Inflammatory-Related Genetic Variants in Non-Muscle-Invasive Bladder Cancer Prognosis: A Multimarker Bayesian Assessment.
Identifieur interne : 001B67 ( PubMed/Curation ); précédent : 001B66; suivant : 001B68Inflammatory-Related Genetic Variants in Non-Muscle-Invasive Bladder Cancer Prognosis: A Multimarker Bayesian Assessment.
Auteurs : Alexandra Masson-Lecomte [France] ; Evangelina L Pez De Maturana [Espagne] ; Michael E. Goddard [Australie] ; Antoni Picornell [Espagne] ; Marta Rava [Espagne] ; Anna González-Neira [Espagne] ; Mirari Márquez [Espagne] ; Alfredo Carrato [Espagne] ; Adonina Tardon [Espagne] ; Josep Lloreta [Espagne] ; Montserrat Garcia-Closas [Royaume-Uni] ; Debra Silverman [États-Unis] ; Nathaniel Rothman [États-Unis] ; Manolis Kogevinas [Espagne] ; Yves Allory [France] ; Stephen J. Chanock [États-Unis] ; Francisco X. Real [Espagne] ; Núria Malats [Espagne]Source :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1538-7755 ] ; 2016.
Abstract
Increasing evidence points to the role of tumor immunologic environment on urothelial bladder cancer prognosis. This effect might be partly dependent on the host genetic context. We evaluated the association of SNPs in inflammation-related genes with non-muscle-invasive bladder cancer (NMIBC) risk-of-recurrence and risk-of-progression.
DOI: 10.1158/1055-9965.EPI-15-0894
PubMed: 27197286
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inflammatory-Related Genetic Variants in Non-Muscle-Invasive Bladder Cancer Prognosis: A Multimarker Bayesian Assessment.</title><author><name sortKey="Masson Lecomte, Alexandra" sort="Masson Lecomte, Alexandra" uniqKey="Masson Lecomte A" first="Alexandra" last="Masson-Lecomte">Alexandra Masson-Lecomte</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Urology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Urology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="L Pez De Maturana, Evangelina" sort="L Pez De Maturana, Evangelina" uniqKey="L Pez De Maturana E" first="Evangelina" last="L Pez De Maturana">Evangelina L Pez De Maturana</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Goddard, Michael E" sort="Goddard, Michael E" uniqKey="Goddard M" first="Michael E" last="Goddard">Michael E. Goddard</name><affiliation wicri:level="1"><nlm:affiliation>Biosciences Research Division, Department of Environment and Primary Industries, Agribio, Bundoora, Victoria, Australia. Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biosciences Research Division, Department of Environment and Primary Industries, Agribio, Bundoora, Victoria, Australia. Department of Food and Agricultural Systems, University of Melbourne, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Picornell, Antoni" sort="Picornell, Antoni" uniqKey="Picornell A" first="Antoni" last="Picornell">Antoni Picornell</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Rava, Marta" sort="Rava, Marta" uniqKey="Rava M" first="Marta" last="Rava">Marta Rava</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:affiliation>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Marquez, Mirari" sort="Marquez, Mirari" uniqKey="Marquez M" first="Mirari" last="Márquez">Mirari Márquez</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Carrato, Alfredo" sort="Carrato, Alfredo" uniqKey="Carrato A" first="Alfredo" last="Carrato">Alfredo Carrato</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Oncología, Hospital Universitario Ramon y Cajal, Madrid, and Servicio de Oncología, Hospital Universitario de Elche, Elche, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Oncología, Hospital Universitario Ramon y Cajal, Madrid, and Servicio de Oncología, Hospital Universitario de Elche, Elche</wicri:regionArea></affiliation></author><author><name sortKey="Tardon, Adonina" sort="Tardon, Adonina" uniqKey="Tardon A" first="Adonina" last="Tardon">Adonina Tardon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Universidad de Oviedo, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Preventive Medicine, Universidad de Oviedo, Oviedo</wicri:regionArea></affiliation></author><author><name sortKey="Lloreta, Josep" sort="Lloreta, Josep" uniqKey="Lloreta J" first="Josep" last="Lloreta">Josep Lloreta</name><affiliation wicri:level="1"><nlm:affiliation>Institut Municipal d'Investigació Mèdica - Hospital del Mar and Departament de Patologia, Hospital del Mar - IMAS, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut Municipal d'Investigació Mèdica - Hospital del Mar and Departament de Patologia, Hospital del Mar - IMAS, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Silverman, Debra" sort="Silverman, Debra" uniqKey="Silverman D" first="Debra" last="Silverman">Debra Silverman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Environmental Epidemiology (CREAL) and Institut Municipal d'Investigació Mèdica - Hospital del Mar, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL) and Institut Municipal d'Investigació Mèdica - Hospital del Mar, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Allory, Yves" sort="Allory, Yves" uniqKey="Allory Y" first="Yves" last="Allory">Yves Allory</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, INSERM, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pathology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, INSERM, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Real, Francisco X" sort="Real, Francisco X" uniqKey="Real F" first="Francisco X" last="Real">Francisco X. Real</name><affiliation wicri:level="1"><nlm:affiliation>Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. nmalats@cnio.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27197286</idno><idno type="pmid">27197286</idno><idno type="doi">10.1158/1055-9965.EPI-15-0894</idno><idno type="wicri:Area/PubMed/Corpus">001B91</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B91</idno><idno type="wicri:Area/PubMed/Curation">001B67</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inflammatory-Related Genetic Variants in Non-Muscle-Invasive Bladder Cancer Prognosis: A Multimarker Bayesian Assessment.</title><author><name sortKey="Masson Lecomte, Alexandra" sort="Masson Lecomte, Alexandra" uniqKey="Masson Lecomte A" first="Alexandra" last="Masson-Lecomte">Alexandra Masson-Lecomte</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Urology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Urology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="L Pez De Maturana, Evangelina" sort="L Pez De Maturana, Evangelina" uniqKey="L Pez De Maturana E" first="Evangelina" last="L Pez De Maturana">Evangelina L Pez De Maturana</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Goddard, Michael E" sort="Goddard, Michael E" uniqKey="Goddard M" first="Michael E" last="Goddard">Michael E. Goddard</name><affiliation wicri:level="1"><nlm:affiliation>Biosciences Research Division, Department of Environment and Primary Industries, Agribio, Bundoora, Victoria, Australia. Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Biosciences Research Division, Department of Environment and Primary Industries, Agribio, Bundoora, Victoria, Australia. Department of Food and Agricultural Systems, University of Melbourne, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Picornell, Antoni" sort="Picornell, Antoni" uniqKey="Picornell A" first="Antoni" last="Picornell">Antoni Picornell</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Rava, Marta" sort="Rava, Marta" uniqKey="Rava M" first="Marta" last="Rava">Marta Rava</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:affiliation>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Marquez, Mirari" sort="Marquez, Mirari" uniqKey="Marquez M" first="Mirari" last="Márquez">Mirari Márquez</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Carrato, Alfredo" sort="Carrato, Alfredo" uniqKey="Carrato A" first="Alfredo" last="Carrato">Alfredo Carrato</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Oncología, Hospital Universitario Ramon y Cajal, Madrid, and Servicio de Oncología, Hospital Universitario de Elche, Elche, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Oncología, Hospital Universitario Ramon y Cajal, Madrid, and Servicio de Oncología, Hospital Universitario de Elche, Elche</wicri:regionArea></affiliation></author><author><name sortKey="Tardon, Adonina" sort="Tardon, Adonina" uniqKey="Tardon A" first="Adonina" last="Tardon">Adonina Tardon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine, Universidad de Oviedo, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Preventive Medicine, Universidad de Oviedo, Oviedo</wicri:regionArea></affiliation></author><author><name sortKey="Lloreta, Josep" sort="Lloreta, Josep" uniqKey="Lloreta J" first="Josep" last="Lloreta">Josep Lloreta</name><affiliation wicri:level="1"><nlm:affiliation>Institut Municipal d'Investigació Mèdica - Hospital del Mar and Departament de Patologia, Hospital del Mar - IMAS, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut Municipal d'Investigació Mèdica - Hospital del Mar and Departament de Patologia, Hospital del Mar - IMAS, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Silverman, Debra" sort="Silverman, Debra" uniqKey="Silverman D" first="Debra" last="Silverman">Debra Silverman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Environmental Epidemiology (CREAL) and Institut Municipal d'Investigació Mèdica - Hospital del Mar, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Research in Environmental Epidemiology (CREAL) and Institut Municipal d'Investigació Mèdica - Hospital del Mar, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Allory, Yves" sort="Allory, Yves" uniqKey="Allory Y" first="Yves" last="Allory">Yves Allory</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, INSERM, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pathology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, INSERM, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Real, Francisco X" sort="Real, Francisco X" uniqKey="Real F" first="Francisco X" last="Real">Francisco X. Real</name><affiliation wicri:level="1"><nlm:affiliation>Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Núria" last="Malats">Núria Malats</name><affiliation wicri:level="1"><nlm:affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. nmalats@cnio.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="eISSN">1538-7755</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increasing evidence points to the role of tumor immunologic environment on urothelial bladder cancer prognosis. This effect might be partly dependent on the host genetic context. We evaluated the association of SNPs in inflammation-related genes with non-muscle-invasive bladder cancer (NMIBC) risk-of-recurrence and risk-of-progression.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27197286</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-7755</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>7</Issue><PubDate><Year>2016</Year><Month>07</Month></PubDate></JournalIssue><Title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</Title><ISOAbbreviation>Cancer Epidemiol. Biomarkers Prev.</ISOAbbreviation></Journal><ArticleTitle>Inflammatory-Related Genetic Variants in Non-Muscle-Invasive Bladder Cancer Prognosis: A Multimarker Bayesian Assessment.</ArticleTitle><Pagination><MedlinePgn>1144-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/1055-9965.EPI-15-0894</ELocationID><Abstract><AbstractText Label="BACKGROUND">Increasing evidence points to the role of tumor immunologic environment on urothelial bladder cancer prognosis. This effect might be partly dependent on the host genetic context. We evaluated the association of SNPs in inflammation-related genes with non-muscle-invasive bladder cancer (NMIBC) risk-of-recurrence and risk-of-progression.</AbstractText><AbstractText Label="METHODS">We considered 822 NMIBC included in the SBC/EPICURO Study followed-up >10 years. We selected 1,679 SNPs belonging to 251 inflammatory genes. The association of SNPs with risk-of-recurrence and risk-of-progression was assessed using Cox regression single-marker (SMM) and multimarker methods (MMM) Bayes A and Bayesian LASSO. Discriminative abilities of the models were calculated using the c index and validated with bootstrap cross-validation procedures.</AbstractText><AbstractText Label="RESULTS">While no SNP was found to be associated with risk-of-recurrence using SMM, three SNPs in TNIP1, CD5, and JAK3 showed very strong association with posterior probabilities >90% using MMM. Regarding risk-of-progression, one SNP in CD3G was significantly associated using SMM (HR, 2.69; P = 1.55 × 10(-5)) and two SNPs in MASP1 and AIRE, showed a posterior probability ≥80% with MMM. Validated discriminative abilities of the models without and with the SNPs were 58.4% versus 60.5% and 72.1% versus 72.8% for risk-of-recurrence and risk-of-progression, respectively.</AbstractText><AbstractText Label="CONCLUSIONS">Using innovative analytic approaches, we demonstrated that SNPs in inflammatory-related genes were associated with NMIBC prognosis and that they improve the discriminative ability of prognostic clinical models for NMIBC.</AbstractText><AbstractText Label="IMPACT">This study provides proof of concept for the joint effect of genetic variants in improving the discriminative ability of clinical prognostic models. The approach may be extended to other diseases. Cancer Epidemiol Biomarkers Prev; 25(7); 1144-50. ©2016 AACR.</AbstractText><CopyrightInformation>©2016 American Association for Cancer Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Masson-Lecomte</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Urology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López de Maturana</LastName><ForeName>Evangelina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goddard</LastName><ForeName>Michael E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Biosciences Research Division, Department of Environment and Primary Industries, Agribio, Bundoora, Victoria, Australia. Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Picornell</LastName><ForeName>Antoni</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rava</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González-Neira</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Márquez</LastName><ForeName>Mirari</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carrato</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Servicio de Oncología, Hospital Universitario Ramon y Cajal, Madrid, and Servicio de Oncología, Hospital Universitario de Elche, Elche, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tardon</LastName><ForeName>Adonina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, Universidad de Oviedo, Oviedo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lloreta</LastName><ForeName>Josep</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institut Municipal d'Investigació Mèdica - Hospital del Mar and Departament de Patologia, Hospital del Mar - IMAS, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garcia-Closas</LastName><ForeName>Montserrat</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silverman</LastName><ForeName>Debra</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rothman</LastName><ForeName>Nathaniel</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kogevinas</LastName><ForeName>Manolis</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Research in Environmental Epidemiology (CREAL) and Institut Municipal d'Investigació Mèdica - Hospital del Mar, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allory</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Pathology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, INSERM, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chanock</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Real</LastName><ForeName>Francisco X</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malats</LastName><ForeName>Núria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. nmalats@cnio.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>SBC/EPICURO Study Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>N02CP11015</GrantID><Acronym>CP</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>05</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Epidemiol Biomarkers Prev</MedlineTA><NlmUniqueID>9200608</NlmUniqueID><ISSNLinking>1055-9965</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>04</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27197286</ArticleId><ArticleId IdType="pii">1055-9965.EPI-15-0894</ArticleId><ArticleId IdType="doi">10.1158/1055-9965.EPI-15-0894</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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