Intratracheal Administration of Antimicrobial Agents in Mechanically Ventilated Adults: An International Survey on Delivery Practices and Safety.
Identifieur interne : 001A44 ( PubMed/Curation ); précédent : 001A43; suivant : 001A45Intratracheal Administration of Antimicrobial Agents in Mechanically Ventilated Adults: An International Survey on Delivery Practices and Safety.
Auteurs : Candela Solé-Lleonart [Espagne] ; Jean-Jacques Rouby [France] ; Jean Chastre [France] ; Garyfallia Poulakou [Grèce] ; Lucy B. Palmer [États-Unis] ; Stijn Blot [Belgique] ; Tim Felton [Royaume-Uni] ; Matteo Bassetti [Italie] ; Charles-Eduard Luyt [France] ; Joao Manuel Pereira [Portugal] ; Jordi Riera [Espagne] ; Tobias Welte [Allemagne] ; Jason A. Roberts [Australie] ; Jordi Rello [Espagne]Source :
- Respiratory care [ 1943-3654 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Anti-infectieux (administration et posologie), Enquêtes et questionnaires, Femelle, Humains, Intubation trachéale (), Intubation trachéale (normes), Mâle, Nébuliseurs et vaporisateurs (utilisation), Systèmes de délivrance de médicaments (), Systèmes de délivrance de médicaments (normes), Unités de soins intensifs (), Unités de soins intensifs (normes), Ventilation artificielle (), Ventilation artificielle (normes).
- MESH :
- administration et posologie : Anti-infectieux.
- normes : Intubation trachéale, Systèmes de délivrance de médicaments, Unités de soins intensifs, Ventilation artificielle.
- utilisation : Nébuliseurs et vaporisateurs.
- Adulte, Enquêtes et questionnaires, Femelle, Humains, Intubation trachéale, Mâle, Systèmes de délivrance de médicaments, Unités de soins intensifs, Ventilation artificielle.
English descriptors
- KwdEn :
- Adult, Anti-Infective Agents (administration & dosage), Drug Delivery Systems (methods), Drug Delivery Systems (standards), Drug Delivery Systems (statistics & numerical data), Female, Humans, Intensive Care Units (standards), Intensive Care Units (statistics & numerical data), Intubation, Intratracheal (methods), Intubation, Intratracheal (standards), Intubation, Intratracheal (statistics & numerical data), Male, Nebulizers and Vaporizers (utilization), Respiration, Artificial (standards), Respiration, Artificial (statistics & numerical data), Surveys and Questionnaires.
- MESH :
- chemical , administration & dosage : Anti-Infective Agents.
- methods : Drug Delivery Systems, Intubation, Intratracheal.
- standards : Drug Delivery Systems, Intensive Care Units, Intubation, Intratracheal, Respiration, Artificial.
- statistics & numerical data : Drug Delivery Systems, Intensive Care Units, Intubation, Intratracheal, Respiration, Artificial.
- utilization : Nebulizers and Vaporizers.
- Adult, Female, Humans, Male, Surveys and Questionnaires.
Abstract
Intratracheal antibiotic administration is increasingly used for treating respiratory infections. Limited information is available on delivery devices, techniques, and safety.
DOI: 10.4187/respcare.04519
PubMed: 26957647
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Roberts</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, University of Queensland, Butterfield Street, Herston, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, University of Queensland, Butterfield Street, Herston, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name><affiliation wicri:level="1"><nlm:affiliation>Vall d'Hebron University Hospital, CIBERES, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona, Spain. jrello@crips.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital, CIBERES, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26957647</idno><idno type="pmid">26957647</idno><idno type="doi">10.4187/respcare.04519</idno><idno type="wicri:Area/PubMed/Corpus">001A68</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A68</idno><idno type="wicri:Area/PubMed/Curation">001A44</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Intratracheal Administration of Antimicrobial Agents in Mechanically Ventilated Adults: An International Survey on Delivery Practices and Safety.</title><author><name sortKey="Sole Lleonart, Candela" sort="Sole Lleonart, Candela" uniqKey="Sole Lleonart C" first="Candela" last="Solé-Lleonart">Candela Solé-Lleonart</name><affiliation wicri:level="1"><nlm:affiliation>University of Toronto, UHN & Mount Sinai Hospital, Toronto, Canada and Universitat Autonoma de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University of Toronto, UHN & Mount Sinai Hospital, Toronto, Canada and Universitat Autonoma de Barcelona, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Rouby, Jean Jacques" sort="Rouby, Jean Jacques" uniqKey="Rouby J" first="Jean-Jacques" last="Rouby">Jean-Jacques Rouby</name><affiliation wicri:level="1"><nlm:affiliation>Multidisciplinary Intensive Care Unit, Department of Anesthesiology and Critical Care, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie (UPMC) of Paris 6, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Multidisciplinary Intensive Care Unit, Department of Anesthesiology and Critical Care, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie (UPMC) of Paris 6, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name><affiliation wicri:level="1"><nlm:affiliation>Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Poulakou, Garyfallia" sort="Poulakou, Garyfallia" uniqKey="Poulakou G" first="Garyfallia" last="Poulakou">Garyfallia Poulakou</name><affiliation wicri:level="1"><nlm:affiliation>4th Department of Internal Medicine, Athens University School of Medicine, Attikon University General Hospital, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>4th Department of Internal Medicine, Athens University School of Medicine, Attikon University General Hospital, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Palmer, Lucy B" sort="Palmer, Lucy B" uniqKey="Palmer L" first="Lucy B" last="Palmer">Lucy B. Palmer</name><affiliation wicri:level="2"><nlm:affiliation>Pulmonary, Critical Care, and Sleep Division, Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Pulmonary, Critical Care, and Sleep Division, Department of Medicine, State University of New York at Stony Brook, Stony Brook</wicri:cityArea></affiliation></author><author><name sortKey="Blot, Stijn" sort="Blot, Stijn" uniqKey="Blot S" first="Stijn" last="Blot">Stijn Blot</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Faculty of Medicine and Health Science, Ghent University, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medicine and Health Science, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Felton, Tim" sort="Felton, Tim" uniqKey="Felton T" first="Tim" last="Felton">Tim Felton</name><affiliation wicri:level="1"><nlm:affiliation>Acute Intensive Care Unit, University Hospital of South Manchester, Manchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Acute Intensive Care Unit, University Hospital of South Manchester, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Division, Santa Maria Misericordia University Hospital, Udine, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Diseases Division, Santa Maria Misericordia University Hospital, Udine</wicri:regionArea></affiliation></author><author><name sortKey="Luyt, Charles Eduard" sort="Luyt, Charles Eduard" uniqKey="Luyt C" first="Charles-Eduard" last="Luyt">Charles-Eduard Luyt</name><affiliation wicri:level="1"><nlm:affiliation>Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Pereira, Joao Manuel" sort="Pereira, Joao Manuel" uniqKey="Pereira J" first="Joao Manuel" last="Pereira">Joao Manuel Pereira</name><affiliation wicri:level="1"><nlm:affiliation>Emergency and Intensive Care Department, Centro Hospitalar S João EPE, University of Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Emergency and Intensive Care Department, Centro Hospitalar S João EPE, University of Porto, Porto</wicri:regionArea></affiliation></author><author><name sortKey="Riera, Jordi" sort="Riera, Jordi" uniqKey="Riera J" first="Jordi" last="Riera">Jordi Riera</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Department, Vall d'Hebron University Hospital, Centro Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Vall d'Hebron Institute of Research, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Critical Care Department, Vall d'Hebron University Hospital, Centro Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Vall d'Hebron Institute of Research, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary Medicine, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pulmonary Medicine, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, University of Queensland, Butterfield Street, Herston, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, University of Queensland, Butterfield Street, Herston, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name><affiliation wicri:level="1"><nlm:affiliation>Vall d'Hebron University Hospital, CIBERES, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona, Spain. jrello@crips.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital, CIBERES, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona</wicri:regionArea></affiliation></author></analytic><series><title level="j">Respiratory care</title><idno type="eISSN">1943-3654</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anti-Infective Agents (administration & dosage)</term><term>Drug Delivery Systems (methods)</term><term>Drug Delivery Systems (standards)</term><term>Drug Delivery Systems (statistics & numerical data)</term><term>Female</term><term>Humans</term><term>Intensive Care Units (standards)</term><term>Intensive Care Units (statistics & numerical data)</term><term>Intubation, Intratracheal (methods)</term><term>Intubation, Intratracheal (standards)</term><term>Intubation, Intratracheal (statistics & numerical data)</term><term>Male</term><term>Nebulizers and Vaporizers (utilization)</term><term>Respiration, Artificial (standards)</term><term>Respiration, Artificial (statistics & numerical data)</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anti-infectieux (administration et posologie)</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Humains</term><term>Intubation trachéale ()</term><term>Intubation trachéale (normes)</term><term>Mâle</term><term>Nébuliseurs et vaporisateurs (utilisation)</term><term>Systèmes de délivrance de médicaments ()</term><term>Systèmes de délivrance de médicaments (normes)</term><term>Unités de soins intensifs ()</term><term>Unités de soins intensifs (normes)</term><term>Ventilation artificielle ()</term><term>Ventilation artificielle (normes)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Infective Agents</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anti-infectieux</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Delivery Systems</term><term>Intubation, Intratracheal</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Intubation trachéale</term><term>Systèmes de délivrance de médicaments</term><term>Unités de soins intensifs</term><term>Ventilation artificielle</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Drug Delivery Systems</term><term>Intensive Care Units</term><term>Intubation, Intratracheal</term><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Drug Delivery Systems</term><term>Intensive Care Units</term><term>Intubation, Intratracheal</term><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="utilisation" xml:lang="fr"><term>Nébuliseurs et vaporisateurs</term></keywords><keywords scheme="MESH" qualifier="utilization" xml:lang="en"><term>Nebulizers and Vaporizers</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Humains</term><term>Intubation trachéale</term><term>Mâle</term><term>Systèmes de délivrance de médicaments</term><term>Unités de soins intensifs</term><term>Ventilation artificielle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intratracheal antibiotic administration is increasingly used for treating respiratory infections. Limited information is available on delivery devices, techniques, and safety.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26957647</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>25</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1943-3654</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><Issue>8</Issue><PubDate><Year>2016</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Respiratory care</Title><ISOAbbreviation>Respir Care</ISOAbbreviation></Journal><ArticleTitle>Intratracheal Administration of Antimicrobial Agents in Mechanically Ventilated Adults: An International Survey on Delivery Practices and Safety.</ArticleTitle><Pagination><MedlinePgn>1008-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4187/respcare.04519</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Intratracheal antibiotic administration is increasingly used for treating respiratory infections. Limited information is available on delivery devices, techniques, and safety.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">An online survey on intratracheal administration of anti-infective agents in mechanically ventilated adults was answered by health-care workers from 192 ICUs to assess the most commonly used devices, current delivery practices, and safety issues. We investigated whether ICU usage experience (≥3 y) impacted its performance.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Intratracheal antibiotic administration was a current practice in 87 ICUs (45.3%), with 40 (46%) having experience with the technique (≥3 y). Sixty-six (78.6%) of 84 health-care workers reported avoiding intratracheal antibiotic administration due to an absence of evidence-based guidelines (78.6%). Jet nebulizers were the most commonly used devices for delivery, in 24 less experienced ICUs (27.6%) and in 18 (20.7%) experienced ICUs. Direct tracheal instillation (6; 6.9%) was still considered for drug prescription in 12 ICUs (6.9%). More experience resulted in neither greater adherence to measures improving the drug's delivery efficiency (93 measures in the experienced group; 27.9%) nor a greater adoption of measures to increase safety. Indeed, the expiratory filter was changed after each nebulization in only 2 experienced ICUs (6.9%), whereas 15 (51.7%) changed it daily instead.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Intratracheal antibiotic administration is a common therapeutic modality in ICUs, but inadequate practices were widely encountered, independent of the level of experience with the technique. This suggests a need to develop standardization to reduce variability and improve safety and efficacy.</AbstractText><CopyrightInformation>Copyright © 2016 by Daedalus Enterprises.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Solé-Lleonart</LastName><ForeName>Candela</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Toronto, UHN & Mount Sinai Hospital, Toronto, Canada and Universitat Autonoma de Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouby</LastName><ForeName>Jean-Jacques</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Multidisciplinary Intensive Care Unit, Department of Anesthesiology and Critical Care, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie (UPMC) of Paris 6, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chastre</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poulakou</LastName><ForeName>Garyfallia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>4th Department of Internal Medicine, Athens University School of Medicine, Attikon University General Hospital, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palmer</LastName><ForeName>Lucy B</ForeName><Initials>LB</Initials><AffiliationInfo><Affiliation>Pulmonary, Critical Care, and Sleep Division, Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blot</LastName><ForeName>Stijn</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medicine and Health Science, Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Felton</LastName><ForeName>Tim</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Acute Intensive Care Unit, University Hospital of South Manchester, Manchester, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bassetti</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Infectious Diseases Division, Santa Maria Misericordia University Hospital, Udine, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luyt</LastName><ForeName>Charles-Eduard</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie of Paris, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pereira</LastName><ForeName>Joao Manuel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Emergency and Intensive Care Department, Centro Hospitalar S João EPE, University of Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riera</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Critical Care Department, Vall d'Hebron University Hospital, Centro Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Vall d'Hebron Institute of Research, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Welte</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Medicine, Hannover Medical School, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roberts</LastName><ForeName>Jason A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Burns Trauma and Critical Care Research Centre, University of Queensland, Butterfield Street, Herston, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rello</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Vall d'Hebron University Hospital, CIBERES, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Barcelona, Spain. jrello@crips.es.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G1000417</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Respir Care</MedlineTA><NlmUniqueID>7510357</NlmUniqueID><ISSNLinking>0020-1324</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000890">Anti-Infective Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Respir Care. 2016 Aug;61(8):1131-2</RefSource><PMID Version="1">27451375</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000890" MajorTopicYN="N">Anti-Infective Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016503" MajorTopicYN="N">Drug Delivery Systems</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName><QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007442" MajorTopicYN="N">Intubation, Intratracheal</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009330" MajorTopicYN="N">Nebulizers and Vaporizers</DescriptorName><QualifierName UI="Q000656" MajorTopicYN="N">utilization</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName><QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">aerosol therapy</Keyword><Keyword MajorTopicYN="N">antibiotics</Keyword><Keyword MajorTopicYN="N">delivery device</Keyword><Keyword MajorTopicYN="N">nebulizer</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26957647</ArticleId><ArticleId IdType="pii">respcare.04519</ArticleId><ArticleId IdType="doi">10.4187/respcare.04519</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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