GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.
Identifieur interne : 001C77 ( PubMed/Curation ); précédent : 001C76; suivant : 001C78GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.
Auteurs : Julien Averous [France] ; Sarah Lambert-Langlais [France] ; Florent Mesclon [France] ; Valérie Carraro [France] ; Laurent Parry [France] ; Céline Jousse [France] ; Alain Bruhat [France] ; Anne-Catherine Maurin [France] ; Philippe Pierre [France] ; Christopher G. Proud [Australie] ; Pierre Fafournoux [France]Source :
- Scientific reports [ 2045-2322 ] ; 2016.
Abstract
It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid availability relies on the capacity of GCN2 to sense the increased levels of uncharged tRNAs upon amino acid scarcity. In contrast, despite recent progress in the understanding of the regulation of mTORC1 by amino acids, key aspects of this process remain unsolved. In particular, while leucine is well known to be a potent regulator of mTORC1, the mechanisms by which this amino acid is sensed and control mTORC1 activity are not well defined. Our data establish that GCN2 is involved in the inhibition of mTORC1 upon leucine or arginine deprivation. However, the activation of GCN2 alone is not sufficient to inhibit mTORC1 activity, indicating that leucine and arginine exert regulation via additional mechanisms. While the mechanism by which GCN2 contributes to the initial step of mTORC1 inhibition involves the phosphorylation of eIF2α, we show that it is independent of the downstream transcription factor ATF4. These data point to a novel role for GCN2 and phosphorylation of eIF2α in the control of mTORC1 by certain amino acids.
DOI: 10.1038/srep27698
PubMed: 27297692
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001D01
Links to Exploration step
pubmed:27297692Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.</title><author><name sortKey="Averous, Julien" sort="Averous, Julien" uniqKey="Averous J" first="Julien" last="Averous">Julien Averous</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Lambert Langlais, Sarah" sort="Lambert Langlais, Sarah" uniqKey="Lambert Langlais S" first="Sarah" last="Lambert-Langlais">Sarah Lambert-Langlais</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Mesclon, Florent" sort="Mesclon, Florent" uniqKey="Mesclon F" first="Florent" last="Mesclon">Florent Mesclon</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Carraro, Valerie" sort="Carraro, Valerie" uniqKey="Carraro V" first="Valérie" last="Carraro">Valérie Carraro</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Parry, Laurent" sort="Parry, Laurent" uniqKey="Parry L" first="Laurent" last="Parry">Laurent Parry</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Jousse, Celine" sort="Jousse, Celine" uniqKey="Jousse C" first="Céline" last="Jousse">Céline Jousse</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Bruhat, Alain" sort="Bruhat, Alain" uniqKey="Bruhat A" first="Alain" last="Bruhat">Alain Bruhat</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Maurin, Anne Catherine" sort="Maurin, Anne Catherine" uniqKey="Maurin A" first="Anne-Catherine" last="Maurin">Anne-Catherine Maurin</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Pierre, Philippe" sort="Pierre, Philippe" uniqKey="Pierre P" first="Philippe" last="Pierre">Philippe Pierre</name><affiliation wicri:level="1"><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Proud, Christopher G" sort="Proud, Christopher G" uniqKey="Proud C" first="Christopher G" last="Proud">Christopher G. Proud</name><affiliation wicri:level="1"><nlm:affiliation>Nutrition and Metabolism, South Australian Health &Medical Research Institute, PO Box 11060, Adelaide, SA5001, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Nutrition and Metabolism, South Australian Health &Medical Research Institute, PO Box 11060, Adelaide, SA5001</wicri:regionArea></affiliation></author><author><name sortKey="Fafournoux, Pierre" sort="Fafournoux, Pierre" uniqKey="Fafournoux P" first="Pierre" last="Fafournoux">Pierre Fafournoux</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27297692</idno><idno type="pmid">27297692</idno><idno type="doi">10.1038/srep27698</idno><idno type="wicri:Area/PubMed/Corpus">001D01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D01</idno><idno type="wicri:Area/PubMed/Curation">001C77</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.</title><author><name sortKey="Averous, Julien" sort="Averous, Julien" uniqKey="Averous J" first="Julien" last="Averous">Julien Averous</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Lambert Langlais, Sarah" sort="Lambert Langlais, Sarah" uniqKey="Lambert Langlais S" first="Sarah" last="Lambert-Langlais">Sarah Lambert-Langlais</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Mesclon, Florent" sort="Mesclon, Florent" uniqKey="Mesclon F" first="Florent" last="Mesclon">Florent Mesclon</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Carraro, Valerie" sort="Carraro, Valerie" uniqKey="Carraro V" first="Valérie" last="Carraro">Valérie Carraro</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Parry, Laurent" sort="Parry, Laurent" uniqKey="Parry L" first="Laurent" last="Parry">Laurent Parry</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Jousse, Celine" sort="Jousse, Celine" uniqKey="Jousse C" first="Céline" last="Jousse">Céline Jousse</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Bruhat, Alain" sort="Bruhat, Alain" uniqKey="Bruhat A" first="Alain" last="Bruhat">Alain Bruhat</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Maurin, Anne Catherine" sort="Maurin, Anne Catherine" uniqKey="Maurin A" first="Anne-Catherine" last="Maurin">Anne-Catherine Maurin</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author><author><name sortKey="Pierre, Philippe" sort="Pierre, Philippe" uniqKey="Pierre P" first="Philippe" last="Pierre">Philippe Pierre</name><affiliation wicri:level="1"><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Proud, Christopher G" sort="Proud, Christopher G" uniqKey="Proud C" first="Christopher G" last="Proud">Christopher G. Proud</name><affiliation wicri:level="1"><nlm:affiliation>Nutrition and Metabolism, South Australian Health &Medical Research Institute, PO Box 11060, Adelaide, SA5001, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Nutrition and Metabolism, South Australian Health &Medical Research Institute, PO Box 11060, Adelaide, SA5001</wicri:regionArea></affiliation></author><author><name sortKey="Fafournoux, Pierre" sort="Fafournoux, Pierre" uniqKey="Fafournoux P" first="Pierre" last="Fafournoux">Pierre Fafournoux</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid availability relies on the capacity of GCN2 to sense the increased levels of uncharged tRNAs upon amino acid scarcity. In contrast, despite recent progress in the understanding of the regulation of mTORC1 by amino acids, key aspects of this process remain unsolved. In particular, while leucine is well known to be a potent regulator of mTORC1, the mechanisms by which this amino acid is sensed and control mTORC1 activity are not well defined. Our data establish that GCN2 is involved in the inhibition of mTORC1 upon leucine or arginine deprivation. However, the activation of GCN2 alone is not sufficient to inhibit mTORC1 activity, indicating that leucine and arginine exert regulation via additional mechanisms. While the mechanism by which GCN2 contributes to the initial step of mTORC1 inhibition involves the phosphorylation of eIF2α, we show that it is independent of the downstream transcription factor ATF4. These data point to a novel role for GCN2 and phosphorylation of eIF2α in the control of mTORC1 by certain amino acids.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27297692</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>14</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><PubDate><Year>2016</Year><Month>Jun</Month><Day>14</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.</ArticleTitle><Pagination><MedlinePgn>27698</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/srep27698</ELocationID><Abstract><AbstractText>It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid availability relies on the capacity of GCN2 to sense the increased levels of uncharged tRNAs upon amino acid scarcity. In contrast, despite recent progress in the understanding of the regulation of mTORC1 by amino acids, key aspects of this process remain unsolved. In particular, while leucine is well known to be a potent regulator of mTORC1, the mechanisms by which this amino acid is sensed and control mTORC1 activity are not well defined. Our data establish that GCN2 is involved in the inhibition of mTORC1 upon leucine or arginine deprivation. However, the activation of GCN2 alone is not sufficient to inhibit mTORC1 activity, indicating that leucine and arginine exert regulation via additional mechanisms. While the mechanism by which GCN2 contributes to the initial step of mTORC1 inhibition involves the phosphorylation of eIF2α, we show that it is independent of the downstream transcription factor ATF4. These data point to a novel role for GCN2 and phosphorylation of eIF2α in the control of mTORC1 by certain amino acids.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Averous</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lambert-Langlais</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mesclon</LastName><ForeName>Florent</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carraro</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parry</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jousse</LastName><ForeName>Céline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruhat</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maurin</LastName><ForeName>Anne-Catherine</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pierre</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, U2M, 13288 Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM, U1104, 13288 Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, UMR 7280, 13288 Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Research in Biomedicine - iBiMED and Aveiro Health Sciences Program, University of Aveiro, 3810-193 Aveiro, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Proud</LastName><ForeName>Christopher G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Nutrition and Metabolism, South Australian Health &Medical Research Institute, PO Box 11060, Adelaide, SA5001, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Biological Sciences, University of Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fafournoux</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019 Nutrition Humaine, Centre de Clermont-Ferrand-Theix, F-63122 Saint Genès Champanelle, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Clermont 1, UFR Médecine, UMR 1019 Nutrition Humaine, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>06</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Eur J Biochem. 1999 Oct;265(2):754-62</RefSource><PMID Version="1">10504407</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2014 Feb 13;156(4):786-99</RefSource><PMID Version="1">24529380</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1998 Jun 5;273(23):14484-94</RefSource><PMID Version="1">9603962</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2005 Nov 18;123(4):569-80</RefSource><PMID Version="1">16286006</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2003 Mar;11(3):619-33</RefSource><PMID Version="1">12667446</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Signal. 2013 Dec;25(12):2709-16</RefSource><PMID Version="1">24018049</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2014 Nov 10;26(5):754-69</RefSource><PMID Version="1">25446900</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2000 Aug;6(2):269-79</RefSource><PMID Version="1">10983975</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1432-7</RefSource><PMID Version="1">9465032</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2004 Aug 27;279(35):36553-61</RefSource><PMID Version="1">15213227</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2016 May 17;35(10 ):1058-76</RefSource><PMID Version="1">26988032</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2002 Jul 5;277(27):24120-7</RefSource><PMID Version="1">11960987</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2015 Nov 15;29(22):2331-6</RefSource><PMID Version="1">26543160</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2012 Aug 10;47(3):349-58</RefSource><PMID Version="1">22749528</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2000 Nov;6(5):1099-108</RefSource><PMID Version="1">11106749</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2015 Mar 26;519(7544):477-81</RefSource><PMID Version="1">25561175</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Res. 2016 Jan;26(1):7-20</RefSource><PMID Version="1">26658722</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2001 Jun;7(6):1165-76</RefSource><PMID Version="1">11430820</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2013 Sep;41(16):7683-99</RefSource><PMID Version="1">23804767</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11269-74</RefSource><PMID Version="1">15277680</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2014 Nov 14;289(46):31827-36</RefSource><PMID Version="1">25246524</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Diabetes. 2011 Mar;60(3):746-56</RefSource><PMID Version="1">21282364</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2010 Apr 16;141(2):290-303</RefSource><PMID Version="1">20381137</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2016 Jan 1;351(6268):43-8</RefSource><PMID Version="1">26449471</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2015 Jan 9;347(6218):188-94</RefSource><PMID Version="1">25567906</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2007 Oct;81(20):11106-15</RefSource><PMID Version="1">17670836</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1972 Jun 25;247(12):3854-7</RefSource><PMID Version="1">4338230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 2003 Jun 1;372(Pt 2):555-66</RefSource><PMID Version="1">12611592</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2000 Sep 22;275(38):29900-6</RefSource><PMID Version="1">10893413</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 2007 Feb 15;402(1):163-73</RefSource><PMID Version="1">17042743</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Signal. 2014 Sep;26(9):1918-27</RefSource><PMID Version="1">24793303</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2009 Dec;29(24):6515-26</RefSource><PMID Version="1">19822663</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol. 1998 Jan;274(1 Pt 1):C206-13</RefSource><PMID Version="1">9458729</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2012 Apr 13;149(2):410-24</RefSource><PMID Version="1">22424946</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):67-73</RefSource><PMID Version="1">26560525</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2002 Jul 26;110(2):163-75</RefSource><PMID Version="1">12150925</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4843-8</RefSource><PMID Version="1">12655043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2008 Jun 13;320(5882):1496-501</RefSource><PMID Version="1">18497260</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC4906353</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>12</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27297692</ArticleId><ArticleId IdType="pii">srep27698</ArticleId><ArticleId IdType="doi">10.1038/srep27698</ArticleId><ArticleId IdType="pmc">PMC4906353</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C77 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001C77 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:27297692
|texte= GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27297692" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |