, Joan T" sort="Merrill, Joan T" uniqKey="Merrill J" first="Joan T" last="Merrill">Joan T. Merrill</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name><affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Utset, Tammy O" sort="Utset, Tammy O" uniqKey="Utset T" first="Tammy O" last="Utset">Tammy O. Utset</name><affiliation wicri:level="2"><nlm:affiliation>University of Chicago Pritzker School of Medicine, Chicago, IL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago Pritzker School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Bottinger, Erwin P" sort="Bottinger, Erwin P" uniqKey="Bottinger E" first="Erwin P" last="Bottinger">Erwin P. Bottinger</name><affiliation wicri:level="2"><nlm:affiliation>Charles R. Bronfman Institute for personalized medicine, Mount Sinai Hospital, 1468 Madison Avenue, New York, NY 10029.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Charles R. Bronfman Institute for personalized medicine, Mount Sinai Hospital, 1468 Madison Avenue, New York</wicri:cityArea></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH</wicri:regionArea></affiliation></author><author><name sortKey="Siminovitch, Katherine A" sort="Siminovitch, Katherine A" uniqKey="Siminovitch K" first="Katherine A" last="Siminovitch">Katherine A. Siminovitch</name><affiliation wicri:level="4"><nlm:affiliation>Lunenfeld Tanenbaum and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:affiliation>Rhumatologie, Responsable de l'Unité de Recherche Clinique Hôpitaux Universitaire Paris-Sud Université Paris-Sud, INSERM U1184 Head of Autoimmunity team, IMVA : Immunology of viral Infections and Autoimmune Diseases.</nlm:affiliation><wicri:noCountry code="subField">IMVA : Immunology of viral Infections and Autoimmune Diseases</wicri:noCountry></affiliation></author><author><name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author><author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name><affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio</wicri:regionArea></affiliation></author><author><name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R Hal" last="Scofield">R Hal Scofield</name><affiliation wicri:level="1"><nlm:affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea></affiliation></author></analytic><series><title level="j">Arthritis & rheumatology (Hoboken, N.J.)</title><idno type="eISSN">2326-5205</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthritis, Rheumatoid (epidemiology)</term><term>Autoimmune Diseases (epidemiology)</term><term>Case-Control Studies</term><term>Chromosomes, Human, X</term><term>Female</term><term>Gene Dosage</term><term>Humans</term><term>In Situ Hybridization, Fluorescence</term><term>Liver Cirrhosis, Biliary (epidemiology)</term><term>Lupus Erythematosus, Systemic (epidemiology)</term><term>Prevalence</term><term>Sarcoidosis (epidemiology)</term><term>Sex Chromosome Aberrations</term><term>Sex Chromosome Disorders of Sex Development (epidemiology)</term><term>Sex Distribution</term><term>Sjogren's Syndrome (epidemiology)</term><term>Trisomy</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aberrations des chromosomes sexuels</term><term>Chromosomes X humains</term><term>Cirrhose biliaire (épidémiologie)</term><term>Dosage génique</term><term>Femelle</term><term>Humains</term><term>Lupus érythémateux disséminé (épidémiologie)</term><term>Maladies auto-immunes (épidémiologie)</term><term>Polyarthrite rhumatoïde (épidémiologie)</term><term>Prévalence</term><term>Répartition par sexe</term><term>Sarcoïdose (épidémiologie)</term><term>Syndrome de Gougerot-Sjögren (épidémiologie)</term><term>Technique FISH</term><term>Trisomie</term><term>Troubles du développement sexuel avec anomalie des gonosomes (épidémiologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Autoimmune Diseases</term><term>Liver Cirrhosis, Biliary</term><term>Lupus Erythematosus, Systemic</term><term>Sarcoidosis</term><term>Sex Chromosome Disorders of Sex Development</term><term>Sjogren's Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Cirrhose biliaire</term><term>Lupus érythémateux disséminé</term><term>Maladies auto-immunes</term><term>Polyarthrite rhumatoïde</term><term>Sarcoïdose</term><term>Syndrome de Gougerot-Sjögren</term><term>Troubles du développement sexuel avec anomalie des gonosomes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Chromosomes, Human, X</term><term>Female</term><term>Gene Dosage</term><term>Humans</term><term>In Situ Hybridization, Fluorescence</term><term>Prevalence</term><term>Sex Chromosome Aberrations</term><term>Sex Distribution</term><term>Trisomy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aberrations des chromosomes sexuels</term><term>Chromosomes X humains</term><term>Dosage génique</term><term>Femelle</term><term>Humains</term><term>Prévalence</term><term>Répartition par sexe</term><term>Technique FISH</term><term>Trisomie</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ∼1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26713507</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>28</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>07</Day></DateCompleted><DateRevised><Year>2017</Year><Month>10</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2326-5205</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>May</Month></PubDate></JournalIssue><Title>Arthritis & rheumatology (Hoboken, N.J.)</Title></Journal><ArticleTitle>X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.</ArticleTitle><Pagination><MedlinePgn>1290-1300</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/art.39560</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ∼1 in 1,000 live female births) would be increased in patients with female-predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis, and rheumatoid arthritis [RA]) compared to patients with diseases without female predominance (sarcoidosis) and compared to controls.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">All subjects in this study were female. We identified subjects with 47,XXX using aggregate data from single-nucleotide polymorphism arrays, and, when possible, we confirmed the presence of 47,XXX using fluorescence in situ hybridization or quantitative polymerase chain reaction.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We found 47,XXX in 7 of 2,826 SLE patients and in 3 of 1,033 SS patients, but in only 2 of 7,074 controls (odds ratio in the SLE and primary SS groups 8.78 [95% confidence interval 1.67-86.79], P = 0.003 and odds ratio 10.29 [95% confidence interval 1.18-123.47], P = 0.02, respectively). One in 404 women with SLE and 1 in 344 women with SS had 47,XXX. There was an excess of 47,XXX among SLE and SS patients.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The estimated prevalence of SLE and SS in women with 47,XXX was ∼2.5 and ∼2.9 times higher, respectively, than that in women with 46,XX and ∼25 and ∼41 times higher, respectively, than that in men with 46,XY. No statistically significant increase of 47,XXX was observed in other female-biased diseases (primary biliary cirrhosis or RA), supporting the idea of multiple pathways to sex bias in autoimmunity.</AbstractText><CopyrightInformation>© 2016, American College of Rheumatology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Ke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kurien</LastName><ForeName>Biji T</ForeName><Initials>BT</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zimmerman</LastName><ForeName>Sarah L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaufman</LastName><ForeName>Kenneth M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>U.S. Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taft</LastName><ForeName>Diana H</ForeName><Initials>DH</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kottyan</LastName><ForeName>Leah C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lazaro</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weaver</LastName><ForeName>Carrie A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ice</LastName><ForeName>John A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adler</LastName><ForeName>Adam J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chodosh</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Radfar</LastName><ForeName>Lida</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rasmussen</LastName><ForeName>Astrid</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stone</LastName><ForeName>Donald U</ForeName><Initials>DU</Initials><AffiliationInfo><Affiliation>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>David M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Shibo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koelsch</LastName><ForeName>Kristi A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Igoe</LastName><ForeName>Ann</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Talsania</LastName><ForeName>Mitali</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Jay</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maier-Moore</LastName><ForeName>Jacen S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Laboratory Sciences, University of Texas at El Paso, El Paso, TX 79968.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Valerie M</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gopalakrishnan</LastName><ForeName>Rajaram</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jonsson</LastName><ForeName>Roland</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lessard</LastName><ForeName>James A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Valley Bone & Joint Clinic, 3035 DeMers Avenue, Grand Forks, ND 58201, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Xianglan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gottenberg</LastName><ForeName>Jacques-Eric</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Strasbourg University, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anaya</LastName><ForeName>Juan-Manuel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cunninghame-Graham</LastName><ForeName>Deborah S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Andrew J W</ForeName><Initials>AJW</Initials><AffiliationInfo><Affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brennan</LastName><ForeName>Michael T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hughes</LastName><ForeName>Pamela</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Illei</LastName><ForeName>Gabor G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Molecular Physiology and Therapeutics Branch, National Institutes of Health, Bethesda, MD 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miceli-Richard</LastName><ForeName>Corinne</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keystone</LastName><ForeName>Edward C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bykerk</LastName><ForeName>Vivian P</ForeName><Initials>VP</Initials><AffiliationInfo><Affiliation>Hospital for Special Surgery, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hirschfield</LastName><ForeName>Gideon</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Gang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Lunenfeld Tanenbaum and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Wan-Fai</ForeName><Initials>WF</Initials><AffiliationInfo><Affiliation>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nordmark</LastName><ForeName>Gunnel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>Per</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Omdal</LastName><ForeName>Roald</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rhodus</LastName><ForeName>Nelson L</ForeName><Initials>NL</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rischmueller</LastName><ForeName>Maureen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rohrer</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Segal</LastName><ForeName>Barbara M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vyse</LastName><ForeName>Timothy J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wahren-Herlenius</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witte</LastName><ForeName>Torsten</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pons-Estel</LastName><ForeName>Bernardo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Sanatorio Parque, Rosario, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alarcon-Riquelme</LastName><ForeName>Marta E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guthridge</LastName><ForeName>Joel M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>James</LastName><ForeName>Judith A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lessard</LastName><ForeName>Christopher J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelly</LastName><ForeName>Jennifer A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Susan D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaffney</LastName><ForeName>Patrick M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montgomery</LastName><ForeName>Courtney G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edberg</LastName><ForeName>Jeffrey C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kimberly</LastName><ForeName>Robert P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alarcón</LastName><ForeName>Graciela S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langefeld</LastName><ForeName>Carl L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Center for Public Health Genomics and Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gilkeson</LastName><ForeName>Gary S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Ralph H. Johnson VA Medical Center, Charleston, SC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamen</LastName><ForeName>Diane L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsao</LastName><ForeName>Betty P</ForeName><Initials>BP</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine, UCLA School of Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCune</LastName><ForeName>W Joseph</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine, University of Michigan College of Medicine, Ann Arbor, Michigan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salmon</LastName><ForeName>Jane E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merrill</LastName><ForeName>Joan T</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weisman</LastName><ForeName>Michael H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallace</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Utset</LastName><ForeName>Tammy O</ForeName><Initials>TO</Initials><AffiliationInfo><Affiliation>University of Chicago Pritzker School of Medicine, Chicago, IL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bottinger</LastName><ForeName>Erwin P</ForeName><Initials>EP</Initials><AffiliationInfo><Affiliation>Charles R. Bronfman Institute for personalized medicine, Mount Sinai Hospital, 1468 Madison Avenue, New York, NY 10029.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amos</LastName><ForeName>Christopher I</ForeName><Initials>CI</Initials><AffiliationInfo><Affiliation>Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siminovitch</LastName><ForeName>Katherine A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Lunenfeld Tanenbaum and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mariette</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Rhumatologie, Responsable de l'Unité de Recherche Clinique Hôpitaux Universitaire Paris-Sud Université Paris-Sud, INSERM U1184 Head of Autoimmunity team, IMVA : Immunology of viral Infections and Autoimmune Diseases.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sivils</LastName><ForeName>Kathy L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Harley</LastName><ForeName>John B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>U.S. Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Scofield</LastName><ForeName>R Hal</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AR057106</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 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AI024717</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AR048929</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AR070549</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>I01 BX001451</GrantID><Acronym>BX</Acronym><Agency>BLRD VA</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 AR048940</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AR053734</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G0800629</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>UL1 TR001417</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RC2 AR058959</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AI083194</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AR049084</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AR047363</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P60 AR062755</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arthritis Rheumatol</MedlineTA><NlmUniqueID>101623795</NlmUniqueID><ISSNLinking>2326-5191</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C535318">Triple X syndrome</SupplMeshName></SupplMeshList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Eur J Rheumatol Inflamm. 1983;6(3):228-32</RefSource><PMID Version="1">6439564</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rheumatology (Oxford). 2011 Jan;50(1):47-59</RefSource><PMID Version="1">20864496</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lupus. 2006;15(5):308-18</RefSource><PMID Version="1">16761508</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Hum Genet. 2010 Mar;18(3):265-71</RefSource><PMID Version="1">19568271</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2009 Jun 11;360(24):2544-55</RefSource><PMID Version="1">19458352</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Jul 1;175(1):575-8</RefSource><PMID Version="1">15972694</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2010 Jun;62(6):1781-91</RefSource><PMID Version="1">20191588</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2007 Nov 1;179(9):6352-8</RefSource><PMID Version="1">17947713</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2005 Mar 17;434(7031):400-4</RefSource><PMID Version="1">15772666</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(8):e43907</RefSource><PMID Version="1">22952805</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biomed Biotechnol. 2011;2011:370195</RefSource><PMID Version="1">21318170</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 2002 Jun;61(6):554-8</RefSource><PMID Version="1">12006334</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Rheumatol. 2010 Sep;6(9):538-46</RefSource><PMID Version="1">20683438</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Med Genet. 1992 Feb;29(2):103-8</RefSource><PMID Version="1">1613759</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2012 Dec 1;21(23):5209-21</RefSource><PMID Version="1">22936693</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Care Res (Hoboken). 2012 Aug;64(8):1135-43</RefSource><PMID Version="1">22505270</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2008 Aug;58(8):2511-7</RefSource><PMID Version="1">18668569</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2004 Feb 14;363(9408):533-5</RefSource><PMID Version="1">14975617</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Care Res (Hoboken). 2012 Apr;64(4):475-87</RefSource><PMID Version="1">22563590</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Reprod Med. 1999 Apr;44(4):321-4</RefSource><PMID Version="1">10319299</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Autoimmun. 2012 May;38(2-3):J129-34</RefSource><PMID Version="1">22154021</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rheum Dis Clin North Am. 2001 May;27(2):269-81</RefSource><PMID Version="1">11396092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Reprod. 2012 Jul;27(7):2201-7</RefSource><PMID Version="1">22513983</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Autoimmun. 2012 May;38(2-3):J109-19</RefSource><PMID Version="1">22079680</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2009 Jul;50(1):291-308</RefSource><PMID Version="1">19554543</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sarcoidosis Vasc Diffuse Lung Dis. 2005 Jun;22(2):115-22</RefSource><PMID Version="1">16053026</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2008 Jan;58(1):15-25</RefSource><PMID Version="1">18163481</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2003 May 1;167(9):1225-31</RefSource><PMID Version="1">12615619</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Jul;41(7):820-3</RefSource><PMID Version="1">19503088</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Nov;45(11):1284-92</RefSource><PMID Version="1">24097067</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Orphanet J Rare Dis. 2010 May 11;5:8</RefSource><PMID Version="1">20459843</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2013 Jun;65(6):1457-67</RefSource><PMID Version="1">23460240</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Rheumatol. 2010 Jan;37(1):38-44</RefSource><PMID Version="1">20008925</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 1988 Mar;31(3):315-24</RefSource><PMID Version="1">3358796</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nihon Naika Gakkai Zasshi. 1980 Jul 10;69(7):861-6</RefSource><PMID Version="1">7419949</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 1982 Nov;25(11):1271-7</RefSource><PMID Version="1">7138600</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Genet. 1991 May;87(1):81-3</RefSource><PMID Version="1">2037286</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2002 Dec;87(12):5495-8</RefSource><PMID Version="1">12466343</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Birth Defects Orig Artic Ser. 1979;15(1):3-14</RefSource><PMID Version="1">444646</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Can Med Assoc J. 1969 Sep 6;101(5):247-58</RefSource><PMID Version="1">5812107</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2013 Jun;45(6):664-9</RefSource><PMID Version="1">23603761</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Rheumatol. 1999;18(2):158-62</RefSource><PMID Version="1">10357123</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Epidemiol. 1995 Jul;5(4):297-302</RefSource><PMID Version="1">8520712</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2008 May 12;205(5):1099-108</RefSource><PMID Version="1">18443225</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Immun. 2009 Jul;10(5):478-81</RefSource><PMID Version="1">19458623</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Autoimmun. 2007 Aug;29(1):1-9</RefSource><PMID Version="1">17582741</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2011 May 7;377(9777):1600-9</RefSource><PMID Version="1">21529926</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Rheum Dis. 2012 Aug;71(8):1418-22</RefSource><PMID Version="1">22580585</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2007 Sep;1110:84-91</RefSource><PMID Version="1">17911423</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J 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