Resting pulmonary artery pressure of 21-24 mmHg predicts abnormal exercise haemodynamics.
Identifieur interne : 001F23 ( PubMed/Curation ); précédent : 001F22; suivant : 001F24Resting pulmonary artery pressure of 21-24 mmHg predicts abnormal exercise haemodynamics.
Auteurs : Edmund M T. Lau [Australie] ; Laurent Godinas ; Olivier Sitbon [France] ; David Montani [France] ; Laurent Savale [France] ; Xavier Jaïs [France] ; Frederic Lador [France] ; Sven Gunther [France] ; David S. Celermajer [Australie] ; Gérald Simonneau [France] ; Marc Humbert [France] ; Denis Chemla [France] ; Philippe Herve [France]Source :
- The European respiratory journal [ 1399-3003 ] ; 2016.
Abstract
A resting mean pulmonary artery pressure (mPAP) of 21-24 mmHg is above the upper limit of normal but does not reach criteria for the diagnosis of pulmonary hypertension (PH). We sought to determine whether an mPAP of 21-24 mmHg is associated with an increased risk of developing an abnormal pulmonary vascular response during exercise.Consecutive patients (n=290) with resting mPAP <25 mmHg who underwent invasive exercise haemodynamics were analysed. Risk factors for pulmonary vascular disease or left heart disease were present in 63.4% and 43.8% of subjects. An abnormal pulmonary vascular response (or exercise PH) was defined by mPAP >30 mmHg and total pulmonary vascular resistance >3 WU at maximal exercise.Exercise PH occurred in 74 (86.0%) out of 86 versus 96 (47.1%) out of 204 in the mPAP of 21-24 mmHg and mPAP <21 mmHg groups, respectively (OR 6.9, 95% CI: 3.6-13.6; p<0.0001). Patients with mPAP of 21-24 mmHg had lower 6-min walk distance (p=0.002) and higher New York Heart Association functional class status (p=0.03). Decreasing levels of mPAP were associated with a lower prevalence of exercise PH, which occurred in 60.3%, 38.7% and 7.7% of patients with mPAP of 17-20, 13-16 and <13 mmHg, respectively.In an at-risk population, a resting mPAP between 21-24 mmHg is closely associated with exercise PH together with worse functional capacity.
DOI: 10.1183/13993003.01684-2015
PubMed: 26965292
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Laurent Godinas<affiliation><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France CHU Mont-Godinne, Université Catholique de Louvain, Yvoir, Belgium Both authors contributed equally.</nlm:affiliation>
<wicri:noCountry code="subField">Belgium Both authors contributed equally</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
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<author><name sortKey="Montani, David" sort="Montani, David" uniqKey="Montani D" first="David" last="Montani">David Montani</name>
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<author><name sortKey="Jais, Xavier" sort="Jais, Xavier" uniqKey="Jais X" first="Xavier" last="Jaïs">Xavier Jaïs</name>
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<author><name sortKey="Lador, Frederic" sort="Lador, Frederic" uniqKey="Lador F" first="Frederic" last="Lador">Frederic Lador</name>
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<author><name sortKey="Gunther, Sven" sort="Gunther, Sven" uniqKey="Gunther S" first="Sven" last="Gunther">Sven Gunther</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
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<author><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S" last="Celermajer">David S. Celermajer</name>
<affiliation wicri:level="1"><nlm:affiliation>Sydney Medical School, University of Sydney, Camperdown, Australia.</nlm:affiliation>
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<author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gérald" last="Simonneau">Gérald Simonneau</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
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<author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
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<author><name sortKey="Chemla, Denis" sort="Chemla, Denis" uniqKey="Chemla D" first="Denis" last="Chemla">Denis Chemla</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
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<author><name sortKey="Herve, Philippe" sort="Herve, Philippe" uniqKey="Herve P" first="Philippe" last="Herve">Philippe Herve</name>
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<country xml:lang="fr">France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Resting pulmonary artery pressure of 21-24 mmHg predicts abnormal exercise haemodynamics.</title>
<author><name sortKey="Lau, Edmund M T" sort="Lau, Edmund M T" uniqKey="Lau E" first="Edmund M T" last="Lau">Edmund M T. Lau</name>
<affiliation wicri:level="1"><nlm:affiliation>Sydney Medical School, University of Sydney, Camperdown, Australia Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France Both authors contributed equally edmund.lau@sydney.edu.au.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>Sydney Medical School, University of Sydney, Camperdown, Australia Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
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<author><name sortKey="Godinas, Laurent" sort="Godinas, Laurent" uniqKey="Godinas L" first="Laurent" last="Godinas">Laurent Godinas</name>
<affiliation><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France CHU Mont-Godinne, Université Catholique de Louvain, Yvoir, Belgium Both authors contributed equally.</nlm:affiliation>
<wicri:noCountry code="subField">Belgium Both authors contributed equally</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
</affiliation>
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<author><name sortKey="Montani, David" sort="Montani, David" uniqKey="Montani D" first="David" last="Montani">David Montani</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
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<author><name sortKey="Savale, Laurent" sort="Savale, Laurent" uniqKey="Savale L" first="Laurent" last="Savale">Laurent Savale</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
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<author><name sortKey="Jais, Xavier" sort="Jais, Xavier" uniqKey="Jais X" first="Xavier" last="Jaïs">Xavier Jaïs</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
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<author><name sortKey="Lador, Frederic" sort="Lador, Frederic" uniqKey="Lador F" first="Frederic" last="Lador">Frederic Lador</name>
<affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France Dept de Chirurgie Thoracique, Vasculaire et de Transplantation Pulmonaire, Hopital Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France Dept de Chirurgie Thoracique, Vasculaire et de Transplantation Pulmonaire, Hopital Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
</affiliation>
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<author><name sortKey="Gunther, Sven" sort="Gunther, Sven" uniqKey="Gunther S" first="Sven" last="Gunther">Sven Gunther</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S" last="Celermajer">David S. Celermajer</name>
<affiliation wicri:level="1"><nlm:affiliation>Sydney Medical School, University of Sydney, Camperdown, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sydney Medical School, University of Sydney, Camperdown</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gérald" last="Simonneau">Gérald Simonneau</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chemla, Denis" sort="Chemla, Denis" uniqKey="Chemla D" first="Denis" last="Chemla">Denis Chemla</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Paris-Sud, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Herve, Philippe" sort="Herve, Philippe" uniqKey="Herve P" first="Philippe" last="Herve">Philippe Herve</name>
<affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France Dept de Chirurgie Thoracique, Vasculaire et de Transplantation Pulmonaire, Hopital Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France Dept de Chirurgie Thoracique, Vasculaire et de Transplantation Pulmonaire, Hopital Marie Lannelongue, Le Plessis Robinson</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The European respiratory journal</title>
<idno type="eISSN">1399-3003</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">A resting mean pulmonary artery pressure (mPAP) of 21-24 mmHg is above the upper limit of normal but does not reach criteria for the diagnosis of pulmonary hypertension (PH). We sought to determine whether an mPAP of 21-24 mmHg is associated with an increased risk of developing an abnormal pulmonary vascular response during exercise.Consecutive patients (n=290) with resting mPAP <25 mmHg who underwent invasive exercise haemodynamics were analysed. Risk factors for pulmonary vascular disease or left heart disease were present in 63.4% and 43.8% of subjects. An abnormal pulmonary vascular response (or exercise PH) was defined by mPAP >30 mmHg and total pulmonary vascular resistance >3 WU at maximal exercise.Exercise PH occurred in 74 (86.0%) out of 86 versus 96 (47.1%) out of 204 in the mPAP of 21-24 mmHg and mPAP <21 mmHg groups, respectively (OR 6.9, 95% CI: 3.6-13.6; p<0.0001). Patients with mPAP of 21-24 mmHg had lower 6-min walk distance (p=0.002) and higher New York Heart Association functional class status (p=0.03). Decreasing levels of mPAP were associated with a lower prevalence of exercise PH, which occurred in 60.3%, 38.7% and 7.7% of patients with mPAP of 17-20, 13-16 and <13 mmHg, respectively.In an at-risk population, a resting mPAP between 21-24 mmHg is closely associated with exercise PH together with worse functional capacity.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">26965292</PMID>
<DateCreated><Year>2016</Year>
<Month>05</Month>
<Day>02</Day>
</DateCreated>
<DateRevised><Year>2016</Year>
<Month>05</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1399-3003</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>47</Volume>
<Issue>5</Issue>
<PubDate><Year>2016</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>The European respiratory journal</Title>
<ISOAbbreviation>Eur. Respir. J.</ISOAbbreviation>
</Journal>
<ArticleTitle>Resting pulmonary artery pressure of 21-24 mmHg predicts abnormal exercise haemodynamics.</ArticleTitle>
<Pagination><MedlinePgn>1436-44</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1183/13993003.01684-2015</ELocationID>
<Abstract><AbstractText>A resting mean pulmonary artery pressure (mPAP) of 21-24 mmHg is above the upper limit of normal but does not reach criteria for the diagnosis of pulmonary hypertension (PH). We sought to determine whether an mPAP of 21-24 mmHg is associated with an increased risk of developing an abnormal pulmonary vascular response during exercise.Consecutive patients (n=290) with resting mPAP <25 mmHg who underwent invasive exercise haemodynamics were analysed. Risk factors for pulmonary vascular disease or left heart disease were present in 63.4% and 43.8% of subjects. An abnormal pulmonary vascular response (or exercise PH) was defined by mPAP >30 mmHg and total pulmonary vascular resistance >3 WU at maximal exercise.Exercise PH occurred in 74 (86.0%) out of 86 versus 96 (47.1%) out of 204 in the mPAP of 21-24 mmHg and mPAP <21 mmHg groups, respectively (OR 6.9, 95% CI: 3.6-13.6; p<0.0001). Patients with mPAP of 21-24 mmHg had lower 6-min walk distance (p=0.002) and higher New York Heart Association functional class status (p=0.03). Decreasing levels of mPAP were associated with a lower prevalence of exercise PH, which occurred in 60.3%, 38.7% and 7.7% of patients with mPAP of 17-20, 13-16 and <13 mmHg, respectively.In an at-risk population, a resting mPAP between 21-24 mmHg is closely associated with exercise PH together with worse functional capacity.</AbstractText>
<CopyrightInformation>Copyright ©ERS 2016.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lau</LastName>
<ForeName>Edmund M T</ForeName>
<Initials>EM</Initials>
<AffiliationInfo><Affiliation>Sydney Medical School, University of Sydney, Camperdown, Australia Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France Both authors contributed equally edmund.lau@sydney.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Godinas</LastName>
<ForeName>Laurent</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France CHU Mont-Godinne, Université Catholique de Louvain, Yvoir, Belgium Both authors contributed equally.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sitbon</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Montani</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Savale</LastName>
<ForeName>Laurent</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jaïs</LastName>
<ForeName>Xavier</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lador</LastName>
<ForeName>Frederic</ForeName>
<Initials>F</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4276-635X</Identifier>
<AffiliationInfo><Affiliation>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France Dept de Chirurgie Thoracique, Vasculaire et de Transplantation Pulmonaire, Hopital Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gunther</LastName>
<ForeName>Sven</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Celermajer</LastName>
<ForeName>David S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Sydney Medical School, University of Sydney, Camperdown, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Simonneau</LastName>
<ForeName>Gérald</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Humbert</LastName>
<ForeName>Marc</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-0703-2892</Identifier>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chemla</LastName>
<ForeName>Denis</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Univ. Paris-Sud, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herve</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France INSERM UMR_S999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France Dept de Chirurgie Thoracique, Vasculaire et de Transplantation Pulmonaire, Hopital Marie Lannelongue, Le Plessis Robinson, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>03</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Eur Respir J</MedlineTA>
<NlmUniqueID>8803460</NlmUniqueID>
<ISSNLinking>0903-1936</ISSNLinking>
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<CitationSubset>IM</CitationSubset>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>10</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>01</Month>
<Day>18</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>3</Month>
<Day>12</Day>
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