Influence of the overall stiffness of a load-bearing porous titanium implant on bone ingrowth in critical-size mandibular bone defects in sheep.
Identifieur interne : 001D13 ( PubMed/Curation ); précédent : 001D12; suivant : 001D14Influence of the overall stiffness of a load-bearing porous titanium implant on bone ingrowth in critical-size mandibular bone defects in sheep.
Auteurs : T. Schouman [France] ; M. Schmitt [France] ; C. Adam [Australie] ; G. Dubois [France] ; P. Rouch [France]Source :
- Journal of the mechanical behavior of biomedical materials [ 1878-0180 ] ; 2016.
Abstract
The aim of this work was to assess the influence of reduction of the apparent mechanical properties of fully load-bearing porous titanium implants used in mandibular bone defects. Segmental 18mm long bone defects were created bilaterally in the lower jaws of adult ewes. One group of 6 ewes (group A) was treated with load-bearing 'rigid' (high stiffness) porous implants on the right side, and with control on the left side. A second group of 6 ewes (group B) was treated with 'flexible' porous and control implants exhibiting apparent mechanical properties ten times lower than the rigid implants. The mechanical behavior of the reconstructed hemi-mandibles was assessed by cantilever testing and bone ingrowth into the segmental defects was assessed by BV/TV measurement within the implant using micro-CT 12 weeks after implantation. A significantly higher rigidity was identified for porous implants compared with control implants at the anterior interface in group B. BV/TV of porous implants was significantly higher than that of control implants in group A. BV/TV differences were significant between porous and control implants in group B and were homogeneous along the main axis. Significantly higher BV/TV was identified in most sub-volumes of group B porous implants compared with group A. This work highlights the critical importance of the tuning of scaffolds to promote bone ingrowth with reference to the local strains occurring within the porous scaffold, which in this application was achieved using fully load-bearing low-stiffness porous titanium implants.
DOI: 10.1016/j.jmbbm.2016.02.036
PubMed: 26999620
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Schouman</name><affiliation wicri:level="1"><nlm:affiliation>APHP-Pitie Salpetriere University Hospital, Department of Oral and Maxillofacial Surgery, Paris, France; Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris, France. Electronic address: thomas.schouman@aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHP-Pitie Salpetriere University Hospital, Department of Oral and Maxillofacial Surgery, Paris, France; Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Schmitt, M" sort="Schmitt, M" uniqKey="Schmitt M" first="M" last="Schmitt">M. Schmitt</name><affiliation wicri:level="1"><nlm:affiliation>Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris, France; OBL, Chatillon, France. 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Rouch</name><affiliation wicri:level="1"><nlm:affiliation>Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris, France. Electronic address: philippe.rouch@ensam.eu.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of the mechanical behavior of biomedical materials</title><idno type="eISSN">1878-0180</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this work was to assess the influence of reduction of the apparent mechanical properties of fully load-bearing porous titanium implants used in mandibular bone defects. Segmental 18mm long bone defects were created bilaterally in the lower jaws of adult ewes. One group of 6 ewes (group A) was treated with load-bearing 'rigid' (high stiffness) porous implants on the right side, and with control on the left side. A second group of 6 ewes (group B) was treated with 'flexible' porous and control implants exhibiting apparent mechanical properties ten times lower than the rigid implants. The mechanical behavior of the reconstructed hemi-mandibles was assessed by cantilever testing and bone ingrowth into the segmental defects was assessed by BV/TV measurement within the implant using micro-CT 12 weeks after implantation. A significantly higher rigidity was identified for porous implants compared with control implants at the anterior interface in group B. BV/TV of porous implants was significantly higher than that of control implants in group A. BV/TV differences were significant between porous and control implants in group B and were homogeneous along the main axis. Significantly higher BV/TV was identified in most sub-volumes of group B porous implants compared with group A. This work highlights the critical importance of the tuning of scaffolds to promote bone ingrowth with reference to the local strains occurring within the porous scaffold, which in this application was achieved using fully load-bearing low-stiffness porous titanium implants.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">26999620</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>07</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-0180</ISSN><JournalIssue CitedMedium="Internet"><Volume>59</Volume><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of the mechanical behavior of biomedical materials</Title><ISOAbbreviation>J Mech Behav Biomed Mater</ISOAbbreviation></Journal><ArticleTitle>Influence of the overall stiffness of a load-bearing porous titanium implant on bone ingrowth in critical-size mandibular bone defects in sheep.</ArticleTitle><Pagination><MedlinePgn>484-496</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1751-6161(16)30009-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jmbbm.2016.02.036</ELocationID><Abstract><AbstractText>The aim of this work was to assess the influence of reduction of the apparent mechanical properties of fully load-bearing porous titanium implants used in mandibular bone defects. Segmental 18mm long bone defects were created bilaterally in the lower jaws of adult ewes. One group of 6 ewes (group A) was treated with load-bearing 'rigid' (high stiffness) porous implants on the right side, and with control on the left side. A second group of 6 ewes (group B) was treated with 'flexible' porous and control implants exhibiting apparent mechanical properties ten times lower than the rigid implants. The mechanical behavior of the reconstructed hemi-mandibles was assessed by cantilever testing and bone ingrowth into the segmental defects was assessed by BV/TV measurement within the implant using micro-CT 12 weeks after implantation. A significantly higher rigidity was identified for porous implants compared with control implants at the anterior interface in group B. BV/TV of porous implants was significantly higher than that of control implants in group A. BV/TV differences were significant between porous and control implants in group B and were homogeneous along the main axis. Significantly higher BV/TV was identified in most sub-volumes of group B porous implants compared with group A. This work highlights the critical importance of the tuning of scaffolds to promote bone ingrowth with reference to the local strains occurring within the porous scaffold, which in this application was achieved using fully load-bearing low-stiffness porous titanium implants.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schouman</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>APHP-Pitie Salpetriere University Hospital, Department of Oral and Maxillofacial Surgery, Paris, France; Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris, France. Electronic address: thomas.schouman@aphp.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris, France; OBL, Chatillon, France. Electronic address: m.schmitt@oblparis.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adam</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Paediatric Spine Research Group, School of Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, Australia. Electronic address: c.adam@qut.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubois</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris, France; OBL, Chatillon, France. Electronic address: g.dubois@oblparis.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouch</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Arts et Metiers ParisTech, LBM/Institut de Biomecanique Humaine Georges Charpak, Paris, France. Electronic address: philippe.rouch@ensam.eu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Mech Behav Biomed Mater</MedlineTA><NlmUniqueID>101322406</NlmUniqueID><ISSNLinking>1878-0180</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bone substitute</Keyword><Keyword MajorTopicYN="N">Bone tissue engineering</Keyword><Keyword MajorTopicYN="N">Large animal model</Keyword><Keyword MajorTopicYN="N">Mandibular reconstruction</Keyword><Keyword MajorTopicYN="N">Porous titanium scaffold</Keyword><Keyword MajorTopicYN="N">Sheep</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>11</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>02</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26999620</ArticleId><ArticleId IdType="pii">S1751-6161(16)30009-1</ArticleId><ArticleId IdType="doi">10.1016/j.jmbbm.2016.02.036</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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