Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout.
Identifieur interne : 001B23 ( PubMed/Curation ); précédent : 001B22; suivant : 001B24Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout.
Auteurs : Humaira Rasheed [Pakistan] ; Amanda J. Phipps-Green [Nouvelle-Zélande] ; Ruth Topless [Nouvelle-Zélande] ; Malcolm D. Smith ; Catherine Hill [Australie] ; Susan Lester [Australie] ; Maureen Rischmueller [Australie] ; Matthijs Janssen ; Timothy L. Jansen ; Leo A. Joosten [Pays-Bas] ; Timothy R. Radstake [Pays-Bas] ; Philip L. Riches [Royaume-Uni] ; Anne-Kathrin Tausche [Allemagne] ; Frederic Lioté [France] ; Alexander So [Suisse] ; Andre Van Rij ; Gregory T. Jones ; Sally P. Mccormick [Nouvelle-Zélande] ; Andrew A. Harrison ; Lisa K. Stamp ; Nicola Dalbeth [Nouvelle-Zélande] ; Tony R. Merriman [Nouvelle-Zélande]Source :
- Rheumatology (Oxford, England) [ 1462-0332 ] ; 2016.
Descripteurs français
- KwdFr :
- Acide urique (métabolisme), Adulte, Adulte d'âge moyen, Apolipoprotéine A-I (génétique), Apolipoprotéine C-III (génétique), Apolipoprotéines C (génétique), Facteurs de risque, Famille multigénique (génétique), Femelle, Goutte (génétique), Génotype, Humains, Mâle, Population d'origine européenne (génétique), Population d'origine océanique (génétique), Études cas-témoins.
- MESH :
- génétique : Apolipoprotéine A-I, Apolipoprotéine C-III, Apolipoprotéines C, Famille multigénique, Goutte, Population d'origine européenne, Population d'origine océanique.
- métabolisme : Acide urique.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Génotype, Humains, Mâle, Études cas-témoins.
English descriptors
- KwdEn :
- Adult, Apolipoprotein A-I (genetics), Apolipoprotein C-III (genetics), Apolipoproteins C (genetics), Case-Control Studies, European Continental Ancestry Group (genetics), Female, Genotype, Gout (genetics), Humans, Male, Middle Aged, Multigene Family (genetics), Oceanic Ancestry Group (genetics), Risk Factors, Uric Acid (metabolism).
- MESH :
- chemical , genetics : Apolipoprotein A-I, Apolipoprotein C-III, Apolipoproteins C.
- genetics : European Continental Ancestry Group, Gout, Multigene Family, Oceanic Ancestry Group.
- chemical , metabolism : Uric Acid.
- Adult, Case-Control Studies, Female, Genotype, Humans, Male, Middle Aged, Risk Factors.
Abstract
Gout is associated with dyslipidaemia. Association of the apolipoprotein A1-C3-A4 gene cluster with gout has previously been reported in a small study. To investigate a possible causal role for this locus in gout, we tested the association of genetic variants from APOA1 (rs670) and APOC3 (rs5128) with gout.
DOI: 10.1093/rheumatology/kew057
PubMed: 27094595
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Malcolm D. Smith<affiliation><nlm:affiliation>Department of Medicine, Flinders Medical Centre and Repatriation General Hospital, Adelaide.</nlm:affiliation><wicri:noCountry code="subField">Adelaide</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Rheumatology, Rijnstate Hospital, Arnhem.</nlm:affiliation><wicri:noCountry code="subField">Arnhem</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of IQ HealthCare, VieCuri Medical Centre, Venlo.</nlm:affiliation><wicri:noCountry code="subField">Venlo</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Surgery, University of Otago, Dunedin.</nlm:affiliation><wicri:noCountry code="subField">Dunedin</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Surgery, University of Otago, Dunedin.</nlm:affiliation><wicri:noCountry code="subField">Dunedin</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Medicine, University of Otago, Wellington.</nlm:affiliation><wicri:noCountry code="subField">Wellington</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Medicine, University of Otago, Christchurch.</nlm:affiliation><wicri:noCountry code="subField">Christchurch</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout.</title><author><name sortKey="Rasheed, Humaira" sort="Rasheed, Humaira" uniqKey="Rasheed H" first="Humaira" last="Rasheed">Humaira Rasheed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin, New Zealand Department of Chemistry, University of Engineering and Technology, Lahore</wicri:regionArea></affiliation></author><author><name sortKey="Phipps Green, Amanda J" sort="Phipps Green, Amanda J" uniqKey="Phipps Green A" first="Amanda J" last="Phipps-Green">Amanda J. Phipps-Green</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin</wicri:regionArea></affiliation></author><author><name sortKey="Topless, Ruth" sort="Topless, Ruth" uniqKey="Topless R" first="Ruth" last="Topless">Ruth Topless</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Malcolm D" sort="Smith, Malcolm D" uniqKey="Smith M" first="Malcolm D" last="Smith">Malcolm D. Smith</name><affiliation><nlm:affiliation>Department of Medicine, Flinders Medical Centre and Repatriation General Hospital, Adelaide.</nlm:affiliation><wicri:noCountry code="subField">Adelaide</wicri:noCountry></affiliation></author><author><name sortKey="Hill, Catherine" sort="Hill, Catherine" uniqKey="Hill C" first="Catherine" last="Hill">Catherine Hill</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA</wicri:regionArea></affiliation></author><author><name sortKey="Lester, Susan" sort="Lester, Susan" uniqKey="Lester S" first="Susan" last="Lester">Susan Lester</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA</wicri:regionArea></affiliation></author><author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA</wicri:regionArea></affiliation></author><author><name sortKey="Janssen, Matthijs" sort="Janssen, Matthijs" uniqKey="Janssen M" first="Matthijs" last="Janssen">Matthijs Janssen</name><affiliation><nlm:affiliation>Department of Rheumatology, Rijnstate Hospital, Arnhem.</nlm:affiliation><wicri:noCountry code="subField">Arnhem</wicri:noCountry></affiliation></author><author><name sortKey="Jansen, Timothy L" sort="Jansen, Timothy L" uniqKey="Jansen T" first="Timothy L" last="Jansen">Timothy L. Jansen</name><affiliation><nlm:affiliation>Department of IQ HealthCare, VieCuri Medical Centre, Venlo.</nlm:affiliation><wicri:noCountry code="subField">Venlo</wicri:noCountry></affiliation></author><author><name sortKey="Joosten, Leo A" sort="Joosten, Leo A" uniqKey="Joosten L" first="Leo A" last="Joosten">Leo A. Joosten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine and Radboud Institute of Molecular Life Science, Radboud University Medical Center, Nijmegen.</nlm:affiliation><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName><wicri:orgArea>Department of Internal Medicine and Radboud Institute of Molecular Life Science, Radboud University Medical Center</wicri:orgArea></affiliation></author><author><name sortKey="Radstake, Timothy R" sort="Radstake, Timothy R" uniqKey="Radstake T" first="Timothy R" last="Radstake">Timothy R. Radstake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Riches, Philip L" sort="Riches, Philip L" uniqKey="Riches P" first="Philip L" last="Riches">Philip L. Riches</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Tausche, Anne Kathrin" sort="Tausche, Anne Kathrin" uniqKey="Tausche A" first="Anne-Kathrin" last="Tausche">Anne-Kathrin Tausche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, University Clinic Carl-Gustav-Carus, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Rheumatology, University Clinic Carl-Gustav-Carus, Dresden</wicri:regionArea></affiliation></author><author><name sortKey="Liote, Frederic" sort="Liote, Frederic" uniqKey="Liote F" first="Frederic" last="Lioté">Frederic Lioté</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, UMR-S 1132, Hospital Lariboisière University Paris Diderot (UFR de Médecine), Sorbonne Paris Cité, Paris, F-75205, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR-S 1132, Hospital Lariboisière University Paris Diderot (UFR de Médecine), Sorbonne Paris Cité, Paris, F-75205</wicri:regionArea></affiliation></author><author><name sortKey="So, Alexander" sort="So, Alexander" uniqKey="So A" first="Alexander" last="So">Alexander So</name><affiliation wicri:level="1"><nlm:affiliation>DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV, Nestlé 05-5029, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV, Nestlé 05-5029, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Van Rij, Andre" sort="Van Rij, Andre" uniqKey="Van Rij A" first="Andre" last="Van Rij">Andre Van Rij</name><affiliation><nlm:affiliation>Department of Surgery, University of Otago, Dunedin.</nlm:affiliation><wicri:noCountry code="subField">Dunedin</wicri:noCountry></affiliation></author><author><name sortKey="Jones, Gregory T" sort="Jones, Gregory T" uniqKey="Jones G" first="Gregory T" last="Jones">Gregory T. Jones</name><affiliation><nlm:affiliation>Department of Surgery, University of Otago, Dunedin.</nlm:affiliation><wicri:noCountry code="subField">Dunedin</wicri:noCountry></affiliation></author><author><name sortKey="Mccormick, Sally P" sort="Mccormick, Sally P" uniqKey="Mccormick S" first="Sally P" last="Mccormick">Sally P. Mccormick</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin</wicri:regionArea></affiliation></author><author><name sortKey="Harrison, Andrew A" sort="Harrison, Andrew A" uniqKey="Harrison A" first="Andrew A" last="Harrison">Andrew A. Harrison</name><affiliation><nlm:affiliation>Department of Medicine, University of Otago, Wellington.</nlm:affiliation><wicri:noCountry code="subField">Wellington</wicri:noCountry></affiliation></author><author><name sortKey="Stamp, Lisa K" sort="Stamp, Lisa K" uniqKey="Stamp L" first="Lisa K" last="Stamp">Lisa K. Stamp</name><affiliation><nlm:affiliation>Department of Medicine, University of Otago, Christchurch.</nlm:affiliation><wicri:noCountry code="subField">Christchurch</wicri:noCountry></affiliation></author><author><name sortKey="Dalbeth, Nicola" sort="Dalbeth, Nicola" uniqKey="Dalbeth N" first="Nicola" last="Dalbeth">Nicola Dalbeth</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Auckland, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Auckland, Auckland</wicri:regionArea></affiliation></author><author><name sortKey="Merriman, Tony R" sort="Merriman, Tony R" uniqKey="Merriman T" first="Tony R" last="Merriman">Tony R. Merriman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand tony.merriman@otago.ac.nz.</nlm:affiliation><country wicri:rule="url">Nouvelle-Zélande</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27094595</idno><idno type="pmid">27094595</idno><idno type="doi">10.1093/rheumatology/kew057</idno><idno type="wicri:Area/PubMed/Corpus">001B47</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B47</idno><idno type="wicri:Area/PubMed/Curation">001B23</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout.</title><author><name sortKey="Rasheed, Humaira" sort="Rasheed, Humaira" uniqKey="Rasheed H" first="Humaira" last="Rasheed">Humaira Rasheed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin, New Zealand Department of Chemistry, University of Engineering and Technology, Lahore</wicri:regionArea></affiliation></author><author><name sortKey="Phipps Green, Amanda J" sort="Phipps Green, Amanda J" uniqKey="Phipps Green A" first="Amanda J" last="Phipps-Green">Amanda J. Phipps-Green</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin</wicri:regionArea></affiliation></author><author><name sortKey="Topless, Ruth" sort="Topless, Ruth" uniqKey="Topless R" first="Ruth" last="Topless">Ruth Topless</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Malcolm D" sort="Smith, Malcolm D" uniqKey="Smith M" first="Malcolm D" last="Smith">Malcolm D. Smith</name><affiliation><nlm:affiliation>Department of Medicine, Flinders Medical Centre and Repatriation General Hospital, Adelaide.</nlm:affiliation><wicri:noCountry code="subField">Adelaide</wicri:noCountry></affiliation></author><author><name sortKey="Hill, Catherine" sort="Hill, Catherine" uniqKey="Hill C" first="Catherine" last="Hill">Catherine Hill</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA</wicri:regionArea></affiliation></author><author><name sortKey="Lester, Susan" sort="Lester, Susan" uniqKey="Lester S" first="Susan" last="Lester">Susan Lester</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA</wicri:regionArea></affiliation></author><author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA</wicri:regionArea></affiliation></author><author><name sortKey="Janssen, Matthijs" sort="Janssen, Matthijs" uniqKey="Janssen M" first="Matthijs" last="Janssen">Matthijs Janssen</name><affiliation><nlm:affiliation>Department of Rheumatology, Rijnstate Hospital, Arnhem.</nlm:affiliation><wicri:noCountry code="subField">Arnhem</wicri:noCountry></affiliation></author><author><name sortKey="Jansen, Timothy L" sort="Jansen, Timothy L" uniqKey="Jansen T" first="Timothy L" last="Jansen">Timothy L. Jansen</name><affiliation><nlm:affiliation>Department of IQ HealthCare, VieCuri Medical Centre, Venlo.</nlm:affiliation><wicri:noCountry code="subField">Venlo</wicri:noCountry></affiliation></author><author><name sortKey="Joosten, Leo A" sort="Joosten, Leo A" uniqKey="Joosten L" first="Leo A" last="Joosten">Leo A. Joosten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine and Radboud Institute of Molecular Life Science, Radboud University Medical Center, Nijmegen.</nlm:affiliation><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName><wicri:orgArea>Department of Internal Medicine and Radboud Institute of Molecular Life Science, Radboud University Medical Center</wicri:orgArea></affiliation></author><author><name sortKey="Radstake, Timothy R" sort="Radstake, Timothy R" uniqKey="Radstake T" first="Timothy R" last="Radstake">Timothy R. Radstake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Riches, Philip L" sort="Riches, Philip L" uniqKey="Riches P" first="Philip L" last="Riches">Philip L. Riches</name><affiliation wicri:level="1"><nlm:affiliation>Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Tausche, Anne Kathrin" sort="Tausche, Anne Kathrin" uniqKey="Tausche A" first="Anne-Kathrin" last="Tausche">Anne-Kathrin Tausche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, University Clinic Carl-Gustav-Carus, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Rheumatology, University Clinic Carl-Gustav-Carus, Dresden</wicri:regionArea></affiliation></author><author><name sortKey="Liote, Frederic" sort="Liote, Frederic" uniqKey="Liote F" first="Frederic" last="Lioté">Frederic Lioté</name><affiliation wicri:level="1"><nlm:affiliation>INSERM, UMR-S 1132, Hospital Lariboisière University Paris Diderot (UFR de Médecine), Sorbonne Paris Cité, Paris, F-75205, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR-S 1132, Hospital Lariboisière University Paris Diderot (UFR de Médecine), Sorbonne Paris Cité, Paris, F-75205</wicri:regionArea></affiliation></author><author><name sortKey="So, Alexander" sort="So, Alexander" uniqKey="So A" first="Alexander" last="So">Alexander So</name><affiliation wicri:level="1"><nlm:affiliation>DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV, Nestlé 05-5029, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV, Nestlé 05-5029, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Van Rij, Andre" sort="Van Rij, Andre" uniqKey="Van Rij A" first="Andre" last="Van Rij">Andre Van Rij</name><affiliation><nlm:affiliation>Department of Surgery, University of Otago, Dunedin.</nlm:affiliation><wicri:noCountry code="subField">Dunedin</wicri:noCountry></affiliation></author><author><name sortKey="Jones, Gregory T" sort="Jones, Gregory T" uniqKey="Jones G" first="Gregory T" last="Jones">Gregory T. Jones</name><affiliation><nlm:affiliation>Department of Surgery, University of Otago, Dunedin.</nlm:affiliation><wicri:noCountry code="subField">Dunedin</wicri:noCountry></affiliation></author><author><name sortKey="Mccormick, Sally P" sort="Mccormick, Sally P" uniqKey="Mccormick S" first="Sally P" last="Mccormick">Sally P. Mccormick</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin</wicri:regionArea></affiliation></author><author><name sortKey="Harrison, Andrew A" sort="Harrison, Andrew A" uniqKey="Harrison A" first="Andrew A" last="Harrison">Andrew A. Harrison</name><affiliation><nlm:affiliation>Department of Medicine, University of Otago, Wellington.</nlm:affiliation><wicri:noCountry code="subField">Wellington</wicri:noCountry></affiliation></author><author><name sortKey="Stamp, Lisa K" sort="Stamp, Lisa K" uniqKey="Stamp L" first="Lisa K" last="Stamp">Lisa K. Stamp</name><affiliation><nlm:affiliation>Department of Medicine, University of Otago, Christchurch.</nlm:affiliation><wicri:noCountry code="subField">Christchurch</wicri:noCountry></affiliation></author><author><name sortKey="Dalbeth, Nicola" sort="Dalbeth, Nicola" uniqKey="Dalbeth N" first="Nicola" last="Dalbeth">Nicola Dalbeth</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Auckland, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, University of Auckland, Auckland</wicri:regionArea></affiliation></author><author><name sortKey="Merriman, Tony R" sort="Merriman, Tony R" uniqKey="Merriman T" first="Tony R" last="Merriman">Tony R. Merriman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand tony.merriman@otago.ac.nz.</nlm:affiliation><country wicri:rule="url">Nouvelle-Zélande</country><wicri:regionArea>Department of Biochemistry, University of Otago, Dunedin</wicri:regionArea></affiliation></author></analytic><series><title level="j">Rheumatology (Oxford, England)</title><idno type="eISSN">1462-0332</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Apolipoprotein A-I (genetics)</term><term>Apolipoprotein C-III (genetics)</term><term>Apolipoproteins C (genetics)</term><term>Case-Control Studies</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Genotype</term><term>Gout (genetics)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multigene Family (genetics)</term><term>Oceanic Ancestry Group (genetics)</term><term>Risk Factors</term><term>Uric Acid (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide urique (métabolisme)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Apolipoprotéine A-I (génétique)</term><term>Apolipoprotéine C-III (génétique)</term><term>Apolipoprotéines C (génétique)</term><term>Facteurs de risque</term><term>Famille multigénique (génétique)</term><term>Femelle</term><term>Goutte (génétique)</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Population d'origine européenne (génétique)</term><term>Population d'origine océanique (génétique)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoprotein A-I</term><term>Apolipoprotein C-III</term><term>Apolipoproteins C</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term><term>Gout</term><term>Multigene Family</term><term>Oceanic Ancestry Group</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéine A-I</term><term>Apolipoprotéine C-III</term><term>Apolipoprotéines C</term><term>Famille multigénique</term><term>Goutte</term><term>Population d'origine européenne</term><term>Population d'origine océanique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Uric Acid</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide urique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gout is associated with dyslipidaemia. Association of the apolipoprotein A1-C3-A4 gene cluster with gout has previously been reported in a small study. To investigate a possible causal role for this locus in gout, we tested the association of genetic variants from APOA1 (rs670) and APOC3 (rs5128) with gout.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27094595</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>25</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>06</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1462-0332</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>8</Issue><PubDate><Year>2016</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Rheumatology (Oxford, England)</Title><ISOAbbreviation>Rheumatology (Oxford)</ISOAbbreviation></Journal><ArticleTitle>Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout.</ArticleTitle><Pagination><MedlinePgn>1421-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/rheumatology/kew057</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Gout is associated with dyslipidaemia. Association of the apolipoprotein A1-C3-A4 gene cluster with gout has previously been reported in a small study. To investigate a possible causal role for this locus in gout, we tested the association of genetic variants from APOA1 (rs670) and APOC3 (rs5128) with gout.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We studied data for 2452 controls and 2690 clinically ascertained gout cases of European and New Zealand Polynesian (Māori and Pacific) ancestry. Data were also used from the publicly available Atherosclerosis Risk in Communities study (n = 5367) and the Framingham Heart Study (n = 2984). Multivariate adjusted logistic and linear regression was used to test the association of single-nucleotide polymorphisms with gout risk, serum urate, triglyceride and high-density lipoprotein cholesterol (HDL-C).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In Polynesians, the T-allele of rs670 (APOA1) increased (odds ratio, OR = 1.53, P = 4.9 × 10(-6)) and the G-allele of rs5128 (APOC3) decreased the risk of gout (OR = 0.86, P = 0.026). In Europeans, there was a strong trend to a risk effect of the T-allele for rs670 (OR = 1.11, P = 0.055), with a significant protective effect of the G-allele for rs5128 being observed after adjustment for triglycerides and HDL-C (OR = 0.81, P = 0.039). The effect at rs5128 was specific to males in both Europeans and Polynesians. Association in Polynesians was independent of any effect of rs670 and rs5128 on triglyceride and HDL-C levels. There was no evidence for association of either single-nucleotide polymorphism with serum urate levels (P ⩾ 0.10).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our data, replicating a previous study, supports the hypothesis that the apolipoprotein A1-C3-A4 gene cluster plays a causal role in gout.</AbstractText><CopyrightInformation>© The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rasheed</LastName><ForeName>Humaira</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phipps-Green</LastName><ForeName>Amanda J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Topless</LastName><ForeName>Ruth</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Malcolm D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Medicine, Flinders Medical Centre and Repatriation General Hospital, Adelaide.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lester</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rischmueller</LastName><ForeName>Maureen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janssen</LastName><ForeName>Matthijs</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Rijnstate Hospital, Arnhem.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jansen</LastName><ForeName>Timothy L</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Department of IQ HealthCare, VieCuri Medical Centre, Venlo.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joosten</LastName><ForeName>Leo A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Radboud Institute of Molecular Life Science, Radboud University Medical Center, Nijmegen.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Radstake</LastName><ForeName>Timothy R</ForeName><Initials>TR</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riches</LastName><ForeName>Philip L</ForeName><Initials>PL</Initials><AffiliationInfo><Affiliation>Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tausche</LastName><ForeName>Anne-Kathrin</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, University Clinic Carl-Gustav-Carus, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lioté</LastName><ForeName>Frederic</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM, UMR-S 1132, Hospital Lariboisière University Paris Diderot (UFR de Médecine), Sorbonne Paris Cité, Paris, F-75205, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>So</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>DAL, Service of Rheumatology, Laboratory of Rheumatology, University of Lausanne, CHUV, Nestlé 05-5029, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Rij</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Otago, Dunedin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Gregory T</ForeName><Initials>GT</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Otago, Dunedin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCormick</LastName><ForeName>Sally P</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harrison</LastName><ForeName>Andrew A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Otago, Wellington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stamp</LastName><ForeName>Lisa K</ForeName><Initials>LK</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Otago, Christchurch.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalbeth</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Auckland, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merriman</LastName><ForeName>Tony R</ForeName><Initials>TR</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Otago, Dunedin, New Zealand tony.merriman@otago.ac.nz.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Rheumatology (Oxford)</MedlineTA><NlmUniqueID>100883501</NlmUniqueID><ISSNLinking>1462-0324</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C505693">APOA1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C097349">APOC4 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016632">Apolipoprotein A-I</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053305">Apolipoprotein C-III</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001056">Apolipoproteins C</NameOfSubstance></Chemical><Chemical><RegistryNumber>268B43MJ25</RegistryNumber><NameOfSubstance UI="D014527">Uric Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016632" MajorTopicYN="N">Apolipoprotein A-I</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053305" MajorTopicYN="N">Apolipoprotein C-III</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001056" MajorTopicYN="N">Apolipoproteins C</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044465" MajorTopicYN="N">European Continental Ancestry Group</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006073" MajorTopicYN="N">Gout</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005810" MajorTopicYN="N">Multigene Family</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044468" MajorTopicYN="N">Oceanic Ancestry Group</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014527" MajorTopicYN="N">Uric Acid</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">apolipoprotein</Keyword><Keyword MajorTopicYN="N">association</Keyword><Keyword MajorTopicYN="N">gene</Keyword><Keyword MajorTopicYN="N">gout</Keyword><Keyword MajorTopicYN="N">hyperuricaemia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27094595</ArticleId><ArticleId IdType="pii">kew057</ArticleId><ArticleId IdType="doi">10.1093/rheumatology/kew057</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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