Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice.
Identifieur interne : 001D94 ( PubMed/Curation ); précédent : 001D93; suivant : 001D95Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice.
Auteurs : Artur Jurczyszyn [Pologne] ; Norbert Grzasko [Pologne] ; Alessandro Gozzetti [Italie] ; Jacek Czepiel [Pologne] ; Alfonso Cerase [Italie] ; Vania Hungria [Brésil] ; Edvan Crusoe [Brésil] ; Ana Luiza Miranda Silva Dias [Brésil] ; Ravi Vij [États-Unis] ; Mark A. Fiala [États-Unis] ; Jo Caers [Belgique] ; Leo Rasche [Allemagne] ; Ajay K. Nooka [Géorgie (pays)] ; Sagar Lonial [Géorgie (pays)] ; David H. Vesole [États-Unis] ; Sandhya Philip [États-Unis] ; Shane Gangatharan [Australie] ; Agnieszka Druzd-Sitek [Pologne] ; Jan Walewski [Pologne] ; Alessandro Corso [Italie] ; Federica Cocito [Italie] ; Marie-Christine M. Vekemans [Belgique] ; Erden Atilla [Turquie] ; Meral Beksac [Turquie] ; Xavier Leleu [France] ; Julio Davila [Espagne] ; Ashraf Badros [États-Unis] ; Ekta Aneja [États-Unis] ; Niels Abildgaard [Danemark] ; Efstathios Kastritis [Grèce] ; Dorotea Fantl [Argentine] ; Natalia Schutz [Argentine] ; Tomas Pika [République tchèque] ; Aleksandra Butrym [Pologne] ; Magdalena Olszewska-Szopa [Pologne] ; Lidia Usnarska-Zubkiewicz [Pologne] ; Saad Z. Usmani [États-Unis] ; Hareth Nahi [Suède] ; Chor S. Chim [Hong Kong] ; Chaim Shustik [Canada] ; Krzysztof Madry [Pologne] ; Suzanne Lentzsch [États-Unis] ; Alina Swiderska [Pologne] ; Grzegorz Helbig [Pologne] ; Renata Guzicka-Kazimierczak [Pologne] ; Nikoletta Lendvai [États-Unis] ; Anders Waage [Norvège] ; Kristian T. Andersen [Danemark] ; Hirokazu Murakami [Japon] ; Sonja Zweegman [Pays-Bas] ; Jorge J. Castillo [États-Unis]Source :
- American journal of hematology [ 1096-8652 ] ; 2016.
Descripteurs français
- KwdFr :
- Aberrations des chromosomes, Adulte, Adulte d'âge moyen, Analyse de survie, Antinéoplasiques (usage thérapeutique), Association thérapeutique, Femelle, Humains, Myélome multiple (), Myélome multiple (anatomopathologie), Myélome multiple (mortalité), Mâle, Pronostic, Radiothérapie, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Tumeurs du système nerveux central (), Tumeurs du système nerveux central (diagnostic), Tumeurs du système nerveux central (mortalité), Tumeurs du système nerveux central (secondaire), Études rétrospectives.
- MESH :
- anatomopathologie : Myélome multiple.
- diagnostic : Tumeurs du système nerveux central.
- mortalité : Myélome multiple, Tumeurs du système nerveux central.
- secondaire : Tumeurs du système nerveux central.
- usage thérapeutique : Antinéoplasiques.
- Aberrations des chromosomes, Adulte, Adulte d'âge moyen, Analyse de survie, Association thérapeutique, Femelle, Humains, Myélome multiple, Mâle, Pronostic, Radiothérapie, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Tumeurs du système nerveux central, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents (therapeutic use), Central Nervous System Neoplasms (diagnosis), Central Nervous System Neoplasms (mortality), Central Nervous System Neoplasms (secondary), Central Nervous System Neoplasms (therapy), Chromosome Aberrations, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Multiple Myeloma (complications), Multiple Myeloma (mortality), Multiple Myeloma (pathology), Multiple Myeloma (therapy), Prognosis, Radiotherapy, Retrospective Studies, Survival Analysis, Survival Rate, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Antineoplastic Agents.
- complications : Multiple Myeloma.
- diagnosis : Central Nervous System Neoplasms.
- mortality : Central Nervous System Neoplasms, Multiple Myeloma.
- pathology : Multiple Myeloma.
- secondary : Central Nervous System Neoplasms.
- therapy : Central Nervous System Neoplasms, Multiple Myeloma.
- Adult, Aged, Aged, 80 and over, Chromosome Aberrations, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Prognosis, Radiotherapy, Retrospective Studies, Survival Analysis, Survival Rate, Treatment Outcome.
Abstract
The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of patients with multiple myeloma (MM) involving the central nervous system (CNS). Univariate and multivariate analyses were performed to identify prognostic factors for survival. The median time from MM diagnosis to CNS MM diagnosis was 3 years. Thirty-eight patients (22%) were diagnosed with CNS involvement at the time of initial MM diagnosis and 134 (78%) at relapse/progression. Upon diagnosis of CNS MM, 97% patients received initial therapy for CNS disease, of which 76% received systemic therapy, 36% radiotherapy and 32% intrathecal therapy. After a median follow-up of 3.5 years, the median overall survival (OS) from the onset of CNS involvement for the entire group was 7 months. Untreated and treated patients had median OS of 2 and 8 months, respectively (P < 0.001). At least one previous line of therapy for MM before the diagnosis of CNS disease and >1 cytogenetic abnormality detected by FISH were independently associated with worse OS. The median OS for patients with 0, 1 and 2 of these risk factors were 25 months, 5.5 months and 2 months, respectively (P < 0.001). Neurological manifestations, not considered chemotherapy-related, observed at any time after initial diagnosis of MM should raise a suspicion of CNS involvement. Although prognosis is generally poor, the survival of previously untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy. Am. J. Hematol. 91:575-580, 2016. © 2016 Wiley Periodicals, Inc.
DOI: 10.1002/ajh.24351
PubMed: 26955792
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001E18
Links to Exploration step
pubmed:26955792Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice.</title><author><name sortKey="Jurczyszyn, Artur" sort="Jurczyszyn, Artur" uniqKey="Jurczyszyn A" first="Artur" last="Jurczyszyn">Artur Jurczyszyn</name><affiliation wicri:level="1"><nlm:affiliation>Jagiellonian University Medical College, Cracow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Jagiellonian University Medical College, Cracow</wicri:regionArea></affiliation></author><author><name sortKey="Grzasko, Norbert" sort="Grzasko, Norbert" uniqKey="Grzasko N" first="Norbert" last="Grzasko">Norbert Grzasko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin</wicri:regionArea></affiliation></author><author><name sortKey="Gozzetti, Alessandro" sort="Gozzetti, Alessandro" uniqKey="Gozzetti A" first="Alessandro" last="Gozzetti">Alessandro Gozzetti</name><affiliation wicri:level="1"><nlm:affiliation>Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea></affiliation></author><author><name sortKey="Czepiel, Jacek" sort="Czepiel, Jacek" uniqKey="Czepiel J" first="Jacek" last="Czepiel">Jacek Czepiel</name><affiliation wicri:level="1"><nlm:affiliation>Jagiellonian University Medical College, Cracow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Jagiellonian University Medical College, Cracow</wicri:regionArea></affiliation></author><author><name sortKey="Cerase, Alfonso" sort="Cerase, Alfonso" uniqKey="Cerase A" first="Alfonso" last="Cerase">Alfonso Cerase</name><affiliation wicri:level="1"><nlm:affiliation>Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea></affiliation></author><author><name sortKey="Hungria, Vania" sort="Hungria, Vania" uniqKey="Hungria V" first="Vania" last="Hungria">Vania Hungria</name><affiliation wicri:level="1"><nlm:affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Crusoe, Edvan" sort="Crusoe, Edvan" uniqKey="Crusoe E" first="Edvan" last="Crusoe">Edvan Crusoe</name><affiliation wicri:level="1"><nlm:affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Silva Dias, Ana Luiza Miranda" sort="Silva Dias, Ana Luiza Miranda" uniqKey="Silva Dias A" first="Ana Luiza Miranda" last="Silva Dias">Ana Luiza Miranda Silva Dias</name><affiliation wicri:level="1"><nlm:affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><affiliation wicri:level="2"><nlm:affiliation>Washington University School of Medicine, St. Louis, Missouri.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Fiala, Mark A" sort="Fiala, Mark A" uniqKey="Fiala M" first="Mark A" last="Fiala">Mark A. Fiala</name><affiliation wicri:level="2"><nlm:affiliation>Washington University School of Medicine, St. Louis, Missouri.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Caers, Jo" sort="Caers, Jo" uniqKey="Caers J" first="Jo" last="Caers">Jo Caers</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Liege, Liege, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire de Liege, Liege</wicri:regionArea></affiliation></author><author><name sortKey="Rasche, Leo" sort="Rasche, Leo" uniqKey="Rasche L" first="Leo" last="Rasche">Leo Rasche</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Wuerzburg, Wuerzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Wuerzburg, Wuerzburg</wicri:regionArea></affiliation></author><author><name sortKey="Nooka, Ajay K" sort="Nooka, Ajay K" uniqKey="Nooka A" first="Ajay K" last="Nooka">Ajay K. Nooka</name><affiliation wicri:level="1"><nlm:affiliation>Winship Cancer Institute, Emory University, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Winship Cancer Institute, Emory University, Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Lonial, Sagar" sort="Lonial, Sagar" uniqKey="Lonial S" first="Sagar" last="Lonial">Sagar Lonial</name><affiliation wicri:level="1"><nlm:affiliation>Winship Cancer Institute, Emory University, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Winship Cancer Institute, Emory University, Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Vesole, David H" sort="Vesole, David H" uniqKey="Vesole D" first="David H" last="Vesole">David H. Vesole</name><affiliation wicri:level="2"><nlm:affiliation>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Philip, Sandhya" sort="Philip, Sandhya" uniqKey="Philip S" first="Sandhya" last="Philip">Sandhya Philip</name><affiliation wicri:level="2"><nlm:affiliation>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Gangatharan, Shane" sort="Gangatharan, Shane" uniqKey="Gangatharan S" first="Shane" last="Gangatharan">Shane Gangatharan</name><affiliation wicri:level="1"><nlm:affiliation>Fremantle Hospital, Fremantle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Fremantle Hospital, Fremantle</wicri:regionArea></affiliation></author><author><name sortKey="Druzd Sitek, Agnieszka" sort="Druzd Sitek, Agnieszka" uniqKey="Druzd Sitek A" first="Agnieszka" last="Druzd-Sitek">Agnieszka Druzd-Sitek</name><affiliation wicri:level="1"><nlm:affiliation>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Walewski, Jan" sort="Walewski, Jan" uniqKey="Walewski J" first="Jan" last="Walewski">Jan Walewski</name><affiliation wicri:level="1"><nlm:affiliation>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Corso, Alessandro" sort="Corso, Alessandro" uniqKey="Corso A" first="Alessandro" last="Corso">Alessandro Corso</name><affiliation wicri:level="1"><nlm:affiliation>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Cocito, Federica" sort="Cocito, Federica" uniqKey="Cocito F" first="Federica" last="Cocito">Federica Cocito</name><affiliation wicri:level="1"><nlm:affiliation>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Vekemans, Marie Christine M" sort="Vekemans, Marie Christine M" uniqKey="Vekemans M" first="Marie-Christine M" last="Vekemans">Marie-Christine M. Vekemans</name><affiliation wicri:level="1"><nlm:affiliation>Cliniques Universitaires Saint-Luc, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Cliniques Universitaires Saint-Luc, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Atilla, Erden" sort="Atilla, Erden" uniqKey="Atilla E" first="Erden" last="Atilla">Erden Atilla</name><affiliation wicri:level="1"><nlm:affiliation>Ankara University Medical School, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Ankara University Medical School, Ankara</wicri:regionArea></affiliation></author><author><name sortKey="Beksac, Meral" sort="Beksac, Meral" uniqKey="Beksac M" first="Meral" last="Beksac">Meral Beksac</name><affiliation wicri:level="1"><nlm:affiliation>Ankara University Medical School, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Ankara University Medical School, Ankara</wicri:regionArea></affiliation></author><author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name><affiliation wicri:level="1"><nlm:affiliation>Hopital La Miletrie, CHU Poitiers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital La Miletrie, CHU Poitiers</wicri:regionArea></affiliation></author><author><name sortKey="Davila, Julio" sort="Davila, Julio" uniqKey="Davila J" first="Julio" last="Davila">Julio Davila</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario de Salamanca, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario de Salamanca, Salamanca</wicri:regionArea></affiliation></author><author><name sortKey="Badros, Ashraf" sort="Badros, Ashraf" uniqKey="Badros A" first="Ashraf" last="Badros">Ashraf Badros</name><affiliation wicri:level="2"><nlm:affiliation>University of Maryland Medical Center, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>University of Maryland Medical Center, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Aneja, Ekta" sort="Aneja, Ekta" uniqKey="Aneja E" first="Ekta" last="Aneja">Ekta Aneja</name><affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea></affiliation></author><author><name sortKey="Abildgaard, Niels" sort="Abildgaard, Niels" uniqKey="Abildgaard N" first="Niels" last="Abildgaard">Niels Abildgaard</name><affiliation wicri:level="1"><nlm:affiliation>Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Odense University Hospital, Odense</wicri:regionArea></affiliation></author><author><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name><affiliation wicri:level="1"><nlm:affiliation>National and Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>National and Kapodistrian University of Athens, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Fantl, Dorotea" sort="Fantl, Dorotea" uniqKey="Fantl D" first="Dorotea" last="Fantl">Dorotea Fantl</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital Italiano de Buenos Aires, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Schutz, Natalia" sort="Schutz, Natalia" uniqKey="Schutz N" first="Natalia" last="Schutz">Natalia Schutz</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital Italiano de Buenos Aires, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Pika, Tomas" sort="Pika, Tomas" uniqKey="Pika T" first="Tomas" last="Pika">Tomas Pika</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Olomouc, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital Olomouc, Olomouc</wicri:regionArea></affiliation></author><author><name sortKey="Butrym, Aleksandra" sort="Butrym, Aleksandra" uniqKey="Butrym A" first="Aleksandra" last="Butrym">Aleksandra Butrym</name><affiliation wicri:level="1"><nlm:affiliation>Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea></affiliation></author><author><name sortKey="Olszewska Szopa, Magdalena" sort="Olszewska Szopa, Magdalena" uniqKey="Olszewska Szopa M" first="Magdalena" last="Olszewska-Szopa">Magdalena Olszewska-Szopa</name><affiliation wicri:level="1"><nlm:affiliation>Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea></affiliation></author><author><name sortKey="Usnarska Zubkiewicz, Lidia" sort="Usnarska Zubkiewicz, Lidia" uniqKey="Usnarska Zubkiewicz L" first="Lidia" last="Usnarska-Zubkiewicz">Lidia Usnarska-Zubkiewicz</name><affiliation wicri:level="1"><nlm:affiliation>Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea></affiliation></author><author><name sortKey="Usmani, Saad Z" sort="Usmani, Saad Z" uniqKey="Usmani S" first="Saad Z" last="Usmani">Saad Z. Usmani</name><affiliation wicri:level="2"><nlm:affiliation>Levine Cancer Institute/Carolinas HealthCare System, Charlotte, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Levine Cancer Institute/Carolinas HealthCare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Nahi, Hareth" sort="Nahi, Hareth" uniqKey="Nahi H" first="Hareth" last="Nahi">Hareth Nahi</name><affiliation wicri:level="1"><nlm:affiliation>Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska University Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Chim, Chor S" sort="Chim, Chor S" uniqKey="Chim C" first="Chor S" last="Chim">Chor S. Chim</name><affiliation wicri:level="1"><nlm:affiliation>Queen Mary Hospital, University of Hong Kong, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Queen Mary Hospital, University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Shustik, Chaim" sort="Shustik, Chaim" uniqKey="Shustik C" first="Chaim" last="Shustik">Chaim Shustik</name><affiliation wicri:level="1"><nlm:affiliation>Royal Victoria Hospital, McGill University, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Royal Victoria Hospital, McGill University, Montreal</wicri:regionArea></affiliation></author><author><name sortKey="Madry, Krzysztof" sort="Madry, Krzysztof" uniqKey="Madry K" first="Krzysztof" last="Madry">Krzysztof Madry</name><affiliation wicri:level="1"><nlm:affiliation>Medical University, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Medical University, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name><affiliation wicri:level="2"><nlm:affiliation>Columbia University Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Columbia University Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Swiderska, Alina" sort="Swiderska, Alina" uniqKey="Swiderska A" first="Alina" last="Swiderska">Alina Swiderska</name><affiliation wicri:level="1"><nlm:affiliation>Provincial Hospital, Zielona Gora, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Provincial Hospital, Zielona Gora</wicri:regionArea></affiliation></author><author><name sortKey="Helbig, Grzegorz" sort="Helbig, Grzegorz" uniqKey="Helbig G" first="Grzegorz" last="Helbig">Grzegorz Helbig</name><affiliation wicri:level="1"><nlm:affiliation>Silesian Medical University, Katowice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Silesian Medical University, Katowice</wicri:regionArea></affiliation></author><author><name sortKey="Guzicka Kazimierczak, Renata" sort="Guzicka Kazimierczak, Renata" uniqKey="Guzicka Kazimierczak R" first="Renata" last="Guzicka-Kazimierczak">Renata Guzicka-Kazimierczak</name><affiliation wicri:level="1"><nlm:affiliation>Pomeranian Medical University, Szczecin, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Lendvai, Nikoletta" sort="Lendvai, Nikoletta" uniqKey="Lendvai N" first="Nikoletta" last="Lendvai">Nikoletta Lendvai</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan-Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Memorial Sloan-Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name><affiliation wicri:level="1"><nlm:affiliation>Norwegian University of Science and Technology, Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Norwegian University of Science and Technology, Trondheim</wicri:regionArea></affiliation></author><author><name sortKey="Andersen, Kristian T" sort="Andersen, Kristian T" uniqKey="Andersen K" first="Kristian T" last="Andersen">Kristian T. Andersen</name><affiliation wicri:level="1"><nlm:affiliation>Vejle Hospital, Vejle, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Vejle Hospital, Vejle</wicri:regionArea></affiliation></author><author><name sortKey="Murakami, Hirokazu" sort="Murakami, Hirokazu" uniqKey="Murakami H" first="Hirokazu" last="Murakami">Hirokazu Murakami</name><affiliation wicri:level="1"><nlm:affiliation>Gunma University Graduate School of Health Sciences, Gunma, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Gunma University Graduate School of Health Sciences, Gunma</wicri:regionArea></affiliation></author><author><name sortKey="Zweegman, Sonja" sort="Zweegman, Sonja" uniqKey="Zweegman S" first="Sonja" last="Zweegman">Sonja Zweegman</name><affiliation wicri:level="1"><nlm:affiliation>VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Castillo, Jorge J" sort="Castillo, Jorge J" uniqKey="Castillo J" first="Jorge J" last="Castillo">Jorge J. Castillo</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Harvard Medical School, Boston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26955792</idno><idno type="pmid">26955792</idno><idno type="doi">10.1002/ajh.24351</idno><idno type="wicri:Area/PubMed/Corpus">001E18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E18</idno><idno type="wicri:Area/PubMed/Curation">001D94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice.</title><author><name sortKey="Jurczyszyn, Artur" sort="Jurczyszyn, Artur" uniqKey="Jurczyszyn A" first="Artur" last="Jurczyszyn">Artur Jurczyszyn</name><affiliation wicri:level="1"><nlm:affiliation>Jagiellonian University Medical College, Cracow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Jagiellonian University Medical College, Cracow</wicri:regionArea></affiliation></author><author><name sortKey="Grzasko, Norbert" sort="Grzasko, Norbert" uniqKey="Grzasko N" first="Norbert" last="Grzasko">Norbert Grzasko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin</wicri:regionArea></affiliation></author><author><name sortKey="Gozzetti, Alessandro" sort="Gozzetti, Alessandro" uniqKey="Gozzetti A" first="Alessandro" last="Gozzetti">Alessandro Gozzetti</name><affiliation wicri:level="1"><nlm:affiliation>Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea></affiliation></author><author><name sortKey="Czepiel, Jacek" sort="Czepiel, Jacek" uniqKey="Czepiel J" first="Jacek" last="Czepiel">Jacek Czepiel</name><affiliation wicri:level="1"><nlm:affiliation>Jagiellonian University Medical College, Cracow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Jagiellonian University Medical College, Cracow</wicri:regionArea></affiliation></author><author><name sortKey="Cerase, Alfonso" sort="Cerase, Alfonso" uniqKey="Cerase A" first="Alfonso" last="Cerase">Alfonso Cerase</name><affiliation wicri:level="1"><nlm:affiliation>Azienda Ospedaliera Universitaria Senese, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea></affiliation></author><author><name sortKey="Hungria, Vania" sort="Hungria, Vania" uniqKey="Hungria V" first="Vania" last="Hungria">Vania Hungria</name><affiliation wicri:level="1"><nlm:affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Crusoe, Edvan" sort="Crusoe, Edvan" uniqKey="Crusoe E" first="Edvan" last="Crusoe">Edvan Crusoe</name><affiliation wicri:level="1"><nlm:affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Silva Dias, Ana Luiza Miranda" sort="Silva Dias, Ana Luiza Miranda" uniqKey="Silva Dias A" first="Ana Luiza Miranda" last="Silva Dias">Ana Luiza Miranda Silva Dias</name><affiliation wicri:level="1"><nlm:affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><affiliation wicri:level="2"><nlm:affiliation>Washington University School of Medicine, St. Louis, Missouri.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Fiala, Mark A" sort="Fiala, Mark A" uniqKey="Fiala M" first="Mark A" last="Fiala">Mark A. Fiala</name><affiliation wicri:level="2"><nlm:affiliation>Washington University School of Medicine, St. Louis, Missouri.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Caers, Jo" sort="Caers, Jo" uniqKey="Caers J" first="Jo" last="Caers">Jo Caers</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Liege, Liege, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire de Liege, Liege</wicri:regionArea></affiliation></author><author><name sortKey="Rasche, Leo" sort="Rasche, Leo" uniqKey="Rasche L" first="Leo" last="Rasche">Leo Rasche</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Wuerzburg, Wuerzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Wuerzburg, Wuerzburg</wicri:regionArea></affiliation></author><author><name sortKey="Nooka, Ajay K" sort="Nooka, Ajay K" uniqKey="Nooka A" first="Ajay K" last="Nooka">Ajay K. Nooka</name><affiliation wicri:level="1"><nlm:affiliation>Winship Cancer Institute, Emory University, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Winship Cancer Institute, Emory University, Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Lonial, Sagar" sort="Lonial, Sagar" uniqKey="Lonial S" first="Sagar" last="Lonial">Sagar Lonial</name><affiliation wicri:level="1"><nlm:affiliation>Winship Cancer Institute, Emory University, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Winship Cancer Institute, Emory University, Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Vesole, David H" sort="Vesole, David H" uniqKey="Vesole D" first="David H" last="Vesole">David H. Vesole</name><affiliation wicri:level="2"><nlm:affiliation>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Philip, Sandhya" sort="Philip, Sandhya" uniqKey="Philip S" first="Sandhya" last="Philip">Sandhya Philip</name><affiliation wicri:level="2"><nlm:affiliation>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Gangatharan, Shane" sort="Gangatharan, Shane" uniqKey="Gangatharan S" first="Shane" last="Gangatharan">Shane Gangatharan</name><affiliation wicri:level="1"><nlm:affiliation>Fremantle Hospital, Fremantle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Fremantle Hospital, Fremantle</wicri:regionArea></affiliation></author><author><name sortKey="Druzd Sitek, Agnieszka" sort="Druzd Sitek, Agnieszka" uniqKey="Druzd Sitek A" first="Agnieszka" last="Druzd-Sitek">Agnieszka Druzd-Sitek</name><affiliation wicri:level="1"><nlm:affiliation>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Walewski, Jan" sort="Walewski, Jan" uniqKey="Walewski J" first="Jan" last="Walewski">Jan Walewski</name><affiliation wicri:level="1"><nlm:affiliation>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Corso, Alessandro" sort="Corso, Alessandro" uniqKey="Corso A" first="Alessandro" last="Corso">Alessandro Corso</name><affiliation wicri:level="1"><nlm:affiliation>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Cocito, Federica" sort="Cocito, Federica" uniqKey="Cocito F" first="Federica" last="Cocito">Federica Cocito</name><affiliation wicri:level="1"><nlm:affiliation>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Vekemans, Marie Christine M" sort="Vekemans, Marie Christine M" uniqKey="Vekemans M" first="Marie-Christine M" last="Vekemans">Marie-Christine M. Vekemans</name><affiliation wicri:level="1"><nlm:affiliation>Cliniques Universitaires Saint-Luc, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Cliniques Universitaires Saint-Luc, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Atilla, Erden" sort="Atilla, Erden" uniqKey="Atilla E" first="Erden" last="Atilla">Erden Atilla</name><affiliation wicri:level="1"><nlm:affiliation>Ankara University Medical School, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Ankara University Medical School, Ankara</wicri:regionArea></affiliation></author><author><name sortKey="Beksac, Meral" sort="Beksac, Meral" uniqKey="Beksac M" first="Meral" last="Beksac">Meral Beksac</name><affiliation wicri:level="1"><nlm:affiliation>Ankara University Medical School, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Ankara University Medical School, Ankara</wicri:regionArea></affiliation></author><author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name><affiliation wicri:level="1"><nlm:affiliation>Hopital La Miletrie, CHU Poitiers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital La Miletrie, CHU Poitiers</wicri:regionArea></affiliation></author><author><name sortKey="Davila, Julio" sort="Davila, Julio" uniqKey="Davila J" first="Julio" last="Davila">Julio Davila</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario de Salamanca, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario de Salamanca, Salamanca</wicri:regionArea></affiliation></author><author><name sortKey="Badros, Ashraf" sort="Badros, Ashraf" uniqKey="Badros A" first="Ashraf" last="Badros">Ashraf Badros</name><affiliation wicri:level="2"><nlm:affiliation>University of Maryland Medical Center, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>University of Maryland Medical Center, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Aneja, Ekta" sort="Aneja, Ekta" uniqKey="Aneja E" first="Ekta" last="Aneja">Ekta Aneja</name><affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea></affiliation></author><author><name sortKey="Abildgaard, Niels" sort="Abildgaard, Niels" uniqKey="Abildgaard N" first="Niels" last="Abildgaard">Niels Abildgaard</name><affiliation wicri:level="1"><nlm:affiliation>Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Odense University Hospital, Odense</wicri:regionArea></affiliation></author><author><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name><affiliation wicri:level="1"><nlm:affiliation>National and Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>National and Kapodistrian University of Athens, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Fantl, Dorotea" sort="Fantl, Dorotea" uniqKey="Fantl D" first="Dorotea" last="Fantl">Dorotea Fantl</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital Italiano de Buenos Aires, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Schutz, Natalia" sort="Schutz, Natalia" uniqKey="Schutz N" first="Natalia" last="Schutz">Natalia Schutz</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital Italiano de Buenos Aires, Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Pika, Tomas" sort="Pika, Tomas" uniqKey="Pika T" first="Tomas" last="Pika">Tomas Pika</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Olomouc, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital Olomouc, Olomouc</wicri:regionArea></affiliation></author><author><name sortKey="Butrym, Aleksandra" sort="Butrym, Aleksandra" uniqKey="Butrym A" first="Aleksandra" last="Butrym">Aleksandra Butrym</name><affiliation wicri:level="1"><nlm:affiliation>Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea></affiliation></author><author><name sortKey="Olszewska Szopa, Magdalena" sort="Olszewska Szopa, Magdalena" uniqKey="Olszewska Szopa M" first="Magdalena" last="Olszewska-Szopa">Magdalena Olszewska-Szopa</name><affiliation wicri:level="1"><nlm:affiliation>Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea></affiliation></author><author><name sortKey="Usnarska Zubkiewicz, Lidia" sort="Usnarska Zubkiewicz, Lidia" uniqKey="Usnarska Zubkiewicz L" first="Lidia" last="Usnarska-Zubkiewicz">Lidia Usnarska-Zubkiewicz</name><affiliation wicri:level="1"><nlm:affiliation>Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea></affiliation></author><author><name sortKey="Usmani, Saad Z" sort="Usmani, Saad Z" uniqKey="Usmani S" first="Saad Z" last="Usmani">Saad Z. Usmani</name><affiliation wicri:level="2"><nlm:affiliation>Levine Cancer Institute/Carolinas HealthCare System, Charlotte, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Levine Cancer Institute/Carolinas HealthCare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Nahi, Hareth" sort="Nahi, Hareth" uniqKey="Nahi H" first="Hareth" last="Nahi">Hareth Nahi</name><affiliation wicri:level="1"><nlm:affiliation>Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska University Hospital, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Chim, Chor S" sort="Chim, Chor S" uniqKey="Chim C" first="Chor S" last="Chim">Chor S. Chim</name><affiliation wicri:level="1"><nlm:affiliation>Queen Mary Hospital, University of Hong Kong, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Queen Mary Hospital, University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Shustik, Chaim" sort="Shustik, Chaim" uniqKey="Shustik C" first="Chaim" last="Shustik">Chaim Shustik</name><affiliation wicri:level="1"><nlm:affiliation>Royal Victoria Hospital, McGill University, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Royal Victoria Hospital, McGill University, Montreal</wicri:regionArea></affiliation></author><author><name sortKey="Madry, Krzysztof" sort="Madry, Krzysztof" uniqKey="Madry K" first="Krzysztof" last="Madry">Krzysztof Madry</name><affiliation wicri:level="1"><nlm:affiliation>Medical University, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Medical University, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name><affiliation wicri:level="2"><nlm:affiliation>Columbia University Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Columbia University Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Swiderska, Alina" sort="Swiderska, Alina" uniqKey="Swiderska A" first="Alina" last="Swiderska">Alina Swiderska</name><affiliation wicri:level="1"><nlm:affiliation>Provincial Hospital, Zielona Gora, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Provincial Hospital, Zielona Gora</wicri:regionArea></affiliation></author><author><name sortKey="Helbig, Grzegorz" sort="Helbig, Grzegorz" uniqKey="Helbig G" first="Grzegorz" last="Helbig">Grzegorz Helbig</name><affiliation wicri:level="1"><nlm:affiliation>Silesian Medical University, Katowice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Silesian Medical University, Katowice</wicri:regionArea></affiliation></author><author><name sortKey="Guzicka Kazimierczak, Renata" sort="Guzicka Kazimierczak, Renata" uniqKey="Guzicka Kazimierczak R" first="Renata" last="Guzicka-Kazimierczak">Renata Guzicka-Kazimierczak</name><affiliation wicri:level="1"><nlm:affiliation>Pomeranian Medical University, Szczecin, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Lendvai, Nikoletta" sort="Lendvai, Nikoletta" uniqKey="Lendvai N" first="Nikoletta" last="Lendvai">Nikoletta Lendvai</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan-Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Memorial Sloan-Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name><affiliation wicri:level="1"><nlm:affiliation>Norwegian University of Science and Technology, Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Norwegian University of Science and Technology, Trondheim</wicri:regionArea></affiliation></author><author><name sortKey="Andersen, Kristian T" sort="Andersen, Kristian T" uniqKey="Andersen K" first="Kristian T" last="Andersen">Kristian T. Andersen</name><affiliation wicri:level="1"><nlm:affiliation>Vejle Hospital, Vejle, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Vejle Hospital, Vejle</wicri:regionArea></affiliation></author><author><name sortKey="Murakami, Hirokazu" sort="Murakami, Hirokazu" uniqKey="Murakami H" first="Hirokazu" last="Murakami">Hirokazu Murakami</name><affiliation wicri:level="1"><nlm:affiliation>Gunma University Graduate School of Health Sciences, Gunma, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Gunma University Graduate School of Health Sciences, Gunma</wicri:regionArea></affiliation></author><author><name sortKey="Zweegman, Sonja" sort="Zweegman, Sonja" uniqKey="Zweegman S" first="Sonja" last="Zweegman">Sonja Zweegman</name><affiliation wicri:level="1"><nlm:affiliation>VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Castillo, Jorge J" sort="Castillo, Jorge J" uniqKey="Castillo J" first="Jorge J" last="Castillo">Jorge J. Castillo</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Harvard Medical School, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">American journal of hematology</title><idno type="eISSN">1096-8652</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antineoplastic Agents (therapeutic use)</term><term>Central Nervous System Neoplasms (diagnosis)</term><term>Central Nervous System Neoplasms (mortality)</term><term>Central Nervous System Neoplasms (secondary)</term><term>Central Nervous System Neoplasms (therapy)</term><term>Chromosome Aberrations</term><term>Combined Modality Therapy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple Myeloma (complications)</term><term>Multiple Myeloma (mortality)</term><term>Multiple Myeloma (pathology)</term><term>Multiple Myeloma (therapy)</term><term>Prognosis</term><term>Radiotherapy</term><term>Retrospective Studies</term><term>Survival Analysis</term><term>Survival Rate</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aberrations des chromosomes</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Antinéoplasiques (usage thérapeutique)</term><term>Association thérapeutique</term><term>Femelle</term><term>Humains</term><term>Myélome multiple ()</term><term>Myélome multiple (anatomopathologie)</term><term>Myélome multiple (mortalité)</term><term>Mâle</term><term>Pronostic</term><term>Radiothérapie</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>Tumeurs du système nerveux central ()</term><term>Tumeurs du système nerveux central (diagnostic)</term><term>Tumeurs du système nerveux central (mortalité)</term><term>Tumeurs du système nerveux central (secondaire)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Myélome multiple</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Central Nervous System Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tumeurs du système nerveux central</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Central Nervous System Neoplasms</term><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Myélome multiple</term><term>Tumeurs du système nerveux central</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du système nerveux central</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Central Nervous System Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Central Nervous System Neoplasms</term><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chromosome Aberrations</term><term>Combined Modality Therapy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Radiotherapy</term><term>Retrospective Studies</term><term>Survival Analysis</term><term>Survival Rate</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aberrations des chromosomes</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Association thérapeutique</term><term>Femelle</term><term>Humains</term><term>Myélome multiple</term><term>Mâle</term><term>Pronostic</term><term>Radiothérapie</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>Tumeurs du système nerveux central</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of patients with multiple myeloma (MM) involving the central nervous system (CNS). Univariate and multivariate analyses were performed to identify prognostic factors for survival. The median time from MM diagnosis to CNS MM diagnosis was 3 years. Thirty-eight patients (22%) were diagnosed with CNS involvement at the time of initial MM diagnosis and 134 (78%) at relapse/progression. Upon diagnosis of CNS MM, 97% patients received initial therapy for CNS disease, of which 76% received systemic therapy, 36% radiotherapy and 32% intrathecal therapy. After a median follow-up of 3.5 years, the median overall survival (OS) from the onset of CNS involvement for the entire group was 7 months. Untreated and treated patients had median OS of 2 and 8 months, respectively (P < 0.001). At least one previous line of therapy for MM before the diagnosis of CNS disease and >1 cytogenetic abnormality detected by FISH were independently associated with worse OS. The median OS for patients with 0, 1 and 2 of these risk factors were 25 months, 5.5 months and 2 months, respectively (P < 0.001). Neurological manifestations, not considered chemotherapy-related, observed at any time after initial diagnosis of MM should raise a suspicion of CNS involvement. Although prognosis is generally poor, the survival of previously untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy. Am. J. Hematol. 91:575-580, 2016. © 2016 Wiley Periodicals, Inc.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26955792</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>17</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>23</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-8652</ISSN><JournalIssue CitedMedium="Internet"><Volume>91</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>American journal of hematology</Title><ISOAbbreviation>Am. J. Hematol.</ISOAbbreviation></Journal><ArticleTitle>Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice.</ArticleTitle><Pagination><MedlinePgn>575-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ajh.24351</ELocationID><Abstract><AbstractText>The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of patients with multiple myeloma (MM) involving the central nervous system (CNS). Univariate and multivariate analyses were performed to identify prognostic factors for survival. The median time from MM diagnosis to CNS MM diagnosis was 3 years. Thirty-eight patients (22%) were diagnosed with CNS involvement at the time of initial MM diagnosis and 134 (78%) at relapse/progression. Upon diagnosis of CNS MM, 97% patients received initial therapy for CNS disease, of which 76% received systemic therapy, 36% radiotherapy and 32% intrathecal therapy. After a median follow-up of 3.5 years, the median overall survival (OS) from the onset of CNS involvement for the entire group was 7 months. Untreated and treated patients had median OS of 2 and 8 months, respectively (P < 0.001). At least one previous line of therapy for MM before the diagnosis of CNS disease and >1 cytogenetic abnormality detected by FISH were independently associated with worse OS. The median OS for patients with 0, 1 and 2 of these risk factors were 25 months, 5.5 months and 2 months, respectively (P < 0.001). Neurological manifestations, not considered chemotherapy-related, observed at any time after initial diagnosis of MM should raise a suspicion of CNS involvement. Although prognosis is generally poor, the survival of previously untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy. Am. J. Hematol. 91:575-580, 2016. © 2016 Wiley Periodicals, Inc.</AbstractText><CopyrightInformation>© 2016 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jurczyszyn</LastName><ForeName>Artur</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Jagiellonian University Medical College, Cracow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grzasko</LastName><ForeName>Norbert</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Hematology, St. John's Cancer Center, Lublin, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gozzetti</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Azienda Ospedaliera Universitaria Senese, Siena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czepiel</LastName><ForeName>Jacek</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Jagiellonian University Medical College, Cracow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerase</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Azienda Ospedaliera Universitaria Senese, Siena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hungria</LastName><ForeName>Vania</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crusoe</LastName><ForeName>Edvan</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silva Dias</LastName><ForeName>Ana Luiza Miranda</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Santa Casa Medical School, Sao Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vij</LastName><ForeName>Ravi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Washington University School of Medicine, St. Louis, Missouri.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiala</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Washington University School of Medicine, St. Louis, Missouri.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caers</LastName><ForeName>Jo</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Liege, Liege, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rasche</LastName><ForeName>Leo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>University Hospital Wuerzburg, Wuerzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nooka</LastName><ForeName>Ajay K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Winship Cancer Institute, Emory University, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lonial</LastName><ForeName>Sagar</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Winship Cancer Institute, Emory University, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vesole</LastName><ForeName>David H</ForeName><Initials>DH</Initials><AffiliationInfo><Affiliation>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington, DC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Philip</LastName><ForeName>Sandhya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>John Theurer Cancer Center at Hackensack UMC, New Jersey and Georgetown University, Washington, DC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gangatharan</LastName><ForeName>Shane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Fremantle Hospital, Fremantle, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Druzd-Sitek</LastName><ForeName>Agnieszka</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walewski</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corso</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cocito</LastName><ForeName>Federica</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vekemans</LastName><ForeName>Marie-Christine M</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Cliniques Universitaires Saint-Luc, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atilla</LastName><ForeName>Erden</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Ankara University Medical School, Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beksac</LastName><ForeName>Meral</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Ankara University Medical School, Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leleu</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Hopital La Miletrie, CHU Poitiers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davila</LastName><ForeName>Julio</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Universitario de Salamanca, Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Badros</LastName><ForeName>Ashraf</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Maryland Medical Center, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aneja</LastName><ForeName>Ekta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Weill Cornell Medical College, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abildgaard</LastName><ForeName>Niels</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kastritis</LastName><ForeName>Efstathios</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>National and Kapodistrian University of Athens, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fantl</LastName><ForeName>Dorotea</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schutz</LastName><ForeName>Natalia</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pika</LastName><ForeName>Tomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>University Hospital Olomouc, Olomouc, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butrym</LastName><ForeName>Aleksandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Wroclaw Medical University, Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olszewska-Szopa</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Wroclaw Medical University, Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Usnarska-Zubkiewicz</LastName><ForeName>Lidia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Wroclaw Medical University, Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Usmani</LastName><ForeName>Saad Z</ForeName><Initials>SZ</Initials><AffiliationInfo><Affiliation>Levine Cancer Institute/Carolinas HealthCare System, Charlotte, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nahi</LastName><ForeName>Hareth</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chim</LastName><ForeName>Chor S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Queen Mary Hospital, University of Hong Kong, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shustik</LastName><ForeName>Chaim</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Royal Victoria Hospital, McGill University, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madry</LastName><ForeName>Krzysztof</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medical University, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lentzsch</LastName><ForeName>Suzanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Columbia University Medical Center, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Swiderska</LastName><ForeName>Alina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Provincial Hospital, Zielona Gora, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helbig</LastName><ForeName>Grzegorz</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Silesian Medical University, Katowice, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guzicka-Kazimierczak</LastName><ForeName>Renata</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Pomeranian Medical University, Szczecin, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lendvai</LastName><ForeName>Nikoletta</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Memorial Sloan-Kettering Cancer Center, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waage</LastName><ForeName>Anders</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Norwegian University of Science and Technology, Trondheim, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andersen</LastName><ForeName>Kristian T</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>Vejle Hospital, Vejle, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murakami</LastName><ForeName>Hirokazu</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Gunma University Graduate School of Health Sciences, Gunma, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zweegman</LastName><ForeName>Sonja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>VU University Medical Center, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castillo</LastName><ForeName>Jorge J</ForeName><Initials>JJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9490-7532</Identifier><AffiliationInfo><Affiliation>Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 CA008748</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Hematol</MedlineTA><NlmUniqueID>7610369</NlmUniqueID><ISSNLinking>0361-8609</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Neurol Sci. 2014 Dec 15;347(1-2):359-60</RefSource><PMID Version="1">25456462</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Neurosci. 2010 Aug;17(8):1071-2</RefSource><PMID Version="1">20488713</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Haematol. 2006 Apr;76(4):358-9</RefSource><PMID Version="1">16519710</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 2002 Apr;117(1):103-8</RefSource><PMID Version="1">11918539</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Imaging. 2015 Mar-Apr;39(2):213-9</RefSource><PMID Version="1">25547625</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurooncol. 2012 May;107(3):659-63</RefSource><PMID Version="1">22249693</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Exp Hematop. 2014;54(2):129-36</RefSource><PMID Version="1">25318945</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 2006 Apr;104(4):608-10</RefSource><PMID Version="1">16619666</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Leuk Lymphoma. 2013 Apr;54(4):864-6</RefSource><PMID Version="1">22880953</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Leuk Lymphoma. 2000 Dec;40(1-2):219-20</RefSource><PMID Version="1">11426625</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cent Nerv Syst Agents Med Chem. 2014;14(1):23-7</RefSource><PMID Version="1">25134940</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Neurosci. 2006 Jan;13(1):122-3</RefSource><PMID Version="1">16410212</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 2013 Aug;162(3):371-5</RefSource><PMID Version="1">23718539</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2004 Sep;61(9):1423-9</RefSource><PMID Version="1">15364689</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 2013 Aug;162(4):483-8</RefSource><PMID Version="1">23772701</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hematol Oncol. 2016 Mar;34(1):2-8</RefSource><PMID Version="1">25524637</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Haematol. 2003 Mar;70(3):198-9</RefSource><PMID Version="1">12605668</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroradiology. 2008 Aug;50(8):665-74</RefSource><PMID Version="1">18516599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Leuk Lymphoma. 2004 Feb;45(2):291-300</RefSource><PMID Version="1">15101714</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Haematol. 2014;92(5):454-5</RefSource><PMID Version="1">24330308</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vojnosanit Pregl. 2012 Feb;69(2):209-13</RefSource><PMID Version="1">22500379</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Haematol. 2008 Jan;80(1):1-9</RefSource><PMID Version="1">17961180</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Przegl Lek. 2014;71(4):221-30</RefSource><PMID Version="1">25141582</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer. 2008 Apr 1;112(7):1562-7</RefSource><PMID Version="1">18260094</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Haematol. 2004 Nov;127(3):280-4</RefSource><PMID Version="1">15491286</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer. 2012 Mar 15;118(6):1574-84</RefSource><PMID Version="1">21932386</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Leuk Lymphoma. 2005 May;46(5):737-41</RefSource><PMID Version="1">16019512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hematol. 1999 Dec;62(4):228-33</RefSource><PMID Version="1">10589078</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Lymphoma Myeloma Leuk. 2010 Jun;10(3):220-3</RefSource><PMID Version="1">20511169</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Oncol. 2010 Feb;21(2):325-30</RefSource><PMID Version="1">19633044</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Lymphoma Myeloma Leuk. 2014 Jun;14(3):211-4</RefSource><PMID Version="1">24373936</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016543" MajorTopicYN="N">Central Nervous System Neoplasms</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000556" MajorTopicYN="N">secondary</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002869" MajorTopicYN="N">Chromosome Aberrations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009101" MajorTopicYN="N">Multiple Myeloma</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011878" MajorTopicYN="N">Radiotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>11</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26955792</ArticleId><ArticleId IdType="doi">10.1002/ajh.24351</ArticleId><ArticleId IdType="pmc">PMC5502095</ArticleId><ArticleId IdType="mid">NIHMS864615</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D94 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001D94 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:26955792
|texte= Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:26955792" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |